TR200001023T2 - Alfa-aril-N-Alkilnitronlar ve onları içeren farmasötik kompozisyonlar. - Google Patents

Alfa-aril-N-Alkilnitronlar ve onları içeren farmasötik kompozisyonlar.

Info

Publication number
TR200001023T2
TR200001023T2 TR2000/01023T TR200001023T TR200001023T2 TR 200001023 T2 TR200001023 T2 TR 200001023T2 TR 2000/01023 T TR2000/01023 T TR 2000/01023T TR 200001023 T TR200001023 T TR 200001023T TR 200001023 T2 TR200001023 T2 TR 200001023T2
Authority
TR
Turkey
Prior art keywords
aryl
pharmaceutical compositions
compositions containing
alpha
alkylnitrons
Prior art date
Application number
TR2000/01023T
Other languages
English (en)
Inventor
A. Kelleher Judith
R. Maples Kirk
Zhang Yong-Kang
L. Wilcox Allan
Levell Julian
Dykman Alina
Original Assignee
Centaur Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centaur Pharmaceuticals, Inc. filed Critical Centaur Pharmaceuticals, Inc.
Publication of TR200001023T2 publication Critical patent/TR200001023T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/04—Nitro compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • C07C291/04—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds containing amino-oxide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

Abstract

Yeni alfa-aril-N-alkilnitron biesimleri ve bu tür bilesimleri içeren farmasötik kompozisyonlar açiklanmaktadir. Açiklanan bilesimler memelilerde nörodejeneratif, bagisiklik ve iltihapli durumlari önlemek ve/veya tedavi etmek için ilaç olarak ve serbest radikalleri saptamak için analitik belirteçler olarak yararlidir.
TR2000/01023T 1997-10-17 1998-10-16 Alfa-aril-N-Alkilnitronlar ve onları içeren farmasötik kompozisyonlar. TR200001023T2 (tr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6232497P 1997-10-17 1997-10-17
US6373697P 1997-10-29 1997-10-29
US9047598P 1998-06-24 1998-06-24

Publications (1)

Publication Number Publication Date
TR200001023T2 true TR200001023T2 (tr) 2000-11-21

Family

ID=27370256

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/01023T TR200001023T2 (tr) 1997-10-17 1998-10-16 Alfa-aril-N-Alkilnitronlar ve onları içeren farmasötik kompozisyonlar.

Country Status (24)

Country Link
US (5) US6046232A (tr)
EP (1) EP1025079B1 (tr)
JP (1) JP2001520217A (tr)
KR (1) KR20010024520A (tr)
CN (1) CN1281432A (tr)
AR (1) AR015969A1 (tr)
AT (1) ATE288419T1 (tr)
AU (1) AU1083399A (tr)
BR (1) BR9813256A (tr)
CA (1) CA2305798A1 (tr)
DE (1) DE69828895T2 (tr)
ES (1) ES2235374T3 (tr)
HU (1) HUP0004398A3 (tr)
ID (1) ID25543A (tr)
IL (1) IL135646A0 (tr)
MA (1) MA26553A1 (tr)
NO (1) NO20001914L (tr)
NZ (1) NZ503910A (tr)
PL (1) PL340003A1 (tr)
SK (1) SK5512000A3 (tr)
TN (1) TNSN98187A1 (tr)
TR (1) TR200001023T2 (tr)
TW (1) TWI226882B (tr)
WO (1) WO1999020601A1 (tr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6046232A (en) * 1997-10-17 2000-04-04 Centaur Pharmaceuticals, Inc. α-aryl-N-alkylnitrones and pharmaceutical compositions containing the same
US6194465B1 (en) 1998-05-19 2001-02-27 Centaur Pharmaceuticals, Inc. Benzamide therapeutics for the treatment of inflammatory bowel disease
US6083989A (en) * 1999-05-18 2000-07-04 Centaur Pharmaceuticals, Inc. Aryl nitrone therapeutics for the treatment of inflammatory bowel disease
PT1077694E (pt) * 1998-05-19 2004-12-31 Renovis Inc Produtos terapeuticos de arilnitrona para o tratamento da doenca inflamatoria dointestino
US6197826B1 (en) 1998-07-17 2001-03-06 Centaur Pharmaceuticals, Inc. α-(2-hydroxyphenyl) nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation
US6730700B2 (en) 1998-12-02 2004-05-04 Renovis, Inc. 3,4,5,-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing the same
UA66401C2 (en) * 1998-12-02 2004-05-17 Sentor Pharmaceuticals Inc 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical composition containing the same
BR9904931A (pt) * 1999-10-18 2001-06-12 Sergio Teixeira Ferreira Inibição de amiloidoses
WO2001035951A2 (en) * 1999-11-18 2001-05-25 Centaur Pharmaceuticals, Inc. Aryl nitrone therapeutics and methods for treating inflammatory bowel disease
US6444702B1 (en) 2000-02-22 2002-09-03 Neuromolecular, Inc. Aminoadamantane derivatives as therapeutic agents
US6664297B1 (en) 2000-10-18 2003-12-16 Universidade Federal Do Rio De Janeiro Methods for inhibition and dissolution of amyloidoses by administration of compositions comprising 2,4-dinitrophenol
US20040122090A1 (en) * 2001-12-07 2004-06-24 Lipton Stuart A. Methods for treating neuropsychiatric disorders with nmda receptor antagonists
WO2002065993A2 (en) 2001-01-08 2002-08-29 Centaur Pharmaceuticals, Inc. Use of aryl nitrone compounds in methods for treating neuropathic pain
JP2004527520A (ja) * 2001-04-02 2004-09-09 パノラマ リサーチ，インコーポレイティド 治療剤としての抗酸化ニトロキシドおよびニトロン
US7115666B2 (en) * 2002-10-15 2006-10-03 Renovis, Inc. Nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation and neuropathic pain
US6762322B1 (en) 2002-12-20 2004-07-13 Goodyear Tire & Rubber Company Preparation of nitrone derivatives
WO2004103233A1 (en) * 2003-05-15 2004-12-02 Cutanix Corporation Compositions containing a combination of a pharmaceutical agent or a cosmetic agent and an oxy group-bearing aromatic aldehyde
US20050059638A1 (en) * 2003-08-04 2005-03-17 Kelly Michael G. Aryl, heteroaromatic and bicyclic aryl nitrone compounds, prodrugs and pharmaceutical compositions of the same to treat human disorders
US20050182060A1 (en) * 2004-02-13 2005-08-18 Kelly Michael G. 2-Substituted and 4-substituted aryl nitrone compounds
US7619007B2 (en) * 2004-11-23 2009-11-17 Adamas Pharmaceuticals, Inc. Method and composition for administering an NMDA receptor antagonist to a subject
BRPI0607017B8 (pt) 2005-04-06 2021-05-25 Adamas Pharmaceuticals Inc composição farmacêutica compreendendo memantina e donezepil, e seu uso para o tratamento de condições relacionadas ao snc
FR2898602B1 (fr) * 2006-03-17 2012-06-22 Ts Pharma Nouveaux derives amphiphiles de l'alpha-c-phenyl-n-tert butyl nitrone
CN101468970B (zh) * 2008-04-25 2011-05-11 暨南大学 一种硝酮类化合物及其制备方法和在制药中的应用
CN106389381A (zh) 2009-12-02 2017-02-15 阿达玛斯医药公司 金刚烷胺组合物及其使用方法
CN102311396B (zh) * 2010-07-05 2015-01-07 暨南大学 一种吡嗪类衍生物和其制备方法及在制药中的应用
JP6378878B2 (ja) 2011-01-07 2018-08-22 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ メラニン改変組成物および使用方法
WO2014204933A1 (en) 2013-06-17 2014-12-24 Adamas Pharmaceuticals, Inc. Amantadine compositions and methods of use
CN107522635B (zh) * 2017-06-22 2020-02-14 东北师范大学 一类n-环丙基硝酮衍生物及其制备方法
CN107488090B (zh) * 2017-06-22 2020-06-02 东北师范大学 一种n-环丙基硝酮化合物的高效催化不对称制备方法
CN109438288B (zh) * 2018-10-22 2021-05-07 河南中医药大学 一种n-硝酮取代芳香酰胺衍生物及其制备方法
CN112479936A (zh) * 2020-12-16 2021-03-12 怀化学院 一种苯偶酰衍生物硝酮的制备方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3666754A (en) * 1965-11-06 1972-05-30 Dainippon Pharmaceutical Co 2-(5-nitrofuryl) nitrone derivatives
US3834073A (en) * 1971-05-03 1974-09-10 Scm Corp Phenyl nitrone derivatives useful as seed protectants
US3849934A (en) * 1971-05-03 1974-11-26 Scm Corp Alpha-aryl-n-lower alkyl nitrone-containing compositions useful as anti-fungal agents
US3917700A (en) * 1974-01-30 1975-11-04 Goodyear Tire & Rubber Nitrone compounds
US3903049A (en) * 1974-01-30 1975-09-02 Goodyear Tire & Rubber Oxidation resistant sulfur curable rubbery polymers
IT1133010B (it) * 1980-05-15 1986-07-09 Sigma Tau Ind Farmaceuti Metodo terapuetico per il trattamento del diabete mellito a insorgenza giovanile e composizione farmaceutica per tale metodo
GB2137619A (en) * 1983-03-30 1984-10-10 Gerald Scott Nitrone compounds and stabilised rubber compositions containing them
US5723502A (en) * 1985-07-18 1998-03-03 Proctor; Peter H. Topical spin trap composition and method
US5352442A (en) * 1985-07-18 1994-10-04 Proctor Peter H Topical tempo
ATE110954T1 (de) * 1988-01-29 1994-09-15 Peter H Proctor Haarwachstumanregung mit nitroxyd und anderen radikalen.
KR960008230B1 (ko) * 1989-10-17 1996-06-21 윌리엄 쥐.씨먼 중추신경계의 산화적 손상에 관련된 질병들을 억제하기 위한 조성물들
ATE209908T1 (de) * 1991-06-18 2001-12-15 Oklahoma Med Res Found RADIKALFÄNGER (ßSPIN TRAPSß) ZUR BEHANDLUNG VON MIT OXIDATION VON LIPIDEN UND PROTEINEN VERBUNDENEN ERKRANKUNGEN
US5292746A (en) * 1991-09-12 1994-03-08 Merrell Dow Pharmaceuticals Inc. Cyclic nitrones, pharmaceutical compositions thereof and their use in treating shock
US5455272A (en) * 1993-10-22 1995-10-03 Oklahoma Medical Research Foundation Spin trap nitronyl hindered phenols
US5488145A (en) * 1993-12-23 1996-01-30 Oklahoma Medical Research Foundation 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps
WO1997019054A1 (en) * 1995-11-17 1997-05-29 Florida International University Azulenyl nitrone spin trapping agents, methods of making and using same
TW429241B (en) * 1996-09-26 2001-04-11 Sumitomo Pharma Nitrone derivatives
US6046232A (en) * 1997-10-17 2000-04-04 Centaur Pharmaceuticals, Inc. α-aryl-N-alkylnitrones and pharmaceutical compositions containing the same

Also Published As

Publication number Publication date
US6441032B1 (en) 2002-08-27
CA2305798A1 (en) 1999-04-29
ES2235374T3 (es) 2005-07-01
IL135646A0 (en) 2001-05-20
DE69828895T2 (de) 2006-01-19
EP1025079A1 (en) 2000-08-09
NO20001914L (no) 2000-06-02
DE69828895D1 (de) 2005-03-10
TWI226882B (en) 2005-01-21
WO1999020601A1 (en) 1999-04-29
US20050124691A1 (en) 2005-06-09
KR20010024520A (ko) 2001-03-26
ID25543A (id) 2000-10-12
EP1025079B1 (en) 2005-02-02
HUP0004398A2 (hu) 2001-05-28
US6046232A (en) 2000-04-04
MA26553A1 (fr) 2004-12-20
US6433008B1 (en) 2002-08-13
AR015969A1 (es) 2001-05-30
SK5512000A3 (en) 2001-01-18
JP2001520217A (ja) 2001-10-30
CN1281432A (zh) 2001-01-24
NO20001914D0 (no) 2000-04-12
ATE288419T1 (de) 2005-02-15
AU1083399A (en) 1999-05-10
TNSN98187A1 (fr) 2005-03-15
PL340003A1 (en) 2001-01-15
HUP0004398A3 (en) 2001-11-28
BR9813256A (pt) 2000-08-29
US20030087957A1 (en) 2003-05-08
NZ503910A (en) 2002-09-27

Similar Documents

Publication Publication Date Title
TR200001023T2 (tr) Alfa-aril-N-Alkilnitronlar ve onları içeren farmasötik kompozisyonlar.
DE69840025D1 (de) Assoziierter antworten
TR200001218T2 (tr) İkameli karboksamidotiazoller, bunların üretimi ve bunları içeren farmasötik bileşimler.
PT817847E (pt) Receptor de il-17
DE69939864D1 (de) Ppar-gamma modulatoren
AR004357A1 (es) Compuestos de 1-fenil-2-dimetilaminometil-ciclohexan-1-ol, y procedimiento de preparacion para dichos compuestos.
DK0960107T3 (da) 6-Thiosubstituerede paclitaxeler
DE50306232D1 (de) Ampholytisches copolymer und dessen verwendung
TR200102029T2 (tr) 1-Heterosiklil ikameli diarilaminler.
TR199801302T2 (tr) Ikame edilmis aza ve diazasikolopentan ve siklooktan bilesikleri.
YU15299A (sh) Farmaceutski sastavi
ES2146774T3 (es) Polimeros de ioneno que contienen aniones biologicamente activos.
ATE369346T1 (de) Halogenpyrimidinylaryl(thio)ether als pestizide
EA200100732A1 (ru) Противовоспалительные и иммуносупрессорные соединения, ингибирующие клеточную адгезию
TR199802240T2 (tr)
TR200100462T2 (tr) Muskarinik agonistleri ve antagonistleri
DE69729302T2 (de) Illudin analoge verwendet als antitumormittel
TR199900161T2 (tr) Tibbi ürünler üretimi için aminler.
BR0008732A (pt) Métodos para detectar atividade de caspase derivada de membrana e seus moduladores
UA22113C2 (uk) Радіальhий підшипhик
DE69706659T2 (de) Prüfung von elektrischen anlagen
BR9709406B1 (pt) fluorenonas alquiloxiamino substituìdas e composição farmacêutica contendo as mesmas.
ATE305517T1 (de) Neurotrypsin
ATE228123T1 (de) Thiophennitronderivate
DE69917643D1 (de) Alpha-(2-hydroxyphenyl)nitrone, diese enthaltenden pharmazeutische zubereitungen sowie deren verwendung zur behandlung von entzündungen