HUE035612T2 - lH-pirazolo[3,4-b]piridinek és terápiás alkalmazásuk - Google Patents

lH-pirazolo[3,4-b]piridinek és terápiás alkalmazásuk Download PDF

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Publication number
HUE035612T2
HUE035612T2 HUE15174246A HUE15174246A HUE035612T2 HU E035612 T2 HUE035612 T2 HU E035612T2 HU E15174246 A HUE15174246 A HU E15174246A HU E15174246 A HUE15174246 A HU E15174246A HU E035612 T2 HUE035612 T2 HU E035612T2
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alkyl
group
compound
pyridin
syndrome
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HUE15174246A
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English (en)
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John Hood
Sunil Kumar Kc
David Mark Wallace
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Samumed Llc
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Publication of HUE035612T2 publication Critical patent/HUE035612T2/hu

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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Claims (3)

  1. Síédmsisdmi sgon ο< mtok i. Egy H> általános képlet szerinti vegyület vagy annak gyógyászati lag elfogadható sója: ahol a képletben:
    R\ R\ R , R' R' ts K' cs.omástól thgpetlem'd az alahHak kimből vala&amp;ztott; Indrogenatom. t . t k? ÍKise$coat il f ,ükd) κηΊχνΑΡΰί {<?,, Jk>Uhoo?:o<.sMok o alkil)nnHIR’'‘k ~'{'CS,§ alktlXhelétóattliCk *(C?,.s alkil)sÖR;\ ~(Cus aikúVsR ~, -(0:.-,- alkil)nS(«O)Ríö~, alkihxOR aiki0^(R9}SO2H';-, -{C^ alkil}sSG}N{Rv)?.-s á.lkiiX,N{-R^h-, "(C;.? állal ‘ ,\tR')€(::::A}N(lV}j-·* -(C > .9 ÍÜk;IiflC(";A)N(.R;í):;-, *{C.U 3ΙΜΙ}^{ΚΥΧ-Α)Κ\ -(€;.<> ;RkH)ftN(lV)C(-A}CH(R'!}r·- ~NOr> -CN·, -<€'«.=> alkiOXOjR5'- és A C:.a; k i i)(!G(~ A jRAcsöpori vagy R! és R\ RJ és R\ vagy R' és R" mindegyikének egyike együtt gyárát alkot, amely az alábbiak köréből választott: arik hetcroarik
    < < s-’xe's, <. > elvű·» ο-, t <ι| p -cjs Ion > kiouh λ\ vu vayv I U n > 0 0 minden R' egymástól függetlenül az alábbiak k<« Attól választott: hidrogénatom, €t.>> alkik -CFr·. <k - x üköt , tv Akiiphotonnűkul A' > otkdt,<éil e> íC > oikO> henn\»d csépért; vagy két szomszédos R.*' a hozzájuk kapcsolódé atomokkal együtt karboeikkk vagy heterociklll· csoportét íókothiit:. minden R'a egyórástól fdggetleoöi az alábbiak köréből választott C(.., alklk, -ΌΙΑ-, -iC.., ídkli)Rkarboclkhk -te.., alksllJieieroeiklik “{Cj,>, slkilkaril·· és -«.(., alkiOaheteroaribesopotl; nmAnk yu!..ie fl«u} , ml ük , ·> k , os » \> us?'e4J minden R:<: jelentése 1-5 szíibsKtíósesís·, apielyek romöégyske az· alábbiak kőiéből yáigsAptt: hidrogénatom, <?>.·, s.dkib, kakmm-k!-, -Ok-, karboeiidü-, heiorneiklík árit-, hétéróárík, '·<<·;.-, ÍÜk!£}«Olk’“, -((.(., alkib„SR.\ -iC.., alk.fi>.-«S(™O.>R8‘’“e <« alkiíjnSöjRk "(Cm aikiÓ^R'^SCbR^, -{Cj.9 altói^SOjNÍR^Xr, «C;.< alfcil)flN(R,9}r5 ·(((., slkikN(R,J)CC-A>N(R' }.··, tC a'k4iy'!í~M\íR'} -λ ' a&amp;!O\X,\\ V»R , (C , ,-dkih Arid )t\ AKlhR'l \<> -CAri, -(Cm alkB)nüOjRü gy -(Cr.v aik!Í);C(::S:ÁjRAí;sopo?'t; Ru és Rb egymástól íbggédentil az alábbiák. köréből választott hidrogénatom, Cp$ -álluk hídogeoid*, -CP,-, -(€(.«, alkíl áikarboeikhlR^, --(0:,, alkikheteroeiklilR^-, --((.(.., álkíÍAarii^!i-> -<C adok \eU'u\»öl< , <j' Ak.öük'C ££ , ,dks"> \R , iR\ > alkil',\ ΌΨ ' , o s alks!)nSOdf-. ·(€(.« aikilAAíR'bSOjkA, ,(esΛ; alkU^SOjNCkh-’, <(.<; ükk >f/N(k}r> -1(.(.., \ \\UÍ b < V)\(xR"V <v akik. OA^KO R < .dkOAriOkf \ C i( a!kil}eN(R’}C(:::?l>CH(Rv!.:~s -NO?.·, --C.R-, --((.(.,alkiiKCXAk'-- és -ÍC(., alkd)f!C(--;-A}Rv-csopon; \ao> R c\ R 'egsoe a m,a állok ae>eb vit > p»'e? koséi»» ha a ,?un’ minden Λ egy mástól tnggeUemd e\igentítt>m$ kénatom vs AR.i!-eso»ort köréből választott; ö \ ;e( »,-<£ >,en iiun \ ' ídonisso ínnoyonat.vn e> R? nincs jeles; és minden n ériéke 0 vagy i,
  2. 2, Az 1. igénypmri szerinti vegyidet, -ahol R* és lé' jelentése hidrogénatom és IC "karbogikblR^-, -hetes oeikhilC , műik es-hek"<w:sR -csoport koréból választott. ( Λ , -genxpeni í-cüiíí. ssgsdkt thol R xlenks, hete»fau!!C -,ζοηοΟ e„ betetem tl-esogeU piridinesopori. -» V t igénspnm smi.ní; segsaiei, ahol Rf2 -NHCi===O)N(Ryh--> -C(«O.>N(Rs‘h-·, ~NHC{-ö)R!k Alk.. < »!rif !{R’"l e, - AdISOdC-eseport kóréból választott. ' \ i 'ge'.sp-ne ,,e;"!. \ez\uiet, (hot R klwuvf " s aikí \arinomlh m hete’OvJl.h! -csoport köréből válaszolt, η V -genxpemek hmn.ehike vmmn \egsnkn. ássd k" es k' tekntese -sJúíogenstn.o o- R' t? aiabbmk koíeöi'i rah'sztott hidrogénatom, -heieíeeiklilR/’- -atnR . hAme .uSR , \.jbV( .!}\tkb <\ \iR'k( por', x«\i thciiíkb, <\, cor\
    'C(!í:Ö}R’-'CSöpöí’L ?< A Ű< igénypont szerinti vegyidet, sitol R' 4míetöclkii.t&amp;!\. -ardR’S· és -hetéroarilR^-caoport· köu'hOt \ V B >O5í 8. A ?, igénypont szerinti vegyniet, ahol a heteroaril-esopoA piridincsoporl 9. A ?. vagy 8. igénypont szerinti vegyülő*, ahol Ru hidrogénatom és halogenid köréből választott. W. A 6. .igénypont szerinti vegyülét, ahol R? hidrogén stosó.. -C(X>)N(Rv>y·» ás -CN-esoport köréből választott. 11. A 10. igénypont szerinti vegyidet» ahol R* hidrogénatom és -Cs.., alkilesoport bőréből választott, vagy IV a nitrogénatommal együtt kondenzált gyűrűt alkot.
  3. 12. Az t. igénypont szerinti vegttdet, amely az alábbiak köréből választott szerkezetű:
    η
    vagy annak gyógyászai llag sífegabható sója, IX Égy !, Igéóyponi szórini! vegynlatnt vagy annak gyógyászati feg eliógaóható «óját és agy gyógyászaühg elfogadható segéónayagat tartsbnazó gyógyászat! kompozíció, |4> Egy I -Ί X igéoygomók bárraciytke szerinti vegyidet gyógyászatban való átkaim ázásra. IS, Égy k Igény igény gom szerinti vegynbt vagy annak gyógyászat! ing eMbgaáható sála egy i'iiAh’t\>\,' \ ig\ n:?' >c '-eai'scnrc a kalnvn >\ ih '< a meókk \'s\ea ·,,',>.'-< tan > 'a tndófibrózis, renraátoló arfritisz, psznriázls, csont- vagy porcbetegség, eszmoártrlbsz és óik kóréból választóit, tó, Egy k Igény igény-pont szerint! vegyibe! vagy annak gyógyászat!tág eibvgáóbató sója egy rendellenesség vagy betegség kezelésében való alkalmazásra, ahöl a rendellenesség vagy beiagség polyposis col!, miina analogeaozia, !»g»ln!rónobór ólszpiázia, Wltós-imaop szksieiábs dsszp!áz!&amp;:, és iokáiis donnái is Inpopiázia tórából sÉlasztott,
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