BR0008732A - Métodos para detectar atividade de caspase derivada de membrana e seus moduladores - Google Patents

Métodos para detectar atividade de caspase derivada de membrana e seus moduladores

Info

Publication number
BR0008732A
BR0008732A BR0008732-7A BR0008732A BR0008732A BR 0008732 A BR0008732 A BR 0008732A BR 0008732 A BR0008732 A BR 0008732A BR 0008732 A BR0008732 A BR 0008732A
Authority
BR
Brazil
Prior art keywords
methods
membrane
caspase activity
modulators
derived caspase
Prior art date
Application number
BR0008732-7A
Other languages
English (en)
Inventor
Lawrence C Fritz
Joseph F Krebs
Original Assignee
Idun Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idun Pharmaceuticals Inc filed Critical Idun Pharmaceuticals Inc
Publication of BR0008732A publication Critical patent/BR0008732A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96466—Cysteine endopeptidases (3.4.22)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"MéTODOS PARA DETECTAR ATIVIDADE DE CASPASE DERIVADA DE MEMBRANA E SEUS MODULADORES". São fornecidos métodos para a detecção de atividade apoptóticas derivada de membrana. Em uma realização, a invenção atual fornece métodos para a identificação da atividade de caspase derivada de membrana. Em outras realizações, são fornecidos métodos de descoberta da droga para a peneiragem de compostos que inibem ou aumentam a atividade de caspase derivada de membrana. Nas várias realizações, as frações pesadas de membrana são utilizadas para as metodologias de peneiragem descritas aqui.
BR0008732-7A 1999-03-05 2000-03-06 Métodos para detectar atividade de caspase derivada de membrana e seus moduladores BR0008732A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/263,590 US6391575B1 (en) 1999-03-05 1999-03-05 Methods for detecting membrane derived caspase activity and modulators thereof
PCT/US2000/005889 WO2000052194A2 (en) 1999-03-05 2000-03-06 Methods for detecting membrane derived caspase activity and modulators thereof

Publications (1)

Publication Number Publication Date
BR0008732A true BR0008732A (pt) 2002-04-09

Family

ID=23002423

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0008732-7A BR0008732A (pt) 1999-03-05 2000-03-06 Métodos para detectar atividade de caspase derivada de membrana e seus moduladores

Country Status (11)

Country Link
US (2) US6391575B1 (pt)
EP (1) EP1161556A2 (pt)
JP (1) JP2002537818A (pt)
KR (1) KR20020008122A (pt)
CN (1) CN1345378A (pt)
AU (1) AU3728100A (pt)
BR (1) BR0008732A (pt)
CA (1) CA2366918A1 (pt)
MX (1) MXPA01008971A (pt)
NZ (1) NZ513923A (pt)
WO (1) WO2000052194A2 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7083945B1 (en) * 2000-10-27 2006-08-01 The Board Of Regents Of The University Of Texas System Isolation of binding proteins with high affinity to ligands
US7927871B2 (en) * 2002-01-29 2011-04-19 Oncoimmunin, Inc. Visualization and quantitation of cellular cytotoxicity using cell-permeable fluorogenic protease substrates and caspase activity indicator markers
CA2474695A1 (en) 2002-02-01 2003-08-14 Promega Corporation Bioluminescent protease assay
US7118877B2 (en) * 2002-07-08 2006-10-10 Wyeth Caspase 9 activation and uses therefor
AU2003298412A1 (en) * 2002-09-03 2004-03-29 Zeptosens Ag Analytical platform and identification method
CA2513769A1 (en) * 2003-01-28 2004-08-12 Georgetown University Method for evaluating the efficacy of certain cancer treatments
US20040254108A1 (en) * 2003-06-13 2004-12-16 Jing Ma Preparation and application of anti-tumor bifunctional fusion proteins
US20050232931A1 (en) * 2003-06-13 2005-10-20 Oncomax Acquisition Corp. Preparation and application of anti-tumor bifunctional fusion proteins
US7416854B2 (en) 2004-01-22 2008-08-26 Promega Corporation Luminogenic and nonluminogenic multiplex assay
US7553632B2 (en) 2004-01-22 2009-06-30 Promega Corporation Luminogenic and nonluminogenic multiplex assay
JP4029298B2 (ja) * 2004-07-26 2008-01-09 大塚製薬株式会社 粘着性マイクロベシクルの除去方法
JP4322757B2 (ja) * 2004-09-06 2009-09-02 富士フイルム株式会社 パターン形成材料及びパターン形成方法
US8227205B2 (en) 2007-04-13 2012-07-24 Promega Corporation Luminescent live and dead cell assay
KR100909996B1 (ko) * 2007-09-19 2009-07-29 한국생명공학연구원 카스파제-3(ｃａｓｐａｓｅ-3)의 활성 검출용 융합 단백질및 이를 이용한 카스파제-3의 활성 검출방법
WO2012061786A1 (en) * 2010-11-05 2012-05-10 Brandeis University Ice cleaved alpha-synuclein a biomarker
WO2019126960A1 (zh) * 2017-12-25 2019-07-04 清华大学 一种具有蛋白酶活性的多肽及其应用
CN110412179A (zh) * 2018-04-26 2019-11-05 缪荣明 一种液相色谱检测颗粒酶a的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998002579A1 (en) 1996-07-12 1998-01-22 Emory University Regulation of apoptosis and in vitro model for studies thereof
IL125190A (en) 1996-09-12 2003-01-12 Idun Pharmaceuticals Inc Tricyclic compounds for the inhibition of the ice/ced-3 protease family of enzymes and pharmaceutical compositions containing the same
US5837837A (en) * 1997-02-27 1998-11-17 Millennium Pharmaceuticals, Inc. Nucleic acids molecules encoding Caspase-8h and Caspase-8i
DE19820328A1 (de) * 1998-05-07 1999-11-11 Roche Diagnostics Gmbh Verfahren und Reagenz zum Nachweis apoptotischer Zellen bzw. einer bei Apoptose aktivierten Protease
WO2000004914A1 (en) 1998-07-21 2000-02-03 Cytovia, Inc. Novel fluorescence dyes and their applications for whole cell fluorescence screening assays for caspases, peptidases, proteases and other enzymes and the use thereof

Also Published As

Publication number Publication date
WO2000052194A2 (en) 2000-09-08
NZ513923A (en) 2004-01-30
EP1161556A2 (en) 2001-12-12
CA2366918A1 (en) 2000-09-08
US20020090666A1 (en) 2002-07-11
CN1345378A (zh) 2002-04-17
AU3728100A (en) 2000-09-21
KR20020008122A (ko) 2002-01-29
WO2000052194A9 (en) 2002-07-11
JP2002537818A (ja) 2002-11-12
MXPA01008971A (es) 2002-08-30
US6391575B1 (en) 2002-05-21
WO2000052194A3 (en) 2000-12-21

Similar Documents

Publication Publication Date Title
BR0008732A (pt) Métodos para detectar atividade de caspase derivada de membrana e seus moduladores
PT1087750E (pt) Formulacoes farmaceuticas para aerossois com duas ou mais substancias activas
DK0960107T3 (da) 6-Thiosubstituerede paclitaxeler
NL1008636A1 (nl) Multidisplay-monitor.
BR9906070A (pt) Benzamidas substituìdas
BR9709406B1 (pt) fluorenonas alquiloxiamino substituìdas e composição farmacêutica contendo as mesmas.
PT929299E (pt) 1,2,3,4-tetra-hidro-2-dibenzofuranaminas e 2-aminociclo-hepta ¬b| benzofuranos substituidos
BR9802803A (pt) ação e composições farmacêuticas contendo os mesmos.
DE29505969U1 (de) Frontfolie für Folientastaturen o.dgl.
ES2135535T3 (es) Derivados tiazolotriazol y tiazolodiazol con actividad fungicida.
IT242987Y1 (it) Guarnitura per mobili.
DE29902682U1 (de) Beleuchtungseinrichtung für Möbel, Regale u.dgl.
TR199700771A3 (tr) Sinerjistik aktif madde kombinasyonlari.
DK1011329T3 (da) 7-Methylthiooxomethyl- og 7-methylthiodioxomethyl-paclitaxeler
ES2186909T3 (es) Agentes antipaludicos y antibabesiosis y composiciones farmaceuticas que los contienen.
BR0007907A (pt) Análise espectrofotométrica para detecção de degradação da hemoglobina
DE29621397U1 (de) Gerüst für Spannungsverteiler, Schaltschränke o.dgl.
DE29613353U1 (de) Grundplatte für Verkaufs-, Präsentations- oder sonstige Regalsysteme
DE9420592U1 (de) Beschlag zur Abstützung von Fachböden o.dgl.
DE29622124U1 (de) Regal- bzw. Regalsystem
ES1042230Y (es) Disposicion para la union de piezas que disponen al menos un plano de union.
IT1311936B1 (it) Piede per mobili.
SE9803271D0 (sv) A drug for well-being
ES1042906Y (es) Disposicion laminar perfeccionada aplicable para la presentacion, distribucion y montado de micro-aviones planeadores.
DE29706854U1 (de) Sammelregal für Werbezollstöcke o.dgl.

Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]