HUE036302T2 - Mutáns penicillin-G-acilázok - Google Patents

Mutáns penicillin-G-acilázok

Info

Publication number
HUE036302T2
HUE036302T2 HUE09796734A HUE09796734A HUE036302T2 HU E036302 T2 HUE036302 T2 HU E036302T2 HU E09796734 A HUE09796734 A HU E09796734A HU E09796734 A HUE09796734 A HU E09796734A HU E036302 T2 HUE036302 T2 HU E036302T2
Authority
HU
Hungary
Prior art keywords
acylases
mutant penicillin
penicillin
mutant
Prior art date
Application number
HUE09796734A
Other languages
English (en)
Inventor
Der Laan Jan Metske Van
Harold Moody
Richard Kerkman
Der Does Thomas Van
Original Assignee
Dsm Sinochem Pharm Nl Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40585574&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUE036302(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Dsm Sinochem Pharm Nl Bv filed Critical Dsm Sinochem Pharm Nl Bv
Publication of HUE036302T2 publication Critical patent/HUE036302T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C12N9/84—Penicillin amidase (3.5.1.11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01011—Penicillin amidase (3.5.1.11), i.e. penicillin-amidohydrolase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HUE09796734A 2008-12-23 2009-12-22 Mutáns penicillin-G-acilázok HUE036302T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08172831 2008-12-23

Publications (1)

Publication Number Publication Date
HUE036302T2 true HUE036302T2 (hu) 2018-07-30

Family

ID=40585574

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE09796734A HUE036302T2 (hu) 2008-12-23 2009-12-22 Mutáns penicillin-G-acilázok

Country Status (15)

Country Link
US (1) US8541199B2 (hu)
EP (1) EP2367940B1 (hu)
JP (1) JP2012513196A (hu)
KR (1) KR101735126B1 (hu)
CN (2) CN103642780B (hu)
BR (1) BRPI0922510B8 (hu)
DK (1) DK2367940T3 (hu)
HR (1) HRP20180318T1 (hu)
HU (1) HUE036302T2 (hu)
LT (1) LT2367940T (hu)
MX (1) MX2011006802A (hu)
NO (1) NO2367940T3 (hu)
SG (1) SG171964A1 (hu)
SI (1) SI2367940T1 (hu)
WO (1) WO2010072765A2 (hu)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103108879B (zh) 2010-09-07 2016-08-17 中化帝斯曼制药有限公司荷兰公司 用于生产头孢菌素类的方法
EP2723881A2 (en) * 2011-06-23 2014-04-30 DSM Sinochem Pharmaceuticals Netherlands B.V. Novel crystalline cefoperazone intermediate
EP2723882B1 (en) * 2011-06-23 2019-05-01 Centrient Pharmaceuticals Netherlands B.V. Process for preparing 3'-thiosubstituted cephalosporins employing a penicillin g acylase
US20150112057A1 (en) * 2011-06-23 2015-04-23 Dsm Sinochem Pharmaceuticals Netherlands B.V. Novel crystalline cefoperazone intermediate
WO2013057196A1 (en) 2011-10-20 2013-04-25 Dsm Sinochem Pharmaceuticals Netherlands B.V. Process for the preparation of cefamandole nafate
WO2013057197A1 (en) 2011-10-20 2013-04-25 Dsm Sinochem Pharmaceuticals Netherlands B.V. Process for the formylation of cefamandole
RU2564578C2 (ru) * 2012-04-25 2015-10-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) МУТАНТ ПЕНИЦИЛЛИНАЦИЛАЗЫ ИЗ E.coli С УЛУЧШЕННЫМИ СВОЙСТВАМИ
CN103074320B (zh) * 2012-05-25 2018-06-08 石药集团中奇制药技术（石家庄）有限公司 含有一个或几个点突变的青霉素g酰化酶
CN103667418B (zh) * 2013-12-18 2015-03-25 华北制药河北华民药业有限责任公司 高活性β-内酰胺抗生素合成用酶的高通量筛选方法
KR102604503B1 (ko) * 2015-05-07 2023-11-20 코덱시스, 인코포레이티드 페니실린-g 아실라아제
CN105087533B (zh) * 2015-09-30 2018-03-27 湖南福来格生物技术有限公司 一种青霉素g酰化酶的突变体及其制备方法和应用
CN105483105B (zh) * 2016-02-23 2018-08-31 上海星维生物技术有限公司 一种青霉素g酰化酶突变体
WO2017186864A1 (en) 2016-04-27 2017-11-02 Sandoz Ag Enzymatic process for the production of beta-lactam antibiotics in the presence of particulate inoculum
EP3565893A4 (en) 2017-01-05 2020-12-09 Codexis, Inc. PENICILLIN G ACYLASES
CN108660127B (zh) * 2017-03-27 2021-09-21 珠海联邦制药股份有限公司 一种人工设计的青霉素g酰化酶原及其编码序列与应用
CN107099523B (zh) * 2017-06-15 2019-09-27 清华大学 头孢拉定合成酶突变体及其编码基因
KR101985911B1 (ko) * 2017-12-28 2019-06-04 아미코젠주식회사 Achromobacter sp. CCM 4824 유래 페니실린 G 아실라제 변이체 및 이의 이용
KR102363768B1 (ko) * 2019-11-15 2022-02-16 아미코젠주식회사 세파졸린 생산성이 증가된 페니실린 g 아실라제 변이체 및 이의 이용
WO2021140526A1 (en) * 2020-01-08 2021-07-15 Fermenta Biotech Limited Mutant penicillin g acylases of achromobacter ccm4824
CN111500564B (zh) * 2020-06-02 2022-01-18 南京工业大学 青霉素g酰化酶突变体及其在酶法合成头孢孟多中的应用
WO2022195603A1 (en) * 2021-03-18 2022-09-22 Fermenta Biotech Limited A ONE STEP PROCESS FOR THE ENZYMATIC SYNTHESIS OF SEMISYNTHETIC β-LACTAM ANTIBIOTICS
CN113567607A (zh) * 2021-07-23 2021-10-29 河北冀安检测服务有限公司 一种头孢克洛中青霉素g酰基转移酶含量的检测方法
CN113584008B (zh) * 2021-07-30 2023-04-11 湖南福来格生物技术有限公司 一种青霉素g酰化酶突变体及其应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT83746B (pt) 1985-11-15 1988-08-17 Gist Brocades Nv Processo para a preparacao de novos biocatalisadores imobilizados e para a producao de etanol por fermentacao
ES2144139T3 (es) * 1994-08-12 2000-06-01 Dsm Nv Genes de la penicilina g-acilasa mutados.
ES2318851T3 (es) * 1995-07-18 2009-05-01 Dsm Ip Assets B.V. Penilicina g acilasa inmovilizada mejorada.
CA2270400C (en) * 1996-11-05 2010-09-28 Bristol-Myers Squibb Company Mutant penicillin g acylases
US6562958B1 (en) * 1998-06-09 2003-05-13 Genome Therapeutics Corporation Nucleic acid and amino acid sequences relating to Acinetobacter baumannii for diagnostics and therapeutics
CZ291154B6 (cs) 2001-08-03 2002-12-11 Mikrobiologický Ústav Av Čr Kmen mikroorganismu Comamonas testosteroni CCM 4824
WO2003055998A2 (en) 2001-12-27 2003-07-10 Dsm Ip Assets B.V. Process for the preparation of a beta-lactam antibiotic with mutated penicillin acylase
DE10251747A1 (de) 2002-11-05 2004-05-19 Tuhh-Technologie-Gmbh Gentechnisch veränderte Penicillinamidase und Verfahren zu ihrer Herstellung
CN100507000C (zh) * 2003-07-03 2009-07-01 帝斯曼知识产权资产管理有限公司 制备头孢拉定的方法
WO2005003367A2 (en) 2003-07-03 2005-01-13 Dsm Ip Assets B.V. Process for the preparation of cephradine
JP5022913B2 (ja) 2004-12-27 2012-09-12 ディーエスエム シノケム ファーマシューティカルズ ネザーランズ ビー．ヴイ． セファクロルの合成方法
CN101177688B (zh) 2006-11-08 2010-12-01 中国科学院上海生命科学研究院 突变青霉素g酰化酶、其重组表达质粒及转化的工程菌株
ES2365831T3 (es) 2007-03-09 2011-10-11 Dsm Ip Assets B.V. Proceso para preparar compuestos beta-lactámicos.

Also Published As

Publication number Publication date
LT2367940T (lt) 2018-03-26
HRP20180318T1 (hr) 2018-03-23
BRPI0922510B1 (pt) 2021-01-19
EP2367940B1 (en) 2017-11-22
BRPI0922510B8 (pt) 2021-05-25
NO2367940T3 (hu) 2018-04-21
KR101735126B1 (ko) 2017-05-12
WO2010072765A2 (en) 2010-07-01
US20110256585A1 (en) 2011-10-20
US8541199B2 (en) 2013-09-24
MX2011006802A (es) 2011-07-20
SG171964A1 (en) 2011-07-28
DK2367940T3 (en) 2018-03-05
CN103642780B (zh) 2017-06-20
CN102264904A (zh) 2011-11-30
CN102264904B (zh) 2013-10-23
CN103642780A (zh) 2014-03-19
SI2367940T1 (en) 2018-04-30
JP2012513196A (ja) 2012-06-14
WO2010072765A3 (en) 2010-08-26
KR20110099137A (ko) 2011-09-06
EP2367940A2 (en) 2011-09-28
BRPI0922510A2 (pt) 2015-08-04

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