ATE262882T1 - Verbesserte stabilität für injektionslösungen - Google Patents

Verbesserte stabilität für injektionslösungen

Info

Publication number
ATE262882T1
ATE262882T1 AT99946504T AT99946504T ATE262882T1 AT E262882 T1 ATE262882 T1 AT E262882T1 AT 99946504 T AT99946504 T AT 99946504T AT 99946504 T AT99946504 T AT 99946504T AT E262882 T1 ATE262882 T1 AT E262882T1
Authority
AT
Austria
Prior art keywords
improved stability
injection solutions
injection
solutions
stability
Prior art date
Application number
AT99946504T
Other languages
German (de)
English (en)
Inventor
Anna Lundgren
Mats Sundgren
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of ATE262882T1 publication Critical patent/ATE262882T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A61J1/062—Carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1468—Containers characterised by specific material properties

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Detergent Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT99946504T 1998-09-01 1999-08-24 Verbesserte stabilität für injektionslösungen ATE262882T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9802938A SE9802938D0 (sv) 1998-09-01 1998-09-01 Improved stability for injection solutions
PCT/SE1999/001440 WO2000012043A1 (en) 1998-09-01 1999-08-24 Improved stability for injection solutions

Publications (1)

Publication Number Publication Date
ATE262882T1 true ATE262882T1 (de) 2004-04-15

Family

ID=20412436

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99946504T ATE262882T1 (de) 1998-09-01 1999-08-24 Verbesserte stabilität für injektionslösungen

Country Status (33)

Country Link
US (4) US6576245B1 (enExample)
EP (1) EP1109526B1 (enExample)
JP (1) JP2002523184A (enExample)
KR (1) KR100614162B1 (enExample)
CN (1) CN1230141C (enExample)
AR (1) AR033788A1 (enExample)
AT (1) ATE262882T1 (enExample)
AU (1) AU754447C (enExample)
BR (1) BR9913261A (enExample)
CA (1) CA2340238C (enExample)
CZ (1) CZ2001743A3 (enExample)
DE (1) DE69916082T2 (enExample)
DK (1) DK1109526T3 (enExample)
EE (1) EE04768B1 (enExample)
ES (1) ES2217808T3 (enExample)
HU (1) HUP0104161A3 (enExample)
ID (1) ID28015A (enExample)
IL (2) IL141333A0 (enExample)
IS (1) IS2230B (enExample)
MY (1) MY120822A (enExample)
NO (1) NO322292B1 (enExample)
NZ (1) NZ509985A (enExample)
PL (1) PL195244B1 (enExample)
PT (1) PT1109526E (enExample)
RU (1) RU2224499C2 (enExample)
SA (1) SA99200573B1 (enExample)
SE (1) SE9802938D0 (enExample)
SK (1) SK285474B6 (enExample)
TR (1) TR200100679T2 (enExample)
TW (1) TWI228987B (enExample)
UA (1) UA73282C2 (enExample)
WO (1) WO2000012043A1 (enExample)
ZA (1) ZA200101590B (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9802938D0 (sv) * 1998-09-01 1998-09-01 Astra Ab Improved stability for injection solutions
US6462021B1 (en) 2000-11-06 2002-10-08 Astrazeneca Ab Use of low molecular weight thrombin inhibitor
AR035216A1 (es) * 2000-12-01 2004-05-05 Astrazeneca Ab Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios
US7129233B2 (en) * 2000-12-01 2006-10-31 Astrazeneca Ab Mandelic acid derivatives and their use as thrombin inhibitors
AR034517A1 (es) * 2001-06-21 2004-02-25 Astrazeneca Ab Formulacion farmaceutica
US6802828B2 (en) * 2001-11-23 2004-10-12 Duoject Medical Systems, Inc. System for filling and assembling pharmaceutical delivery devices
SE0201659D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab Modified release pharmaceutical formulation
SE0201661D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab New salts
PT1569912E (pt) 2002-12-03 2015-09-15 Pharmacyclics Llc Derivados 2-(2-hidroxibifenil-3-il)-1h-benzoimidazole-5- carboxamidina como inibidores do fator viia
AU2004206842A1 (en) * 2003-01-14 2004-08-05 Teva Pharmaceutical Industries, Ltd. Parenteral formulations of peptides for the treatment of systemic lupus erythematosus
KR100505557B1 (ko) * 2003-02-10 2005-08-03 조을룡 약병마개 제조용 고무 조성물
US7781424B2 (en) * 2003-05-27 2010-08-24 Astrazeneca Ab Modified release pharmaceutical formulation
US8476010B2 (en) 2003-07-10 2013-07-02 App Pharmaceuticals Llc Propofol formulations with non-reactive container closures
US7524354B2 (en) * 2005-07-07 2009-04-28 Research Foundation Of State University Of New York Controlled synthesis of highly monodispersed gold nanoparticles
US20070166187A1 (en) * 2006-01-18 2007-07-19 Song Jing F Stabilization of paricalcitol using chlorobutyl or chlorinated butyl stoppers
TW200827336A (en) * 2006-12-06 2008-07-01 Astrazeneca Ab New crystalline forms
US20090061000A1 (en) * 2007-08-31 2009-03-05 Astrazeneca Ab Pharmaceutical formulation use 030
US8939943B2 (en) 2011-01-26 2015-01-27 Kaleo, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US8627816B2 (en) * 2011-02-28 2014-01-14 Intelliject, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
JP6144264B2 (ja) * 2011-09-27 2017-06-07 ベクトン ディキンソン フランス 医療用注射装置においてプラズマ処理したシリコーンオイルのコーティングとしての使用
US9517307B2 (en) 2014-07-18 2016-12-13 Kaleo, Inc. Devices and methods for delivering opioid antagonists including formulations for naloxone

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4381779A (en) 1981-07-16 1983-05-03 Sterling Drug Inc. Deformable slidable piston to provide self-aspiration in hypodermic cartridge ampoules
ATE84205T1 (de) 1989-03-28 1993-01-15 Duphar Int Res Vorgefuellte injektionsvorrichtung mit einem fass, das mit einer fluessigen diazepam-formulierung gefuellt ist.
US5219328A (en) * 1990-01-03 1993-06-15 Cryolife, Inc. Fibrin sealant delivery method
SE9103612D0 (sv) 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
SE9301916D0 (sv) 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
SE9402332D0 (sv) * 1994-07-01 1994-07-01 Pharmacia Ab Igf-1
SE9501472D0 (sv) 1995-04-21 1995-04-21 Pharmacia Ab Truncated IGF-I
SA96170106A (ar) 1995-07-06 2005-12-03 أسترا أكتيبولاج مشتقات حامض أميني جديدة
AR005245A1 (es) 1995-12-21 1999-04-28 Astrazeneca Ab Prodrogas de inhibidores de trombina, una formulación farmaceutica que las comprende, el uso de dichas prodrogas para la manufactura de un medicamento y un procedimiento para su preparacion
SE9601556D0 (sv) * 1996-04-24 1996-04-24 Astra Ab New pharmaceutical formulation of a thrombin inhibitor for parenteral use
SE9802938D0 (sv) 1998-09-01 1998-09-01 Astra Ab Improved stability for injection solutions

Also Published As

Publication number Publication date
US6576245B1 (en) 2003-06-10
RU2224499C2 (ru) 2004-02-27
PT1109526E (pt) 2004-07-30
SK2822001A3 (en) 2001-08-06
WO2000012043A1 (en) 2000-03-09
IL141333A (en) 2006-07-05
US20040235731A1 (en) 2004-11-25
CN1314804A (zh) 2001-09-26
EE04768B1 (et) 2007-02-15
HK1035482A1 (en) 2001-11-30
KR20010073070A (ko) 2001-07-31
US20060233778A1 (en) 2006-10-19
NO322292B1 (no) 2006-09-11
BR9913261A (pt) 2001-05-22
TR200100679T2 (tr) 2001-07-23
DK1109526T3 (da) 2004-07-05
EP1109526B1 (en) 2004-03-31
NO20011032L (no) 2001-04-30
ZA200101590B (en) 2002-05-27
AU5890399A (en) 2000-03-21
PL346471A1 (en) 2002-02-11
JP2002523184A (ja) 2002-07-30
AU754447C (en) 2006-10-19
IL141333A0 (en) 2002-03-10
US6998136B2 (en) 2006-02-14
SK285474B6 (sk) 2007-02-01
SE9802938D0 (sv) 1998-09-01
DE69916082T2 (de) 2004-10-21
CA2340238C (en) 2009-01-06
MY120822A (en) 2005-11-30
HUP0104161A3 (en) 2002-08-28
HUP0104161A2 (hu) 2002-04-29
PL195244B1 (pl) 2007-08-31
UA73282C2 (en) 2005-07-15
EP1109526A1 (en) 2001-06-27
AU754447B2 (en) 2002-11-14
SA99200573B1 (ar) 2006-09-20
ES2217808T3 (es) 2004-11-01
EE200100131A (et) 2002-06-17
ID28015A (id) 2001-05-03
SA99200573A (ar) 2005-12-03
NO20011032D0 (no) 2001-02-28
IS2230B (is) 2007-04-15
DE69916082D1 (de) 2004-05-06
US6660279B2 (en) 2003-12-09
KR100614162B1 (ko) 2006-08-25
US20030190310A1 (en) 2003-10-09
CN1230141C (zh) 2005-12-07
TWI228987B (en) 2005-03-11
CZ2001743A3 (cs) 2002-01-16
CA2340238A1 (en) 2000-03-09
IS5845A (is) 2001-02-15
AR033788A1 (es) 2004-01-07
NZ509985A (en) 2002-12-20

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