HU219987B - Imidazodiazepinek, eljárás előállításukra és ezeket tartalmazó gyógyászati készítmények - Google Patents

Imidazodiazepinek, eljárás előállításukra és ezeket tartalmazó gyógyászati készítmények Download PDF

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Publication number
HU219987B
HU219987B HU9500743A HU9500743A HU219987B HU 219987 B HU219987 B HU 219987B HU 9500743 A HU9500743 A HU 9500743A HU 9500743 A HU9500743 A HU 9500743A HU 219987 B HU219987 B HU 219987B
Authority
HU
Hungary
Prior art keywords
imidazo
dihydro
mmol
oxadiazol
benzodiazepin
Prior art date
Application number
HU9500743A
Other languages
English (en)
Hungarian (hu)
Other versions
HU9500743D0 (en
HUT71817A (en
Inventor
Thierry Godel
Walter Hunkeler
Heinz Stadler
Ulrich Widmer
Original Assignee
F. Hoffmann-La Roche Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag. filed Critical F. Hoffmann-La Roche Ag.
Publication of HU9500743D0 publication Critical patent/HU9500743D0/hu
Publication of HUT71817A publication Critical patent/HUT71817A/hu
Publication of HU219987B publication Critical patent/HU219987B/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
HU9500743A 1994-03-16 1995-03-13 Imidazodiazepinek, eljárás előállításukra és ezeket tartalmazó gyógyászati készítmények HU219987B (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH78394 1994-03-16
CH1095 1995-01-03

Publications (3)

Publication Number Publication Date
HU9500743D0 HU9500743D0 (en) 1995-04-28
HUT71817A HUT71817A (en) 1996-02-28
HU219987B true HU219987B (hu) 2001-10-28

Family

ID=25683249

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9500743A HU219987B (hu) 1994-03-16 1995-03-13 Imidazodiazepinek, eljárás előállításukra és ezeket tartalmazó gyógyászati készítmények

Country Status (27)

Country Link
US (1) US5665718A (fi)
EP (1) EP0672666B1 (fi)
JP (1) JP2690282B2 (fi)
KR (1) KR100214800B1 (fi)
CN (1) CN1036995C (fi)
AT (1) ATE203536T1 (fi)
AU (1) AU679608B2 (fi)
BG (1) BG62210B1 (fi)
CA (1) CA2143246C (fi)
CZ (1) CZ288594B6 (fi)
DE (1) DE59509432D1 (fi)
DK (1) DK0672666T3 (fi)
ES (1) ES2160646T3 (fi)
FI (1) FI112487B (fi)
GR (1) GR3037019T3 (fi)
HU (1) HU219987B (fi)
IL (1) IL112955A (fi)
IS (1) IS4273A (fi)
LV (1) LV11327B (fi)
MA (1) MA23479A1 (fi)
NO (1) NO303731B1 (fi)
NZ (1) NZ270685A (fi)
PH (1) PH31443A (fi)
PT (1) PT672666E (fi)
RO (1) RO117698B1 (fi)
RU (1) RU2139873C1 (fi)
SK (1) SK33995A3 (fi)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW349100B (en) * 1994-11-11 1999-01-01 Hoffmann La Roche Oxazolyl- and thiazolylimidazo-benzo- and thienodiazepines
US5905176A (en) * 1998-08-28 1999-05-18 Eastman Chemical Company Process for the production of cyclobutyl halides
CN1164590C (zh) * 1999-05-12 2004-09-01 弗·哈夫曼-拉罗切有限公司 咪唑二氮杂�衍生物
US7160880B1 (en) * 1999-05-14 2007-01-09 Cenes Limited Short-acting benzodiazepines
US20060065608A1 (en) * 2004-09-29 2006-03-30 Choate Chris E Process and apparatus for generating useful biomass from organic waste streams
DE602006021535D1 (de) * 2005-01-19 2011-06-09 Merck Sharp & Dohme Als inhibitoren von beta-secretase aktive tertiäre carbinamine mit substituierten heterocyclen zur behandlung der alzheimer-krankheit
US7820674B2 (en) * 2005-01-19 2010-10-26 Merck, Sharp & Dohme Corp. Aminomethyl beta-secretase inhibitors for the treatment of alzheimer's disease
CA2607226A1 (en) * 2005-05-16 2007-02-15 Wisys Technology Foundation, Inc. Gabaergic agents to treat memory deficits
GB0613693D0 (en) * 2006-07-10 2006-08-16 Cenes Ltd Benzodiazepine salts (3)
CA2657347C (en) 2006-07-10 2014-11-18 Paion Uk Limited Short-acting benzodiazepine salts and their polymorphic forms
US20090054412A1 (en) * 2007-08-20 2009-02-26 John Alan Kemp Treatment of Sleep Disorders
WO2009024324A2 (en) * 2007-08-20 2009-02-26 Evotec Neurosciences Gmbh Treatment of sleep disorders
WO2009024325A2 (en) * 2007-08-20 2009-02-26 Evotec Neurosciences Gmbh Treatment of sleep disorders
RU2503681C2 (ru) * 2008-09-30 2014-01-10 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Новое конденсированное производное аминодигидротиазина
EP2450039A1 (en) 2010-11-08 2012-05-09 PAION UK Ltd. Dosing regimen for sedation with CNS 7056 (Remimazolam)
ES2651389T3 (es) 2012-05-22 2018-01-26 Paion Uk Limited Composiciones que comprenden benzodiazepinas de acción corta
AR094963A1 (es) 2013-03-04 2015-09-09 Ono Pharmaceutical Co Reacción de oxidación excelente en el índice de conversión
JP6521977B2 (ja) 2013-09-06 2019-05-29 オーリジーン ディスカバリー テクノロジーズ リミテッドＡｕｒｉｇｅｎｅ Ｄｉｓｃｏｖｅｒｙ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｌｉｍｉｔｅｄ 免疫調節剤としての１，２，４−オキサジアゾール誘導体
EP3267985A4 (en) * 2015-03-10 2018-07-25 Aurigene Discovery Technologies Limited 3-substituted-1,2,4-oxadiazole and thiadiazole compounds as immunomodulators
EP3267984B1 (en) * 2015-03-10 2021-11-24 Aurigene Discovery Technologies Limited 1,2,4-oxadiazole and thiadiazole compounds as immunomodulators
CN109641000A (zh) 2016-04-14 2019-04-16 Paion英国有限公司 经口吸入和经鼻用的苯并二氮杂*类
WO2019061324A1 (en) 2017-09-29 2019-04-04 Curis Inc. CRYSTALLINE FORMS OF IMMUNOMODULATORS
SG11202003081WA (en) 2017-10-11 2020-05-28 Aurigene Discovery Tech Ltd Crystalline forms of 3-substituted 1,2,4-oxadiazole
JP7378394B2 (ja) 2017-11-03 2023-11-13 オーリジーン オンコロジー リミテッド Ｔｉｍ－３およびｐｄ－１経路の二重阻害剤
JP7378395B2 (ja) 2017-11-06 2023-11-13 オーリジーン オンコロジー リミテッド 免疫調節のためのコンジョイントセラピー

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK151808C (da) * 1982-11-16 1988-06-20 Ferrosan As Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater
IL74070A (en) * 1984-01-19 1988-12-30 Hoffmann La Roche Imidazodiazepine derivatives,their manufacture and pharmaceutical compositions containing them
AU587802B2 (en) * 1985-03-08 1989-08-31 Ferrosan A/S Novel oxadiazolyl imidazobenzodiazepine derivatives and methods of preparing such compounds
US4622320A (en) * 1985-05-17 1986-11-11 As Ferrosan Oxadiazolylimidazobenzodiazepine, compositions, and method
DK476885D0 (da) * 1985-10-17 1985-10-17 Ferrosan As Heterocycliske forbindelser og fremgangsmaader til fremstilling heraf
DK174086D0 (da) * 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
US4939139A (en) * 1989-07-26 1990-07-03 Merck & Co., Inc. 7-chloro-5,6-dihydro-3-(5-(1,2-dihydroxy-isopropyl)-1,2,4-oxadiazol-3-yl)-5-methyl-6-oxo-4H-imidazo[1,5A][1,4]benzodiazepine
US4904654A (en) * 1989-07-26 1990-02-27 Merck & Co., Inc. 7-chloro-5,6-dihydro-3-(5-(2-hydroxy-isopropyl)-1,2,4-oxadiazol-3-yl)-5-methyl-6-oxo-4H-imidazo[1,5a][1,4]benzodiazepine

Also Published As

Publication number Publication date
EP0672666B1 (de) 2001-07-25
IL112955A (en) 1998-02-08
ATE203536T1 (de) 2001-08-15
NZ270685A (en) 1996-05-28
GR3037019T3 (en) 2002-01-31
LV11327B (en) 1996-10-20
PT672666E (pt) 2002-01-30
KR950032199A (ko) 1995-12-20
DK0672666T3 (da) 2001-11-12
US5665718A (en) 1997-09-09
IL112955A0 (en) 1995-06-29
BG99505A (en) 1996-01-31
EP0672666A3 (de) 1995-11-08
RU95103921A (ru) 1996-12-10
FI951251A (fi) 1995-09-17
HU9500743D0 (en) 1995-04-28
DE59509432D1 (de) 2001-08-30
LV11327A (lv) 1996-06-20
IS4273A (is) 1995-09-17
JP2690282B2 (ja) 1997-12-10
KR100214800B1 (ko) 1999-08-02
FI112487B (fi) 2003-12-15
NO950999L (no) 1995-09-18
RO117698B1 (ro) 2002-06-28
AU1476095A (en) 1995-09-28
BG62210B1 (bg) 1999-05-31
ES2160646T3 (es) 2001-11-16
MA23479A1 (fr) 1995-10-01
RU2139873C1 (ru) 1999-10-20
CA2143246C (en) 2000-08-22
JPH07258260A (ja) 1995-10-09
CN1036995C (zh) 1998-01-14
HUT71817A (en) 1996-02-28
CN1111632A (zh) 1995-11-15
AU679608B2 (en) 1997-07-03
FI951251A0 (fi) 1995-03-16
EP0672666A2 (de) 1995-09-20
CZ288594B6 (cs) 2001-07-11
NO303731B1 (no) 1998-08-24
PH31443A (en) 1998-11-03
CZ66395A3 (en) 1995-10-18
CA2143246A1 (en) 1995-09-17
NO950999D0 (no) 1995-03-15
SK33995A3 (en) 1995-10-11

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Legal Events

Date Code Title Description
HMM4 Cancellation of final prot. due to non-payment of fee