HUE029570T2 - Intracelluláris kalciumot módosító vegyületek - Google Patents
Intracelluláris kalciumot módosító vegyületek Download PDFInfo
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- HUE029570T2 HUE029570T2 HUE11777791A HUE11777791A HUE029570T2 HU E029570 T2 HUE029570 T2 HU E029570T2 HU E11777791 A HUE11777791 A HU E11777791A HU E11777791 A HUE11777791 A HU E11777791A HU E029570 T2 HUE029570 T2 HU E029570T2
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- calcium
- compound
- pharmaceutically acceptable
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- aryl
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (3)
- ÍNTRáCRÍXULÁRíÍs KALCIUMOT MÓDOSÍTÓ VEGV Ü'LETEK izstösäalM Igénypontok L (VI ) képlerü vegvötep(VI) ahol: R’i jelentése vagy1-5 jsleatése -MH-C(=<0- vagy -<L“C>}NH'·; X jelentése CRi vagy K:: Y jelentése ggymàsMl függetlenül a kttvetkasôfc közül választott: €RS vagy N; .Re jelentése Cf-C^aUdl» Crüghmtoüíkíl, Cr€foak>alkil CrCshelsroc-MealSksl, CrCáSlkiMa-Cj-CabeigföcMö·* alkii, mik lieteroartl, koödeaxáU mit vagy kondenzált heterottril; ahol a €rCytlkiL €r€foetere>slkiL Cr •»Cshaíoslkii, Cj-Cssüetgroeikteaikik Qä-QaMÄ-0rC^«fdoMöalkl!5 ad), heseromik kondeegált m& vagy konáesszált hekromil adott eaofbes legalább egy R; csoporttal fedyefteítsMg R;í Identes«, egymástöl niggefekl a kovetkex.dk közti! választott;: H, F, D, Cl By 1, -CM . -NOy, -OH, -CIO, -ÔCF3, -ORe CrCpdldl, Cfo-Cseikloalkil, CpUfoeteroalkll -CrC«habaRiI». Cj-CjteíenteikieaMl, adott esetbe« sxyksxíitnált atib ttíioíf esetben sztibsxiltaalt O-afíI, s4ott-«sstlx?».sayfcsaöösáh hpiçsx®*-*!, a érteim (B2, bármely egész szánt; Ríj jelentése egymástól függetlenül a következők közül választott: H, I>, halogén, CrCsatkit, CrCsbnioaikÜ, -OIÇ., -OCFj, Créé karbenslaiki! vagy -GFg vagy két. agyssnahhoa a sxésmsomhox kapcsolódó Rs oxetáé gyűrűt képez; Ría jelentése s következők közül választott: halogén, Çj»€§8lkik CrQfealoâfM, 'ORs, «OClPs, CrC*·· karbonilaikil, vágy --01¾¾ Rj jelentése egymástól függetlenül a következők közül választott: H, CyCkálkfk Cr-€foáloaikii, €r -CjcikkíSÍki!, feni! ésbenzil; vagy gyógyákzatilag elfbgttdhaso sója vagy gyógyászaidag elfogadható SttOlvátjá, X Az 1 igéttyponl. szerbül vegyüiet almi X jelentése FI, 3. A 2, igénypont szeriöli vegyülök ahol az mii jelentése fenik 4. A 3. Igénypont szerinti vegyüiet, ahol. a -fosni legalább egy IL csoporttal helyettesített, amely a következők közül választott: Cl .Rr,.F51, CF;(, CrCsalkll vagy OCVCgikü. S. A 4. igénypont azfâôsîi vagyidei, sk©I s joientése meök e*8, |Ko-js:ôpüs B-bsätiiv izo-bnol vagy tm>budi. 4. Λ 3. Îÿtoypoftt $mM vegytlet, áö( a Ml legaÂj^'-:%; következők közöl választok: Q, Br, F ex L ï, Âîk!gé«ypO)ôt sseiWkvegwfeg ahu! R,.-j jeleatése halogén. R A» I. Igénypont <νκτι»ϋ vegyileg ahol R» jelentése heteroatï?» amely a következek közöl váMztóít: demi hanihrctnh turil ptranii, tünliazoh). heajhMiadi&zolll, szobenzoiusoil· temoslí. SáoíeBÖ/föaossttók pirrohk stntdazoiií, pirazolil, izouazohi, szowolik ptridil, pirazimly pMmíöigl], pládazinil ^doifémííj. izoindoiü, Zfi-mdolil, iaàoHh sndazoHÍ, pumni, JM-kiaobíZÍml tóokiPöMg. MnölFL, IMaesöfí, tmúríáirái, ksnoxaíiail, kinazolinik oxaz-eHl, emaolmil. pkmdinih ^atf-ksxbazoiU, kísrbasólil, kakhöhiní. fémmhidmik aknai iáik peytmidtntl, l«ním.trotinil, fetiazinii, ifpa^zihillkf^ophaztail, latasanil és ísBosaznuí, 9 A A igénypont «.zerintí vágyóiét. ahol a hessK-aiil legalább: egy % osoporttsí hslyettesííett; a következőkközül válasKtva: jPs-CÍy&> l OB* és Ci-ÊsülkïL ÍÖ, , Aigéítypesészesoií vogyüiet, ahol : a feteroanl legalább agy F atôîssïst. szubsztíösáík H. Az l, igéïiypoat szarlatiAegjàiloi,akii R* jekmöksos K,> s 'k'jnéae Η 1' >. Λ n d hakspa. C < „K&tfconilidkF.,\age í Γ. 43. A 11. igénypont szérián vegyülök ahoi Ríö jetehiése halogén, amely ^alábbiak kszüî választott: k. Ci, Br és I
- 13. Vegyület, amely a következők: közöl választó«:vagy győgysssafoag élfogadhaîô söjg, vagy gyógyászai!íag élíhgadhatö s«ëlvâijâ.
- 14, Az I. igénypocf sxocùni (Vl.A) képlete vagyätei;(VI, À) ahol RS, Ej» %is -i«î jeíaatéss «s s értéke az 1. sgénypoirtfesa ajsgh&iàîOzott, •IS. Oyogyássau késsíísfony, améíy tártaimé?: gyógyásggiilag eífögadixatö higltösserg segédaeysgot vagy köíőasiyágöt és ay L igé&ypmt 'szerinti' vegyííieiéi vagy amsak gyégyàsyatdag eliögsiÖíalá stgái vagy gvó-gyásssiilag elfogadkafo ageiváiját tartalmazza.
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AU (1) | AU2011248877B9 (hu) |
CA (1) | CA2797663C (hu) |
DK (1) | DK2563776T3 (hu) |
ES (1) | ES2591004T3 (hu) |
HU (1) | HUE029570T2 (hu) |
PL (1) | PL2563776T3 (hu) |
PT (1) | PT2563776T (hu) |
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US9120751B2 (en) | 2015-09-01 |
WO2011139489A2 (en) | 2011-11-10 |
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JP2017101044A (ja) | 2017-06-08 |
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AR080974A1 (es) | 2012-05-23 |
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EP2563776A4 (en) | 2013-09-11 |
CA2797663A1 (en) | 2011-11-10 |
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AU2011248877A1 (en) | 2012-12-06 |
ES2591004T3 (es) | 2016-11-24 |
DK2563776T3 (en) | 2016-09-19 |
US20130345240A1 (en) | 2013-12-26 |
US8980629B2 (en) | 2015-03-17 |
US20130345193A1 (en) | 2013-12-26 |
PT2563776T (pt) | 2016-09-19 |
WO2011139489A3 (en) | 2012-01-26 |
EP2563776B1 (en) | 2016-06-08 |
TWI574959B (zh) | 2017-03-21 |
JP6112486B2 (ja) | 2017-04-12 |
JP2013525433A (ja) | 2013-06-20 |
JP6436463B2 (ja) | 2018-12-12 |
PL2563776T3 (pl) | 2017-01-31 |
AU2011248877B9 (en) | 2015-11-05 |
US8546403B2 (en) | 2013-10-01 |
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