HUE028499T2 - Janus-kináz-inhibitorok száraz szem és más, szemmel kapcsolatos betegségek kezelésére - Google Patents

Janus-kináz-inhibitorok száraz szem és más, szemmel kapcsolatos betegségek kezelésére Download PDF

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Publication number
HUE028499T2
HUE028499T2 HUE09737257A HUE09737257A HUE028499T2 HU E028499 T2 HUE028499 T2 HU E028499T2 HU E09737257 A HUE09737257 A HU E09737257A HU E09737257 A HUE09737257 A HU E09737257A HU E028499 T2 HUE028499 T2 HU E028499T2
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Hungary
Prior art keywords
agent
dry eye
tear
active ingredient
eye
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HUE09737257A
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English (en)
Inventor
Paul A Friedman
Jordan S Fridman
Monica E Luchi
William V Williams
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Incyte Holdings Corp
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Application filed by Incyte Holdings Corp filed Critical Incyte Holdings Corp
Publication of HUE028499T2 publication Critical patent/HUE028499T2/hu

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Claims (6)

  1. SZEM ÉS MÁS, SÍMMEL KAPCSOLATOS vkobségsk wemiMÉm Szabadalmi igénypontok
    1, Hatóanyag páciensben é&m szem jmæÉeitassség kezeiéSies történő alkalmazásra, ahol a hatóanyag S-aMopeabJ-3~P-f7K~pin-DlO'[2,3^d]~p:ài;âa!dih-4-âl|-!:li^piraKo!'î-âj:-|>rapàîîftitôâ vagy gyógyászatilag elfogadható sója. |, ás I. igéhjpsni. sxé#ii hatóanyag m 8# mdglsmározöít aMmmtásra, ahol a hatóanyag (3&>-3- vagy |yögyász«triag éímgád- ható séta. & Λ» h imgy 2.. Igénypmt szerinti ItÄnydg m dît meghatározott alkalmazásra, ahol a -sates -psa* rendellenesség: (ál & könny elégtéjesryfzíaztakna miatti száraz szent, φ} pmolgâsos száras szem, (c) S}SgmíP;saá)sk^aival: ősszgiíggő száraz: sse® vagy Pl szánsz szem, «elv sem függ Össze ^SgmivSztórőmavaL
  2. 4. Az 1-3. igénypontok bármelyike szerint:. hsióanytsg az ott moghatározött alkalmazásra, ahol a kezelés magában foglalja a kővetkezők közül választott tünetek közül bármelyik enyhítését: szemdtszkomihri, láiasza-var, ISögylIm issfáfeillíiss, könny hiperozmolamfca és a szemlelsgiít gynlkifása.
  3. 5. Az 1-4. igénypontok' bármelyike szerinti hatóanyag az ott nmgbstarozoít alkrimazásra, ahol a kezelés magába» foglalja gyógyászati készítmény beadását a páciensnek,; almi a készítmény tartalmazna hatóanyagot é$ tartalmaz gyógyászatiísg elfogadható hordozót. tk Az 5, igénypont: szerinti Iktéttnyag az ott meghätferiott alkalmazásra, ahol a gyógyászati készitsnény: orális adagolási forma,
  4. 7. Az 1*4, Igénypontok ymelyikeszenaíi kigöáttyág: az ott irtóghatározott alkalmazásra, ahol s kezelés ítztgábatt foglalja szemészeti készítmény beadását a pAbehstÄ áfeol ri kássiíroény tamimazzs. a h&Äryagot és tartalmaz szemészeíilsg eMógadlisíó hordozót g, A '% igéaÿ|K>nt szenük hmóanysg az otlrnnghathrozoit alkalmazásra, ahol a szemészeti készítmény (a) h%j Mszhsnódy vagy (b| vizes keszilmóny, vizes áznszpenzié, kesróes vagy gél §. A !.. igénypont szerinti hatóanyag az: ott meghatározott alkalmazásra, ahol a szemészefs készítmény szemészeti «mplantátum. ÍO. A $. tgdnypm sîœrmd hatóanyag a*. n« «xeghsate^tt alkálmaAbra, ahol |s$ 1n^kmátUHm»krcig$mbök«i tartalmát #) 8: mîkfefSMîisfcei ·& sasai Mkő szegœemèkigj: a ckoApdeáiiií terfee, s sakldÄa, a vi&ettiHha vagy saabretisaltsas kgektMitdq (e)is5|feÂ$s tanalmag kollágáól xseïi vagy poismit, aboi a polimer a köÄesök kősód válását««: foKfeps&íteafe: &CL)> eblAdml-acetà: kopoitm«· (BVA)t> ipÉÂÂ-càÂ^àfeâîâl;,. 'pljdjsila*. aybn, :aíkí(ál-laküd^kö-g!&o!id> {PL&êft vagy esek feârmeiyikdodk vagy (til a s^ateifc implaatábmot a falsé szsftihdf alà, a sxem Misé saegkstkébh, a cküAnfeàks térbe, a: sgkkraha, a vitmmobâ vagy s:mbretkMissæ beäibtpk. H. Á2 l~l& Igbaypodlek bânodyike sacrbii hatôaayag sa oit megbatározott alkalmazásra, amely tar· bkn&r legalább egy további terápiás hatóanyagot is.
  5. 12. A II. ígéaypontsaerioU htu&mvag aa ott meghatározott alkálmasásm, ahol C#) a továfelb terápiás feaíótmysg Ätespom dexameksoo, llxbipqk», kortfepo, pmánkolotg toaetökm, elvárnád, tetős»«*»»» seabekalÄfb 15~|skbidtmioikozae btraéHsáv, véS.3S,4R,5R}'3í4-dihsckoxirS”PH[{3-gddlfea!l)-íímiilm:atKo|--5X8áH-k--íl]-N-'m^aiiko;so!áa-'2-'kajixsta~ ,trá;l getársu?, cevHemia, áoxikíio, œ&iocflrffcx» oxibíraetklm,: vtádbspsr&k î««§îi»©a». pik-· karplo, t&krolinmsA jpimekro!>«xus2, bbprednoketakoíták ri^tafe, dlqualbsolAabasoáimíi, dehiáro-epkmdrosxbioo, a&ákmrsg oklkmaah» mtkofeaoMbxstóöía, etaseriisph MtawUorokM vágy blídomld, vagy ¢1)} « további torspás Mö&hyag sátnma'Ríáfdtdaáí, tótesMty, pidivksikaJkobok híáftPipmpsI·' metilcöMÓK, giberb, polisiibo-glskoi vagy karköxknaiikaéiafe.
  6. 13. Hatóanyag aíkabnaaása száraz szem rptsMIesasság kezelésére szolgáló gyégysze* előállására, ahol a hatóanyag 3-cikbpsiitil-:i[4-i71Apirrob~[2,3~dj-pidm!disk-d}~lH'pjra»)hl-irj-pri>pa?mimi vagy gyógyásaa-dkg sllbgaáhaté sója. 14. A 13, igésypoot szerioti alkalmazás, ahol a habtmvag 3R}~3-eskkpaalil-3-:[4-{711-pirrokv|2.3-d]· paimidk-ó-tlVlH^Irsxol'· kij-qsöpámltni vagy gyogyászalikg elfogadható spa.
HUE09737257A 2008-10-02 2009-10-01 Janus-kináz-inhibitorok száraz szem és más, szemmel kapcsolatos betegségek kezelésére HUE028499T2 (hu)

Applications Claiming Priority (1)

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US10224208P 2008-10-02 2008-10-02

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Country Link
US (4) US20100113416A1 (hu)
EP (2) EP3042655A1 (hu)
JP (5) JP2012504639A (hu)
AR (2) AR073530A1 (hu)
CA (2) CA3064247A1 (hu)
CL (1) CL2009001884A1 (hu)
CY (1) CY1117317T1 (hu)
DK (1) DK2349260T3 (hu)
ES (1) ES2564203T3 (hu)
HK (1) HK1160607A1 (hu)
HR (1) HRP20160330T1 (hu)
HU (1) HUE028499T2 (hu)
PL (1) PL2349260T3 (hu)
PT (1) PT2349260E (hu)
RS (1) RS54651B1 (hu)
SI (1) SI2349260T1 (hu)
SM (1) SMT201600080B (hu)
TW (2) TWI591068B (hu)
WO (1) WO2010039939A1 (hu)

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