HUP0004398A2 - Alfa-aril-N-alkil-nitronok és alfa-aril-N-alkil-nitronokat tartalmazó gyógyászati készítmények - Google Patents
Alfa-aril-N-alkil-nitronok és alfa-aril-N-alkil-nitronokat tartalmazó gyógyászati készítményekInfo
- Publication number
- HUP0004398A2 HUP0004398A2 HU0004398A HUP0004398A HUP0004398A2 HU P0004398 A2 HUP0004398 A2 HU P0004398A2 HU 0004398 A HU0004398 A HU 0004398A HU P0004398 A HUP0004398 A HU P0004398A HU P0004398 A2 HUP0004398 A2 HU P0004398A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- hydrogen atom
- attached
- cycloalkyl
- alkyl
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 10
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 5
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 4
- -1 n-butoxy, n-pentyloxy Chemical group 0.000 abstract 4
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 abstract 3
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000005530 alkylenedioxy group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000005160 aryl oxy alkyl group Chemical group 0.000 abstract 1
- 230000001363 autoimmune Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000005112 cycloalkylalkoxy group Chemical group 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 125000001298 n-hexoxy group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])O* 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 230000000626 neurodegenerative effect Effects 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/04—Nitro compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
- C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
- C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
- C07C291/04—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds containing amino-oxide bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
Abstract
A találmány tárgyát képezik az (I) általános képletű - ahol R1jelentése alkoxi-, aril-alkoxi-, cikloalkil-alkoxi-, aril-oxi- vagycikloalkoxicsoport; R2 jelentése hidrogénatom, alkoxi-, cikloalkil-alkoxi-, cikloalkoxicsoport vagy halogénatom, vagy - ahol az R1 és R2szomszédos szénatomokhoz kapcsolódik - R1 és R2 egymássalösszekapcsolódva egy alkilén-dioxi-csoportot képeznek; R3 jelentésehidrogénatom, alkoxi-, cikloalkil-alkoxi-, cikloalkoxicsoport vagyhalogéantom; R4 jelentése hidrogénatom vagy alkilcsoport; R5 jelentése1-3 szénatomos alkilcsoport, helyettesített 1-3 szénatomosalkilcsoport vagy cikloalkilcsoport; azzal a feltétellel, hogy (i) haR2 és R3 jelentése egymástól függetlenül hidrogénatom vagymetoxicsoport, R1 jelentése nem lehet metoxicsoport; (ii) ha R2, R3 ésR4 jelentése hidrogénatom és R5 jelentése terc-butil-csoport, akkor R1nem lehet a 4-es helyen csatlakozó n-butoxi-, n-pentil-oxi- vagy n-hexil-oxi-csoport; (iii) ha R2, R3 és R4 jelentése hidrogénatom és R5jelentése izopropilcsoport, akkor R1 jelentése nem lehet a 4-es helyencsatlakozó etoxicsoport; (iv) ha R1 és R2 egymással kapcsolódva egy, a3-as és 4-es helyen csatlakozó metilén-dioxi-csoportot képez és R3,valamint R4 jelentése hidrogénatom, akkor R5 jelentése nem lehetizopropil- vagy terc-butil-csoport; (v) ha R2, R3 és R4 jelentésehidrogénatom és R5 jelentése 1-hidroxi-2-metil-prop-2-il-csoport,akkor R1 jelentése nem lehet 2-es helyen csatlakozó etoxicsoport; (vi)ha R1 jelentése 4-es helyen csatlakozó metoxicsoport, R2 jelentése 3-as helyen csatlakozó etoxicsoport és R3, valamint R4 jelentésehidrogénatom, akkor R5 jelentése nem lehet 2,2-dimetil-but-3-il- vagy1-hidroxi-2-metil-prop-2-il-csoport; és (vii) ha R3 és R4 jelentésehidrogénatom és R5 jelentése terc-butil-csoport, akkor R1 jelentésenem lehet a 4-es helyen csatlakozó metoxicsoport, ha R2 jelentése 2-eshelyen csatlakozó fluoratom és R1 jelentése nem lehet 2-es helyencsatlakozó metoxicsoport, ha R2 jelentése 4-es helyen csatlakozófluoratom - vegyületek, és e vegyületeket tartalmazó,neurodegeneratív, autoimmun és/vagy gyulladásos betegségekmegelőzésére és/vagy kezelésére szolgáló gyógyszerkészítmények. Ó
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6232497P | 1997-10-17 | 1997-10-17 | |
| US6373697P | 1997-10-29 | 1997-10-29 | |
| US9047598P | 1998-06-24 | 1998-06-24 | |
| PCT/US1998/021624 WO1999020601A1 (en) | 1997-10-17 | 1998-10-16 | α-ARYL-N-ALKYLNITRONES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0004398A2 true HUP0004398A2 (hu) | 2001-05-28 |
| HUP0004398A3 HUP0004398A3 (en) | 2001-11-28 |
Family
ID=27370256
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0004398A HUP0004398A3 (en) | 1997-10-17 | 1998-10-16 | Alpha-aryl-n-alkylnitrones and pharmaceutical compositions containing the same |
Country Status (24)
| Country | Link |
|---|---|
| US (5) | US6046232A (hu) |
| EP (1) | EP1025079B1 (hu) |
| JP (1) | JP2001520217A (hu) |
| KR (1) | KR20010024520A (hu) |
| CN (1) | CN1281432A (hu) |
| AR (1) | AR015969A1 (hu) |
| AT (1) | ATE288419T1 (hu) |
| AU (1) | AU1083399A (hu) |
| BR (1) | BR9813256A (hu) |
| CA (1) | CA2305798A1 (hu) |
| DE (1) | DE69828895T2 (hu) |
| ES (1) | ES2235374T3 (hu) |
| HU (1) | HUP0004398A3 (hu) |
| ID (1) | ID25543A (hu) |
| IL (1) | IL135646A0 (hu) |
| MA (1) | MA26553A1 (hu) |
| NO (1) | NO20001914L (hu) |
| NZ (1) | NZ503910A (hu) |
| PL (1) | PL340003A1 (hu) |
| SK (1) | SK5512000A3 (hu) |
| TN (1) | TNSN98187A1 (hu) |
| TR (1) | TR200001023T2 (hu) |
| TW (1) | TWI226882B (hu) |
| WO (1) | WO1999020601A1 (hu) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6046232A (en) * | 1997-10-17 | 2000-04-04 | Centaur Pharmaceuticals, Inc. | α-aryl-N-alkylnitrones and pharmaceutical compositions containing the same |
| US6194465B1 (en) | 1998-05-19 | 2001-02-27 | Centaur Pharmaceuticals, Inc. | Benzamide therapeutics for the treatment of inflammatory bowel disease |
| US6083989A (en) * | 1999-05-18 | 2000-07-04 | Centaur Pharmaceuticals, Inc. | Aryl nitrone therapeutics for the treatment of inflammatory bowel disease |
| PT1077694E (pt) * | 1998-05-19 | 2004-12-31 | Renovis Inc | Produtos terapeuticos de arilnitrona para o tratamento da doenca inflamatoria dointestino |
| US6197826B1 (en) | 1998-07-17 | 2001-03-06 | Centaur Pharmaceuticals, Inc. | α-(2-hydroxyphenyl) nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation |
| US6730700B2 (en) | 1998-12-02 | 2004-05-04 | Renovis, Inc. | 3,4,5,-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing the same |
| UA66401C2 (en) * | 1998-12-02 | 2004-05-17 | Sentor Pharmaceuticals Inc | 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical composition containing the same |
| BR9904931A (pt) * | 1999-10-18 | 2001-06-12 | Sergio Teixeira Ferreira | Inibição de amiloidoses |
| WO2001035951A2 (en) * | 1999-11-18 | 2001-05-25 | Centaur Pharmaceuticals, Inc. | Aryl nitrone therapeutics and methods for treating inflammatory bowel disease |
| US6444702B1 (en) | 2000-02-22 | 2002-09-03 | Neuromolecular, Inc. | Aminoadamantane derivatives as therapeutic agents |
| US6664297B1 (en) | 2000-10-18 | 2003-12-16 | Universidade Federal Do Rio De Janeiro | Methods for inhibition and dissolution of amyloidoses by administration of compositions comprising 2,4-dinitrophenol |
| US20040122090A1 (en) * | 2001-12-07 | 2004-06-24 | Lipton Stuart A. | Methods for treating neuropsychiatric disorders with nmda receptor antagonists |
| WO2002065993A2 (en) | 2001-01-08 | 2002-08-29 | Centaur Pharmaceuticals, Inc. | Use of aryl nitrone compounds in methods for treating neuropathic pain |
| JP2004527520A (ja) * | 2001-04-02 | 2004-09-09 | パノラマ リサーチ，インコーポレイティド | 治療剤としての抗酸化ニトロキシドおよびニトロン |
| US7115666B2 (en) * | 2002-10-15 | 2006-10-03 | Renovis, Inc. | Nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation and neuropathic pain |
| US6762322B1 (en) | 2002-12-20 | 2004-07-13 | Goodyear Tire & Rubber Company | Preparation of nitrone derivatives |
| WO2004103233A1 (en) * | 2003-05-15 | 2004-12-02 | Cutanix Corporation | Compositions containing a combination of a pharmaceutical agent or a cosmetic agent and an oxy group-bearing aromatic aldehyde |
| US20050059638A1 (en) * | 2003-08-04 | 2005-03-17 | Kelly Michael G. | Aryl, heteroaromatic and bicyclic aryl nitrone compounds, prodrugs and pharmaceutical compositions of the same to treat human disorders |
| US20050182060A1 (en) * | 2004-02-13 | 2005-08-18 | Kelly Michael G. | 2-Substituted and 4-substituted aryl nitrone compounds |
| US7619007B2 (en) * | 2004-11-23 | 2009-11-17 | Adamas Pharmaceuticals, Inc. | Method and composition for administering an NMDA receptor antagonist to a subject |
| BRPI0607017B8 (pt) | 2005-04-06 | 2021-05-25 | Adamas Pharmaceuticals Inc | composição farmacêutica compreendendo memantina e donezepil, e seu uso para o tratamento de condições relacionadas ao snc |
| FR2898602B1 (fr) * | 2006-03-17 | 2012-06-22 | Ts Pharma | Nouveaux derives amphiphiles de l'alpha-c-phenyl-n-tert butyl nitrone |
| CN101468970B (zh) * | 2008-04-25 | 2011-05-11 | 暨南大学 | 一种硝酮类化合物及其制备方法和在制药中的应用 |
| CN106389381A (zh) | 2009-12-02 | 2017-02-15 | 阿达玛斯医药公司 | 金刚烷胺组合物及其使用方法 |
| CN102311396B (zh) * | 2010-07-05 | 2015-01-07 | 暨南大学 | 一种吡嗪类衍生物和其制备方法及在制药中的应用 |
| JP6378878B2 (ja) | 2011-01-07 | 2018-08-22 | アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ | メラニン改変組成物および使用方法 |
| WO2014204933A1 (en) | 2013-06-17 | 2014-12-24 | Adamas Pharmaceuticals, Inc. | Amantadine compositions and methods of use |
| CN107522635B (zh) * | 2017-06-22 | 2020-02-14 | 东北师范大学 | 一类n-环丙基硝酮衍生物及其制备方法 |
| CN107488090B (zh) * | 2017-06-22 | 2020-06-02 | 东北师范大学 | 一种n-环丙基硝酮化合物的高效催化不对称制备方法 |
| CN109438288B (zh) * | 2018-10-22 | 2021-05-07 | 河南中医药大学 | 一种n-硝酮取代芳香酰胺衍生物及其制备方法 |
| CN112479936A (zh) * | 2020-12-16 | 2021-03-12 | 怀化学院 | 一种苯偶酰衍生物硝酮的制备方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3666754A (en) * | 1965-11-06 | 1972-05-30 | Dainippon Pharmaceutical Co | 2-(5-nitrofuryl) nitrone derivatives |
| US3834073A (en) * | 1971-05-03 | 1974-09-10 | Scm Corp | Phenyl nitrone derivatives useful as seed protectants |
| US3849934A (en) * | 1971-05-03 | 1974-11-26 | Scm Corp | Alpha-aryl-n-lower alkyl nitrone-containing compositions useful as anti-fungal agents |
| US3917700A (en) * | 1974-01-30 | 1975-11-04 | Goodyear Tire & Rubber | Nitrone compounds |
| US3903049A (en) * | 1974-01-30 | 1975-09-02 | Goodyear Tire & Rubber | Oxidation resistant sulfur curable rubbery polymers |
| IT1133010B (it) * | 1980-05-15 | 1986-07-09 | Sigma Tau Ind Farmaceuti | Metodo terapuetico per il trattamento del diabete mellito a insorgenza giovanile e composizione farmaceutica per tale metodo |
| GB2137619A (en) * | 1983-03-30 | 1984-10-10 | Gerald Scott | Nitrone compounds and stabilised rubber compositions containing them |
| US5723502A (en) * | 1985-07-18 | 1998-03-03 | Proctor; Peter H. | Topical spin trap composition and method |
| US5352442A (en) * | 1985-07-18 | 1994-10-04 | Proctor Peter H | Topical tempo |
| ATE110954T1 (de) * | 1988-01-29 | 1994-09-15 | Peter H Proctor | Haarwachstumanregung mit nitroxyd und anderen radikalen. |
| KR960008230B1 (ko) * | 1989-10-17 | 1996-06-21 | 윌리엄 쥐.씨먼 | 중추신경계의 산화적 손상에 관련된 질병들을 억제하기 위한 조성물들 |
| ATE209908T1 (de) * | 1991-06-18 | 2001-12-15 | Oklahoma Med Res Found | RADIKALFÄNGER (ßSPIN TRAPSß) ZUR BEHANDLUNG VON MIT OXIDATION VON LIPIDEN UND PROTEINEN VERBUNDENEN ERKRANKUNGEN |
| US5292746A (en) * | 1991-09-12 | 1994-03-08 | Merrell Dow Pharmaceuticals Inc. | Cyclic nitrones, pharmaceutical compositions thereof and their use in treating shock |
| US5455272A (en) * | 1993-10-22 | 1995-10-03 | Oklahoma Medical Research Foundation | Spin trap nitronyl hindered phenols |
| US5488145A (en) * | 1993-12-23 | 1996-01-30 | Oklahoma Medical Research Foundation | 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps |
| WO1997019054A1 (en) * | 1995-11-17 | 1997-05-29 | Florida International University | Azulenyl nitrone spin trapping agents, methods of making and using same |
| TW429241B (en) * | 1996-09-26 | 2001-04-11 | Sumitomo Pharma | Nitrone derivatives |
| US6046232A (en) * | 1997-10-17 | 2000-04-04 | Centaur Pharmaceuticals, Inc. | α-aryl-N-alkylnitrones and pharmaceutical compositions containing the same |
-
1998
- 1998-10-15 US US09/172,763 patent/US6046232A/en not_active Expired - Fee Related
- 1998-10-15 MA MA25299A patent/MA26553A1/fr unknown
- 1998-10-16 ES ES98953466T patent/ES2235374T3/es not_active Expired - Lifetime
- 1998-10-16 WO PCT/US1998/021624 patent/WO1999020601A1/en not_active Application Discontinuation
- 1998-10-16 PL PL98340003A patent/PL340003A1/xx unknown
- 1998-10-16 HU HU0004398A patent/HUP0004398A3/hu unknown
- 1998-10-16 ID IDW20000694A patent/ID25543A/id unknown
- 1998-10-16 JP JP2000516943A patent/JP2001520217A/ja active Pending
- 1998-10-16 KR KR1020007004099A patent/KR20010024520A/ko not_active Application Discontinuation
- 1998-10-16 AU AU10833/99A patent/AU1083399A/en not_active Abandoned
- 1998-10-16 DE DE69828895T patent/DE69828895T2/de not_active Expired - Fee Related
- 1998-10-16 EP EP98953466A patent/EP1025079B1/en not_active Expired - Lifetime
- 1998-10-16 CN CN98811221A patent/CN1281432A/zh active Pending
- 1998-10-16 TN TNTNSN98187A patent/TNSN98187A1/fr unknown
- 1998-10-16 AT AT98953466T patent/ATE288419T1/de not_active IP Right Cessation
- 1998-10-16 BR BR9813256-3A patent/BR9813256A/pt not_active Application Discontinuation
- 1998-10-16 CA CA002305798A patent/CA2305798A1/en not_active Abandoned
- 1998-10-16 AR ARP980105168A patent/AR015969A1/es unknown
- 1998-10-16 NZ NZ503910A patent/NZ503910A/xx unknown
- 1998-10-16 SK SK551-2000A patent/SK5512000A3/sk unknown
- 1998-10-16 IL IL13564698A patent/IL135646A0/xx unknown
- 1998-10-16 TR TR2000/01023T patent/TR200001023T2/xx unknown
- 1998-10-17 TW TW087117185A patent/TWI226882B/zh not_active IP Right Cessation
-
2000
- 2000-04-12 NO NO20001914A patent/NO20001914L/no unknown
- 2000-07-18 US US09/529,555 patent/US6433008B1/en not_active Expired - Fee Related
- 2000-08-09 US US09/635,527 patent/US6441032B1/en not_active Expired - Fee Related
-
2002
- 2002-02-11 US US10/074,595 patent/US20030087957A1/en not_active Abandoned
-
2004
- 2004-03-05 US US10/792,910 patent/US20050124691A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US6441032B1 (en) | 2002-08-27 |
| CA2305798A1 (en) | 1999-04-29 |
| ES2235374T3 (es) | 2005-07-01 |
| IL135646A0 (en) | 2001-05-20 |
| DE69828895T2 (de) | 2006-01-19 |
| EP1025079A1 (en) | 2000-08-09 |
| NO20001914L (no) | 2000-06-02 |
| DE69828895D1 (de) | 2005-03-10 |
| TWI226882B (en) | 2005-01-21 |
| WO1999020601A1 (en) | 1999-04-29 |
| US20050124691A1 (en) | 2005-06-09 |
| KR20010024520A (ko) | 2001-03-26 |
| ID25543A (id) | 2000-10-12 |
| EP1025079B1 (en) | 2005-02-02 |
| TR200001023T2 (tr) | 2000-11-21 |
| US6046232A (en) | 2000-04-04 |
| MA26553A1 (fr) | 2004-12-20 |
| US6433008B1 (en) | 2002-08-13 |
| AR015969A1 (es) | 2001-05-30 |
| SK5512000A3 (en) | 2001-01-18 |
| JP2001520217A (ja) | 2001-10-30 |
| CN1281432A (zh) | 2001-01-24 |
| NO20001914D0 (no) | 2000-04-12 |
| ATE288419T1 (de) | 2005-02-15 |
| AU1083399A (en) | 1999-05-10 |
| TNSN98187A1 (fr) | 2005-03-15 |
| PL340003A1 (en) | 2001-01-15 |
| HUP0004398A3 (en) | 2001-11-28 |
| BR9813256A (pt) | 2000-08-29 |
| US20030087957A1 (en) | 2003-05-08 |
| NZ503910A (en) | 2002-09-27 |
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