HUE053863T2 - Penicillin-G acilázok - Google Patents

Penicillin-G acilázok

Info

Publication number
HUE053863T2
HUE053863T2 HUE16790135A HUE16790135A HUE053863T2 HU E053863 T2 HUE053863 T2 HU E053863T2 HU E16790135 A HUE16790135 A HU E16790135A HU E16790135 A HUE16790135 A HU E16790135A HU E053863 T2 HUE053863 T2 HU E053863T2
Authority
HU
Hungary
Prior art keywords
acylases
penicillin
Prior art date
Application number
HUE16790135A
Other languages
English (en)
Inventor
Goutami Banerjee
Jie Yang
Xiyun Zhang
Erika Milczek
Melissa Mayo
Stephan Jenne
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of HUE053863T2 publication Critical patent/HUE053863T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C12N9/84—Penicillin amidase (3.5.1.11)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01011—Penicillin amidase (3.5.1.11), i.e. penicillin-amidohydrolase

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HUE16790135A 2015-05-07 2016-05-06 Penicillin-G acilázok HUE053863T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562158118P 2015-05-07 2015-05-07

Publications (1)

Publication Number Publication Date
HUE053863T2 true HUE053863T2 (hu) 2021-07-28

Family

ID=57218075

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE16790135A HUE053863T2 (hu) 2015-05-07 2016-05-06 Penicillin-G acilázok

Country Status (13)

Country Link
US (5) US9944916B2 (hu)
EP (1) EP3292136B1 (hu)
JP (1) JP6755886B2 (hu)
KR (1) KR102604503B1 (hu)
CN (1) CN107531762A (hu)
AU (1) AU2016258091B2 (hu)
CA (1) CA2983620A1 (hu)
DK (1) DK3292136T3 (hu)
HU (1) HUE053863T2 (hu)
IL (1) IL255245B (hu)
MX (1) MX2017014213A (hu)
SG (1) SG11201708356PA (hu)
WO (1) WO2016179464A1 (hu)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6755886B2 (ja) 2015-05-07 2020-09-16 コデクシス， インコーポレイテッド ペニシリンｇアシラーゼ
US10724025B2 (en) 2016-05-05 2020-07-28 Codexis, Inc. Penicillin-G acylases
KR102696584B1 (ko) * 2017-01-05 2024-08-19 코덱시스, 인코포레이티드 페니실린 ｇ 아실라아제
CA3064577A1 (en) * 2017-06-27 2019-01-03 Codexis, Inc. Penicillin-g acylases
KR101985911B1 (ko) * 2017-12-28 2019-06-04 아미코젠주식회사 Achromobacter sp. CCM 4824 유래 페니실린 G 아실라제 변이체 및 이의 이용
CN109207466B (zh) * 2018-11-08 2021-01-08 山东鲁抗医药股份有限公司 一种青霉素酰化酶的固定化方法及固定化酶
KR102363768B1 (ko) * 2019-11-15 2022-02-16 아미코젠주식회사 세파졸린 생산성이 증가된 페니실린 g 아실라제 변이체 및 이의 이용

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US6395547B1 (en) 1994-02-17 2002-05-28 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
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US5834252A (en) 1995-04-18 1998-11-10 Glaxo Group Limited End-complementary polymerase reaction
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US6406855B1 (en) 1994-02-17 2002-06-18 Maxygen, Inc. Methods and compositions for polypeptide engineering
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ATE294871T1 (de) 1994-06-30 2005-05-15 Novozymes Biotech Inc Nicht-toxisches, nicht-toxigenes, nicht- pathogenes fusarium expressionssystem und darin zu verwendende promotoren und terminatoren
US5891703A (en) * 1994-08-12 1999-04-06 Gist-Hrocades Mutated penicillin G acylase genes
FI104465B (fi) 1995-06-14 2000-02-15 Valio Oy Proteiinihydrolysaatteja allergioiden hoitamiseksi tai estämiseksi, niiden valmistus ja käyttö
US6096548A (en) 1996-03-25 2000-08-01 Maxygen, Inc. Method for directing evolution of a virus
US6506602B1 (en) 1996-03-25 2003-01-14 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
DK1717322T3 (da) 1997-01-17 2012-10-22 Codexis Mayflower Holdings Llc Udvikling af hele celler og organismer ved rekursiv sekvensrekombination
US6326204B1 (en) 1997-01-17 2001-12-04 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
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EP2367940B1 (en) * 2008-12-23 2017-11-22 DSM Sinochem Pharmaceuticals Netherlands B.V. Mutant penicillin G acylases
CN103074320B (zh) * 2012-05-25 2018-06-08 石药集团中奇制药技术（石家庄）有限公司 含有一个或几个点突变的青霉素g酰化酶
JP6755886B2 (ja) 2015-05-07 2020-09-16 コデクシス， インコーポレイテッド ペニシリンｇアシラーゼ

Also Published As

Publication number Publication date
CA2983620A1 (en) 2016-11-10
US20160326508A1 (en) 2016-11-10
US10400231B2 (en) 2019-09-03
US20190345474A1 (en) 2019-11-14
US20180201919A1 (en) 2018-07-19
US10781436B2 (en) 2020-09-22
JP6755886B2 (ja) 2020-09-16
IL255245A0 (en) 2017-12-31
EP3292136A4 (en) 2019-04-10
US11180747B2 (en) 2021-11-23
EP3292136B1 (en) 2021-02-17
AU2016258091B2 (en) 2020-10-01
US20200385699A1 (en) 2020-12-10
DK3292136T3 (da) 2021-03-22
IL255245B (en) 2020-03-31
MX2017014213A (es) 2018-03-28
US9944916B2 (en) 2018-04-17
JP2018515089A (ja) 2018-06-14
SG11201708356PA (en) 2017-11-29
CN107531762A (zh) 2018-01-02
KR20180004169A (ko) 2018-01-10
NZ736220A (en) 2024-03-22
WO2016179464A1 (en) 2016-11-10
AU2016258091A1 (en) 2017-11-02
US20220042004A1 (en) 2022-02-10
EP3292136A1 (en) 2018-03-14
KR102604503B1 (ko) 2023-11-20

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