HUP0102714A2 - Matrix metalloproteináz inhibitor hatású triciklusos szulfonamidszármazékok és azokat tartalmazó gyógyszerkészítmények - Google Patents

Matrix metalloproteináz inhibitor hatású triciklusos szulfonamidszármazékok és azokat tartalmazó gyógyszerkészítmények

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Publication number
HUP0102714A2
HUP0102714A2 HU0102714A HUP0102714A HUP0102714A2 HU P0102714 A2 HUP0102714 A2 HU P0102714A2 HU 0102714 A HU0102714 A HU 0102714A HU P0102714 A HUP0102714 A HU P0102714A HU P0102714 A2 HUP0102714 A2 HU P0102714A2
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HU
Hungary
Prior art keywords
integer
value
derivatives
tricyclic
sulfonamid
Prior art date
Application number
HU0102714A
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English (en)
Inventor
Patrick Michael O'brien
Joseph Armand Picard
Drago Robert Sliskovic
Original Assignee
Warner-Lambert Company
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Publication date
Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company
Publication of HUP0102714A2 publication Critical patent/HUP0102714A2/hu
Publication of HUP0102714A3 publication Critical patent/HUP0102714A3/hu

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    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
    • A—HUMAN NECESSITIES
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    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04M—TELEPHONIC COMMUNICATION
    • H04M15/00—Arrangements for metering, time-control or time indication ; Metering, charging or billing arrangements for voice wireline or wireless communications, e.g. VoIP
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    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04M—TELEPHONIC COMMUNICATION
    • H04M15/00—Arrangements for metering, time-control or time indication ; Metering, charging or billing arrangements for voice wireline or wireless communications, e.g. VoIP
    • H04M15/28—Arrangements for metering, time-control or time indication ; Metering, charging or billing arrangements for voice wireline or wireless communications, e.g. VoIP with meter at substation or with calculation of charges at terminal
    • H04M15/30—Arrangements for metering, time-control or time indication ; Metering, charging or billing arrangements for voice wireline or wireless communications, e.g. VoIP with meter at substation or with calculation of charges at terminal the meter or calculation of charges not being controlled from an exchange
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04M—TELEPHONIC COMMUNICATION
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    • H04M—TELEPHONIC COMMUNICATION
    • H04M15/00—Arrangements for metering, time-control or time indication ; Metering, charging or billing arrangements for voice wireline or wireless communications, e.g. VoIP
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    • H04M15/8044—Least cost routing
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    • H04M15/83—Notification aspects
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    • H04M—TELEPHONIC COMMUNICATION
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    • H04M2215/96—Distributed calculation of charges, e.g. in different nodes like for mobiles between HLR and VLR, or between the terminal and the billing function

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
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  • Tropical Medicine & Parasitology (AREA)
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Abstract

A találmány tárgya (I) általános képletű új triciklusos szulfonamid-származékok - ahol n jelentése 0 vagy egész szám, melynek értéke 1-2,X jelentése -O-, -NR2-, -CH2- vagy =CO csoport, R jelentésehidrogénatom vagy alifás, vagy adott esetben szubsztituált aromásszénhidrogén gyök, D jelentése 0 vagy egész szám, melynek értéke 1-3,L jelentése 0 vagy egész szám, melynek értéke 1-3, R1 jelentésehidrogénatom vagy egy természetes, vagy nem természetes aminosavoldallánca, Y jelentése OR3 , vagy NH-OR4 csoport, - és megfelelőizomerjeik, valamint gyógyászailag alkalmazható sóik, az ezeket avegyületeket tartalmazó gyógyszerkészítmények, továbbá eljárás az újvegyületek előállítására. A találmány szerinti vegyületek mátrixmetalloproteináz gátló hatásúak, így számos betegség gyógyításábanalkalmazhatók. Ó
HU0102714A 1998-07-30 1999-06-02 Tricyclic sulfonamid derivatives as inhibitors of matrix metalloproteinases and medicaments containing the same HUP0102714A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9500698P 1998-07-30 1998-07-30
PCT/US1999/012273 WO2000006561A1 (en) 1998-07-30 1999-06-02 Tricyclic sulfonamides and their derivatives as inhibitors of matrix metalloproteinases

Publications (2)

Publication Number Publication Date
HUP0102714A2 true HUP0102714A2 (hu) 2002-01-28
HUP0102714A3 HUP0102714A3 (en) 2003-01-28

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HU0102714A HUP0102714A3 (en) 1998-07-30 1999-06-02 Tricyclic sulfonamid derivatives as inhibitors of matrix metalloproteinases and medicaments containing the same

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US (2) US6420408B1 (hu)
EP (1) EP1100792B1 (hu)
JP (1) JP2002521478A (hu)
KR (1) KR20010072089A (hu)
CN (1) CN1310716A (hu)
AP (1) AP2001002037A0 (hu)
AT (1) ATE261954T1 (hu)
AU (1) AU758619B2 (hu)
BG (1) BG105185A (hu)
BR (1) BR9912600A (hu)
CA (1) CA2335077A1 (hu)
DE (1) DE69915634T2 (hu)
DK (1) DK1100792T3 (hu)
EA (1) EA200100158A1 (hu)
EE (1) EE200100063A (hu)
ES (1) ES2216614T3 (hu)
GE (1) GEP20033052B (hu)
HR (1) HRP20010078A2 (hu)
HU (1) HUP0102714A3 (hu)
ID (1) ID27192A (hu)
IL (1) IL140746A0 (hu)
IS (1) IS5810A (hu)
NO (1) NO20010479L (hu)
NZ (1) NZ509439A (hu)
OA (1) OA11589A (hu)
PL (1) PL345776A1 (hu)
PT (1) PT1100792E (hu)
SK (1) SK1192001A3 (hu)
TR (1) TR200100239T2 (hu)
WO (1) WO2000006561A1 (hu)
YU (1) YU6701A (hu)
ZA (1) ZA200100455B (hu)

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US20050095267A1 (en) * 2002-12-04 2005-05-05 Todd Campbell Nanoparticle-based controlled release polymer coatings for medical implants
JP2006516548A (ja) 2002-12-30 2006-07-06 アンジオテック インターナショナル アクツィエン ゲゼルシャフト 迅速ゲル化ポリマー組成物からの薬物送達法
ES2369498T3 (es) 2003-04-04 2011-12-01 Yeda Research And Development Co., Ltd. Anticuerpos para inhibir la actividad de mmp-2 y mmp-9.
EP1613269B1 (en) 2003-04-04 2015-02-25 Incyte Corporation Compositions, methods and kits relating to her-2 cleavage
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CA2676946A1 (en) 2009-08-28 2011-02-28 Lucie Peduto Adam12 inhibitors and their use against inflammation-induced fibrosis
BR112013008008A2 (pt) 2010-09-24 2016-06-21 Ranbaxy Lab Ltd composto, composição farmacêutica e processo para preparar um composto
WO2017134265A1 (en) 2016-02-05 2017-08-10 Institut Pasteur Use of inhibitors of adam12 as adjuvants in tumor therapies
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EA200100158A1 (ru) 2001-08-27
NO20010479D0 (no) 2001-01-29
AU4329299A (en) 2000-02-21
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EP1100792B1 (en) 2004-03-17
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ATE261954T1 (de) 2004-04-15
CN1310716A (zh) 2001-08-29
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