HUP0104161A3 - Improved stability for injection solutions, containing peptid-based thrombin inhibitor and process for preparation thereof - Google Patents

Improved stability for injection solutions, containing peptid-based thrombin inhibitor and process for preparation thereof

Info

Publication number
HUP0104161A3
HUP0104161A3 HU0104161A HUP0104161A HUP0104161A3 HU P0104161 A3 HUP0104161 A3 HU P0104161A3 HU 0104161 A HU0104161 A HU 0104161A HU P0104161 A HUP0104161 A HU P0104161A HU P0104161 A3 HUP0104161 A3 HU P0104161A3
Authority
HU
Hungary
Prior art keywords
peptid
preparation
improved stability
injection solutions
thrombin inhibitor
Prior art date
Application number
HU0104161A
Other languages
English (en)
Hungarian (hu)
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of HUP0104161A2 publication Critical patent/HUP0104161A2/hu
Publication of HUP0104161A3 publication Critical patent/HUP0104161A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A61J1/062—Carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1468—Containers characterised by specific material properties

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Detergent Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
HU0104161A 1998-09-01 1999-08-24 Improved stability for injection solutions, containing peptid-based thrombin inhibitor and process for preparation thereof HUP0104161A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9802938A SE9802938D0 (sv) 1998-09-01 1998-09-01 Improved stability for injection solutions
PCT/SE1999/001440 WO2000012043A1 (en) 1998-09-01 1999-08-24 Improved stability for injection solutions

Publications (2)

Publication Number Publication Date
HUP0104161A2 HUP0104161A2 (hu) 2002-04-29
HUP0104161A3 true HUP0104161A3 (en) 2002-08-28

Family

ID=20412436

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0104161A HUP0104161A3 (en) 1998-09-01 1999-08-24 Improved stability for injection solutions, containing peptid-based thrombin inhibitor and process for preparation thereof

Country Status (33)

Country Link
US (4) US6576245B1 (enExample)
EP (1) EP1109526B1 (enExample)
JP (1) JP2002523184A (enExample)
KR (1) KR100614162B1 (enExample)
CN (1) CN1230141C (enExample)
AR (1) AR033788A1 (enExample)
AT (1) ATE262882T1 (enExample)
AU (1) AU754447C (enExample)
BR (1) BR9913261A (enExample)
CA (1) CA2340238C (enExample)
CZ (1) CZ2001743A3 (enExample)
DE (1) DE69916082T2 (enExample)
DK (1) DK1109526T3 (enExample)
EE (1) EE04768B1 (enExample)
ES (1) ES2217808T3 (enExample)
HU (1) HUP0104161A3 (enExample)
ID (1) ID28015A (enExample)
IL (2) IL141333A0 (enExample)
IS (1) IS2230B (enExample)
MY (1) MY120822A (enExample)
NO (1) NO322292B1 (enExample)
NZ (1) NZ509985A (enExample)
PL (1) PL195244B1 (enExample)
PT (1) PT1109526E (enExample)
RU (1) RU2224499C2 (enExample)
SA (1) SA99200573B1 (enExample)
SE (1) SE9802938D0 (enExample)
SK (1) SK285474B6 (enExample)
TR (1) TR200100679T2 (enExample)
TW (1) TWI228987B (enExample)
UA (1) UA73282C2 (enExample)
WO (1) WO2000012043A1 (enExample)
ZA (1) ZA200101590B (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9802938D0 (sv) * 1998-09-01 1998-09-01 Astra Ab Improved stability for injection solutions
US6462021B1 (en) 2000-11-06 2002-10-08 Astrazeneca Ab Use of low molecular weight thrombin inhibitor
AR035216A1 (es) * 2000-12-01 2004-05-05 Astrazeneca Ab Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios
US7129233B2 (en) * 2000-12-01 2006-10-31 Astrazeneca Ab Mandelic acid derivatives and their use as thrombin inhibitors
AR034517A1 (es) * 2001-06-21 2004-02-25 Astrazeneca Ab Formulacion farmaceutica
US6802828B2 (en) * 2001-11-23 2004-10-12 Duoject Medical Systems, Inc. System for filling and assembling pharmaceutical delivery devices
SE0201659D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab Modified release pharmaceutical formulation
SE0201661D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab New salts
PT1569912E (pt) 2002-12-03 2015-09-15 Pharmacyclics Llc Derivados 2-(2-hidroxibifenil-3-il)-1h-benzoimidazole-5- carboxamidina como inibidores do fator viia
AU2004206842A1 (en) * 2003-01-14 2004-08-05 Teva Pharmaceutical Industries, Ltd. Parenteral formulations of peptides for the treatment of systemic lupus erythematosus
KR100505557B1 (ko) * 2003-02-10 2005-08-03 조을룡 약병마개 제조용 고무 조성물
US7781424B2 (en) * 2003-05-27 2010-08-24 Astrazeneca Ab Modified release pharmaceutical formulation
US8476010B2 (en) 2003-07-10 2013-07-02 App Pharmaceuticals Llc Propofol formulations with non-reactive container closures
US7524354B2 (en) * 2005-07-07 2009-04-28 Research Foundation Of State University Of New York Controlled synthesis of highly monodispersed gold nanoparticles
US20070166187A1 (en) * 2006-01-18 2007-07-19 Song Jing F Stabilization of paricalcitol using chlorobutyl or chlorinated butyl stoppers
TW200827336A (en) * 2006-12-06 2008-07-01 Astrazeneca Ab New crystalline forms
US20090061000A1 (en) * 2007-08-31 2009-03-05 Astrazeneca Ab Pharmaceutical formulation use 030
US8939943B2 (en) 2011-01-26 2015-01-27 Kaleo, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US8627816B2 (en) * 2011-02-28 2014-01-14 Intelliject, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
JP6144264B2 (ja) * 2011-09-27 2017-06-07 ベクトン ディキンソン フランス 医療用注射装置においてプラズマ処理したシリコーンオイルのコーティングとしての使用
US9517307B2 (en) 2014-07-18 2016-12-13 Kaleo, Inc. Devices and methods for delivering opioid antagonists including formulations for naloxone

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4381779A (en) 1981-07-16 1983-05-03 Sterling Drug Inc. Deformable slidable piston to provide self-aspiration in hypodermic cartridge ampoules
ATE84205T1 (de) 1989-03-28 1993-01-15 Duphar Int Res Vorgefuellte injektionsvorrichtung mit einem fass, das mit einer fluessigen diazepam-formulierung gefuellt ist.
US5219328A (en) * 1990-01-03 1993-06-15 Cryolife, Inc. Fibrin sealant delivery method
SE9103612D0 (sv) 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
SE9301916D0 (sv) 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
SE9402332D0 (sv) * 1994-07-01 1994-07-01 Pharmacia Ab Igf-1
SE9501472D0 (sv) 1995-04-21 1995-04-21 Pharmacia Ab Truncated IGF-I
SA96170106A (ar) 1995-07-06 2005-12-03 أسترا أكتيبولاج مشتقات حامض أميني جديدة
AR005245A1 (es) 1995-12-21 1999-04-28 Astrazeneca Ab Prodrogas de inhibidores de trombina, una formulación farmaceutica que las comprende, el uso de dichas prodrogas para la manufactura de un medicamento y un procedimiento para su preparacion
SE9601556D0 (sv) * 1996-04-24 1996-04-24 Astra Ab New pharmaceutical formulation of a thrombin inhibitor for parenteral use
SE9802938D0 (sv) 1998-09-01 1998-09-01 Astra Ab Improved stability for injection solutions

Also Published As

Publication number Publication date
US6576245B1 (en) 2003-06-10
RU2224499C2 (ru) 2004-02-27
PT1109526E (pt) 2004-07-30
SK2822001A3 (en) 2001-08-06
WO2000012043A1 (en) 2000-03-09
IL141333A (en) 2006-07-05
US20040235731A1 (en) 2004-11-25
CN1314804A (zh) 2001-09-26
EE04768B1 (et) 2007-02-15
HK1035482A1 (en) 2001-11-30
KR20010073070A (ko) 2001-07-31
US20060233778A1 (en) 2006-10-19
NO322292B1 (no) 2006-09-11
BR9913261A (pt) 2001-05-22
TR200100679T2 (tr) 2001-07-23
DK1109526T3 (da) 2004-07-05
EP1109526B1 (en) 2004-03-31
NO20011032L (no) 2001-04-30
ZA200101590B (en) 2002-05-27
AU5890399A (en) 2000-03-21
PL346471A1 (en) 2002-02-11
JP2002523184A (ja) 2002-07-30
AU754447C (en) 2006-10-19
IL141333A0 (en) 2002-03-10
US6998136B2 (en) 2006-02-14
SK285474B6 (sk) 2007-02-01
ATE262882T1 (de) 2004-04-15
SE9802938D0 (sv) 1998-09-01
DE69916082T2 (de) 2004-10-21
CA2340238C (en) 2009-01-06
MY120822A (en) 2005-11-30
HUP0104161A2 (hu) 2002-04-29
PL195244B1 (pl) 2007-08-31
UA73282C2 (en) 2005-07-15
EP1109526A1 (en) 2001-06-27
AU754447B2 (en) 2002-11-14
SA99200573B1 (ar) 2006-09-20
ES2217808T3 (es) 2004-11-01
EE200100131A (et) 2002-06-17
ID28015A (id) 2001-05-03
SA99200573A (ar) 2005-12-03
NO20011032D0 (no) 2001-02-28
IS2230B (is) 2007-04-15
DE69916082D1 (de) 2004-05-06
US6660279B2 (en) 2003-12-09
KR100614162B1 (ko) 2006-08-25
US20030190310A1 (en) 2003-10-09
CN1230141C (zh) 2005-12-07
TWI228987B (en) 2005-03-11
CZ2001743A3 (cs) 2002-01-16
CA2340238A1 (en) 2000-03-09
IS5845A (is) 2001-02-15
AR033788A1 (es) 2004-01-07
NZ509985A (en) 2002-12-20

Similar Documents

Publication Publication Date Title
HUP0104161A3 (en) Improved stability for injection solutions, containing peptid-based thrombin inhibitor and process for preparation thereof
IL128663A0 (en) 1,4-heterocyclic metalloprotease inhibitors
IL128661A0 (en) 1,3-diheterocyclic metalloprotease inhibitors
ZA973647B (en) Inhibitors of metalloprotease, process for preparing them and pharmaceutical compositions containing them.
SI0836615T1 (en) New thrombin inhibitors, their preparation and use
IL150430A0 (en) Cell division inhibitors and process for producing the same
AU5991699A (en) Quinolizinones as integrin inhibitors
ZA974542B (en) New amino acid derivatives and their use as thrombin inhibitors.
IL127751A0 (en) Thrombin inhibitors
HUP0101791A3 (en) Gamma-aminobutyric acid derivatives containing, solid compositions and process for preparing the same
HUP0200856A3 (en) Medicament for localised application, containing fibrinogen, thrombin, transglutaminases and proteinase inhibitors
HUP9900390A3 (en) Serine protease inhibitors, and pharmaceutical compositions containing them
HUP0101779A3 (en) Process for de-chlorinating and de-fouling waste-oil
HUP0101098A3 (en) Streptogramin derivatives, process for preparation thereof and compositions containing same
GB0020717D0 (en) Novel compounds and process
GB9613718D0 (en) Thrombin inhibitors
GB9917593D0 (en) Compound, composition, process and use
ZA974779B (en) Thrombin inhibitors.
ZA977209B (en) Thrombin inhibitors.
IL145220A0 (en) Stabilized composition based on pyridinyl-sulfinyl-benzimidazoles and process
GB9814869D0 (en) Process and composition
HUP0103665A3 (en) Isoquinolines as urokinase inhibitors, peocess for their preparation and medicaments containing them
PL347152A1 (en) Benzamide derivatives as thrombin inhibitors
HUP0103569A3 (en) New medicament and process for its preparation
SI1109526T1 (en) Improved stability for injection solutions

Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees