HK1253364B - 1h-吡唑並[3，4-b]吡啶及其治療應用 - Google Patents

1h-吡唑並[3，4-b]吡啶及其治療應用

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Publication number
HK1253364B
HK1253364B HK18112659.7A HK18112659A HK1253364B HK 1253364 B HK1253364 B HK 1253364B HK 18112659 A HK18112659 A HK 18112659A HK 1253364 B HK1253364 B HK 1253364B
Authority
HK
Hong Kong
Prior art keywords
pyrazolo
pyridines
therapeutic uses
therapeutic
Prior art date
Application number
HK18112659.7A
Other languages
English (en)
Other versions
HK1253364A1 (zh
Inventor
John Hood
Sunil Kumar Kc
David Mark Wallace
Original Assignee
Samumed Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samumed Llc filed Critical Samumed Llc
Publication of HK1253364A1 publication Critical patent/HK1253364A1/zh
Publication of HK1253364B publication Critical patent/HK1253364B/zh

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Epidemiology (AREA)
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  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
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  • Child & Adolescent Psychology (AREA)
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HK18112659.7A 2009-12-21 2018-10-03 1h-吡唑並[3，4-b]吡啶及其治療應用 HK1253364B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28854409P 2009-12-21 2009-12-21

Publications (2)

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HK1253364A1 HK1253364A1 (zh) 2019-06-14
HK1253364B true HK1253364B (zh) 2020-02-07

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HK16111598.5A HK1223247A1 (zh) 2009-12-21 2016-10-05 -吡唑並 吡啶及其治療應用
HK18112659.7A HK1253364B (zh) 2009-12-21 2018-10-03 1h-吡唑並[3，4-b]吡啶及其治療應用

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US (8) US8450340B2 (zh)
EP (3) EP3001903B1 (zh)
JP (3) JP5822844B2 (zh)
CN (2) CN104546846B (zh)
BR (1) BR112012018413A2 (zh)
CA (2) CA2986631C (zh)
CY (1) CY1119844T1 (zh)
DK (1) DK3001903T3 (zh)
ES (2) ES2550820T3 (zh)
HK (2) HK1223247A1 (zh)
HR (1) HRP20171893T1 (zh)
HU (1) HUE035612T2 (zh)
LT (1) LT3001903T (zh)
NO (1) NO3001903T3 (zh)
PL (1) PL3001903T3 (zh)
PT (1) PT3001903T (zh)
RS (1) RS56669B1 (zh)
SI (1) SI3001903T1 (zh)
WO (1) WO2011084486A1 (zh)

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SG10201914059WA (en) 2008-10-22 2020-03-30 Array Biopharma Inc Substituted pyrazolo[1,5-a]pyrimidine compounds as trk kinase inhibitors
CA2770320A1 (en) * 2009-08-10 2011-02-17 Epitherix, Llc Indazoles as wnt/b-catenin signaling pathway inhibitors and therapeutic uses thereof
US8252812B2 (en) 2009-08-10 2012-08-28 Samumed, Llc Indazole inhibitors of the WNT signal pathway and therapeutic uses thereof
JP5822844B2 (ja) * 2009-12-21 2015-11-24 サミュメッド リミテッド ライアビリティ カンパニー １Ｈ−ピラゾロ［３，４−ｂ］ピリジンおよびその治療的使用
EP3473099A1 (en) 2011-09-14 2019-04-24 Samumed, LLC Indazole-3-carboxamides and their use as wnt/b-catenin signaling pathway inhibitors
US20140248294A1 (en) * 2011-10-05 2014-09-04 University Of Bremen Wnt4 and med12 for use in the diagnosis and treatment of tumor diseases
FR2984325A1 (fr) * 2011-12-14 2013-06-21 Sanofi Sa Derives de pyrazolopyridine, leur procede de preparation et leur application en therapeutique
FR2985257B1 (fr) * 2011-12-28 2014-02-14 Sanofi Sa Composes dimeres agonistes des recepteurs des fgfs (fgfrs), leur procede de preparation et leur application en therapeutique
PH12017500997A1 (en) 2012-04-04 2018-02-19 Samumed Llc Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof
AU2013256141B2 (en) * 2012-05-04 2016-05-12 Samumed, Llc 1H-pyrazolo[3,4-b]pyridines and therapeutic uses thereof
MD20140130A2 (ro) 2012-06-29 2015-04-30 Pfizer Inc. 4-(amino-substituite)-7H-pirolo[2,3-d]pirimidine noi ca inhibitori de LRRK2
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