HUE030590T2 - Eljárás diol-szulfonok elõállítására - Google Patents

Eljárás diol-szulfonok elõállítására Download PDF

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Publication number
HUE030590T2
HUE030590T2 HUE12701093A HUE12701093A HUE030590T2 HU E030590 T2 HUE030590 T2 HU E030590T2 HU E12701093 A HUE12701093 A HU E12701093A HU E12701093 A HUE12701093 A HU E12701093A HU E030590 T2 HUE030590 T2 HU E030590T2
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HU
Hungary
Prior art keywords
methyl
compound
mmol
oder
dioxan
Prior art date
Application number
HUE12701093A
Other languages
English (en)
Inventor
Lange Ben De
Peter Hans Riebel
Michael Wolberg
Dennis Heemskerk
Daniel Mink
Original Assignee
Dsm Sinochem Pharm Nl Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Sinochem Pharm Nl Bv filed Critical Dsm Sinochem Pharm Nl Bv
Publication of HUE030590T2 publication Critical patent/HUE030590T2/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
    • C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D419/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Claims (3)

  1. Rssbsdski! \ g:CB> pSBXk V. X % N ' * v \ ^ ^ χ ' S í ' \ V \ C\v RA jtgjyagy (1 b) lltaMfiús. kyRAöi hak}m«1ii vjgygkx vMkdíBS
    i.m tm Sk;>! K: k ÍvBU:'aí bgiygkX gigR R >; ®ö R; jvkmsgj MyvBjsKg RigäkkkbR! i
  2. - ? 2 BVéBRABRRS ájSík Vágj·· s -\SvssgaWRKA slkgna vágj V? :v/Axbsbb*\ cAUsBk-l· \-.;g> 3-v a/Avu^ns;:·: dkivaäkcnil· vágj 6-iö pánsRgíkS Síik vagy Asa vsvBámmóS:svaikütvopösl: vágj sheí Rggs R-; a i./Vssssv-bs· sírba. srsvkBc/ i-ayk.-jkdnsk. gyűrik aivsBvak. ska; iCj jsivsiesv ki SSkBaBjSRsB Síkik vsgy a!kci»k-vn:>>rS, >S alas R · xknBSv aikcRkYSk«· cvuyok: sgy R.-.--S- X skaisam kigk-lk vsgyulsbSk shgi 1% jyfeBigsg sfíkjagsíi as X jgkíRikj® Mciiygtk: vsgj sAakküvaxs vagy srBskssismkss vagy ísfrásikjsákkkiivs^-iök vagy ibsgkisjjgkkk, így vcrvisv si»l vsgj {.Mys akskrax ivpksv vsgykfei<R kapikskv
    PS> |:3fe; (b; s kis) vsgj (3l>jáRgiásíOV klgiigu vggyig«tgyiggtsvg&amp;y jv így rkRkbv (4íi| vágj (4k) aksHaa-:: kipR-Bi sxiiffom kapraik
    (4a) (átg X Ay k. kaXysHav :./craki eyÁSy ahoi R· sderacv. SvXb vagy kas R siasc-a· çfü vsgy mshh <A R SitSKCSV Vi; I VSgj RíKÍR: VSgj R;> RA Ry S VSáSSÍöíSiSSi BgyBkk SBkh BaS Χφί· v.>R-bs;,:;k CikkigCVS ivy Bisk vagy k \ I iS 'V ' ^ V } ; ^ s ' ' i\ V V Sv \ V ' On V. fg îvsnksdrokiî.sn;: vagy Mrahídroiyavavil AX Rsjaia-iBA*: koaehk; iáu-u'3/ο;· Ash ; · Abb· i //-us: avoid -u. AvgAa kukk ; ;i, bssSSiiSSBRj-kä VSgV /· : Ax:a:i a diaoo': :vBAAbo · lka I kiRkk lAi/Ho 3:. Aidk vagy 3. ägdsypam .ve-snä; dks-v·. igvöka 0¾) vágy (glkIrRigyágy kipkn; vgldglddknkiJják asAagy kkala 44s) \.igy i d:>> ikidibw d-pdvi Viip1Hd.«ï ídsiáfHik, 4. Λ<·: :·-3:, nîd·}. porunk harosddkv sv-wd pljgnly. aigd à:?: hkkkksgt à |gvs)kgg4k jddikiâkga vágyadik: lùikagàngîdôxig vsgv Vgyipakiäv va y·. idunaa vagy kau-Bisöp vagy ggy vsgy ptrmatpavvk vagy kmavd: vágy kkuk vagy krPsViat vagy pvrMora! vygÿ ggikpgik yggy i#vd'dg'· hkkopBmxig vagy oxöö vsg\ pvrcvnhviaiP vagy ddggivvagy vveR kBvögksl 3f,;Ag. 1-4 gküysnaud.. bssrsndyki-í savi; éggiáiV dúl ·; (4ag vagy; {4bi ikaknva kcpkVs avdknr k·.· CH-0 illigläsks kapäpui véigkfcud fvagáíuagsk; aliní R. jgkPkyg dklkknsrknslnlAdïsViipKsnibl· (nidov gn c- g )n í koí usakiuhni vagy 3 4 Hlvv ka il)·:· í:- kupidpk·· IH 4 agg i d-à arad Jvhki v agy 3:-á í k kgksisp s H A4 -llguílúfi! 1)1:1 íuRííV-3-kariul .dsh ki vagy N-auguiaKakad ydkvmil -;>· iv<,?5>; xijadfíirirna:; Í5>-1: dy 4 riisiskivsekn· V.nlkavsvnd, öv így:rs.nskc its) vagy: (Sb) áítdaisias kópiáik vegyukidkapánk
    {dk :Sbi a A:·· :· gybr. ins=d vivana·: didd. .ssndyd nsin-sov.äridnxi buda ;ds:niáiáiavs; hajúink vágfií. ?.. A k iiU:ny;:»;;k aayfibg ddm iá-ni a ;!ák1kiUlsiy;yiiUiVbáai% a iia!riuni1v.va;uv;44>s;-4,i/áa. 3 A4 S-3- igágygilggik harsad·;. Ao yaydpk agáim yiTsgkd:y. vádgcidpnp; altávklggvs áv iypkiiáv ggvgk '? láb) vagy ági?) aha ká pa kipl db vagya iig
  3. (3®) S4b; ak>i R·. idva-d·:· indrngvsi vag> agg vagy yaa/gvaaud;! vagy nv··: -dur» vada vagy: ídaapatg: vagy inak*:·· as id H vagy beUsxkbi vagy kkkskidaxiíSökj vagy g-Uiáínviietuihkii'opkaivil: Vágy incküsamci·· vagy k ikn-jvopndívig vagy sgUiahsikyikiiaägR vagy kakiadrnpgaíjg vagy a-amaxjpidpddi vagy s-gákgágg vagy ságiai vagy klóiakg® vagy hddgd:. gs inul kk a kovsaduda alkmís aaapönhki válayaiak:: plvagadkl, plrindgikd-if. gkpgöykäAii'k-lk 1 -ikviií· */·/-anaaivIA.g. | .ki;u· :/;d:.-sr<:/< sî-à-1 kisivu-lkigb Î k-ädrgapi-S-g, k'kkghgiikagih gdk áíivasn-dúnak-a d, sáAdgghi 3, ksv.srd 4 d gy ;;n-4, sünön-1·sí
HUE12701093A 2011-01-18 2012-01-13 Eljárás diol-szulfonok elõállítására HUE030590T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP11151280 2011-01-18

Publications (1)

Publication Number Publication Date
HUE030590T2 true HUE030590T2 (hu) 2017-05-29

Family

ID=43824233

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE12701093A HUE030590T2 (hu) 2011-01-18 2012-01-13 Eljárás diol-szulfonok elõállítására

Country Status (10)

Country Link
US (1) US9150562B2 (hu)
EP (1) EP2665722B1 (hu)
CN (1) CN103328470A (hu)
ES (1) ES2601479T3 (hu)
HU (1) HUE030590T2 (hu)
IL (1) IL227249A (hu)
MX (1) MX2013008285A (hu)
PL (1) PL2665722T3 (hu)
SI (1) SI2665722T1 (hu)
WO (1) WO2012098048A1 (hu)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103360384A (zh) * 2013-07-30 2013-10-23 浙江京新药业股份有限公司 HMG-CoA还原酶抑制剂关键中间体的合成方法
CN104513232A (zh) * 2015-01-08 2015-04-15 苏州莱克施德药业有限公司 罗舒伐他汀乙酯的制备工艺
CN105017158B (zh) * 2015-07-31 2017-10-03 江西富祥药业股份有限公司 一种顺式瑞舒伐他汀钙杂质的制备方法
CN107298675B (zh) * 2017-06-19 2020-08-11 浙江美诺华药物化学有限公司 一种瑞舒伐他汀钙中间体的制备方法
CN112028881B (zh) * 2020-09-02 2023-08-15 能特科技有限公司 一种瑞舒伐他汀钙的高级中间体r-1的合成方法
CN112159403B (zh) 2020-09-30 2022-04-15 复旦大学 一种用于合成他汀类药物的关键中间体的制备方法
CN112679490A (zh) * 2021-01-28 2021-04-20 安徽美诺华药物化学有限公司 瑞舒伐他汀钙含砜结构的手性侧链及其制备方法与用途
CN112592336A (zh) * 2021-01-28 2021-04-02 安徽美诺华药物化学有限公司 一种瑞舒伐他汀钙的高级中间体及其制备方法
CN113754650B (zh) * 2021-08-06 2023-10-20 湖北宇阳药业有限公司 一种瑞舒伐他汀钙中间体的高选择性合成方法
CN114213350B (zh) * 2021-12-29 2024-03-19 江苏福瑞康泰药业有限公司 一种他汀类药物中间体的制备方法
CN114487167B (zh) * 2021-12-31 2023-08-22 乳源东阳光药业有限公司 一种测定他汀侧链中杂质的方法
CN114437052B (zh) * 2021-12-31 2024-03-29 江苏阿尔法集团福瑞药业(宿迁)有限公司 一种利用连续流微通道反应器合成他汀类药物中间体的方法
CN114854019A (zh) * 2022-05-07 2022-08-05 武汉工程大学 一种脂肪族聚砜及合成方法、应用、脂肪族聚砜基固态电解质

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Publication number Priority date Publication date Assignee Title
US5093363A (en) 1989-08-22 1992-03-03 Shionogi & Co., Ltd. 2,4,6-substituted phenol derivatives
EP1619191B1 (en) 1998-08-05 2010-10-27 Kaneka Corporation Process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl] acetic acid derivatives
GB9903472D0 (en) 1999-02-17 1999-04-07 Zeneca Ltd Chemical process
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NL1015744C2 (nl) 2000-07-19 2002-01-22 Dsm Nv Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
PL367133A1 (en) * 2001-06-06 2005-02-21 Bristol-Myers Squibb Company Process for preparing chiral diol sulfones and dihydroxy acid hmg coa reductase inhibitors
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CZ299215B6 (cs) 2005-06-29 2008-05-21 Zentiva, A. S. Zpusob výroby hemivápenaté soli (E)-7-[4-(4-fluorofenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl] (3R,5S)-3,5-dihydroxy-6-heptenovékyseliny
EP2264015A1 (en) 2009-02-02 2010-12-22 LEK Pharmaceuticals d.d. Key intermediates for the synthesis of rosuvastatin or pharmaceutically acceptable salts thereof
KR101157314B1 (ko) 2009-06-05 2012-06-15 주식회사종근당 로수바스타틴의 신규한 제조방법, 이 제조에 유용한 중간체 화합물 및 그의 제조방법

Also Published As

Publication number Publication date
ES2601479T3 (es) 2017-02-15
EP2665722A1 (en) 2013-11-27
WO2012098048A1 (en) 2012-07-26
PL2665722T3 (pl) 2017-03-31
CN103328470A (zh) 2013-09-25
US9150562B2 (en) 2015-10-06
SI2665722T1 (sl) 2016-12-30
EP2665722B1 (en) 2016-08-17
IL227249A (en) 2015-11-30
US20130303779A1 (en) 2013-11-14
MX2013008285A (es) 2013-09-13

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