HUP0105124A2 - 1-(6-Metil-piridin-3-il)-2-[4-metilszulfonil)-fenil]-etanon és eljárás az előállítására - Google Patents

1-(6-Metil-piridin-3-il)-2-[4-metilszulfonil)-fenil]-etanon és eljárás az előállítására

Info

Publication number
HUP0105124A2
HUP0105124A2 HU0105124A HUP0105124A HUP0105124A2 HU P0105124 A2 HUP0105124 A2 HU P0105124A2 HU 0105124 A HU0105124 A HU 0105124A HU P0105124 A HUP0105124 A HU P0105124A HU P0105124 A2 HUP0105124 A2 HU P0105124A2
Authority
HU
Hungary
Prior art keywords
methylsulfonyl
methyl
ethanone
preparation
formula
Prior art date
Application number
HU0105124A
Other languages
English (en)
Inventor
Erich Armbruster
Yves Bessard
David Kuo
James Edward Leresche
Ralf Proplesch
Jean-Paul Roduit
Original Assignee
Lonza Ag.
Merck & Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza Ag., Merck & Co., Inc. filed Critical Lonza Ag.
Publication of HUP0105124A2 publication Critical patent/HUP0105124A2/hu
Publication of HUP0105124A3 publication Critical patent/HUP0105124A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

A tal lm ny az (I) képletű 1-(6-Metil-piridin-3-il)-2-[4-metilszulfonil)-fend]-etanonra, valamint elő llít s ra alkalmas elj rsra vonatkozik. A vegyület gyógy szati hatóanyagok elő llít s banintermedierként alkalmazható. Így llítj k elő, hogy 2-metil-5-vinil-piridint ózonnal kezelnek, majd reduk lnak, a kapott 2-metilpiridin-5-karbaldehidet dialkilaminnal és cianovegyülettel reag ltatj k és azígy kapott (III) ltal nos képletű N,N-dialkilamino-(6-metil-3-piridil)-acetonitrilt, amelynek képletében R1 és R2 jelentése azonosvagy kül"nb"ző és 1-4 szénatomos alkilcsoportot jelent, b zisjelenlétében 4-(metilszulfonil)-benzil-halogeniddel (I) képletű 1-(6-metil-piridin-3-il)-2-[(4-metilszulfonil)-fenil]-etanonn reag ltatj k. Ó
HU0105124A 1999-01-14 2000-01-13 1-(6-methylpyridine-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone and method for its preparation HUP0105124A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99100590 1999-01-14
US14599699P 1999-07-29 1999-07-29
PCT/EP2000/000240 WO2000042014A2 (de) 1999-01-14 2000-01-13 1-(6-methylpyridin-3-yl)-2-((4-(methylsulfonyl)phenyl)ethanon und verfahren zu seiner herstellung

Publications (2)

Publication Number Publication Date
HUP0105124A2 true HUP0105124A2 (hu) 2002-04-29
HUP0105124A3 HUP0105124A3 (en) 2002-05-28

Family

ID=34089809

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0105124A HUP0105124A3 (en) 1999-01-14 2000-01-13 1-(6-methylpyridine-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone and method for its preparation

Country Status (15)

Country Link
EP (2) EP1394149B1 (hu)
JP (1) JP4765167B2 (hu)
CN (2) CN1281589C (hu)
AT (2) ATE253559T1 (hu)
AU (1) AU2290800A (hu)
CA (2) CA2485739C (hu)
CZ (1) CZ302270B6 (hu)
DE (2) DE50009312D1 (hu)
DK (2) DK1159270T3 (hu)
ES (2) ES2235138T3 (hu)
HU (1) HUP0105124A3 (hu)
IL (1) IL143981A0 (hu)
PT (2) PT1159270E (hu)
SK (1) SK284903B6 (hu)
WO (1) WO2000042014A2 (hu)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104725300A (zh) * 2015-02-28 2015-06-24 宁波九胜创新医药科技有限公司 一种1-(6-甲基吡啶-3-基)-2-(4-甲磺酰基苯基)乙酮的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3313683A (en) * 1963-04-22 1967-04-11 Lilly Co Eli Nematocidal and fungicidal methods
FR2074674A1 (en) * 1970-01-16 1971-10-08 Simafex Sulphonamide/aldehyde-bisulphite complexes - antibacterials with very high solubility in water
US4155909A (en) * 1977-06-13 1979-05-22 Philip Morris Incorporated 2-Alkyl nicotinoids and processes for their production
US5596008A (en) * 1995-02-10 1997-01-21 G. D. Searle & Co. 3,4-Diaryl substituted pyridines for the treatment of inflammation
SI0912518T1 (en) * 1996-07-18 2003-12-31 Merck Frosst Canada & Co. Substituted pyridines as selective cyclooxygenase-2 inhibitors
TW492959B (en) * 1997-04-18 2002-07-01 Merck & Co Inc Process for making 2-aryl-3-aryl-5-halo pyridines useful as cox-2 inhibitors
AR015938A1 (es) * 1997-09-25 2001-05-30 Merck Sharp & Dohme Procedimiento para preparar diaril piridinas utiles como inhibidores cox-2 y compuesto intermediario
AU759469B2 (en) * 1998-04-24 2003-04-17 Merck Sharp & Dohme Corp. Process for synthesizing cox-2 inhibitors

Also Published As

Publication number Publication date
AU2290800A (en) 2000-08-01
PT1394149E (pt) 2005-05-31
EP1394149A1 (de) 2004-03-03
CN1170820C (zh) 2004-10-13
DK1159270T3 (da) 2004-02-23
CA2485739C (en) 2009-09-22
CZ20012457A3 (cs) 2002-01-16
CN1583723A (zh) 2005-02-23
DK1394149T3 (da) 2005-04-04
SK9722001A3 (en) 2001-12-03
WO2000042014A3 (de) 2000-12-07
PT1159270E (pt) 2004-03-31
SK284903B6 (sk) 2006-02-02
CA2485739A1 (en) 2000-07-20
DE50009312D1 (de) 2005-02-24
ES2209807T3 (es) 2004-07-01
EP1159270B1 (de) 2003-11-05
JP2003518002A (ja) 2003-06-03
EP1394149B1 (de) 2005-01-19
JP4765167B2 (ja) 2011-09-07
IL143981A0 (en) 2002-04-21
DE50004327D1 (de) 2003-12-11
CN1281589C (zh) 2006-10-25
ATE287396T1 (de) 2005-02-15
CA2359958C (en) 2006-04-04
HUP0105124A3 (en) 2002-05-28
CN1359374A (zh) 2002-07-17
CZ302270B6 (cs) 2011-01-19
CA2359958A1 (en) 2000-07-20
ES2235138T3 (es) 2005-07-01
WO2000042014A2 (de) 2000-07-20
EP1159270A2 (de) 2001-12-05
ATE253559T1 (de) 2003-11-15

Similar Documents

Publication Publication Date Title
ATE194604T1 (de) Nematizide mittel
HUP0303128A2 (hu) O-dezmetil-venlafaxin új szukcinátsója, eljárás az előállításukra, alkalmazása és ezt tartalmazó gyógyszerkészítmény
HUP0104856A2 (hu) Eljárás 5-cianoftalid előállítására
NO20020925L (no) N-heterosykliske derivater av NOS-inhibitorer
BR0309546A (pt) Composto, composição farmacêutica que compreende o mesmo, processo para a sua preparação e utilização e método para tratamento profilático ou terapêutico de diabetes do tipo ii
FI940105A (fi) Menetelmä sertraliinivälituotteiden valmistamiseksi
DK0790824T3 (da) 2,2-dichloralkancarboxylsyrer, fremgangsmåde til fremstilling deraf, lægemidler indeholdende disse og anvendelse af disse lægemidler til behandling af insulinresistens
ATE252097T1 (de) N-heterocyclische derivate als nos inhibitoren
PT1206484E (pt) Compostos e composicoes antipicornavirais, suas utilizacoes farmaceuticas e materiais para a sua sintese
ATE92928T1 (de) Imidazo(2,1-b)benzothiazole und ihre saeureadditionssalze, verfahren und zwischenprodukte zu ihrer herstellung, ihre verwendung als arzneimittel und diese enthaltende pharmazeutische zubereitungen.
HUP0105124A2 (hu) 1-(6-Metil-piridin-3-il)-2-[4-metilszulfonil)-fenil]-etanon és eljárás az előállítására
EE200200252A (et) Antikehade kasutamine vaktsiinidena, antikehi sisaldavad farmatseutilised kompositsioonid, meetod antikehapreparaadi valmistamiseks ja meetod farmatseutilise kompositsiooni valmistamiseks
PT1224455E (pt) Processo de separacao de um composto quimico ou biologico numa mistura de compostos similares por difusao num meio tal como um gel
NO20044466L (no) Plasma-karboksypeptidase B-inhibitorer
EA200100984A1 (ru) Новые кристаллические формы макролидного антибиотика
DE59108566D1 (de) Heteroarylmethylbenzole-Aromatasehemmer
ATE5191T1 (de) 1-(trihalogenmethyl-sulfenyl)-4-aryl-1,2,4triazolidin-5-one,verfahren zu ihrer herstellung, diese enthaltende fungizide und verfahren zur bekaempfung von pilzen mit diesen verbindungen.
MY136928A (en) New isoquinoline compounds, a process for their preparation and pharmaceutical composition containing them
DE60204014D1 (de) Chlormethylierung von thiophene
HUP9901639A1 (hu) Terápiás készítmény asztma ellen
TR199801683A2 (xx) Yeni �re t�revleri.
NO880973L (no) 1-(1-aryl-2-hydroksyetyl)-imidazoler og salter derav samtfremgangsmaater for fremstilling av forbindelsene.
EP1158358A3 (en) Imaging element containing a blocked photographically useful compound
WO2000020399A3 (de) Verwendung von substituierten 5-hydroxypyrazolen, neue 5-hydroxypyrazole, verfahren zu deren herstellung, sowie sie enthaltende mittel
EA199900452A1 (ru) 1-(3-аминоиндазол-5-ил)-3-фенилметилциклические мочевины, полезные в качестве ингибиторов вич-протеазы

Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees