HU215151B - Eljárás difenil-etán-származékok és ezeket tartalmazó gyógyszerkészítmények előállítására - Google Patents
Eljárás difenil-etán-származékok és ezeket tartalmazó gyógyszerkészítmények előállítására Download PDFInfo
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- HU215151B HU215151B HU9203156A HU9203156A HU215151B HU 215151 B HU215151 B HU 215151B HU 9203156 A HU9203156 A HU 9203156A HU 9203156 A HU9203156 A HU 9203156A HU 215151 B HU215151 B HU 215151B
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- 150000008046 alkali metal hydrides Chemical class 0.000 description 1
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- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 description 1
- 230000000973 chemotherapeutic effect Effects 0.000 description 1
- 229960001338 colchicine Drugs 0.000 description 1
- 238000004737 colorimetric analysis Methods 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- LSXDOTMGLUJQCM-UHFFFAOYSA-M copper(i) iodide Chemical compound I[Cu] LSXDOTMGLUJQCM-UHFFFAOYSA-M 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000011157 data evaluation Methods 0.000 description 1
- 230000020176 deacylation Effects 0.000 description 1
- 238000005947 deacylation reaction Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- PBGGNZZGJIKBMJ-UHFFFAOYSA-N di(propan-2-yl)azanide Chemical compound CC(C)[N-]C(C)C PBGGNZZGJIKBMJ-UHFFFAOYSA-N 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 210000005069 ears Anatomy 0.000 description 1
- 229940116977 epidermal growth factor Drugs 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 125000004185 ester group Chemical group 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- AYGAWHWLLYDEDI-UHFFFAOYSA-N ethyl 5-[2-(2,5-dimethoxyphenyl)ethyl]-2-hydroxybenzoate Chemical compound C1=C(O)C(C(=O)OCC)=CC(CCC=2C(=CC=C(OC)C=2)OC)=C1 AYGAWHWLLYDEDI-UHFFFAOYSA-N 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 description 1
- 208000021045 exocrine pancreatic carcinoma Diseases 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 210000004013 groin Anatomy 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000011132 hemopoiesis Effects 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 206010025135 lupus erythematosus Diseases 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000015654 memory Effects 0.000 description 1
- HJTFUJQRQKCILC-UHFFFAOYSA-N methyl 2-acetyloxy-5-[2-(2,5-dimethoxyphenyl)ethyl]benzoate Chemical compound C1=C(OC(C)=O)C(C(=O)OC)=CC(CCC=2C(=CC=C(OC)C=2)OC)=C1 HJTFUJQRQKCILC-UHFFFAOYSA-N 0.000 description 1
- NRSWJTRJHPRZMH-UHFFFAOYSA-N methyl 2-hydroxy-5-iodobenzoate Chemical compound COC(=O)C1=CC(I)=CC=C1O NRSWJTRJHPRZMH-UHFFFAOYSA-N 0.000 description 1
- KXCHILJTHKFYDL-XQRVVYSFSA-N methyl 5-[(z)-2-(2,5-dimethoxyphenyl)ethenyl]-2-hydroxybenzoate Chemical compound C1=C(O)C(C(=O)OC)=CC(\C=C/C=2C(=CC=C(OC)C=2)OC)=C1 KXCHILJTHKFYDL-XQRVVYSFSA-N 0.000 description 1
- XJKWVPNWHOCFBR-UHFFFAOYSA-N methyl 5-formyl-2-hydroxybenzoate Chemical compound COC(=O)C1=CC(C=O)=CC=C1O XJKWVPNWHOCFBR-UHFFFAOYSA-N 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 231100001221 nontumorigenic Toxicity 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 208000008443 pancreatic carcinoma Diseases 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 229910052705 radium Inorganic materials 0.000 description 1
- HCWPIIXVSYCSAN-UHFFFAOYSA-N radium atom Chemical compound [Ra] HCWPIIXVSYCSAN-UHFFFAOYSA-N 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 208000008742 seborrheic dermatitis Diseases 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- ODZPKZBBUMBTMG-UHFFFAOYSA-N sodium amide Chemical compound [NH2-].[Na+] ODZPKZBBUMBTMG-UHFFFAOYSA-N 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229940054269 sodium pyruvate Drugs 0.000 description 1
- 206010041823 squamous cell carcinoma Diseases 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- CCEKAJIANROZEO-UHFFFAOYSA-N sulfluramid Chemical group CCNS(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F CCEKAJIANROZEO-UHFFFAOYSA-N 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/94—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polyesters Or Polycarbonates (AREA)
- External Artificial Organs (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Photoreceptors In Electrophotography (AREA)
- Paints Or Removers (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919121943A GB9121943D0 (en) | 1991-10-16 | 1991-10-16 | Organic compounds,processes for their production and their use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HU9203156D0 HU9203156D0 (en) | 1992-12-28 |
| HUT62850A HUT62850A (en) | 1993-06-28 |
| HU215151B true HU215151B (hu) | 1998-12-28 |
Family
ID=10703010
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9203156A HU215151B (hu) | 1991-10-16 | 1992-10-05 | Eljárás difenil-etán-származékok és ezeket tartalmazó gyógyszerkészítmények előállítására |
| HU95P/P00247P HU211233A9 (en) | 1991-10-16 | 1995-06-19 | Bis (phenyl) ethane derivatives and phamaceuticals containing them |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU95P/P00247P HU211233A9 (en) | 1991-10-16 | 1995-06-19 | Bis (phenyl) ethane derivatives and phamaceuticals containing them |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US5488135A (Sortimente) |
| EP (1) | EP0539326B1 (Sortimente) |
| JP (1) | JP2543298B2 (Sortimente) |
| KR (1) | KR930007880A (Sortimente) |
| AT (1) | ATE136536T1 (Sortimente) |
| AU (1) | AU653441B2 (Sortimente) |
| CA (1) | CA2080555C (Sortimente) |
| CZ (1) | CZ282473B6 (Sortimente) |
| DE (1) | DE69209771T2 (Sortimente) |
| DK (1) | DK0539326T3 (Sortimente) |
| ES (1) | ES2087499T3 (Sortimente) |
| FI (1) | FI924657L (Sortimente) |
| GB (1) | GB9121943D0 (Sortimente) |
| GR (1) | GR3019856T3 (Sortimente) |
| HK (1) | HK146696A (Sortimente) |
| HU (2) | HU215151B (Sortimente) |
| IL (1) | IL103417A (Sortimente) |
| MX (1) | MX9205921A (Sortimente) |
| NO (1) | NO178540C (Sortimente) |
| NZ (1) | NZ244730A (Sortimente) |
| PH (1) | PH31113A (Sortimente) |
| RO (1) | RO111074B1 (Sortimente) |
| RU (1) | RU2118311C1 (Sortimente) |
| SG (1) | SG50542A1 (Sortimente) |
| SK (1) | SK312592A3 (Sortimente) |
| TW (1) | TW221051B (Sortimente) |
| ZA (1) | ZA928021B (Sortimente) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3194963B2 (ja) * | 1995-03-14 | 2001-08-06 | ノバルティス・アクチエンゲゼルシャフト | 三置換フェニル誘導体 |
| DE10015525A1 (de) * | 2000-03-30 | 2001-10-11 | Deutsches Krebsforsch | Synthetische Derivate von Lunularsäure, Arzneimittel enthaltend diese Verbindung, Verfahren zur Herstellung der Lunularsäurederivate sowie deren Verwendung |
| US7103979B2 (en) | 2001-04-20 | 2006-09-12 | Hitachi Koki Co., Ltd. | Portable electric cutting device with blower mechanism |
| ES2204300B1 (es) * | 2002-07-18 | 2005-05-01 | J. URIACH & CIA S.A. | Nuevos derivados del acido 2,4-dihidroxibenzoico. |
| TWI256334B (en) | 2002-10-22 | 2006-06-11 | Hitachi Koki Kk | Portable electric cutting device with blower mechanism |
| JP3765425B2 (ja) | 2004-01-26 | 2006-04-12 | 日立工機株式会社 | 携帯用電動切断機 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE293108C (Sortimente) * | ||||
| DE269619C (Sortimente) * | ||||
| US3657430A (en) * | 1969-06-25 | 1972-04-18 | Merck & Co Inc | Composition and methods for treating inflammation |
| EP0028305B1 (en) * | 1979-09-13 | 1984-02-01 | The Wellcome Foundation Limited | Diaryl compounds and pharmaceutical formulations containing them |
| WO1988003806A1 (en) * | 1986-11-19 | 1988-06-02 | Chemex Pharmaceuticals, Inc. | Pharmacologically active compositions of catecholic butanes with zinc |
| EP0289506A4 (en) * | 1986-11-19 | 1990-12-12 | Chemex Pharmaceuticals, Inc. | Lipoxygenase inhibitors |
| HUT60458A (en) * | 1991-02-01 | 1992-09-28 | Sandoz Ag | Process for producing benzyloxyphenyl derivatives and pharmaceutical compositions comprising same |
| EP0584222B1 (en) * | 1991-05-10 | 1997-10-08 | Rhone-Poulenc Rorer International (Holdings) Inc. | Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit egf and/or pdgf receptor tyrosine kinase |
-
1991
- 1991-10-16 GB GB919121943A patent/GB9121943D0/en active Pending
-
1992
- 1992-10-05 HU HU9203156A patent/HU215151B/hu not_active IP Right Cessation
- 1992-10-13 ES ES92810782T patent/ES2087499T3/es not_active Expired - Lifetime
- 1992-10-13 DK DK92810782.0T patent/DK0539326T3/da active
- 1992-10-13 SG SG1996004564A patent/SG50542A1/en unknown
- 1992-10-13 EP EP92810782A patent/EP0539326B1/en not_active Expired - Lifetime
- 1992-10-13 AT AT92810782T patent/ATE136536T1/de not_active IP Right Cessation
- 1992-10-13 DE DE69209771T patent/DE69209771T2/de not_active Expired - Lifetime
- 1992-10-14 RO RO92-01311A patent/RO111074B1/ro unknown
- 1992-10-14 FI FI924657A patent/FI924657L/fi unknown
- 1992-10-14 CZ CS923125A patent/CZ282473B6/cs not_active IP Right Cessation
- 1992-10-14 CA CA002080555A patent/CA2080555C/en not_active Expired - Fee Related
- 1992-10-14 NO NO923983A patent/NO178540C/no unknown
- 1992-10-14 IL IL10341792A patent/IL103417A/xx not_active IP Right Cessation
- 1992-10-14 NZ NZ244730A patent/NZ244730A/en unknown
- 1992-10-14 AU AU27044/92A patent/AU653441B2/en not_active Ceased
- 1992-10-14 SK SK3125-92A patent/SK312592A3/sk unknown
- 1992-10-15 RU RU92004377A patent/RU2118311C1/ru active
- 1992-10-15 JP JP4277054A patent/JP2543298B2/ja not_active Expired - Fee Related
- 1992-10-15 KR KR1019920018971A patent/KR930007880A/ko not_active Ceased
- 1992-10-15 MX MX9205921A patent/MX9205921A/es not_active IP Right Cessation
- 1992-10-16 US US07/962,370 patent/US5488135A/en not_active Expired - Lifetime
- 1992-10-16 ZA ZA928021A patent/ZA928021B/xx unknown
- 1992-10-16 PH PH45119A patent/PH31113A/en unknown
- 1992-10-17 TW TW081108265A patent/TW221051B/zh active
-
1995
- 1995-06-19 HU HU95P/P00247P patent/HU211233A9/hu unknown
-
1996
- 1996-05-07 GR GR960401241T patent/GR3019856T3/el unknown
- 1996-08-01 HK HK146696A patent/HK146696A/en not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| DGB9 | Succession in title of applicant |
Owner name: NOVARTIS AG., CH |
|
| HMM4 | Cancellation of final prot. due to non-payment of fee |