HUP0004627A2 - Farnezil-protein transzferáz inhibitor hatású új triciklusos szulfonamidszármazékok és a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents
Farnezil-protein transzferáz inhibitor hatású új triciklusos szulfonamidszármazékok és a vegyületeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0004627A2 HUP0004627A2 HU0004627A HUP0004627A HUP0004627A2 HU P0004627 A2 HUP0004627 A2 HU P0004627A2 HU 0004627 A HU0004627 A HU 0004627A HU P0004627 A HUP0004627 A HU P0004627A HU P0004627 A2 HUP0004627 A2 HU P0004627A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- heteroaryl
- cycloalkyl
- group
- compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 102000004357 Transferases Human genes 0.000 title 1
- 108090000992 Transferases Proteins 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 229940124530 sulfonamide Drugs 0.000 title 1
- 150000003456 sulfonamides Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 5
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 3
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 3
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 abstract 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 229910052794 bromium Inorganic materials 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 239000000460 chlorine Substances 0.000 abstract 2
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- 125000000815 N-oxide group Chemical group 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000000464 thioxo group Chemical group S=* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87705097A | 1997-06-17 | 1997-06-17 | |
| PCT/US1998/011508 WO1998057949A1 (en) | 1997-06-17 | 1998-06-15 | Novel tricyclic sulfonamide inhibitors of farnesyl-protein transferase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0004627A2 true HUP0004627A2 (hu) | 2001-10-28 |
Family
ID=25369146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0004627A HUP0004627A2 (hu) | 1997-06-17 | 1998-06-15 | Farnezil-protein transzferáz inhibitor hatású új triciklusos szulfonamidszármazékok és a vegyületeket tartalmazó gyógyszerkészítmények |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0989980A1 (zh) |
| JP (1) | JP2002507192A (zh) |
| KR (1) | KR20010013826A (zh) |
| CN (1) | CN1267290A (zh) |
| AR (1) | AR012989A1 (zh) |
| AU (1) | AU8253698A (zh) |
| CA (1) | CA2293358C (zh) |
| CO (1) | CO4940475A1 (zh) |
| HU (1) | HUP0004627A2 (zh) |
| IL (1) | IL133393A0 (zh) |
| NZ (1) | NZ501619A (zh) |
| PE (1) | PE86199A1 (zh) |
| WO (1) | WO1998057949A1 (zh) |
| ZA (1) | ZA985218B (zh) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6689789B2 (en) | 1997-06-17 | 2004-02-10 | Schering Corporation | Compounds useful for inhibition of farnesyl protein transferase |
| US7517884B2 (en) | 1998-03-30 | 2009-04-14 | Kalypsys Inc. | Sulfonyl-substituted bicyclic compounds as modulators of PPAR |
| US7342016B2 (en) | 2000-08-30 | 2008-03-11 | Schering Corporation | Farnesyl protein transferase inhibitors as antitumor agents |
| CA2429720C (en) * | 2000-11-29 | 2009-12-29 | Schering Corporation | Tricyclic compounds useful for the inhibition of farnesyl protein transferase |
| WO2006055187A1 (en) | 2004-10-29 | 2006-05-26 | Kalypsys, Inc. | Sulfonyl-substituted bicyclic compounds as modulators of ppar |
| KR101464767B1 (ko) | 2005-10-25 | 2014-11-24 | 칼립시스, 인코포레이티드 | Ｐｐａｒ의 조절자의 염 및 대사질환을 치료하는 방법 |
| US20080176861A1 (en) | 2007-01-23 | 2008-07-24 | Kalypsys, Inc. | Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis |
| BR112015019818A2 (pt) * | 2013-02-19 | 2017-07-18 | Icahn School Med Mount Sinai | composto, uso de um composto, e, composição farmacêutica |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUT76057A (en) * | 1993-10-15 | 1997-06-30 | Schering Corp | Tricyclic sulfonamide compounds, pharmaceutical compositions containing them, which are useful for inhibition of g-protein function and for treatment of proliferative diseases and process for producing them |
| IL117797A0 (en) * | 1995-04-07 | 1996-08-04 | Pharmacopeia Inc | Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
| IL117798A (en) * | 1995-04-07 | 2001-11-25 | Schering Plough Corp | Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them |
-
1998
- 1998-06-15 CN CN98808186A patent/CN1267290A/zh active Pending
- 1998-06-15 KR KR1019997011846A patent/KR20010013826A/ko not_active Application Discontinuation
- 1998-06-15 IL IL13339398A patent/IL133393A0/xx unknown
- 1998-06-15 NZ NZ501619A patent/NZ501619A/en unknown
- 1998-06-15 PE PE1998000508A patent/PE86199A1/es not_active Application Discontinuation
- 1998-06-15 JP JP54752198A patent/JP2002507192A/ja active Pending
- 1998-06-15 HU HU0004627A patent/HUP0004627A2/hu unknown
- 1998-06-15 AU AU82536/98A patent/AU8253698A/en not_active Abandoned
- 1998-06-15 WO PCT/US1998/011508 patent/WO1998057949A1/en not_active Application Discontinuation
- 1998-06-15 EP EP98932718A patent/EP0989980A1/en not_active Withdrawn
- 1998-06-15 CA CA002293358A patent/CA2293358C/en not_active Expired - Fee Related
- 1998-06-15 ZA ZA985218A patent/ZA985218B/xx unknown
- 1998-06-16 AR ARP980102859A patent/AR012989A1/es unknown
- 1998-06-16 CO CO98034142A patent/CO4940475A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2293358C (en) | 2008-08-05 |
| ZA985218B (en) | 1998-12-15 |
| AR012989A1 (es) | 2000-11-22 |
| PE86199A1 (es) | 1999-09-24 |
| CN1267290A (zh) | 2000-09-20 |
| AU8253698A (en) | 1999-01-04 |
| NZ501619A (en) | 2002-02-01 |
| CO4940475A1 (es) | 2000-07-24 |
| IL133393A0 (en) | 2001-04-30 |
| JP2002507192A (ja) | 2002-03-05 |
| KR20010013826A (ko) | 2001-02-26 |
| WO1998057949A1 (en) | 1998-12-23 |
| CA2293358A1 (en) | 1998-12-23 |
| EP0989980A1 (en) | 2000-04-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP0002954A2 (hu) | Farnezil-protein transzferáz új N-szubsztituált-karbamid inhibitorai | |
| HUP0000121A2 (hu) | Farnezil-protein transzferáz triciklusos inhibitorai, e vegyületeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| EP1206935A4 (en) | TH2 DIFFERENTIAL INHIBITION | |
| HUP0004627A2 (hu) | Farnezil-protein transzferáz inhibitor hatású új triciklusos szulfonamidszármazékok és a vegyületeket tartalmazó gyógyszerkészítmények | |
| HUP0001109A2 (hu) | Triciklusos farnezil-protein transzferáz inhibitorok mint tumorellenes vegyületek | |
| HUP0401488A2 (hu) | Fungicid hatású 7-amino-triazolopirimidinek, előállításuk, alkalmazásuk és ilyeneket tartalmazó készítmények | |
| ES2048109A1 (es) | Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol. | |
| ES2110620T3 (es) | Derivados de la 4-aza-5-alfa-androstan-3-ona sustituidos en la posicion 17-beta. | |
| HUP0003425A2 (hu) | 2-(4-Aril- vagy heteroaril-piperazin-ilmetil)-1H-indol-származékok és a vegyületeket tartalmazó gyógyászati készítmények | |
| NO930244D0 (no) | Umettede 17beta-substituerte 3-karboksysteroider | |
| AU767923C (en) | Novel 2-(N-cyanoimino)thiazolidin-4-one derivatives | |
| NO913176L (no) | Morfolinylderivater av doxorubicin og deres fremstilling. | |
| HUP0004588A2 (hu) | Szubsztituált 1,2,3,4,5,6-hexahidro-2,6-metano-3-benzazocin-10-ol-származékok, eljárás előállításukra és alkalmazásuk gyógyszerként, valamint a vegyületeket tartalmazó gyógyszerkészítmények | |
| ATE46159T1 (de) | Pyridazinone, inotrope mittel. | |
| NO881759D0 (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive benzo- og tieno- 3,4-dihydro- pyridinderivater. | |
| EP0878196A4 (en) | INHIBITORS OF KAINIC ACID NEUROTOXICITY AND PYRIDOTHIAZINE DERIVATIVES | |
| IE37817L (en) | 3- acylhydrazonomethyl rifamycin sv | |
| ES2003100A6 (es) | Un procedimiento para preparar imidazoles | |
| AU597923B2 (en) | 5-aminoalkyl-beta-carboline derivatives, their production and their use as drugs | |
| IS7100A (is) | Notkun á þíasólafleiðum til framleiðslu á lyfi til að vernda hvatbera | |
| AU6676098A (en) | Substituted tetrahydropyrimidine derivatives and their use as polymerization inhibitors for vinyl aromatic compounds | |
| HUP0204149A2 (hu) | Új szulfoniloxazolamin-származékok, ezeket tartalmazó gyógyszerkészítmények és eljárás a vegyületek előállítására | |
| HUP0004806A2 (hu) | Farnezil-protein transzferáz gátlására alkalmazható benzo [5,6]ciklohepta[1,2-b]piridin-származékok és a vegyületeket tartalmazó gyógyszerkészítmények | |
| HU9600597D0 (en) | 4-alkylthio-pyrimidin-5-yl acetic acid derivates and fungicidal compositions containing them as an active ingredient | |
| DK163922C (da) | 2,3-dihydro-3-phenyl-2-benzofuranonderivater, fremgangsmaader til deres fremstilling og farmaceutiske midler indeholdende dem |