JP2002507192A - ファルネシルタンパク質トランスフェラーゼの新規三環式スルホンアミドインヒビター - Google Patents

ファルネシルタンパク質トランスフェラーゼの新規三環式スルホンアミドインヒビター

Info

Publication number
JP2002507192A
JP2002507192A JP54752198A JP54752198A JP2002507192A JP 2002507192 A JP2002507192 A JP 2002507192A JP 54752198 A JP54752198 A JP 54752198A JP 54752198 A JP54752198 A JP 54752198A JP 2002507192 A JP2002507192 A JP 2002507192A
Authority
JP
Japan
Prior art keywords
compound
alkyl
heteroaryl
hydrogen
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP54752198A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002507192A5 (zh
Inventor
ニョロージ，エフ．ジョージ
ビブルバン，バンチャ
ジー． タベラス，アーサー
ジェイ． ドール，ロナルド
エム． ギリジャバラバン，ビヨール
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of JP2002507192A publication Critical patent/JP2002507192A/ja
Publication of JP2002507192A5 publication Critical patent/JP2002507192A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP54752198A 1997-06-17 1998-06-15 ファルネシルタンパク質トランスフェラーゼの新規三環式スルホンアミドインヒビター Pending JP2002507192A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87705097A 1997-06-17 1997-06-17
US08/877,050 1997-06-17
PCT/US1998/011508 WO1998057949A1 (en) 1997-06-17 1998-06-15 Novel tricyclic sulfonamide inhibitors of farnesyl-protein transferase

Publications (2)

Publication Number Publication Date
JP2002507192A true JP2002507192A (ja) 2002-03-05
JP2002507192A5 JP2002507192A5 (zh) 2005-12-08

Family

ID=25369146

Family Applications (1)

Application Number Title Priority Date Filing Date
JP54752198A Pending JP2002507192A (ja) 1997-06-17 1998-06-15 ファルネシルタンパク質トランスフェラーゼの新規三環式スルホンアミドインヒビター

Country Status (14)

Country Link
EP (1) EP0989980A1 (zh)
JP (1) JP2002507192A (zh)
KR (1) KR20010013826A (zh)
CN (1) CN1267290A (zh)
AR (1) AR012989A1 (zh)
AU (1) AU8253698A (zh)
CA (1) CA2293358C (zh)
CO (1) CO4940475A1 (zh)
HU (1) HUP0004627A2 (zh)
IL (1) IL133393A0 (zh)
NZ (1) NZ501619A (zh)
PE (1) PE86199A1 (zh)
WO (1) WO1998057949A1 (zh)
ZA (1) ZA985218B (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016508521A (ja) * 2013-02-19 2016-03-22 アイカーン スクール オブ メディスン アット マウント サイナイＩｃａｈｎ Ｓｃｈｏｏｌ ｏｆ Ｍｅｄｉｃｉｎｅ ａｔ Ｍｔ． Ｓｉｎａｉ 抗腫瘍剤としての三環式複素環

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6689789B2 (en) 1997-06-17 2004-02-10 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
US7517884B2 (en) 1998-03-30 2009-04-14 Kalypsys Inc. Sulfonyl-substituted bicyclic compounds as modulators of PPAR
US7342016B2 (en) 2000-08-30 2008-03-11 Schering Corporation Farnesyl protein transferase inhibitors as antitumor agents
JP2004514717A (ja) * 2000-11-29 2004-05-20 シェーリング　コーポレイション 新規ファルネシルプロテイントランスフェラーゼインヒビター
BRPI0516435B1 (pt) 2004-10-29 2021-09-21 Kalypsys , Inc Composto, e composição farmacêutica
EP1940815B1 (en) 2005-10-25 2018-08-15 Kalypsys, Inc. Salts of modulators of ppar and methods of treating metabolic disorders
WO2008091863A1 (en) 2007-01-23 2008-07-31 Kalypsys, Inc. Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08510445A (ja) * 1993-10-15 1996-11-05 シェーリング コーポレイション Ｇ−タンパク質機能の阻害および増殖性疾患の治療に有用な三環式スルホンアミド化合物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL117798A (en) * 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them
IL117797A0 (en) * 1995-04-07 1996-08-04 Pharmacopeia Inc Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08510445A (ja) * 1993-10-15 1996-11-05 シェーリング コーポレイション Ｇ−タンパク質機能の阻害および増殖性疾患の治療に有用な三環式スルホンアミド化合物

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016508521A (ja) * 2013-02-19 2016-03-22 アイカーン スクール オブ メディスン アット マウント サイナイＩｃａｈｎ Ｓｃｈｏｏｌ ｏｆ Ｍｅｄｉｃｉｎｅ ａｔ Ｍｔ． Ｓｉｎａｉ 抗腫瘍剤としての三環式複素環

Also Published As

Publication number Publication date
NZ501619A (en) 2002-02-01
PE86199A1 (es) 1999-09-24
ZA985218B (en) 1998-12-15
WO1998057949A1 (en) 1998-12-23
IL133393A0 (en) 2001-04-30
CN1267290A (zh) 2000-09-20
AU8253698A (en) 1999-01-04
CA2293358A1 (en) 1998-12-23
CO4940475A1 (es) 2000-07-24
EP0989980A1 (en) 2000-04-05
CA2293358C (en) 2008-08-05
HUP0004627A2 (hu) 2001-10-28
KR20010013826A (ko) 2001-02-26
AR012989A1 (es) 2000-11-22

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