CA2293358C - Tricyclic sulfonamide inhibitors of farnesyl-protein transferase - Google Patents

Tricyclic sulfonamide inhibitors of farnesyl-protein transferase Download PDF

Info

Publication number
CA2293358C
CA2293358C CA002293358A CA2293358A CA2293358C CA 2293358 C CA2293358 C CA 2293358C CA 002293358 A CA002293358 A CA 002293358A CA 2293358 A CA2293358 A CA 2293358A CA 2293358 C CA2293358 C CA 2293358C
Authority
CA
Canada
Prior art keywords
compound
pharmaceutically acceptable
solvate
acceptable salt
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002293358A
Other languages
English (en)
French (fr)
Other versions
CA2293358A1 (en
Inventor
F. George Njoroge
Bancha Vibulbhan
Arthur G. Taveras
Ronald J. Doll
Viyyoor M. Girijavallabhan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of CA2293358A1 publication Critical patent/CA2293358A1/en
Application granted granted Critical
Publication of CA2293358C publication Critical patent/CA2293358C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA002293358A 1997-06-17 1998-06-15 Tricyclic sulfonamide inhibitors of farnesyl-protein transferase Expired - Fee Related CA2293358C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87705097A 1997-06-17 1997-06-17
US08/877,050 1997-06-17
PCT/US1998/011508 WO1998057949A1 (en) 1997-06-17 1998-06-15 Novel tricyclic sulfonamide inhibitors of farnesyl-protein transferase

Publications (2)

Publication Number Publication Date
CA2293358A1 CA2293358A1 (en) 1998-12-23
CA2293358C true CA2293358C (en) 2008-08-05

Family

ID=25369146

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002293358A Expired - Fee Related CA2293358C (en) 1997-06-17 1998-06-15 Tricyclic sulfonamide inhibitors of farnesyl-protein transferase

Country Status (14)

Country Link
EP (1) EP0989980A1 (zh)
JP (1) JP2002507192A (zh)
KR (1) KR20010013826A (zh)
CN (1) CN1267290A (zh)
AR (1) AR012989A1 (zh)
AU (1) AU8253698A (zh)
CA (1) CA2293358C (zh)
CO (1) CO4940475A1 (zh)
HU (1) HUP0004627A2 (zh)
IL (1) IL133393A0 (zh)
NZ (1) NZ501619A (zh)
PE (1) PE86199A1 (zh)
WO (1) WO1998057949A1 (zh)
ZA (1) ZA985218B (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6689789B2 (en) 1997-06-17 2004-02-10 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
US7517884B2 (en) 1998-03-30 2009-04-14 Kalypsys Inc. Sulfonyl-substituted bicyclic compounds as modulators of PPAR
US7494999B2 (en) 2004-10-29 2009-02-24 Kalypsys, Inc Sulfonyl-substituted bicyclic compounds as modulators of PPAR
US7342016B2 (en) 2000-08-30 2008-03-11 Schering Corporation Farnesyl protein transferase inhibitors as antitumor agents
PE20020635A1 (es) * 2000-11-29 2002-07-11 Schering Corp Compuestos triciclicos como inhibidores de la farnesil transferasa
NZ566831A (en) 2005-10-25 2011-09-30 Kalypsys Inc Salts of modulators of PPAR and methods of treating metabolic disorders
WO2008091863A1 (en) 2007-01-23 2008-07-31 Kalypsys, Inc. Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis
US9796717B2 (en) * 2013-02-19 2017-10-24 Icahn School Of Medicine At Mount Sinai Tricyclic heterocycles as anticancer agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2164717T3 (es) * 1993-10-15 2002-03-01 Schering Corp Compuestos triciclicos de sulfonamida utiles para inhibir la funcion de la proteina-g y para el tratamiento de enfermedades proliferativas.
IL117798A (en) * 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them
IL117797A0 (en) * 1995-04-07 1996-08-04 Pharmacopeia Inc Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases

Also Published As

Publication number Publication date
CO4940475A1 (es) 2000-07-24
PE86199A1 (es) 1999-09-24
HUP0004627A2 (hu) 2001-10-28
EP0989980A1 (en) 2000-04-05
ZA985218B (en) 1998-12-15
IL133393A0 (en) 2001-04-30
CA2293358A1 (en) 1998-12-23
KR20010013826A (ko) 2001-02-26
NZ501619A (en) 2002-02-01
JP2002507192A (ja) 2002-03-05
WO1998057949A1 (en) 1998-12-23
CN1267290A (zh) 2000-09-20
AU8253698A (en) 1999-01-04
AR012989A1 (es) 2000-11-22

Similar Documents

Publication Publication Date Title
CA2293706C (en) N-substituted urea inhibitors of farnesyl-protein transferase
US6358968B1 (en) N-substituted urea inhibitors of farnesyl-protein transferase
WO1998057946A1 (en) Carboxy piperidylacetamide tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases (farnesyl protein transferase inhibitors)
CA2293358C (en) Tricyclic sulfonamide inhibitors of farnesyl-protein transferase
WO1998011106A1 (en) Tricyclic compounds useful as fpt inhibitors
WO1998057970A1 (en) Benzo(5,6)cycloheptapyridine compounds useful as farnesyl protein transferase inhibitors
EP0989978A1 (en) Tricyclic keto amide derivatives useful as farnesyl protein transferase inhibitors
EP0931079A1 (en) Substituted benzocycloheptapyridine derivatives useful for inhibition of farnesyl protein transferase
US6426352B1 (en) Sulfonamide inhibitors of farnesyl-protein transferase
NZ501570A (en) Benzo(5,6) cycloheptapyridine cyclic ureas and lactams useful as farnesyl protein transferase inhibitors
CA2293372C (en) Benzo(5,6)cyclohepta(1,2b)pyridine derivatives useful for inhibition of farnesyl protein transferase
CA2293553C (en) Aminooxyamide tricyclic inhibitors of farnesyl-protein transferase
US5945430A (en) Aminooxyamide tricyclic inhibitors of farnesyl-protein transferase
CA2261724C (en) Novel tricyclic n-cyanoimines useful as inhibitors of farnesyl-protein transferase
CA2293549C (en) Phenyl-substituted tricyclic inhibitors of farnesyl-protein transferase
MXPA99012084A (en) Novel tricyclic sulfonamide inhibitors of farnesyl-protein transferase
EP0927179B1 (en) Substituted benzocycloheptapyridine derivatives useful for inhibition of farnesyl protein transferase
MXPA99012080A (en) Novel aminooxyamide tricyclic inhibitors of farnesylprotein transferase
MXPA99012079A (en) Novel phenyl-substituted tricyclic inhibitors of farnesyl-protein transferase
MXPA99012069A (en) Novel n-substituted urea inhibitors of farnesyl-protein transferase
MXPA99012066A (en) Benzo(5,6)cycloheptapyridine compounds useful as farnesyl protein transferase inhibitors
MXPA99012089A (en) Carboxy piperidylacetamide tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases (farnesyl protein transferase inhibitors)
MXPA99012087A (en) Benzo(5,6)cyclohepta(1,2b)pyridine derivatives useful for inhibition of farnesyl protein transferase

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed