BRPI9808642B8 - processo para preparar eprosartan a partir de 2-n-butil-4-formilidazol - Google Patents

processo para preparar eprosartan a partir de 2-n-butil-4-formilidazol

Info

Publication number
BRPI9808642B8
BRPI9808642B8 BRPI9808642A BR9808642A BRPI9808642B8 BR PI9808642 B8 BRPI9808642 B8 BR PI9808642B8 BR PI9808642 A BRPI9808642 A BR PI9808642A BR 9808642 A BR9808642 A BR 9808642A BR PI9808642 B8 BRPI9808642 B8 BR PI9808642B8
Authority
BR
Brazil
Prior art keywords
formylidazole
butyl
preparing eprosartan
eprosartan
preparing
Prior art date
Application number
BRPI9808642A
Other languages
English (en)
Other versions
BR9808642A (pt
BR9808642B1 (pt
Inventor
Liu Peng
T Matsuoka Richard
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of BR9808642A publication Critical patent/BR9808642A/pt
Publication of BR9808642B1 publication Critical patent/BR9808642B1/pt
Publication of BRPI9808642B8 publication Critical patent/BRPI9808642B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

"processo para preparar eprosartan". a presente invenção refere-se a um processo para preparar eprosartan.
BRPI9808642A 1997-02-14 1998-02-13 processo para preparar eprosartan a partir de 2-n-butil-4-formilidazol BRPI9808642B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3819697P 1997-02-14 1997-02-14
PCT/US1998/002411 WO1998035962A1 (en) 1997-02-14 1998-02-13 Process for preparing eprosartan

Publications (3)

Publication Number Publication Date
BR9808642A BR9808642A (pt) 2000-05-23
BR9808642B1 BR9808642B1 (pt) 2013-11-26
BRPI9808642B8 true BRPI9808642B8 (pt) 2021-05-25

Family

ID=21898590

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9808642A BRPI9808642B8 (pt) 1997-02-14 1998-02-13 processo para preparar eprosartan a partir de 2-n-butil-4-formilidazol

Country Status (41)

Country Link
US (2) US6294675B1 (pt)
EP (1) EP0973769B1 (pt)
JP (1) JP4227671B2 (pt)
KR (1) KR100551667B1 (pt)
CN (1) CN1093128C (pt)
AP (1) AP1202A (pt)
AR (1) AR011126A1 (pt)
AT (1) ATE274511T1 (pt)
AU (1) AU730162B2 (pt)
BG (1) BG63970B1 (pt)
BR (1) BRPI9808642B8 (pt)
CA (1) CA2281471C (pt)
CO (1) CO4950549A1 (pt)
CY (1) CY2551B1 (pt)
CZ (1) CZ296543B6 (pt)
DE (1) DE69825880T2 (pt)
DK (1) DK0973769T3 (pt)
DZ (1) DZ2418A1 (pt)
EA (1) EA001761B1 (pt)
EG (1) EG23780A (pt)
ES (1) ES2224358T3 (pt)
HK (1) HK1026206A1 (pt)
HU (1) HU228098B1 (pt)
ID (1) ID23155A (pt)
IL (4) IL143784A (pt)
IN (1) IN188000B (pt)
MA (1) MA24472A1 (pt)
MY (1) MY120024A (pt)
NO (1) NO317761B1 (pt)
NZ (1) NZ337182A (pt)
OA (1) OA11086A (pt)
PE (1) PE59799A1 (pt)
PL (1) PL192837B1 (pt)
PT (1) PT973769E (pt)
SA (1) SA98190146B1 (pt)
SI (1) SI0973769T1 (pt)
SK (1) SK285125B6 (pt)
TR (1) TR199901935T2 (pt)
UA (1) UA57060C2 (pt)
WO (1) WO1998035962A1 (pt)
ZA (1) ZA981208B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR011126A1 (es) * 1997-02-14 2000-08-02 Smithkline Beecham Corp Procedimiento para preparar eprosartano y compuestos intermediarios.
US6630498B2 (en) * 1997-08-06 2003-10-07 Smithkline Beecham Corporation Eprosartan arginyl charge-neutralization-complex and a process for its preparation and formulation
NZ509378A (en) * 1998-07-20 2003-04-29 Smithkline Beecham Corp Amorphous ammonium salts of eprosartan and pharmaceuticals thereof, useful for blocking angiotensin II receptors and useful for treating hypertension, congestive heart disease and renal failure
US20060099230A1 (en) * 2004-11-10 2006-05-11 Chin-Chih Chiang Novel formulations of eprosartan with enhanced bioavailability
US20100137613A1 (en) * 2006-12-27 2010-06-03 Hetero Drugs Limited Process for eprosartan
NZ584845A (en) * 2007-10-22 2011-09-30 Orchid Res Lab Ltd Histone deacetylase inhibitors
CN101215284B (zh) * 2007-12-31 2010-10-13 浙江华海药业股份有限公司 一种改进的依普罗沙坦的制备方法
WO2011004384A2 (en) 2009-06-05 2011-01-13 Glochem Industries Limited Process for the preparation of eprosartan
CN102584709B (zh) * 2011-12-19 2016-08-17 浙江华海药业股份有限公司 一种改进的依普罗沙坦中间体芳基咪唑醛的制备工艺
CN103288742A (zh) * 2013-06-04 2013-09-11 四川百利药业有限责任公司 一种高纯度英加韦林原料的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE250587T1 (de) * 1989-06-14 2003-10-15 Smithkline Beecham Corp Imidazoalkensäure
US5418250A (en) * 1989-06-14 1995-05-23 Smithkline Beecham Corporation Imidazolyl-alkenoic acids useful as angiotensin II receptor antagonists
US5185351A (en) * 1989-06-14 1993-02-09 Smithkline Beecham Corporation Imidazolyl-alkenoic acids useful as angiotensin II receptor antagonists
NZ239161A (en) * 1990-07-31 1994-01-26 Smithkline Beecham Corp Substituted [1h-imidazol-5-yl] alkanoic acid derivatives; medicaments,
AU9137791A (en) * 1990-12-14 1992-07-08 Smithkline Beecham Corporation Imidazolyl-alkenoic acids
AR011126A1 (es) * 1997-02-14 2000-08-02 Smithkline Beecham Corp Procedimiento para preparar eprosartano y compuestos intermediarios.

Also Published As

Publication number Publication date
IL143785A0 (en) 2002-04-21
EG23780A (en) 2007-08-13
ATE274511T1 (de) 2004-09-15
BR9808642A (pt) 2000-05-23
CA2281471A1 (en) 1998-08-20
TR199901935T2 (xx) 1999-12-21
PL335074A1 (en) 2000-04-10
CO4950549A1 (es) 2000-09-01
OA11086A (en) 2003-03-13
JP4227671B2 (ja) 2009-02-18
AP9901619A0 (en) 1999-09-30
CA2281471C (en) 2007-04-24
SK108699A3 (en) 2000-05-16
US20020028951A1 (en) 2002-03-07
NZ337182A (en) 2001-04-27
SK285125B6 (sk) 2006-06-01
CZ285199A3 (cs) 2000-02-16
US6294675B1 (en) 2001-09-25
HUP0001813A3 (en) 2001-07-30
BG103649A (en) 2000-06-30
EP0973769A4 (en) 2001-01-24
NO317761B1 (no) 2004-12-13
DK0973769T3 (da) 2004-12-13
CZ296543B6 (cs) 2006-04-12
HK1026206A1 (en) 2000-12-08
SA98190146B1 (ar) 2006-08-20
IL143783A0 (en) 2002-04-21
EA001761B1 (ru) 2001-08-27
EA199900741A1 (ru) 2000-02-28
DE69825880D1 (de) 2004-09-30
HUP0001813A2 (hu) 2001-06-28
ES2224358T3 (es) 2005-03-01
BG63970B1 (bg) 2003-08-29
ZA981208B (en) 1998-11-12
IL143783A (en) 2005-05-17
CN1247538A (zh) 2000-03-15
IL131310A (en) 2003-02-12
IL143785A (en) 2004-12-15
JP2001511808A (ja) 2001-08-14
IL143784A (en) 2005-05-17
HU228098B1 (en) 2012-10-29
AP1202A (en) 2003-09-02
EP0973769B1 (en) 2004-08-25
MY120024A (en) 2005-08-30
PT973769E (pt) 2004-11-30
IN188000B (pt) 2002-08-03
PE59799A1 (es) 1999-08-06
DZ2418A1 (fr) 2003-06-26
KR100551667B1 (ko) 2006-02-13
CN1093128C (zh) 2002-10-23
MA24472A1 (fr) 1998-10-01
IL143784A0 (en) 2002-04-21
NO993912L (no) 1999-08-13
EP0973769A1 (en) 2000-01-26
CY2551B1 (en) 2008-07-02
ID23155A (id) 2000-03-23
AR011126A1 (es) 2000-08-02
KR20000071008A (ko) 2000-11-25
PL192837B1 (pl) 2006-12-29
BR9808642B1 (pt) 2013-11-26
DE69825880T2 (de) 2005-09-08
AU730162B2 (en) 2001-03-01
IL131310A0 (en) 2001-01-28
WO1998035962A1 (en) 1998-08-20
SI0973769T1 (en) 2004-12-31
UA57060C2 (uk) 2003-06-16
US6458963B1 (en) 2002-10-01
AU6273298A (en) 1998-09-08
NO993912D0 (no) 1999-08-13

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFERIMENTO DO PRESENTE PEDIDO, UMA VEZ QUE O MESMO APRESENTA REIVINDICACOES QUE NAO ATENDEM AO RQUISITO DE ATIVIDADE INVENTIVA ( ARTIGO 8O COMBINADO COM ARTIGO 13 DA LEI 9279/96)

B12B Appeal against refusal [chapter 12.2 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 26/11/2013, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 13/02/1998 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 13/02/2018