HUE028737T2 - Monoclonal antibodies against glypican-3 - Google Patents

Monoclonal antibodies against glypican-3 Download PDF

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Publication number
HUE028737T2
HUE028737T2 HUE08796249A HUE08796249A HUE028737T2 HU E028737 T2 HUE028737 T2 HU E028737T2 HU E08796249 A HUE08796249 A HU E08796249A HU E08796249 A HUE08796249 A HU E08796249A HU E028737 T2 HUE028737 T2 HU E028737T2
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HU
Hungary
Prior art keywords
seq
antibody
variable region
glypican
antibodies
Prior art date
Application number
HUE08796249A
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English (en)
Hungarian (hu)
Inventor
Jonathan Alexander Terrett
Li-Sheng Lu
Haichun Huang
Dapeng Yao
Chin Pan
Heidi Leblanc
Timothy Sproul
Mark Yamanaka
Original Assignee
Squibb & Sons Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Llc filed Critical Squibb & Sons Llc
Publication of HUE028737T2 publication Critical patent/HUE028737T2/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303Liver or Pancreas
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77Internalization into the cell
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
HUE08796249A 2007-07-17 2008-07-17 Monoclonal antibodies against glypican-3 HUE028737T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95984507P 2007-07-17 2007-07-17

Publications (1)

Publication Number Publication Date
HUE028737T2 true HUE028737T2 (en) 2017-01-30

Family

ID=39874207

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE08796249A HUE028737T2 (en) 2007-07-17 2008-07-17 Monoclonal antibodies against glypican-3

Country Status (18)

Country Link
US (2) US8680247B2 (Direct)
EP (1) EP2178921B1 (Direct)
JP (2) JP5868593B2 (Direct)
KR (2) KR101527342B1 (Direct)
CN (1) CN101815726B (Direct)
AU (1) AU2008275985B2 (Direct)
CY (1) CY1117236T1 (Direct)
DK (1) DK2178921T3 (Direct)
ES (1) ES2562790T3 (Direct)
HR (1) HRP20160270T1 (Direct)
HU (1) HUE028737T2 (Direct)
ME (1) ME02345B (Direct)
MX (1) MX2010000537A (Direct)
PL (1) PL2178921T3 (Direct)
PT (1) PT2178921E (Direct)
RS (1) RS54624B1 (Direct)
SI (1) SI2178921T1 (Direct)
WO (1) WO2009012394A1 (Direct)

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Also Published As

Publication number Publication date
HRP20160270T1 (hr) 2016-05-06
CN101815726B (zh) 2013-04-03
US8680247B2 (en) 2014-03-25
PL2178921T3 (pl) 2016-06-30
ES2562790T3 (es) 2016-03-08
DK2178921T3 (en) 2016-04-04
EP2178921A1 (en) 2010-04-28
RS54624B1 (sr) 2016-08-31
AU2008275985B2 (en) 2013-09-19
US20140186892A1 (en) 2014-07-03
KR20150038732A (ko) 2015-04-08
KR20100056467A (ko) 2010-05-27
CY1117236T1 (el) 2017-04-05
JP5868593B2 (ja) 2016-02-24
JP2010533498A (ja) 2010-10-28
US9217033B2 (en) 2015-12-22
SI2178921T1 (sl) 2016-05-31
KR101527342B1 (ko) 2015-06-09
US20100209432A1 (en) 2010-08-19
KR101570252B1 (ko) 2015-11-19
EP2178921B1 (en) 2016-01-06
ME02345B (me) 2016-08-31
CN101815726A (zh) 2010-08-25
MX2010000537A (es) 2010-03-25
WO2009012394A1 (en) 2009-01-22
PT2178921E (pt) 2016-03-23
JP2014236734A (ja) 2014-12-18
AU2008275985A1 (en) 2009-01-22

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