HU228098B1 - Process for preparing eprosartan and intermediates - Google Patents

Process for preparing eprosartan and intermediates Download PDF

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Publication number
HU228098B1
HU228098B1 HU0001813A HUP0001813A HU228098B1 HU 228098 B1 HU228098 B1 HU 228098B1 HU 0001813 A HU0001813 A HU 0001813A HU P0001813 A HUP0001813 A HU P0001813A HU 228098 B1 HU228098 B1 HU 228098B1
Authority
HU
Hungary
Prior art keywords
formula
compound
alkyl
group
pharmaceutically acceptable
Prior art date
Application number
HU0001813A
Other languages
English (en)
Hungarian (hu)
Inventor
Peng Liu
Richard T Matsuoka
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of HUP0001813A2 publication Critical patent/HUP0001813A2/hu
Publication of HUP0001813A3 publication Critical patent/HUP0001813A3/hu
Publication of HU228098B1 publication Critical patent/HU228098B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HU0001813A 1997-02-14 1998-02-13 Process for preparing eprosartan and intermediates HU228098B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3819697P 1997-02-14 1997-02-14
PCT/US1998/002411 WO1998035962A1 (en) 1997-02-14 1998-02-13 Process for preparing eprosartan

Publications (3)

Publication Number Publication Date
HUP0001813A2 HUP0001813A2 (hu) 2001-06-28
HUP0001813A3 HUP0001813A3 (en) 2001-07-30
HU228098B1 true HU228098B1 (en) 2012-10-29

Family

ID=21898590

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0001813A HU228098B1 (en) 1997-02-14 1998-02-13 Process for preparing eprosartan and intermediates

Country Status (40)

Country Link
US (2) US6294675B1 (OSRAM)
EP (1) EP0973769B1 (OSRAM)
JP (1) JP4227671B2 (OSRAM)
KR (1) KR100551667B1 (OSRAM)
CN (1) CN1093128C (OSRAM)
AP (1) AP1202A (OSRAM)
AR (1) AR011126A1 (OSRAM)
AT (1) ATE274511T1 (OSRAM)
AU (1) AU730162B2 (OSRAM)
BG (1) BG63970B1 (OSRAM)
BR (1) BRPI9808642B8 (OSRAM)
CA (1) CA2281471C (OSRAM)
CO (1) CO4950549A1 (OSRAM)
CY (1) CY2551B1 (OSRAM)
CZ (1) CZ296543B6 (OSRAM)
DE (1) DE69825880T2 (OSRAM)
DK (1) DK0973769T3 (OSRAM)
DZ (1) DZ2418A1 (OSRAM)
EA (1) EA001761B1 (OSRAM)
EG (1) EG23780A (OSRAM)
ES (1) ES2224358T3 (OSRAM)
HU (1) HU228098B1 (OSRAM)
ID (1) ID23155A (OSRAM)
IL (4) IL143784A (OSRAM)
IN (1) IN188000B (OSRAM)
MA (1) MA24472A1 (OSRAM)
MY (1) MY120024A (OSRAM)
NO (1) NO317761B1 (OSRAM)
NZ (1) NZ337182A (OSRAM)
OA (1) OA11086A (OSRAM)
PE (1) PE59799A1 (OSRAM)
PL (1) PL192837B1 (OSRAM)
PT (1) PT973769E (OSRAM)
SA (1) SA98190146B1 (OSRAM)
SI (1) SI0973769T1 (OSRAM)
SK (1) SK285125B6 (OSRAM)
TR (1) TR199901935T2 (OSRAM)
UA (1) UA57060C2 (OSRAM)
WO (1) WO1998035962A1 (OSRAM)
ZA (1) ZA981208B (OSRAM)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR011126A1 (es) * 1997-02-14 2000-08-02 Smithkline Beecham Corp Procedimiento para preparar eprosartano y compuestos intermediarios.
US6630498B2 (en) * 1997-08-06 2003-10-07 Smithkline Beecham Corporation Eprosartan arginyl charge-neutralization-complex and a process for its preparation and formulation
AU763309B2 (en) * 1998-07-20 2003-07-17 Smithkline Beecham Corporation Bioenhanced formulations comprising eprosartan in oral solid dosage form
US7820734B2 (en) 1998-10-07 2010-10-26 Tyco Healthcare Group Lp Antimicrobial lubricious coating
US20060099230A1 (en) * 2004-11-10 2006-05-11 Chin-Chih Chiang Novel formulations of eprosartan with enhanced bioavailability
US20100137613A1 (en) * 2006-12-27 2010-06-03 Hetero Drugs Limited Process for eprosartan
KR20100074288A (ko) * 2007-10-22 2010-07-01 오키드 리서치 레버라토리즈 리미티드 히스톤 디아세틸라제 억제제
CN101215284B (zh) * 2007-12-31 2010-10-13 浙江华海药业股份有限公司 一种改进的依普罗沙坦的制备方法
WO2011004384A2 (en) 2009-06-05 2011-01-13 Glochem Industries Limited Process for the preparation of eprosartan
CN102584709B (zh) * 2011-12-19 2016-08-17 浙江华海药业股份有限公司 一种改进的依普罗沙坦中间体芳基咪唑醛的制备工艺
CN103288742A (zh) * 2013-06-04 2013-09-11 四川百利药业有限责任公司 一种高纯度英加韦林原料的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5418250A (en) * 1989-06-14 1995-05-23 Smithkline Beecham Corporation Imidazolyl-alkenoic acids useful as angiotensin II receptor antagonists
DK0403159T3 (da) 1989-06-14 2000-08-14 Smithkline Beecham Corp Imidazolylalkensyrer
US5185351A (en) * 1989-06-14 1993-02-09 Smithkline Beecham Corporation Imidazolyl-alkenoic acids useful as angiotensin II receptor antagonists
NZ239161A (en) * 1990-07-31 1994-01-26 Smithkline Beecham Corp Substituted [1h-imidazol-5-yl] alkanoic acid derivatives; medicaments,
EP0563238B1 (en) * 1990-12-14 2002-05-22 Smithkline Beecham Corporation Imidazolyl-alkenoic acids
AR011126A1 (es) * 1997-02-14 2000-08-02 Smithkline Beecham Corp Procedimiento para preparar eprosartano y compuestos intermediarios.

Also Published As

Publication number Publication date
AP9901619A0 (en) 1999-09-30
NO993912D0 (no) 1999-08-13
US6294675B1 (en) 2001-09-25
KR100551667B1 (ko) 2006-02-13
IL143785A0 (en) 2002-04-21
ES2224358T3 (es) 2005-03-01
CZ296543B6 (cs) 2006-04-12
BRPI9808642B8 (pt) 2021-05-25
DK0973769T3 (da) 2004-12-13
KR20000071008A (ko) 2000-11-25
MY120024A (en) 2005-08-30
PT973769E (pt) 2004-11-30
JP4227671B2 (ja) 2009-02-18
EP0973769A4 (en) 2001-01-24
CN1093128C (zh) 2002-10-23
CZ285199A3 (cs) 2000-02-16
US6458963B1 (en) 2002-10-01
AU730162B2 (en) 2001-03-01
ATE274511T1 (de) 2004-09-15
PL192837B1 (pl) 2006-12-29
SK108699A3 (en) 2000-05-16
IN188000B (OSRAM) 2002-08-03
IL131310A0 (en) 2001-01-28
NO993912L (no) 1999-08-13
HUP0001813A2 (hu) 2001-06-28
IL143783A (en) 2005-05-17
ID23155A (id) 2000-03-23
DZ2418A1 (fr) 2003-06-26
CO4950549A1 (es) 2000-09-01
IL143784A (en) 2005-05-17
IL143785A (en) 2004-12-15
BG103649A (en) 2000-06-30
DE69825880T2 (de) 2005-09-08
AP1202A (en) 2003-09-02
HUP0001813A3 (en) 2001-07-30
NZ337182A (en) 2001-04-27
PE59799A1 (es) 1999-08-06
SK285125B6 (sk) 2006-06-01
SI0973769T1 (en) 2004-12-31
EP0973769B1 (en) 2004-08-25
US20020028951A1 (en) 2002-03-07
NO317761B1 (no) 2004-12-13
TR199901935T2 (xx) 1999-12-21
CA2281471C (en) 2007-04-24
AR011126A1 (es) 2000-08-02
SA98190146B1 (ar) 2006-08-20
ZA981208B (en) 1998-11-12
EP0973769A1 (en) 2000-01-26
CA2281471A1 (en) 1998-08-20
DE69825880D1 (de) 2004-09-30
OA11086A (en) 2003-03-13
BR9808642B1 (pt) 2013-11-26
CN1247538A (zh) 2000-03-15
BG63970B1 (bg) 2003-08-29
WO1998035962A1 (en) 1998-08-20
MA24472A1 (fr) 1998-10-01
IL143783A0 (en) 2002-04-21
HK1026206A1 (en) 2000-12-08
IL143784A0 (en) 2002-04-21
IL131310A (en) 2003-02-12
JP2001511808A (ja) 2001-08-14
EG23780A (en) 2007-08-13
AU6273298A (en) 1998-09-08
EA199900741A1 (ru) 2000-02-28
EA001761B1 (ru) 2001-08-27
CY2551B1 (en) 2008-07-02
UA57060C2 (uk) 2003-06-16
BR9808642A (pt) 2000-05-23
PL335074A1 (en) 2000-04-10

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