NO20001914L - <alfa>-akryl-N-alkylnitroner og farmasøytiske blandinger som inneholder slike - Google Patents

<alfa>-akryl-N-alkylnitroner og farmasøytiske blandinger som inneholder slike

Info

Publication number
NO20001914L
NO20001914L NO20001914A NO20001914A NO20001914L NO 20001914 L NO20001914 L NO 20001914L NO 20001914 A NO20001914 A NO 20001914A NO 20001914 A NO20001914 A NO 20001914A NO 20001914 L NO20001914 L NO 20001914L
Authority
NO
Norway
Prior art keywords
alkylnitrons
alfa
acrylic
pharmaceutical compositions
compositions containing
Prior art date
Application number
NO20001914A
Other languages
English (en)
Other versions
NO20001914D0 (no
Inventor
Judith A Kelleher
Kirk R Maples
Alina Dykman
Yong-Kang Zhang
Allan Lee Wilcox
Julian Levell
Original Assignee
Centaur Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centaur Pharmaceuticals Inc filed Critical Centaur Pharmaceuticals Inc
Publication of NO20001914D0 publication Critical patent/NO20001914D0/no
Publication of NO20001914L publication Critical patent/NO20001914L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/04Nitro compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • C07C291/04Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds containing amino-oxide bonds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/04Systems containing only non-condensed rings with a four-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/06Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/18Systems containing only non-condensed rings with a ring being at least seven-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/56Ring systems containing bridged rings
    • C07C2603/58Ring systems containing bridged rings containing three rings
    • C07C2603/70Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74Adamantanes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Transplantation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
NO20001914A 1997-10-17 2000-04-12 <alfa>-akryl-N-alkylnitroner og farmasøytiske blandinger som inneholder slike NO20001914L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US6232497P 1997-10-17 1997-10-17
US6373697P 1997-10-29 1997-10-29
US9047598P 1998-06-24 1998-06-24
PCT/US1998/021624 WO1999020601A1 (en) 1997-10-17 1998-10-16 α-ARYL-N-ALKYLNITRONES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

Publications (2)

Publication Number Publication Date
NO20001914D0 NO20001914D0 (no) 2000-04-12
NO20001914L true NO20001914L (no) 2000-06-02

Family

ID=27370256

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20001914A NO20001914L (no) 1997-10-17 2000-04-12 <alfa>-akryl-N-alkylnitroner og farmasøytiske blandinger som inneholder slike

Country Status (24)

Country Link
US (5) US6046232A (no)
EP (1) EP1025079B1 (no)
JP (1) JP2001520217A (no)
KR (1) KR20010024520A (no)
CN (1) CN1281432A (no)
AR (1) AR015969A1 (no)
AT (1) ATE288419T1 (no)
AU (1) AU1083399A (no)
BR (1) BR9813256A (no)
CA (1) CA2305798A1 (no)
DE (1) DE69828895T2 (no)
ES (1) ES2235374T3 (no)
HU (1) HUP0004398A3 (no)
ID (1) ID25543A (no)
IL (1) IL135646A0 (no)
MA (1) MA26553A1 (no)
NO (1) NO20001914L (no)
NZ (1) NZ503910A (no)
PL (1) PL340003A1 (no)
SK (1) SK5512000A3 (no)
TN (1) TNSN98187A1 (no)
TR (1) TR200001023T2 (no)
TW (1) TWI226882B (no)
WO (1) WO1999020601A1 (no)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6046232A (en) 1997-10-17 2000-04-04 Centaur Pharmaceuticals, Inc. α-aryl-N-alkylnitrones and pharmaceutical compositions containing the same
EP1079820A1 (en) 1998-05-19 2001-03-07 Centaur Pharmaceuticals, Inc. Benzamide therapeutics for the treatment of inflammatory bowel disease
DK1077694T3 (da) * 1998-05-19 2004-11-22 Renovis Inc Arylnitron-terapeutika til behandling af inflammatorisk tarmsygdom
US6083989A (en) * 1999-05-18 2000-07-04 Centaur Pharmaceuticals, Inc. Aryl nitrone therapeutics for the treatment of inflammatory bowel disease
AU750599B2 (en) 1998-07-17 2002-07-25 Renovis, Inc. Alpha-(2-hydroxyphenyl) nitrone compounds, pharmaceutical compositions containing the same and their use for treating inflammation
UA66401C2 (en) * 1998-12-02 2004-05-17 Sentor Pharmaceuticals Inc 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical composition containing the same
US6730700B2 (en) 1998-12-02 2004-05-04 Renovis, Inc. 3,4,5,-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing the same
BR9904931A (pt) * 1999-10-18 2001-06-12 Sergio Teixeira Ferreira Inibição de amiloidoses
AU1917301A (en) * 1999-11-18 2001-05-30 Centaur Pharmaceuticals, Inc. Aryl nitrone therapeutics and methods for treating inflammatory bowel disease
US6444702B1 (en) 2000-02-22 2002-09-03 Neuromolecular, Inc. Aminoadamantane derivatives as therapeutic agents
US6664297B1 (en) 2000-10-18 2003-12-16 Universidade Federal Do Rio De Janeiro Methods for inhibition and dissolution of amyloidoses by administration of compositions comprising 2,4-dinitrophenol
US20040122090A1 (en) * 2001-12-07 2004-06-24 Lipton Stuart A. Methods for treating neuropsychiatric disorders with nmda receptor antagonists
AU2002253857A1 (en) 2001-01-08 2002-09-04 Centaur Pharmaceuticals, Inc. Use of aryl nitrone compounds in methods for treating neuropathic pain
EP1389181A4 (en) * 2001-04-02 2005-10-19 Panorama Res Inc ANTIOXIDANT NITROXIDES AND NITRONES AS THERAPEUTIC AGENTS
US7115666B2 (en) * 2002-10-15 2006-10-03 Renovis, Inc. Nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation and neuropathic pain
US6762322B1 (en) 2002-12-20 2004-07-13 Goodyear Tire & Rubber Company Preparation of nitrone derivatives
AU2004241107A1 (en) * 2003-05-15 2004-12-02 Cutanix Corporation Compositions containing a combination of a pharmaceutical agent or a cosmetic agent and an oxy group-bearing aromatic aldehyde
US20050059638A1 (en) * 2003-08-04 2005-03-17 Kelly Michael G. Aryl, heteroaromatic and bicyclic aryl nitrone compounds, prodrugs and pharmaceutical compositions of the same to treat human disorders
US20050182060A1 (en) * 2004-02-13 2005-08-18 Kelly Michael G. 2-Substituted and 4-substituted aryl nitrone compounds
US7619007B2 (en) * 2004-11-23 2009-11-17 Adamas Pharmaceuticals, Inc. Method and composition for administering an NMDA receptor antagonist to a subject
KR101406456B1 (ko) * 2005-04-06 2014-06-20 아다마스 파마슈티칼스, 인코포레이티드 Cns 장애의 치료를 위한 방법 및 조성물
FR2898602B1 (fr) * 2006-03-17 2012-06-22 Ts Pharma Nouveaux derives amphiphiles de l'alpha-c-phenyl-n-tert butyl nitrone
CN101468970B (zh) 2008-04-25 2011-05-11 暨南大学 一种硝酮类化合物及其制备方法和在制药中的应用
CA2782556C (en) 2009-12-02 2018-03-27 Adamas Pharmaceuticals, Inc. Amantadine compositions and methods of use
CN102311396B (zh) * 2010-07-05 2015-01-07 暨南大学 一种吡嗪类衍生物和其制备方法及在制药中的应用
CA2823647C (en) 2011-01-07 2016-07-19 Allergan, Inc. Compositions comprising substituted benzaldehydes and use thereof for lightening skin or treating hyperpigmenation and hypermelanosis disorders
WO2014204933A1 (en) 2013-06-17 2014-12-24 Adamas Pharmaceuticals, Inc. Amantadine compositions and methods of use
CN107488090B (zh) * 2017-06-22 2020-06-02 东北师范大学 一种n-环丙基硝酮化合物的高效催化不对称制备方法
CN107522635B (zh) * 2017-06-22 2020-02-14 东北师范大学 一类n-环丙基硝酮衍生物及其制备方法
CN109438288B (zh) * 2018-10-22 2021-05-07 河南中医药大学 一种n-硝酮取代芳香酰胺衍生物及其制备方法
CN112479936A (zh) * 2020-12-16 2021-03-12 怀化学院 一种苯偶酰衍生物硝酮的制备方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3666754A (en) * 1965-11-06 1972-05-30 Dainippon Pharmaceutical Co 2-(5-nitrofuryl) nitrone derivatives
US3849934A (en) * 1971-05-03 1974-11-26 Scm Corp Alpha-aryl-n-lower alkyl nitrone-containing compositions useful as anti-fungal agents
US3834073A (en) * 1971-05-03 1974-09-10 Scm Corp Phenyl nitrone derivatives useful as seed protectants
US3903049A (en) * 1974-01-30 1975-09-02 Goodyear Tire & Rubber Oxidation resistant sulfur curable rubbery polymers
US3917700A (en) * 1974-01-30 1975-11-04 Goodyear Tire & Rubber Nitrone compounds
IT1133010B (it) * 1980-05-15 1986-07-09 Sigma Tau Ind Farmaceuti Metodo terapuetico per il trattamento del diabete mellito a insorgenza giovanile e composizione farmaceutica per tale metodo
GB2137619A (en) * 1983-03-30 1984-10-10 Gerald Scott Nitrone compounds and stabilised rubber compositions containing them
US5723502A (en) * 1985-07-18 1998-03-03 Proctor; Peter H. Topical spin trap composition and method
US5352442A (en) * 1985-07-18 1994-10-04 Proctor Peter H Topical tempo
ATE110954T1 (de) * 1988-01-29 1994-09-15 Peter H Proctor Haarwachstumanregung mit nitroxyd und anderen radikalen.
ATE110565T1 (de) * 1989-10-17 1994-09-15 Oklahoma Med Res Found Verfahren und zubereitungen zur hemmung von mit oxidativer schädigung assoziierten krankheiten.
ATE209908T1 (de) * 1991-06-18 2001-12-15 Oklahoma Med Res Found RADIKALFÄNGER (ßSPIN TRAPSß) ZUR BEHANDLUNG VON MIT OXIDATION VON LIPIDEN UND PROTEINEN VERBUNDENEN ERKRANKUNGEN
US5292746A (en) * 1991-09-12 1994-03-08 Merrell Dow Pharmaceuticals Inc. Cyclic nitrones, pharmaceutical compositions thereof and their use in treating shock
US5455272A (en) * 1993-10-22 1995-10-03 Oklahoma Medical Research Foundation Spin trap nitronyl hindered phenols
US5488145A (en) * 1993-12-23 1996-01-30 Oklahoma Medical Research Foundation 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps
WO1997019054A1 (en) * 1995-11-17 1997-05-29 Florida International University Azulenyl nitrone spin trapping agents, methods of making and using same
TW429241B (en) * 1996-09-26 2001-04-11 Sumitomo Pharma Nitrone derivatives
US6046232A (en) 1997-10-17 2000-04-04 Centaur Pharmaceuticals, Inc. α-aryl-N-alkylnitrones and pharmaceutical compositions containing the same

Also Published As

Publication number Publication date
ID25543A (id) 2000-10-12
TWI226882B (en) 2005-01-21
JP2001520217A (ja) 2001-10-30
NO20001914D0 (no) 2000-04-12
DE69828895T2 (de) 2006-01-19
BR9813256A (pt) 2000-08-29
US6441032B1 (en) 2002-08-27
AR015969A1 (es) 2001-05-30
TNSN98187A1 (fr) 2005-03-15
KR20010024520A (ko) 2001-03-26
CN1281432A (zh) 2001-01-24
EP1025079A1 (en) 2000-08-09
CA2305798A1 (en) 1999-04-29
US6046232A (en) 2000-04-04
ATE288419T1 (de) 2005-02-15
NZ503910A (en) 2002-09-27
EP1025079B1 (en) 2005-02-02
ES2235374T3 (es) 2005-07-01
PL340003A1 (en) 2001-01-15
HUP0004398A3 (en) 2001-11-28
SK5512000A3 (en) 2001-01-18
MA26553A1 (fr) 2004-12-20
AU1083399A (en) 1999-05-10
US6433008B1 (en) 2002-08-13
IL135646A0 (en) 2001-05-20
US20030087957A1 (en) 2003-05-08
WO1999020601A1 (en) 1999-04-29
HUP0004398A2 (hu) 2001-05-28
TR200001023T2 (tr) 2000-11-21
DE69828895D1 (de) 2005-03-10
US20050124691A1 (en) 2005-06-09

Similar Documents

Publication Publication Date Title
NO20001914L (no) &lt;alfa&gt;-akryl-N-alkylnitroner og farmasøytiske blandinger som inneholder slike
DE69836106D1 (de) Stanolester enthaltende Zusammensetzungen
PT853945E (pt) Formulacoes liquidas contendo gonadotrofina
DE69839157D1 (de) Fullurene enthaltendes katherdersystem
DE69802187T2 (de) Mullit enthaltende schleifgegenstände
NO983581D0 (no) Lysfiltrerende kosmetisk sammensetning
ID20233A (id) Komposisi oral
IS4974A (is) Lyfjasamsetning á þrýstingsúðaformi
DE69823360D1 (de) Feste arzneizubereitung enthaltend benzofuranderivate
NO985564L (no) Lysfiltrerende sammensetning
DE69811029T2 (de) Acrylelastomer-Zusammensetzung
DE59801987D1 (de) Pharmazeutische zusammensetzung enthaltend peptichemio
ID20466A (id) Komposisi oral
EE9800400A (et) Diklofenaaki sisaldavad farmatseutilised kompositsioonid
NO20000682D0 (no) Pakning og dispenser
EE9900440A (et) Farmatseutilised kompositsioonid
DK1005342T3 (da) Farmaceutiske sammensætninger indeholdende tizoxanid og nitazoxanid
DE69822559D1 (de) Siliconzusammensetzung
ID25857A (id) Komposisi farmasi
PT986537E (pt) Novos compostos heteroetinilenos e composicoes farmaceuticas e cosmeticas contendo-os
NO994436D0 (no) Farmasöytiske sammensetninger
IT1272935B (it) Composizione farmaceutica contenente n-acetil-cisteina
DE29710177U1 (de) Sanduhr
DE29716382U1 (de) Zeitanzeige
FR2772264B1 (fr) Pilulier