AR005353A1 - Formulacion de hormona para crecimiento animal de liberacion sostenida, y un procedimiento para la preparacion de la misma - Google Patents
Formulacion de hormona para crecimiento animal de liberacion sostenida, y un procedimiento para la preparacion de la mismaInfo
- Publication number
- AR005353A1 AR005353A1 ARP970100022A ARP970100022A AR005353A1 AR 005353 A1 AR005353 A1 AR 005353A1 AR P970100022 A ARP970100022 A AR P970100022A AR P970100022 A ARP970100022 A AR P970100022A AR 005353 A1 AR005353 A1 AR 005353A1
- Authority
- AR
- Argentina
- Prior art keywords
- formulation
- animal growth
- preparation
- sustained release
- growth hormone
- Prior art date
Links
- 238000009472 formulation Methods 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 4
- 238000002360 preparation method Methods 0.000 title abstract 2
- 238000013268 sustained release Methods 0.000 title abstract 2
- 239000012730 sustained-release form Substances 0.000 title abstract 2
- 229940088597 hormone Drugs 0.000 title 1
- 239000005556 hormone Substances 0.000 title 1
- 102000018997 Growth Hormone Human genes 0.000 abstract 4
- 108010051696 Growth Hormone Proteins 0.000 abstract 4
- 239000000122 growth hormone Substances 0.000 abstract 3
- 239000011248 coating agent Substances 0.000 abstract 2
- 238000000576 coating method Methods 0.000 abstract 2
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 2
- 239000006187 pill Substances 0.000 abstract 2
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 abstract 1
- 229920002988 biodegradable polymer Polymers 0.000 abstract 1
- 239000004621 biodegradable polymer Substances 0.000 abstract 1
- 230000002844 continuous effect Effects 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229960000502 poloxamer Drugs 0.000 abstract 1
- 229920001983 poloxamer Polymers 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Endocrinology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Una formulación de hormona para crecimiento animal de liberación sostenida, y un procedimiento para la preparación de la misma, donde la formulacióncomprende una tableta o píldora que contiene una hormona de crecimiento animal y un excipiente,estan do la tableta recubierta por una película de un polímerobiodegradable y un poloxámero, y dicho procedimiento comprende la producción de dichas tabletas sólidas mediante la mezcla de la hormona de crecimiento animaly un excipiente de acuerdocon un mé todo directo de formación de tabletas y una etapa para recubrir las tabletas con dicha película. La formulación asíobtenida presenta una pequena liberación inicial de droga y muestra un efecto uniforme y contínuo cuando es suministrada.La figura 1 muestra las curvas de compensación de la disolución de somatotropina entre las píldoras recubiertas de la presente invención y quellos sin recubrimiento.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019960000341A KR100210509B1 (ko) | 1996-01-10 | 1996-01-10 | 지속성 동물 성장 호르몬 제형 및 이의 제조 방법 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR005353A1 true AR005353A1 (es) | 1999-04-28 |
Family
ID=19449212
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970100022A AR005353A1 (es) | 1996-01-10 | 1997-01-03 | Formulacion de hormona para crecimiento animal de liberacion sostenida, y un procedimiento para la preparacion de la misma |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5744163A (es) |
| JP (1) | JP2896355B2 (es) |
| KR (1) | KR100210509B1 (es) |
| CN (1) | CN1096869C (es) |
| AR (1) | AR005353A1 (es) |
| AU (1) | AU679150B1 (es) |
| BR (1) | BR9605907A (es) |
| CA (1) | CA2194610C (es) |
| DK (1) | DK3497A (es) |
| ID (1) | ID18535A (es) |
| TW (1) | TW457099B (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69827650T2 (de) * | 1997-09-09 | 2005-11-03 | Alza Corp., Mountain View | Pharmazeutische Überzugszusammensetzung und Verfahren zum Beschichten einer Dosierungsform hiermit |
| EP1053020B1 (en) * | 1998-01-29 | 2004-03-31 | Poly-Med Inc. | Absorbable microparticles |
| US7767708B2 (en) * | 1998-11-04 | 2010-08-03 | Schering-Plough Animal Health Corp. | Growth stimulant compositions |
| TW200800298A (en) | 2000-01-27 | 2008-01-01 | Zentaris Ag | Compressed microparticles for dry injection |
| KR20080011353A (ko) | 2000-02-24 | 2008-02-01 | 몬산토 테크놀로지 엘엘씨 | 소마토트로핀의 지속적인 방출을 위한 비수성 주사제제들 |
| MXPA03000073A (es) * | 2000-06-26 | 2003-09-25 | Monsanto Technology Llc | Formulaciones que contienen agente tensioactivo no acuoso para la liberacion prolongada de somatrotopina. |
| US6664234B1 (en) * | 2000-06-30 | 2003-12-16 | Monsanto Technology Llc | Non-aqueous injectable formulation preparation with pH adjusted for extended release of somatotropin |
| AUPR602401A0 (en) * | 2001-06-29 | 2001-07-26 | Smart Drug Systems Inc | Sustained release delivery system |
| CA2459333A1 (en) * | 2001-09-07 | 2003-03-20 | Pharmacia & Upjohn Company | A pellet implant system and method of administration |
| AU2004216298B2 (en) * | 2003-02-28 | 2009-04-23 | Chugai Seiyaku Kabushiki Kaisha | Stabilized protein-containing formulations |
| US20050008610A1 (en) | 2003-03-24 | 2005-01-13 | Alexander Schwarz | Temporary embolization using inverse thermosensitive polymers |
| WO2005046438A2 (en) * | 2003-11-06 | 2005-05-26 | Pluromed, Inc. | Internal clamp for surgical procedures |
| AR073435A1 (es) * | 2006-10-18 | 2010-11-10 | Senosiain S A De C V Lab | Composicion farmaceutica de liberacion modificada de un musculo relajante y un aine |
| GB0812742D0 (en) * | 2008-07-11 | 2008-08-20 | Critical Pharmaceuticals Ltd | Process |
| GB0812740D0 (en) * | 2008-07-11 | 2008-08-20 | Critical Pharmaceuticals Ltd | Composition |
| CN104017063A (zh) | 2009-12-21 | 2014-09-03 | Ambrx公司 | 经过修饰的猪促生长素多肽和其用途 |
| NZ600361A (en) | 2009-12-21 | 2014-06-27 | Ambrx Inc | Modified bovine somatotropin polypeptides and their uses |
| CN108465104A (zh) * | 2018-03-07 | 2018-08-31 | 佛山实瑞先导材料研究院（普通合伙） | 一种生长激素控释包衣及其制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US531707A (en) * | 1895-01-01 | Brush for dynamo-electric machines | ||
| US5317079A (en) * | 1990-01-19 | 1994-05-31 | Nova Pharmaceutical Corporation | Fatty acid terminated polyanhydride |
| US5091185A (en) * | 1990-06-20 | 1992-02-25 | Monsanto Company | Coated veterinary implants |
| AU1442592A (en) * | 1991-02-20 | 1992-09-15 | Nova Pharmaceutical Corporation | Controlled release microparticulate delivery system for proteins |
| US5328697A (en) * | 1992-02-10 | 1994-07-12 | Mallinckrodt Veterinary, Inc. | Compositions and processes for the sustained release of drugs |
| DK0674506T3 (da) * | 1992-12-02 | 2001-01-08 | Alkermes Inc | Væksthormonholdige mikrosfærer med styret frigivelse |
-
1996
- 1996-01-10 KR KR1019960000341A patent/KR100210509B1/ko not_active IP Right Cessation
- 1996-11-12 AU AU71725/96A patent/AU679150B1/en not_active Ceased
- 1996-11-13 US US08/749,912 patent/US5744163A/en not_active Expired - Fee Related
- 1996-11-14 TW TW085113956A patent/TW457099B/zh not_active IP Right Cessation
- 1996-12-09 BR BR9605907A patent/BR9605907A/pt not_active Application Discontinuation
- 1996-12-11 ID IDP963691A patent/ID18535A/id unknown
-
1997
- 1997-01-02 CN CN97100326A patent/CN1096869C/zh not_active Expired - Fee Related
- 1997-01-03 AR ARP970100022A patent/AR005353A1/es not_active Application Discontinuation
- 1997-01-08 CA CA002194610A patent/CA2194610C/en not_active Expired - Fee Related
- 1997-01-09 JP JP9001883A patent/JP2896355B2/ja not_active Expired - Fee Related
- 1997-01-10 DK DK003497A patent/DK3497A/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2194610C (en) | 1999-05-11 |
| KR970058724A (ko) | 1997-08-12 |
| US5744163A (en) | 1998-04-28 |
| AU679150B1 (en) | 1997-06-19 |
| DK3497A (da) | 1997-07-11 |
| KR100210509B1 (ko) | 1999-07-15 |
| JP2896355B2 (ja) | 1999-05-31 |
| CN1160584A (zh) | 1997-10-01 |
| BR9605907A (pt) | 1998-08-18 |
| TW457099B (en) | 2001-10-01 |
| MX9605929A (es) | 1998-05-31 |
| JPH09194348A (ja) | 1997-07-29 |
| CN1096869C (zh) | 2002-12-25 |
| CA2194610A1 (en) | 1997-07-11 |
| ID18535A (id) | 1998-04-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |