HUP0000851A3 - Novel pyrimidine derivatives, processes for the preparation thereof and pharmaceutical compositions containing them - Google Patents

Novel pyrimidine derivatives, processes for the preparation thereof and pharmaceutical compositions containing them

Info

Publication number
HUP0000851A3
HUP0000851A3 HU0000851A HUP0000851A HUP0000851A3 HU P0000851 A3 HUP0000851 A3 HU P0000851A3 HU 0000851 A HU0000851 A HU 0000851A HU P0000851 A HUP0000851 A HU P0000851A HU P0000851 A3 HUP0000851 A3 HU P0000851A3
Authority
HU
Hungary
Prior art keywords
processes
preparation
pharmaceutical compositions
compositions containing
pyrimidine derivatives
Prior art date
Application number
HU0000851A
Other languages
English (en)
Hungarian (hu)
Original Assignee
Yuhan Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yuhan Corp filed Critical Yuhan Corp
Publication of HUP0000851A1 publication Critical patent/HUP0000851A1/hu
Publication of HUP0000851A3 publication Critical patent/HUP0000851A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HU0000851A 1997-03-27 1998-03-24 Novel pyrimidine derivatives, processes for the preparation thereof and pharmaceutical compositions containing them HUP0000851A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR19970010862 1997-03-27
KR19970010863 1997-03-27
PCT/KR1998/000058 WO1998043968A1 (en) 1997-03-27 1998-03-24 Novel pyrimidine derivatives and processes for the preparation thereof

Publications (2)

Publication Number Publication Date
HUP0000851A1 HUP0000851A1 (hu) 2001-04-28
HUP0000851A3 true HUP0000851A3 (en) 2002-04-29

Family

ID=26632616

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0000851A HUP0000851A3 (en) 1997-03-27 1998-03-24 Novel pyrimidine derivatives, processes for the preparation thereof and pharmaceutical compositions containing them

Country Status (21)

Country Link
US (1) US6352993B1 (enExample)
EP (1) EP1015444B1 (enExample)
JP (1) JP3176379B2 (enExample)
KR (1) KR100278857B1 (enExample)
CN (1) CN1118464C (enExample)
AR (1) AR012181A1 (enExample)
AT (1) ATE241613T1 (enExample)
AU (1) AU720385B2 (enExample)
BR (1) BR9808070A (enExample)
CA (1) CA2284795C (enExample)
DE (1) DE69815126T2 (enExample)
DK (1) DK1015444T3 (enExample)
ES (1) ES2200324T3 (enExample)
HU (1) HUP0000851A3 (enExample)
IN (1) IN188411B (enExample)
PT (1) PT1015444E (enExample)
RU (1) RU2203894C2 (enExample)
TR (1) TR199902383T2 (enExample)
TW (1) TW542831B (enExample)
UY (1) UY24938A1 (enExample)
WO (1) WO1998043968A1 (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100272471B1 (ko) 1998-11-17 2000-11-15 김선진 신규의 피리미딘 유도체 및 그의 제조방법
US6852739B1 (en) 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
AR038368A1 (es) 2002-02-01 2005-01-12 Novartis Ag Compuestos n-pirimidin-2-il-aminas sustituidas como inhibidores de ige, una composicion farmaceutica y el uso de dichos compuestos para la preparacion de un medicamento
WO2004012659A2 (en) 2002-08-01 2004-02-12 Nitromed, Inc. Nitrosated proton pump inhibitors, compositions and methods of use
WO2005009980A1 (en) * 2003-07-22 2005-02-03 Neurogen Corporation Substituted pyridin-2-ylamine analogues
EP1678168B1 (en) * 2003-10-24 2012-07-11 Exelixis, Inc. P70s6 kinase modulators and method of use
CA2544325A1 (en) 2003-11-03 2005-05-12 Astrazeneca Ab Imidazo [1,2-a] pyridine derivatives for the treatment of silent gastro-esophageal reflux
KR101122376B1 (ko) * 2005-03-09 2012-03-26 주식회사유한양행 신규의 5,6-다이메틸피리미딘 유도체 및 그의 제조방법
JP2009511548A (ja) * 2005-10-14 2009-03-19 ノイロサーチ アクティーゼルスカブ 新規ピリミジン−２，４−ジアミン誘導体及び小コンダクタンスのカルシウム依存性カリウムチャネルのモジュレーターとしてのこれらの使用
JP4946482B2 (ja) 2007-02-08 2012-06-06 船井電機株式会社 緩衝用梱包材及びｔｖ受像機の緩衝用梱包材
US8367684B2 (en) * 2007-06-13 2013-02-05 Valeant Pharmaceuticals International Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
CN102171210B (zh) 2008-08-05 2014-04-23 第一三共株式会社 咪唑并吡啶-2-酮衍生物
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
GB0913636D0 (en) 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
KR20140003438A (ko) 2010-11-15 2014-01-09 카톨리에케 유니버시테이트 루벤 항바이러스성 축합 헤테로사이클릭 화합물
US9890138B2 (en) 2011-02-25 2018-02-13 Yuhan Corporation Diaminopyrimidine derivatives and processes for the preparation thereof
JP6141334B2 (ja) * 2012-02-17 2017-06-07 アッヴィ・インコーポレイテッド ヒト呼吸器多核体ウイルス（ｒｓｖ）の阻害剤として有用なジアミノピリミジン
JP6316282B2 (ja) 2012-05-29 2018-04-25 モメンティブ パフォーマンス マテリアルズ ゲーエムベーハー イソシアナートシランの作製
KR20220143164A (ko) 2012-11-21 2022-10-24 피티씨 테라퓨틱스, 인크. 치환된 리버스 피리미딘 ｂｍｉ-1 저해제
US20140275092A1 (en) 2013-03-13 2014-09-18 Constellation Pharmaceuticals, Inc. Pyrazolo compounds and uses thereof
CA2922657C (en) * 2013-08-30 2022-04-12 Ptc Therapeutics, Inc. Substituted pyrimidine bmi-1 inhibitors
EP3055301B1 (en) * 2013-10-07 2019-11-20 Kadmon Corporation, LLC (2-(5-isoindolin-2-yl)pyrimidin-4-yl)-amine derivatives as rho kinase inhibitors for treating autoimmune diseases
US10584115B2 (en) 2013-11-21 2020-03-10 Ptc Therapeutics, Inc. Substituted pyridine and pyrazine BMI-1 inhibitors
JP2018502900A (ja) * 2014-10-22 2018-02-01 ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム ジスコイジンドメイン受容体１を標的化する小分子阻害剤およびその使用
CN105669642B (zh) * 2014-11-19 2020-06-09 江苏天士力帝益药业有限公司 一种盐酸洛氟普啶的制备方法
AU2017205254B2 (en) * 2016-01-04 2021-05-20 Xoma (Us) Lcc Alpha-amino esters of hydroxypropylthiazolidine carboxamide derivative and salt form, crystal polymorph thereof
US11477982B2 (en) * 2017-04-05 2022-10-25 Bayer Cropscience Aktiengesellschaft 2-amino-5-oxyalkyl-pyrimidine derivatives and their use for controlling undesired plant growth
BR112021002630A2 (pt) 2018-08-17 2021-05-11 Ptc Therapeutics, Inc. método para tratar câncer pancreático
CN114685369B (zh) * 2022-05-17 2024-02-02 河南省科学院高新技术研究中心 一种利用离子液体制备1-甲基-1,2,3,4-四氢异喹啉的方法

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4000138A (en) 1966-03-31 1976-12-28 Imperial Chemical Industries Limited Organic compounds and compositions containing them
GB1182584A (en) 1966-03-31 1970-02-25 Ici Ltd Pyrimidine derivates and the use thereof as fungicides
US3980781A (en) 1966-03-31 1976-09-14 Imperial Chemical Industries Limited Fungicidal composition and method containing 2-amino-pyrimidines
US4044136A (en) 1972-09-09 1977-08-23 Pfizer Inc. Aminoquinazoline therapeutic agents
GB1383409A (en) 1972-09-09 1974-02-12 Pfizer Ltd Derivatives of 2-amino- and 4-amino-quinazoline and pharmaceutical compositions containing them
US3956495A (en) 1973-10-30 1976-05-11 Eli Lilly And Company 2,4-Diaminoquinazolines as antithrombotic agents
US4755218A (en) 1985-12-31 1988-07-05 Monsanto Company Haloacyl 1-substituted-1,2,3,4-tetrahydro-isoquinolines as herbicide antidotes
GB8621425D0 (en) * 1986-09-05 1986-10-15 Smith Kline French Lab Compounds
IL88507A (en) * 1987-12-03 1993-02-21 Smithkline Beckman Intercredit 2,4-diaminoquinazolines, process for their preparation and pharmaceutical compositions comprising them
US4966622A (en) 1988-04-12 1990-10-30 Ciba-Geigy Corporation N-phenyl-N-pyrimidin-2-ylureas
HU206337B (en) * 1988-12-29 1992-10-28 Mitsui Petrochemical Ind Process for producing pyrimidine derivatives and pharmaceutical compositions
DE3901448A1 (de) 1989-01-19 1990-07-26 Basf Ag Emulsionscopolymerisate
ES2081863T3 (es) 1989-03-22 1996-03-16 Ciba Geigy Ag Plaguicidas.
GB8910722D0 (en) 1989-05-10 1989-06-28 Smithkline Beckman Intercredit Compounds
CA2015981A1 (en) * 1989-05-10 1990-11-10 Thomas H. Brown Compounds
GB9012592D0 (en) 1990-06-06 1990-07-25 Smithkline Beecham Intercredit Compounds
CA2095213A1 (en) 1990-11-06 1992-05-07 Jotham W. Coe Quinazoline derivatives for enhancing antitumor activity
AU653601B2 (en) * 1991-04-17 1994-10-06 Pfizer Inc. Pyrimidine derivatives for enhancing antitumor activity
US5276186A (en) 1992-03-11 1994-01-04 Ciba-Geigy Corporation Process for the production of guanidine derivatives
KR0144833B1 (ko) * 1992-12-28 1998-07-15 김태훈 신규의 퀴나졸린 유도체 및 그의 제조방법
SK16396A3 (en) * 1993-08-12 1996-09-04 Astra Ab Amidine derivatives with nitric oxide synthetase activities
DK0640599T3 (da) 1993-08-26 1998-09-28 Ono Pharmaceutical Co 4-Aminopyrimidin-derivater
CN1142817A (zh) 1993-10-12 1997-02-12 杜邦麦克制药有限公司 1n-烷基-n-芳基嘧啶胺及其衍生物
JP2896532B2 (ja) * 1994-08-13 1999-05-31 ユーハン コーポレーション 新規なピリミジン誘導体およびその製造方法
EP0900214B1 (en) 1996-05-04 2001-09-26 Yuhan Corporation Process for preparation of pyrimidine derivatives

Also Published As

Publication number Publication date
CN1118464C (zh) 2003-08-20
WO1998043968A1 (en) 1998-10-08
JP2000513014A (ja) 2000-10-03
ES2200324T3 (es) 2004-03-01
TR199902383T2 (xx) 2000-06-21
CN1251586A (zh) 2000-04-26
CA2284795C (en) 2004-01-20
UY24938A1 (es) 2001-01-31
KR100278857B1 (ko) 2001-01-15
EP1015444B1 (en) 2003-05-28
JP3176379B2 (ja) 2001-06-18
ATE241613T1 (de) 2003-06-15
RU2203894C2 (ru) 2003-05-10
DE69815126T2 (de) 2004-04-08
TW542831B (en) 2003-07-21
AU6523998A (en) 1998-10-22
AU720385B2 (en) 2000-06-01
DK1015444T3 (da) 2003-08-18
BR9808070A (pt) 2000-03-08
DE69815126D1 (de) 2003-07-03
KR19980080789A (ko) 1998-11-25
IN188411B (enExample) 2002-09-21
AR012181A1 (es) 2000-09-27
US6352993B1 (en) 2002-03-05
HK1026418A1 (en) 2000-12-15
CA2284795A1 (en) 1998-10-08
HUP0000851A1 (hu) 2001-04-28
EP1015444A1 (en) 2000-07-05
PT1015444E (pt) 2003-10-31

Similar Documents

Publication Publication Date Title
HUP0000851A3 (en) Novel pyrimidine derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
HUP0001508A3 (en) 4-arylmethylene-2-imino-2,3-dihydrothiazole derivatives, their use, process for the preparation thereof and pharmaceutical compositions containing them
HUP0100225A3 (en) Carboxamidothiazole derivatives, preparation, pharmaceutical compositions containing them
HUP0104199A3 (en) Substituted pyrimido pyrimidinone derivatives, pharmaceutical compositions containing the same, process for the preparation thereof and intermediates
HUP0001539A3 (en) 2-(1-iminoethylamino)ethyl-homocysteine, process for its preparation and pharmaceutical compositions containing the same
ZA9811759B (en) Novel indole derivatives, processes for their preparation, their use and pharmaceutical compositions containing them.
IL135920A0 (en) 2-aryl -8-oxodihydropurine derivative, process for the preparation thereof, pharmaceutical composition containing the same and intermediate therefor
HUP9902455A3 (en) 6-phenylpyridyl-2-amine derivatives, pharmaceutical compositions containing them
IL138280A0 (en) 20-KETO-11β-ARYLSTERIODS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND METHODS FOR THE PREPARATION THEREOF
HUP9900974A3 (en) Heterocycle-condensed morphinoid derivatives, process for the preparation thereof, their use and pharmaceutical compositions containing them
HUP0102372A3 (en) Dihydropyrimidines, preparation thereof and pharmaceutical compositions containing the same
HUP0203542A3 (en) 3(5)-amino-pyrazole derivatives, process for their preparation, their use and pharmaceutical compositions containing the same
IL127056A (en) Aryl pyrimidine derivatives, their preparation and pharmaceutical compositions comprising them
HUP0003844A3 (en) Novel spiroazabicyclic heterocyclic compounds, process for their preparation, their use and pharmaceutical compositions containing them
HUP0004024A3 (en) Azabenzimidazole-based compounds, process for their preparation and pharmaceutical composition thereof
IL131415A (en) Anti-inflammatory compounds, processes for their preparation and pharmaceutical compositions comprising them
HUP0004225A3 (en) Pyridine derivatives, use of them for producing pharmaceutical compositions and pharmaceutical compositions containing the same
IL109568A0 (en) Urea derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof
HUP0201122A3 (en) Pyrimidinone compounds, process for their preparation and pharmaceutical compositions containing them
HUP0001555A3 (en) Tetrahydro-imidazo-naphthyridine derivatives, pharmaceutical compositions thereof and process for their preparation
IL140897A0 (en) Benzocycloheptene derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
HUP0002272A3 (en) Aroyl-piperazine derivatives, their preparation pharmaceutical compositions containing them and their use
HUP9601176A3 (en) Amidine derivatives having adhesion-receptor antagonistic effect, pharmaceutical compositions containing the same and process for their preparation
HUP0102512A3 (en) Bridged indenopyrrolocarbazoles, process for their preparation, pharmaceutical compositions containing them and their use
HUP0000762A3 (en) 2-amino-6-(2-substituted-4-phenoxy)-substituted-pyridines, and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees