AU2290800A - 1-(6- methylpyridine- 3-yl)-2-(4- (methylsulfonyl) phenyl) ethanone and method for its preparation - Google Patents

1-(6- methylpyridine- 3-yl)-2-(4- (methylsulfonyl) phenyl) ethanone and method for its preparation

Info

Publication number
AU2290800A
AU2290800A AU22908/00A AU2290800A AU2290800A AU 2290800 A AU2290800 A AU 2290800A AU 22908/00 A AU22908/00 A AU 22908/00A AU 2290800 A AU2290800 A AU 2290800A AU 2290800 A AU2290800 A AU 2290800A
Authority
AU
Australia
Prior art keywords
preparation
ethanone
methylsulfonyl
phenyl
methylpyridin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU22908/00A
Inventor
Erich Armbruster
Yves Bessard
David Kuo
James Edward Leresche
Ralf Proplesch
Jean-Paul Roduit
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lonza AG
Merck and Co Inc
Original Assignee
Lonza AG
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza AG, Merck and Co Inc filed Critical Lonza AG
Publication of AU2290800A publication Critical patent/AU2290800A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

1-(6-Methylpyridin-3-yl)-2-(4-methylsulfonyl-phenyl)-ethanone is new. 1-(6-methylpyridin-3-yl)-2-(4-methylsulfonyl-phenyl)-ethanone of formula (I) is new: Independent claims are also included for the following: (a) a 4-step preparation of (I) where the third step for the preparation of N,N-dialkylamino-(6-methyl-3-pyridyl)acetonitriles of formula (III) and the last step are claimed per se; (b) compounds (III); (c) alkali metal 1-hydroxy-(6-methylpyridin-3-yl)methanesulfonate intermediates of formula (II) (for preparing (III)); (d) preparation of (II) comprising treating 2-methyl-5-vinylpyridine with ozone followed by reduction with an alkali hydrogen sulfite. R1, R2 = 1-4C alkyl; M = alkali metal.
AU22908/00A 1999-01-14 2000-01-13 1-(6- methylpyridine- 3-yl)-2-(4- (methylsulfonyl) phenyl) ethanone and method for its preparation Abandoned AU2290800A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP99100590 1999-01-14
EP99100590 1999-01-14
US14599699P 1999-07-29 1999-07-29
US60145996 1999-07-29
PCT/EP2000/000240 WO2000042014A2 (en) 1999-01-14 2000-01-13 1-(6- methylpyridine- 3-yl)-2-[4- (methylsulfonyl) phenyl] ethanone and method for its preparation

Publications (1)

Publication Number Publication Date
AU2290800A true AU2290800A (en) 2000-08-01

Family

ID=34089809

Family Applications (1)

Application Number Title Priority Date Filing Date
AU22908/00A Abandoned AU2290800A (en) 1999-01-14 2000-01-13 1-(6- methylpyridine- 3-yl)-2-(4- (methylsulfonyl) phenyl) ethanone and method for its preparation

Country Status (15)

Country Link
EP (2) EP1159270B1 (en)
JP (1) JP4765167B2 (en)
CN (2) CN1170820C (en)
AT (2) ATE253559T1 (en)
AU (1) AU2290800A (en)
CA (2) CA2485739C (en)
CZ (1) CZ302270B6 (en)
DE (2) DE50004327D1 (en)
DK (2) DK1394149T3 (en)
ES (2) ES2235138T3 (en)
HU (1) HUP0105124A3 (en)
IL (1) IL143981A0 (en)
PT (2) PT1394149E (en)
SK (1) SK284903B6 (en)
WO (1) WO2000042014A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104725300A (en) * 2015-02-28 2015-06-24 宁波九胜创新医药科技有限公司 Preparation method of 1-(6-methyl pyridine-3-yl)-2-(4-methylsulfonyl phenyl) ethanone

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3313683A (en) * 1963-04-22 1967-04-11 Lilly Co Eli Nematocidal and fungicidal methods
FR2074674A1 (en) * 1970-01-16 1971-10-08 Simafex Sulphonamide/aldehyde-bisulphite complexes - antibacterials with very high solubility in water
US4155909A (en) * 1977-06-13 1979-05-22 Philip Morris Incorporated 2-Alkyl nicotinoids and processes for their production
US5596008A (en) * 1995-02-10 1997-01-21 G. D. Searle & Co. 3,4-Diaryl substituted pyridines for the treatment of inflammation
SK283261B6 (en) * 1996-07-18 2003-04-01 Merck Frosst Canada & Co. / Merck Frosst Canada & Cie. Substituted pyridines, pharmaceutical composition containing them and use
TW492959B (en) * 1997-04-18 2002-07-01 Merck & Co Inc Process for making 2-aryl-3-aryl-5-halo pyridines useful as cox-2 inhibitors
AR015938A1 (en) * 1997-09-25 2001-05-30 Merck Sharp & Dohme PROCEDURE TO PREPARE DIARIL PIRIDINES USEFUL AS COX-2 INHIBITORS AND INTERMEDIATE COMPOUND
ATE272613T1 (en) * 1998-04-24 2004-08-15 Merck & Co Inc METHOD FOR SYNTHESIS OF COX-2 INHIBITORS

Also Published As

Publication number Publication date
CN1583723A (en) 2005-02-23
EP1159270B1 (en) 2003-11-05
EP1159270A2 (en) 2001-12-05
EP1394149B1 (en) 2005-01-19
ES2235138T3 (en) 2005-07-01
JP4765167B2 (en) 2011-09-07
WO2000042014A2 (en) 2000-07-20
CN1170820C (en) 2004-10-13
DK1159270T3 (en) 2004-02-23
ATE287396T1 (en) 2005-02-15
CZ20012457A3 (en) 2002-01-16
DK1394149T3 (en) 2005-04-04
CA2359958A1 (en) 2000-07-20
SK9722001A3 (en) 2001-12-03
DE50009312D1 (en) 2005-02-24
PT1394149E (en) 2005-05-31
PT1159270E (en) 2004-03-31
HUP0105124A2 (en) 2002-04-29
DE50004327D1 (en) 2003-12-11
WO2000042014A3 (en) 2000-12-07
EP1394149A1 (en) 2004-03-03
CA2485739A1 (en) 2000-07-20
JP2003518002A (en) 2003-06-03
CN1281589C (en) 2006-10-25
CA2485739C (en) 2009-09-22
IL143981A0 (en) 2002-04-21
HUP0105124A3 (en) 2002-05-28
CZ302270B6 (en) 2011-01-19
SK284903B6 (en) 2006-02-02
ATE253559T1 (en) 2003-11-15
ES2209807T3 (en) 2004-07-01
CA2359958C (en) 2006-04-04
CN1359374A (en) 2002-07-17

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase