DK1159270T3 - Process for the preparation of 1- (6-methylpyridin-3-yl) -2 - [(4- (methylsulfonyl) phenyl] ethanone - Google Patents
Process for the preparation of 1- (6-methylpyridin-3-yl) -2 - [(4- (methylsulfonyl) phenyl] ethanoneInfo
- Publication number
- DK1159270T3 DK1159270T3 DK00901555T DK00901555T DK1159270T3 DK 1159270 T3 DK1159270 T3 DK 1159270T3 DK 00901555 T DK00901555 T DK 00901555T DK 00901555 T DK00901555 T DK 00901555T DK 1159270 T3 DK1159270 T3 DK 1159270T3
- Authority
- DK
- Denmark
- Prior art keywords
- methylpyridin
- preparation
- ethanone
- methylsulfonyl
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/57—Nitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
Abstract
1-(6-Methylpyridin-3-yl)-2-(4-methylsulfonyl-phenyl)-ethanone is new. 1-(6-methylpyridin-3-yl)-2-(4-methylsulfonyl-phenyl)-ethanone of formula (I) is new: Independent claims are also included for the following: (a) a 4-step preparation of (I) where the third step for the preparation of N,N-dialkylamino-(6-methyl-3-pyridyl)acetonitriles of formula (III) and the last step are claimed per se; (b) compounds (III); (c) alkali metal 1-hydroxy-(6-methylpyridin-3-yl)methanesulfonate intermediates of formula (II) (for preparing (III)); (d) preparation of (II) comprising treating 2-methyl-5-vinylpyridine with ozone followed by reduction with an alkali hydrogen sulfite. R1, R2 = 1-4C alkyl; M = alkali metal.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99100590 | 1999-01-14 | ||
US14599699P | 1999-07-29 | 1999-07-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1159270T3 true DK1159270T3 (en) | 2004-02-23 |
Family
ID=34089809
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK00901555T DK1159270T3 (en) | 1999-01-14 | 2000-01-13 | Process for the preparation of 1- (6-methylpyridin-3-yl) -2 - [(4- (methylsulfonyl) phenyl] ethanone |
DK03024787T DK1394149T3 (en) | 1999-01-14 | 2000-01-13 | Process for the preparation of 1- (6-methylpyridin-3-yl) -2- [4- (methylsulfonyl) phenyl] ethanone |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK03024787T DK1394149T3 (en) | 1999-01-14 | 2000-01-13 | Process for the preparation of 1- (6-methylpyridin-3-yl) -2- [4- (methylsulfonyl) phenyl] ethanone |
Country Status (15)
Country | Link |
---|---|
EP (2) | EP1159270B1 (en) |
JP (1) | JP4765167B2 (en) |
CN (2) | CN1281589C (en) |
AT (2) | ATE287396T1 (en) |
AU (1) | AU2290800A (en) |
CA (2) | CA2485739C (en) |
CZ (1) | CZ302270B6 (en) |
DE (2) | DE50009312D1 (en) |
DK (2) | DK1159270T3 (en) |
ES (2) | ES2209807T3 (en) |
HU (1) | HUP0105124A3 (en) |
IL (1) | IL143981A0 (en) |
PT (2) | PT1159270E (en) |
SK (1) | SK284903B6 (en) |
WO (1) | WO2000042014A2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104725300A (en) * | 2015-02-28 | 2015-06-24 | 宁波九胜创新医药科技有限公司 | Preparation method of 1-(6-methyl pyridine-3-yl)-2-(4-methylsulfonyl phenyl) ethanone |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3313683A (en) * | 1963-04-22 | 1967-04-11 | Lilly Co Eli | Nematocidal and fungicidal methods |
FR2074674A1 (en) * | 1970-01-16 | 1971-10-08 | Simafex | Sulphonamide/aldehyde-bisulphite complexes - antibacterials with very high solubility in water |
US4155909A (en) * | 1977-06-13 | 1979-05-22 | Philip Morris Incorporated | 2-Alkyl nicotinoids and processes for their production |
US5596008A (en) * | 1995-02-10 | 1997-01-21 | G. D. Searle & Co. | 3,4-Diaryl substituted pyridines for the treatment of inflammation |
BRPI9710372B8 (en) * | 1996-07-18 | 2021-05-25 | Merck Canada Inc | compound, and, pharmaceutical composition. |
TW492959B (en) * | 1997-04-18 | 2002-07-01 | Merck & Co Inc | Process for making 2-aryl-3-aryl-5-halo pyridines useful as cox-2 inhibitors |
AR015938A1 (en) * | 1997-09-25 | 2001-05-30 | Merck Sharp & Dohme | PROCEDURE TO PREPARE DIARIL PIRIDINES USEFUL AS COX-2 INHIBITORS AND INTERMEDIATE COMPOUND |
KR100414998B1 (en) * | 1998-04-24 | 2004-01-13 | 머크 앤드 캄파니 인코포레이티드 | Process for synthesizing COX-2 inhibitors |
-
2000
- 2000-01-13 CA CA002485739A patent/CA2485739C/en not_active Expired - Fee Related
- 2000-01-13 DE DE50009312T patent/DE50009312D1/en not_active Expired - Lifetime
- 2000-01-13 CN CNB200410069946XA patent/CN1281589C/en not_active Expired - Fee Related
- 2000-01-13 DE DE50004327T patent/DE50004327D1/en not_active Expired - Lifetime
- 2000-01-13 DK DK00901555T patent/DK1159270T3/en active
- 2000-01-13 ES ES00901555T patent/ES2209807T3/en not_active Expired - Lifetime
- 2000-01-13 DK DK03024787T patent/DK1394149T3/en active
- 2000-01-13 IL IL14398100A patent/IL143981A0/en active IP Right Grant
- 2000-01-13 SK SK972-2001A patent/SK284903B6/en not_active IP Right Cessation
- 2000-01-13 AT AT03024787T patent/ATE287396T1/en active
- 2000-01-13 CN CNB008027218A patent/CN1170820C/en not_active Expired - Fee Related
- 2000-01-13 HU HU0105124A patent/HUP0105124A3/en unknown
- 2000-01-13 CZ CZ20012457A patent/CZ302270B6/en not_active IP Right Cessation
- 2000-01-13 AT AT00901555T patent/ATE253559T1/en active
- 2000-01-13 EP EP00901555A patent/EP1159270B1/en not_active Expired - Lifetime
- 2000-01-13 PT PT00901555T patent/PT1159270E/en unknown
- 2000-01-13 AU AU22908/00A patent/AU2290800A/en not_active Abandoned
- 2000-01-13 ES ES03024787T patent/ES2235138T3/en not_active Expired - Lifetime
- 2000-01-13 EP EP03024787A patent/EP1394149B1/en not_active Expired - Lifetime
- 2000-01-13 JP JP2000593582A patent/JP4765167B2/en not_active Expired - Fee Related
- 2000-01-13 PT PT03024787T patent/PT1394149E/en unknown
- 2000-01-13 WO PCT/EP2000/000240 patent/WO2000042014A2/en active Application Filing
- 2000-01-13 CA CA002359958A patent/CA2359958C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
SK284903B6 (en) | 2006-02-02 |
CZ20012457A3 (en) | 2002-01-16 |
CN1359374A (en) | 2002-07-17 |
CA2359958C (en) | 2006-04-04 |
CA2359958A1 (en) | 2000-07-20 |
JP4765167B2 (en) | 2011-09-07 |
ATE253559T1 (en) | 2003-11-15 |
EP1394149A1 (en) | 2004-03-03 |
HUP0105124A3 (en) | 2002-05-28 |
CN1170820C (en) | 2004-10-13 |
AU2290800A (en) | 2000-08-01 |
EP1159270A2 (en) | 2001-12-05 |
DE50004327D1 (en) | 2003-12-11 |
IL143981A0 (en) | 2002-04-21 |
JP2003518002A (en) | 2003-06-03 |
CA2485739C (en) | 2009-09-22 |
CN1583723A (en) | 2005-02-23 |
CA2485739A1 (en) | 2000-07-20 |
ATE287396T1 (en) | 2005-02-15 |
WO2000042014A2 (en) | 2000-07-20 |
ES2209807T3 (en) | 2004-07-01 |
PT1159270E (en) | 2004-03-31 |
DK1394149T3 (en) | 2005-04-04 |
CN1281589C (en) | 2006-10-25 |
WO2000042014A3 (en) | 2000-12-07 |
DE50009312D1 (en) | 2005-02-24 |
HUP0105124A2 (en) | 2002-04-29 |
ES2235138T3 (en) | 2005-07-01 |
CZ302270B6 (en) | 2011-01-19 |
EP1159270B1 (en) | 2003-11-05 |
EP1394149B1 (en) | 2005-01-19 |
PT1394149E (en) | 2005-05-31 |
SK9722001A3 (en) | 2001-12-03 |
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