HUE029247T2 - Benzimidazol légzõszervi szincitiális vírus inhibitorok - Google Patents
Benzimidazol légzõszervi szincitiális vírus inhibitorok Download PDFInfo
- Publication number
- HUE029247T2 HUE029247T2 HUE11802054A HUE11802054A HUE029247T2 HU E029247 T2 HUE029247 T2 HU E029247T2 HU E11802054 A HUE11802054 A HU E11802054A HU E11802054 A HUE11802054 A HU E11802054A HU E029247 T2 HUE029247 T2 HU E029247T2
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- Prior art keywords
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- compound
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- chemical
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (11)
- SKïbaibtei; jpnyponîok 1. ! .képlerü vegyőlet- a képletben: mindegyik X jelentése egymástéi tÖggetlentiFC vagy K; R: jelentése H: %l$*a^se Br is O stelía: çsi>p®Bbôl ípegaáiaszíoítt R3 jelentése -<CR6R7)„-Ra; t* jeílstiíese Cj”C7dkl<ïalkii, CrC pikeml,:€e«C% és -S%C% alkotta esoprifeói megválssxíöfc ;RS, jele« van, ha X Jefeüése C, mpejiett mindegyik; R* jelentése egymástól iliggetlenül M, €j~eöaíkí:í, CpC^aíköJÓ;,. halogén és CM. a&op esponfeAl megriasztott; Rs nincs jelen, la X jelentése N; Ré| és R7 jelentése egymástól :%géíiepl Hl CrC7& all; és CrCplkiöälkl alkotta csptrből megriasztott vagy % és R? együtt S- vagy ő-tagú alifás vagy aromás gyűrűt alkot amely adott esetben N, S és Ö alkotta csoportból megválasztott:: egy vagy'több heteroaromot tartalmaz; % jelentése H.. OH. CF,, CHFf, CL S02CHv SO:CrCTcikfoalkt]:, NR,-$02Rf>. SÚ2N%Rj, N.Rc/s02C::-C'?eikloalkiL CN, NR6RV, CCIÜH, CÜOR,,, CONR6R7, OCO€rCpkit, €0NR6S07R7, €ÖNH-RrSÖ2R7, €0HI^RrM)2btR6R7CÖ^%S02möR7, Ämip és 5- vagy 6-iagù aillas vagy aromás, adott esetben N, b és 0 alkotta esepribol irnsgyátasziótt egy vagy több heterőatímmt tartalmazó gyára afebá csoportból megv alas/totí; g: éttéSse I: « bpíornányfeői megriasztott Η-οχήΙρρ aMtcIós sója,: kvatemor aminja, femkomplmí©: vágy egy sztereokémiái komét: tormája..
- 2. Az l. igénypont szerinti vegyidéi, ahoi R, jelentése 8r.
- 3. Az 1. igénypont szerinti vegyüisr. ahol R2 jelentése CL
- 4. Az előző IgpypontöR bármelyiké szerinti vegyük-i, ahol R6 és R? jelentése lí.
- 5. Az előző igénypontok bármelyike szerinti vegyőlet ahol n értéke 2-4.
- 6. Az előző igénypontok bármelyike szerinti vegyük;!, ahol % jelentése F, CNX OH, CF\ és RD2£% a*~ kotta esopriből megválasztott
- 7. Ax eídző Î^n^otîtofe ÂSïelysfee szerinti vegyiliet. akot Rs jelentése F, ΟΊ,. ôïi és SÔjCiHR alkotta csoportból megválasztott.
- 8. Az előző igénypontok MttBölytkeszennti: vegySlet, afcoi E4 Jelentése GYC^sikíoalkd vagy €%ργ
- 9. Az előző igénypontok fearmelyikesaertói vegyidet,; ahol R4 jelentése ciklopropi; vagy CR^CÍY lö, Az előző igénypontok, bánaelyike szerintí vegyidet, attól egy M |etemóse H os atöíi^i 2Ç jelentése €. ! 1. Az i... igénypont szerintiképlett vegyidet vagy egyM-exk^a, addiciós sója, kvittemet andnia vagy fétnkontpkse. Í.2. A 11. igénypont szerinti, képleté vegyidet.
- 13, Az I - 12. igéxtypotdokfe^tteiyike szerinti vegyidet gyógyszerted yala stkateaxásra, ΙΑ, %éayászati kompszicté, amely egy gyógyászatilag. eifogadkaté kordozéanyaget és baióattyagkéní terápilsan fèatâsos xseanyiségbeo egyyaz 1 - 12. igénypontok felrstsiyike szerists vegyüleíst tarfetaaz.
- 15, Eljárás a. 14. igénypont szerinti gyógyászati kotopdziçtp előállítására, mely eprás sorén egy gyégy-aszatiag:eiogadkaté ItötdoÄßyagoi és egy, az: t 12. igénypontok bármelyike szerinti vegyidet terápiásán ds* tásos «îsnyfeégéîfeeKSésépsm összekevertek, l é. Az l - 12. igénypontok bármely ikc szerinti vegyfíJeí :RSA/ szaporodásának oldására szolgáló gyógyszerként való alkalmazásra, lift 1 - 12. igénypontok bármelyike: szerinti; végyulet alkalmazása.;RW szaporodásának gátlására szolgáié gyógyszer előállítására.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10195467 | 2010-12-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE029247T2 true HUE029247T2 (hu) | 2017-02-28 |
Family
ID=43875271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE11802054A HUE029247T2 (hu) | 2010-12-16 | 2011-12-16 | Benzimidazol légzõszervi szincitiális vírus inhibitorok |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US8865705B2 (hu) |
| EP (1) | EP2651903B1 (hu) |
| JP (1) | JP6005656B2 (hu) |
| KR (1) | KR101876240B1 (hu) |
| CN (2) | CN103313974A (hu) |
| AR (1) | AR085203A1 (hu) |
| AU (1) | AU2011343255B2 (hu) |
| BR (1) | BR112013012137A2 (hu) |
| CA (1) | CA2821999C (hu) |
| CL (1) | CL2013001713A1 (hu) |
| CY (1) | CY1117751T1 (hu) |
| DK (1) | DK2651903T3 (hu) |
| EA (1) | EA022972B1 (hu) |
| ES (1) | ES2576180T3 (hu) |
| HK (1) | HK1247616A1 (hu) |
| HR (1) | HRP20160650T1 (hu) |
| HU (1) | HUE029247T2 (hu) |
| IL (1) | IL225640A (hu) |
| MX (1) | MX340030B (hu) |
| MY (1) | MY156641A (hu) |
| NZ (1) | NZ609450A (hu) |
| PL (1) | PL2651903T3 (hu) |
| PT (1) | PT2651903E (hu) |
| SG (1) | SG190766A1 (hu) |
| SI (1) | SI2651903T1 (hu) |
| TW (1) | TWI530495B (hu) |
| UA (1) | UA112298C2 (hu) |
| WO (1) | WO2012080446A1 (hu) |
| ZA (1) | ZA201304424B (hu) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI541241B (zh) | 2010-12-16 | 2016-07-11 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類 |
| TWI515187B (zh) * | 2010-12-16 | 2016-01-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之吲哚類 |
| TWI530495B (zh) | 2010-12-16 | 2016-04-21 | 健生科學愛爾蘭無限公司 | 苯并咪唑呼吸道融合病毒抑制劑 |
| TWI527814B (zh) | 2010-12-16 | 2016-04-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類 |
| TWI501967B (zh) * | 2010-12-16 | 2015-10-01 | Janssen R&D Ireland | 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類 |
| EP2864325A1 (en) * | 2012-06-15 | 2015-04-29 | Janssen Sciences Ireland UC | 1,3-dihydro-2h-benzimidazol-2-one derivatives substituted with benzimidazoles as respiratory syncytial virus antiviral agents |
| KR102092612B1 (ko) | 2012-06-15 | 2020-03-25 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 호흡기 합포체 바이러스의 항바이러스제로서의 헤테로사이클로 치환된 1,3-디하이드로-2h-벤즈이미다졸-2-온 유도체 |
| BR112015000392A2 (pt) * | 2012-07-10 | 2017-06-27 | Hoffmann La Roche | novos indazóis para o tratamento e profilaxia da infecção por vírus sincicial respiratório |
| CN104903313B (zh) * | 2012-10-16 | 2017-12-29 | 爱尔兰詹森科学公司 | Rsv抗病毒化合物 |
| AU2014209853B2 (en) * | 2013-01-28 | 2017-12-21 | Janssen Sciences Ireland Uc | Quinoxalinones and dihydroquinoxalinones as respiratory syncytial virus antiviral agents |
| CN105392787B (zh) * | 2013-05-14 | 2017-11-24 | 豪夫迈·罗氏有限公司 | 用于治疗和预防呼吸道合胞病毒感染的氮杂‑氧代‑吲哚 |
| EP2997028A1 (en) | 2013-05-14 | 2016-03-23 | F.Hoffmann-La Roche Ag | Aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection |
| CA2914541A1 (en) * | 2013-08-15 | 2015-02-19 | F. Hoffmann-La Roche Ag | Novel aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection |
| UA123854C2 (uk) | 2013-08-21 | 2021-06-16 | Аліос Біофарма, Інк. | Противірусні сполуки |
| WO2015065336A1 (en) * | 2013-10-29 | 2015-05-07 | Medivir Ab | Respiratory syncytial virus inhibitors |
| TWI671299B (zh) | 2014-04-14 | 2019-09-11 | 愛爾蘭商健生科學愛爾蘭無限公司 | 作為ｒｓｖ抗病毒化合物之螺脲化合物 |
| MA40404A (fr) * | 2014-08-05 | 2017-06-14 | Alios Biopharma Inc | Polythérapie pour traiter un paramyxovirus |
| MA41614A (fr) | 2015-02-25 | 2018-01-02 | Alios Biopharma Inc | Composés antiviraux |
| HUE060259T2 (hu) | 2015-07-22 | 2023-02-28 | Enanta Pharm Inc | Benzodiazepin származékok mint RSV-gátlók |
| CN108699077B (zh) | 2016-01-15 | 2021-03-02 | 英安塔制药有限公司 | 作为rsv抑制剂的杂环化合物 |
| CA3065368A1 (en) | 2017-02-16 | 2018-08-23 | Enanta Pharmaceuticals, Inc. | Processes for the preparation of benzodiazepine derivatives |
| US11091501B2 (en) | 2017-06-30 | 2021-08-17 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as RSV inhibitors |
| BR112020006334A2 (pt) | 2017-09-29 | 2020-09-24 | Enanta Pharmaceuticals, Inc. | combinação de agentes farmacêuticos como inibidores de rsv |
| WO2019094903A1 (en) | 2017-11-13 | 2019-05-16 | Enanta Pharmaceuticals, Inc. | Processes for the resolution of benzodiazepin-2-one and benzoazepin-2-one derivatives |
| KR20210138684A (ko) | 2019-03-18 | 2021-11-19 | 이난타 파마슈티칼스, 인코포레이티드 | Rsv 억제제로서의 벤조디아제핀 유도체 |
| AU2020357452A1 (en) | 2019-10-04 | 2022-05-12 | Enanta Pharmaceuticals, Inc. | Antiviral heterocyclic compounds |
| US11505558B1 (en) | 2019-10-04 | 2022-11-22 | Enanta Pharmaceuticals, Inc. | Antiviral heterocyclic compounds |
| UY39032A (es) | 2020-01-24 | 2021-07-30 | Enanta Pharm Inc | Compuestos heterocíclicos como agentes antivirales |
| US11534439B2 (en) | 2020-07-07 | 2022-12-27 | Enanta Pharmaceuticals, Inc. | Dihydroquinoxaline and dihydropyridopyrazine derivatives as RSV inhibitors |
| WO2022086840A1 (en) | 2020-10-19 | 2022-04-28 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as anti-viral agents |
| BR112023016970A2 (pt) | 2021-02-26 | 2023-10-10 | Enanta Pharm Inc | Compostos heterocíclicos antivirais |
| WO2024174953A1 (zh) * | 2023-02-21 | 2024-08-29 | 苏州隆博泰药业有限公司 | 苯并咪唑类衍生物及其医药用途 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ333696A (en) | 1996-07-08 | 2000-06-23 | Du Pont Pharm Co | Amidinoindoles, amidinoazoles, and analogs thereof as inhibitors of trypsin like protease enzymes like thrombin and Xa factor |
| WO2000020400A1 (en) | 1998-10-05 | 2000-04-13 | Axys Pharmaceuticals, Inc. | Novel compounds and compositions for treating hepatitis c infections |
| SK19122001A3 (sk) | 1999-06-28 | 2003-01-09 | Janssen Pharmaceutica N. V. | Inhibítory replikácie respiračného syncyciálneho vírusu |
| EP1418175A1 (en) | 1999-06-28 | 2004-05-12 | Janssen Pharmaceutica N.V. | Respiratory syncytial virus replication inhibitors |
| US6534535B1 (en) | 1999-08-12 | 2003-03-18 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
| US6489338B2 (en) | 2000-06-13 | 2002-12-03 | Bristol-Myers Squibb Company | Imidazopyridine and imidazopyrimidine antiviral agents |
| US6506738B1 (en) | 2000-09-27 | 2003-01-14 | Bristol-Myers Squibb Company | Benzimidazolone antiviral agents |
| US6919331B2 (en) * | 2001-12-10 | 2005-07-19 | Bristol-Myers Squibb Company | Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents |
| US20040166137A1 (en) | 2002-11-08 | 2004-08-26 | Lackey John William | Hetero-substituted benzimidazole compounds and antiviral uses thereof |
| TWI527814B (zh) | 2010-12-16 | 2016-04-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類 |
| TWI530495B (zh) | 2010-12-16 | 2016-04-21 | 健生科學愛爾蘭無限公司 | 苯并咪唑呼吸道融合病毒抑制劑 |
| TWI515187B (zh) | 2010-12-16 | 2016-01-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之吲哚類 |
| TWI501967B (zh) | 2010-12-16 | 2015-10-01 | Janssen R&D Ireland | 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類 |
| TWI541241B (zh) | 2010-12-16 | 2016-07-11 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類 |
-
2011
- 2011-12-15 TW TW100146390A patent/TWI530495B/zh not_active IP Right Cessation
- 2011-12-16 UA UAA201305027A patent/UA112298C2/uk unknown
- 2011-12-16 ES ES11802054.4T patent/ES2576180T3/es active Active
- 2011-12-16 US US13/993,107 patent/US8865705B2/en active Active
- 2011-12-16 HU HUE11802054A patent/HUE029247T2/hu unknown
- 2011-12-16 JP JP2013543799A patent/JP6005656B2/ja active Active
- 2011-12-16 AR ARP110104739A patent/AR085203A1/es active IP Right Grant
- 2011-12-16 MY MYPI2013001281A patent/MY156641A/en unknown
- 2011-12-16 EA EA201390888A patent/EA022972B1/ru not_active IP Right Cessation
- 2011-12-16 CN CN2011800602778A patent/CN103313974A/zh active Pending
- 2011-12-16 SI SI201130853A patent/SI2651903T1/sl unknown
- 2011-12-16 WO PCT/EP2011/073008 patent/WO2012080446A1/en active Application Filing
- 2011-12-16 CA CA2821999A patent/CA2821999C/en active Active
- 2011-12-16 MX MX2013006886A patent/MX340030B/es active IP Right Grant
- 2011-12-16 PT PT118020544T patent/PT2651903E/pt unknown
- 2011-12-16 PL PL11802054.4T patent/PL2651903T3/pl unknown
- 2011-12-16 SG SG2013026711A patent/SG190766A1/en unknown
- 2011-12-16 AU AU2011343255A patent/AU2011343255B2/en not_active Ceased
- 2011-12-16 EP EP11802054.4A patent/EP2651903B1/en active Active
- 2011-12-16 DK DK11802054.4T patent/DK2651903T3/da active
- 2011-12-16 KR KR1020137016944A patent/KR101876240B1/ko active IP Right Grant
- 2011-12-16 NZ NZ609450A patent/NZ609450A/en not_active IP Right Cessation
- 2011-12-16 CN CN201710103106.8A patent/CN107417683A/zh active Pending
- 2011-12-16 BR BR112013012137A patent/BR112013012137A2/pt not_active Application Discontinuation
-
2013
- 2013-04-09 IL IL225640A patent/IL225640A/en active IP Right Grant
- 2013-06-13 CL CL2013001713A patent/CL2013001713A1/es unknown
- 2013-06-14 ZA ZA2013/04424A patent/ZA201304424B/en unknown
-
2016
- 2016-06-10 HR HRP20160650TT patent/HRP20160650T1/hr unknown
- 2016-06-22 CY CY20161100561T patent/CY1117751T1/el unknown
-
2018
- 2018-05-31 HK HK18107115.5A patent/HK1247616A1/zh unknown
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