DK1015444T3 - Pyrimidinderivater og fremgangsmåder til fremstilling deraf - Google Patents

Pyrimidinderivater og fremgangsmåder til fremstilling deraf

Info

Publication number
DK1015444T3
DK1015444T3 DK98911242T DK98911242T DK1015444T3 DK 1015444 T3 DK1015444 T3 DK 1015444T3 DK 98911242 T DK98911242 T DK 98911242T DK 98911242 T DK98911242 T DK 98911242T DK 1015444 T3 DK1015444 T3 DK 1015444T3
Authority
DK
Denmark
Prior art keywords
processes
preparation
pyrimidine derivatives
pyrimidine
derivatives
Prior art date
Application number
DK98911242T
Other languages
Danish (da)
English (en)
Inventor
Jong Wook Lee
Bong Yong Lee
Chang Seop Kim
Seung Kyu Lee
Keun Seog Song
Song Jin Lee
Woo Jeon Shim
Man Soon Hwang
Original Assignee
Yuhan Corp Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yuhan Corp Ltd filed Critical Yuhan Corp Ltd
Application granted granted Critical
Publication of DK1015444T3 publication Critical patent/DK1015444T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK98911242T 1997-03-27 1998-03-24 Pyrimidinderivater og fremgangsmåder til fremstilling deraf DK1015444T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR19970010863 1997-03-27
KR19970010862 1997-03-27
PCT/KR1998/000058 WO1998043968A1 (en) 1997-03-27 1998-03-24 Novel pyrimidine derivatives and processes for the preparation thereof

Publications (1)

Publication Number Publication Date
DK1015444T3 true DK1015444T3 (da) 2003-08-18

Family

ID=26632616

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98911242T DK1015444T3 (da) 1997-03-27 1998-03-24 Pyrimidinderivater og fremgangsmåder til fremstilling deraf

Country Status (21)

Country Link
US (1) US6352993B1 (enExample)
EP (1) EP1015444B1 (enExample)
JP (1) JP3176379B2 (enExample)
KR (1) KR100278857B1 (enExample)
CN (1) CN1118464C (enExample)
AR (1) AR012181A1 (enExample)
AT (1) ATE241613T1 (enExample)
AU (1) AU720385B2 (enExample)
BR (1) BR9808070A (enExample)
CA (1) CA2284795C (enExample)
DE (1) DE69815126T2 (enExample)
DK (1) DK1015444T3 (enExample)
ES (1) ES2200324T3 (enExample)
HU (1) HUP0000851A3 (enExample)
IN (1) IN188411B (enExample)
PT (1) PT1015444E (enExample)
RU (1) RU2203894C2 (enExample)
TR (1) TR199902383T2 (enExample)
TW (1) TW542831B (enExample)
UY (1) UY24938A1 (enExample)
WO (1) WO1998043968A1 (enExample)

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CA2493618A1 (en) 2002-08-01 2004-02-12 Nitromed, Inc. Nitrosated proton pump inhibitors, compositions and methods of use
AU2004259346A1 (en) * 2003-07-22 2005-02-03 Neurogen Corporation Substituted pyridin-2-ylamine analogues
AU2004283751B2 (en) * 2003-10-24 2011-05-19 Exelixis, Inc. p70S6 kinase modulators and method of use
CA2544325A1 (en) 2003-11-03 2005-05-12 Astrazeneca Ab Imidazo [1,2-a] pyridine derivatives for the treatment of silent gastro-esophageal reflux
KR101122376B1 (ko) * 2005-03-09 2012-03-26 주식회사유한양행 신규의 5,6-다이메틸피리미딘 유도체 및 그의 제조방법
US20090124645A1 (en) * 2005-10-14 2009-05-14 Neurosearch A/S Novel Pyrimidine-2,4-Diamine Derivatives and their Use as Modulators of Small-Conductance Calcium-Activated Potassium Channels
JP4946482B2 (ja) 2007-02-08 2012-06-06 船井電機株式会社 緩衝用梱包材及びｔｖ受像機の緩衝用梱包材
US8367684B2 (en) * 2007-06-13 2013-02-05 Valeant Pharmaceuticals International Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
MY153606A (en) 2008-08-05 2015-02-27 Daiichi Sankyo Co Ltd Imidazopyridin-2-one derivatives
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
GB0913636D0 (en) 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
MX2013005478A (es) 2010-11-15 2013-08-29 Univ Leuven Kath Compuestos heterociclicos condensados antivirales.
CA2827030C (en) 2011-02-25 2019-01-08 Yuhan Corporation Diaminopyrimidine derivatives and processes for the preparation thereof
RU2014137448A (ru) * 2012-02-17 2016-04-10 Эббви Инк. Диаминопиримидины, пригодные в качестве ингибиторов респираторно-синцитиального вируса человека (rsv)
KR102080782B1 (ko) 2012-05-29 2020-02-27 모멘티브 퍼포먼스 머티리얼즈 게엠베하 이소시아네이토 실란의 제조
MX385385B (es) 2012-11-21 2025-03-18 Ptc Therapeutics Inc Inhibidores de bmi-1 de pirimidina inversa sustituida.
EP2970307B1 (en) 2013-03-13 2020-03-11 Genentech, Inc. Pyrazolo compounds and uses thereof
WO2015030847A1 (en) * 2013-08-30 2015-03-05 Ptc Therapeutics, Inc. Substituted pyrimidine bmi-1 inhibitors
ES2779152T3 (es) 2013-10-07 2020-08-13 Kadmon Corporation Llc Derivados de (2-(5-isoindolin-2-il)pirimidin-4-il)-amina como inhibidores de Rho-quinasa para tratar enfermedades autoinmunes
US10584115B2 (en) 2013-11-21 2020-03-10 Ptc Therapeutics, Inc. Substituted pyridine and pyrazine BMI-1 inhibitors
AU2015335980A1 (en) 2014-10-22 2017-05-18 Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences Small-molecule inhibitors targeting discoidin domain receptor 1 and uses thereof
CN105669642B (zh) * 2014-11-19 2020-06-09 江苏天士力帝益药业有限公司 一种盐酸洛氟普啶的制备方法
WO2017118639A1 (en) * 2016-01-04 2017-07-13 ObsEva S.A. Alpha-amino esters of hydroxypropylthiazolidine carboxamide derivative and salt form, crystal polymorph thereof
US11477982B2 (en) * 2017-04-05 2022-10-25 Bayer Cropscience Aktiengesellschaft 2-amino-5-oxyalkyl-pyrimidine derivatives and their use for controlling undesired plant growth
AU2019340402B2 (en) 2018-08-17 2025-04-03 Ptc Therapeutics, Inc. Method for treating pancreatic cancer
CN114685369B (zh) * 2022-05-17 2024-02-02 河南省科学院高新技术研究中心 一种利用离子液体制备1-甲基-1,2,3,4-四氢异喹啉的方法

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GB1182584A (en) 1966-03-31 1970-02-25 Ici Ltd Pyrimidine derivates and the use thereof as fungicides
US4044136A (en) 1972-09-09 1977-08-23 Pfizer Inc. Aminoquinazoline therapeutic agents
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JPH0819121B2 (ja) 1991-04-17 1996-02-28 フアイザー・インコーポレイテツド 抗腫瘍活性を増強するためのピリミジン誘導体
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CA2169280A1 (en) * 1993-08-12 1995-02-23 Robert James Gentile Amidine derivatives with nitric oxide synthetase activities
DK0640599T3 (da) 1993-08-26 1998-09-28 Ono Pharmaceutical Co 4-Aminopyrimidin-derivater
RU2153494C2 (ru) 1993-10-12 2000-07-27 Дзе Дюпон Мерк Фармасьютикал Компани 1-n-алкил-n-арилпиримидинамины, способ лечения заболеваний, фармацевтическая композиция
CA2197298C (en) * 1994-08-13 1999-10-19 Jong Wook Lee Novel pyrimidine derivatives and processes for the preparation thereof
JP3160297B2 (ja) 1996-05-04 2001-04-25 ユーハン・コーポレイション ピリミジン誘導体の製造方法

Also Published As

Publication number Publication date
JP2000513014A (ja) 2000-10-03
EP1015444B1 (en) 2003-05-28
CN1118464C (zh) 2003-08-20
WO1998043968A1 (en) 1998-10-08
US6352993B1 (en) 2002-03-05
IN188411B (enExample) 2002-09-21
DE69815126D1 (de) 2003-07-03
AR012181A1 (es) 2000-09-27
HK1026418A1 (en) 2000-12-15
TW542831B (en) 2003-07-21
PT1015444E (pt) 2003-10-31
RU2203894C2 (ru) 2003-05-10
EP1015444A1 (en) 2000-07-05
ATE241613T1 (de) 2003-06-15
HUP0000851A1 (hu) 2001-04-28
CA2284795A1 (en) 1998-10-08
KR100278857B1 (ko) 2001-01-15
TR199902383T2 (xx) 2000-06-21
CA2284795C (en) 2004-01-20
ES2200324T3 (es) 2004-03-01
AU6523998A (en) 1998-10-22
HUP0000851A3 (en) 2002-04-29
BR9808070A (pt) 2000-03-08
KR19980080789A (ko) 1998-11-25
DE69815126T2 (de) 2004-04-08
CN1251586A (zh) 2000-04-26
JP3176379B2 (ja) 2001-06-18
UY24938A1 (es) 2001-01-31
AU720385B2 (en) 2000-06-01

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