PT1159270E - Processo para a preparacao de 1-(6-metilpiridin-3-il)-2-((4-(metilsulfonil)fenil)etanona - Google Patents

Processo para a preparacao de 1-(6-metilpiridin-3-il)-2-((4-(metilsulfonil)fenil)etanona

Info

Publication number
PT1159270E
PT1159270E PT00901555T PT00901555T PT1159270E PT 1159270 E PT1159270 E PT 1159270E PT 00901555 T PT00901555 T PT 00901555T PT 00901555 T PT00901555 T PT 00901555T PT 1159270 E PT1159270 E PT 1159270E
Authority
PT
Portugal
Prior art keywords
methylpyridin
preparation
phenyl
iii
formula
Prior art date
Application number
PT00901555T
Other languages
English (en)
Inventor
Erich Armbruster
Bessard Dr Yves
David Kuo
James Edward Leresche
Ralf Proplesch
Jean-Paul Roduit
Original Assignee
Merck & Co Inc
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc, Lonza Ag filed Critical Merck & Co Inc
Publication of PT1159270E publication Critical patent/PT1159270E/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57Nitriles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46Oxygen atoms
    • C07D213/50Ketonic radicals
PT00901555T 1999-01-14 2000-01-13 Processo para a preparacao de 1-(6-metilpiridin-3-il)-2-((4-(metilsulfonil)fenil)etanona PT1159270E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99100590 1999-01-14
US14599699P 1999-07-29 1999-07-29

Publications (1)

Publication Number Publication Date
PT1159270E true PT1159270E (pt) 2004-03-31

Family

ID=34089809

Family Applications (2)

Application Number Title Priority Date Filing Date
PT03024787T PT1394149E (pt) 1999-01-14 2000-01-13 Processo para a producao de 1-(6-metilpiridin-3-il)-2-[4-(metilsulfonil)fenil]etanona
PT00901555T PT1159270E (pt) 1999-01-14 2000-01-13 Processo para a preparacao de 1-(6-metilpiridin-3-il)-2-((4-(metilsulfonil)fenil)etanona

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT03024787T PT1394149E (pt) 1999-01-14 2000-01-13 Processo para a producao de 1-(6-metilpiridin-3-il)-2-[4-(metilsulfonil)fenil]etanona

Country Status (15)

Country Link
EP (2) EP1394149B1 (pt)
JP (1) JP4765167B2 (pt)
CN (2) CN1170820C (pt)
AT (2) ATE287396T1 (pt)
AU (1) AU2290800A (pt)
CA (2) CA2485739C (pt)
CZ (1) CZ302270B6 (pt)
DE (2) DE50009312D1 (pt)
DK (2) DK1394149T3 (pt)
ES (2) ES2235138T3 (pt)
HU (1) HUP0105124A3 (pt)
IL (1) IL143981A0 (pt)
PT (2) PT1394149E (pt)
SK (1) SK284903B6 (pt)
WO (1) WO2000042014A2 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104725300A (zh) * 2015-02-28 2015-06-24 宁波九胜创新医药科技有限公司 一种1-(6-甲基吡啶-3-基)-2-(4-甲磺酰基苯基)乙酮的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3313683A (en) * 1963-04-22 1967-04-11 Lilly Co Eli Nematocidal and fungicidal methods
FR2074674A1 (en) * 1970-01-16 1971-10-08 Simafex Sulphonamide/aldehyde-bisulphite complexes - antibacterials with very high solubility in water
US4155909A (en) * 1977-06-13 1979-05-22 Philip Morris Incorporated 2-Alkyl nicotinoids and processes for their production
US5596008A (en) * 1995-02-10 1997-01-21 G. D. Searle & Co. 3,4-Diaryl substituted pyridines for the treatment of inflammation
BRPI9710372B8 (pt) * 1996-07-18 2021-05-25 Merck Canada Inc composto, e, composição farmacêutica.
TW492959B (en) * 1997-04-18 2002-07-01 Merck & Co Inc Process for making 2-aryl-3-aryl-5-halo pyridines useful as cox-2 inhibitors
AR015938A1 (es) * 1997-09-25 2001-05-30 Merck Sharp & Dohme Procedimiento para preparar diaril piridinas utiles como inhibidores cox-2 y compuesto intermediario
PT1071745E (pt) * 1998-04-24 2004-11-30 Merck & Co Inc Processo para sintetizar inibidores cox-2

Also Published As

Publication number Publication date
EP1394149B1 (de) 2005-01-19
EP1159270A2 (de) 2001-12-05
PT1394149E (pt) 2005-05-31
DE50004327D1 (de) 2003-12-11
DK1159270T3 (da) 2004-02-23
CN1281589C (zh) 2006-10-25
SK9722001A3 (en) 2001-12-03
CZ302270B6 (cs) 2011-01-19
WO2000042014A2 (de) 2000-07-20
DE50009312D1 (de) 2005-02-24
JP2003518002A (ja) 2003-06-03
ATE287396T1 (de) 2005-02-15
CN1583723A (zh) 2005-02-23
EP1159270B1 (de) 2003-11-05
ATE253559T1 (de) 2003-11-15
CZ20012457A3 (cs) 2002-01-16
CA2485739A1 (en) 2000-07-20
HUP0105124A2 (hu) 2002-04-29
IL143981A0 (en) 2002-04-21
ES2209807T3 (es) 2004-07-01
CA2359958C (en) 2006-04-04
CA2359958A1 (en) 2000-07-20
CN1170820C (zh) 2004-10-13
ES2235138T3 (es) 2005-07-01
DK1394149T3 (da) 2005-04-04
CN1359374A (zh) 2002-07-17
HUP0105124A3 (en) 2002-05-28
CA2485739C (en) 2009-09-22
AU2290800A (en) 2000-08-01
JP4765167B2 (ja) 2011-09-07
EP1394149A1 (de) 2004-03-03
WO2000042014A3 (de) 2000-12-07
SK284903B6 (sk) 2006-02-02

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