AU8253698A - Novel tricyclic sulfonamide inhibitors of farnesyl-protein transferase - Google Patents

Novel tricyclic sulfonamide inhibitors of farnesyl-protein transferase Download PDF

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Publication number
AU8253698A
AU8253698A AU82536/98A AU8253698A AU8253698A AU 8253698 A AU8253698 A AU 8253698A AU 82536/98 A AU82536/98 A AU 82536/98A AU 8253698 A AU8253698 A AU 8253698A AU 8253698 A AU8253698 A AU 8253698A
Authority
AU
Australia
Prior art keywords
compound
alkyl
cells
heteroaryl
tumor cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU82536/98A
Other languages
English (en)
Inventor
Ronald J. Doll
Viyyoor M. Girijavallabhan
F. George Njoroge
Arthur G. Taveras
Bancha Vibulbhan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of AU8253698A publication Critical patent/AU8253698A/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU82536/98A 1997-06-17 1998-06-15 Novel tricyclic sulfonamide inhibitors of farnesyl-protein transferase Abandoned AU8253698A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87705097A 1997-06-17 1997-06-17
US08877050 1997-06-17
PCT/US1998/011508 WO1998057949A1 (en) 1997-06-17 1998-06-15 Novel tricyclic sulfonamide inhibitors of farnesyl-protein transferase

Publications (1)

Publication Number Publication Date
AU8253698A true AU8253698A (en) 1999-01-04

Family

ID=25369146

Family Applications (1)

Application Number Title Priority Date Filing Date
AU82536/98A Abandoned AU8253698A (en) 1997-06-17 1998-06-15 Novel tricyclic sulfonamide inhibitors of farnesyl-protein transferase

Country Status (14)

Country Link
EP (1) EP0989980A1 (zh)
JP (1) JP2002507192A (zh)
KR (1) KR20010013826A (zh)
CN (1) CN1267290A (zh)
AR (1) AR012989A1 (zh)
AU (1) AU8253698A (zh)
CA (1) CA2293358C (zh)
CO (1) CO4940475A1 (zh)
HU (1) HUP0004627A2 (zh)
IL (1) IL133393A0 (zh)
NZ (1) NZ501619A (zh)
PE (1) PE86199A1 (zh)
WO (1) WO1998057949A1 (zh)
ZA (1) ZA985218B (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6689789B2 (en) 1997-06-17 2004-02-10 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
US7517884B2 (en) 1998-03-30 2009-04-14 Kalypsys Inc. Sulfonyl-substituted bicyclic compounds as modulators of PPAR
US7494999B2 (en) 2004-10-29 2009-02-24 Kalypsys, Inc Sulfonyl-substituted bicyclic compounds as modulators of PPAR
US7342016B2 (en) 2000-08-30 2008-03-11 Schering Corporation Farnesyl protein transferase inhibitors as antitumor agents
PE20020635A1 (es) * 2000-11-29 2002-07-11 Schering Corp Compuestos triciclicos como inhibidores de la farnesil transferasa
NZ566831A (en) 2005-10-25 2011-09-30 Kalypsys Inc Salts of modulators of PPAR and methods of treating metabolic disorders
WO2008091863A1 (en) 2007-01-23 2008-07-31 Kalypsys, Inc. Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis
US9796717B2 (en) * 2013-02-19 2017-10-24 Icahn School Of Medicine At Mount Sinai Tricyclic heterocycles as anticancer agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2164717T3 (es) * 1993-10-15 2002-03-01 Schering Corp Compuestos triciclicos de sulfonamida utiles para inhibir la funcion de la proteina-g y para el tratamiento de enfermedades proliferativas.
IL117798A (en) * 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them
IL117797A0 (en) * 1995-04-07 1996-08-04 Pharmacopeia Inc Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases

Also Published As

Publication number Publication date
CO4940475A1 (es) 2000-07-24
PE86199A1 (es) 1999-09-24
HUP0004627A2 (hu) 2001-10-28
EP0989980A1 (en) 2000-04-05
CA2293358C (en) 2008-08-05
ZA985218B (en) 1998-12-15
IL133393A0 (en) 2001-04-30
CA2293358A1 (en) 1998-12-23
KR20010013826A (ko) 2001-02-26
NZ501619A (en) 2002-02-01
JP2002507192A (ja) 2002-03-05
WO1998057949A1 (en) 1998-12-23
CN1267290A (zh) 2000-09-20
AR012989A1 (es) 2000-11-22

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Legal Events

Date Code Title Description
MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted