HU195733B - Process for preparing a pharmaceutical composition containing tissue plasminogen activator - Google Patents

Process for preparing a pharmaceutical composition containing tissue plasminogen activator Download PDF

Info

Publication number
HU195733B
HU195733B HU862234A HU223486A HU195733B HU 195733 B HU195733 B HU 195733B HU 862234 A HU862234 A HU 862234A HU 223486 A HU223486 A HU 223486A HU 195733 B HU195733 B HU 195733B
Authority
HU
Hungary
Prior art keywords
aqueous solution
plasminogen activator
solution
tissue plasminogen
pharmaceutical composition
Prior art date
Application number
HU862234A
Other languages
English (en)
Hungarian (hu)
Other versions
HUT41638A (en
Inventor
Denis M Johnston
Henry Berger
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858513358A external-priority patent/GB8513358D0/en
Priority claimed from GB858521705A external-priority patent/GB8521705D0/en
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of HUT41638A publication Critical patent/HUT41638A/hu
Publication of HU195733B publication Critical patent/HU195733B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
HU862234A 1985-05-28 1986-05-27 Process for preparing a pharmaceutical composition containing tissue plasminogen activator HU195733B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858513358A GB8513358D0 (en) 1985-05-28 1985-05-28 Formulation
GB858521705A GB8521705D0 (en) 1985-08-31 1985-08-31 Formulation

Publications (2)

Publication Number Publication Date
HUT41638A HUT41638A (en) 1987-05-28
HU195733B true HU195733B (en) 1988-07-28

Family

ID=26289290

Family Applications (1)

Application Number Title Priority Date Filing Date
HU862234A HU195733B (en) 1985-05-28 1986-05-27 Process for preparing a pharmaceutical composition containing tissue plasminogen activator

Country Status (22)

Country Link
US (2) US4929444A (cg-RX-API-DMAC7.html)
JP (1) JPH0759517B2 (cg-RX-API-DMAC7.html)
AU (1) AU567236B2 (cg-RX-API-DMAC7.html)
BE (1) BE904830A (cg-RX-API-DMAC7.html)
CA (1) CA1300008C (cg-RX-API-DMAC7.html)
CH (1) CH665356A5 (cg-RX-API-DMAC7.html)
DE (1) DE3617752A1 (cg-RX-API-DMAC7.html)
DK (1) DK163173C (cg-RX-API-DMAC7.html)
ES (2) ES8800601A1 (cg-RX-API-DMAC7.html)
FI (1) FI85335C (cg-RX-API-DMAC7.html)
FR (1) FR2583984B1 (cg-RX-API-DMAC7.html)
GB (1) GB2176702B (cg-RX-API-DMAC7.html)
GR (1) GR861366B (cg-RX-API-DMAC7.html)
HU (1) HU195733B (cg-RX-API-DMAC7.html)
IL (1) IL78938A (cg-RX-API-DMAC7.html)
IT (1) IT1191926B (cg-RX-API-DMAC7.html)
LU (1) LU86444A1 (cg-RX-API-DMAC7.html)
NL (1) NL8601355A (cg-RX-API-DMAC7.html)
NO (1) NO171345C (cg-RX-API-DMAC7.html)
NZ (1) NZ216307A (cg-RX-API-DMAC7.html)
PT (1) PT82646B (cg-RX-API-DMAC7.html)
SE (1) SE462016B (cg-RX-API-DMAC7.html)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3617753A1 (de) * 1985-05-28 1986-12-04 The Wellcome Foundation Ltd., London Gewebe-plasminogenaktivator, diesen enthaltende pharmazeutische formulierungen sowie ihre herstellung und ihre verwendung in der human- und veterinaermedizin
ZW14486A1 (en) * 1985-07-29 1986-10-22 Smithkline Beckman Corp Pharmaceutical dosage unit
US5034225A (en) * 1985-12-17 1991-07-23 Genentech Inc. Stabilized human tissue plasminogen activator compositions
US4777043A (en) * 1985-12-17 1988-10-11 Genentech, Inc. Stabilized human tissue plasminogen activator compositions
US4976959A (en) * 1986-05-12 1990-12-11 Burroughs Wellcome Co. T-PA and SOD in limiting tissue damage
DK237187A (da) * 1986-05-12 1987-11-13 Wellcome Found Farmaceutisk anvendelse af t-pa
GB8619098D0 (en) * 1986-08-05 1986-09-17 Wellcome Found Combination
US5270198A (en) * 1988-05-20 1993-12-14 Genentech, Inc. DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
US5342616A (en) * 1988-06-20 1994-08-30 The Wellcome Foundation Limited Method of administering tissue plasminogen activator
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
DE3835350A1 (de) * 1988-10-17 1990-04-19 Boehringer Mannheim Gmbh Aktivierung von gentechnologisch hergestellten, in prokaryonten exprimierten antikoerpern
US4980165A (en) * 1989-01-27 1990-12-25 Genetics Institute, Inc. Pharmaceutical formulations of plasminogen activator proteins
DE3942142A1 (de) * 1989-12-20 1991-06-27 Boehringer Mannheim Gmbh Stabilisierung von glykosyliertem t-pa
WO1992011866A1 (en) * 1991-01-14 1992-07-23 Duke University LAMININ SEQUENCE AS tPA ACTIVATOR
PT786257E (pt) * 1992-06-03 2003-12-31 Genentech Inc Variantes de glicosilacao do activador de plasminogenio tissular com propriedades terapeuticas meloradas
US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
KR19990066981A (ko) * 1995-10-23 1999-08-16 윌리엄 뉴우 치료용 맥관형성억제 조성물 및 방법
HUP9900979A3 (en) * 1995-12-13 2001-10-29 Children S Medical Ct Corp Bos Endothelial cell proliferation inhibitor and method of use
EP0827751B1 (en) * 1996-09-06 2003-02-26 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Medicinal composition containing tissue plasminogen activator and nicotinamide
WO2003022997A2 (en) * 2001-09-07 2003-03-20 Global Biotech Inc. Human tissue urokinase type plasminogen activator formulation
US20040091465A1 (en) * 2002-06-26 2004-05-13 Zachary Yim Therapeutic antiangiogenic compositions and methods
EP1636337A4 (en) * 2003-06-20 2007-07-04 Illumina Inc METHODS AND COMPOSITIONS USEFUL FOR THE AMPLIFICATION AND GENOTYPING OF THE GENOME
US7491263B2 (en) * 2004-04-05 2009-02-17 Technology Innovation, Llc Storage assembly
BRPI0607531A2 (pt) * 2005-04-20 2009-09-15 Hutchinson Fred Cancer Res métodos, composições e artigos de fabricação para intensificação da capacidade de sobrevivência de células, tecidos, órgãos e organismos

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3998947A (en) * 1973-11-30 1976-12-21 Pierre Fabre S.A. Process for obtaining a plasminogen activator
FR2252842B1 (cg-RX-API-DMAC7.html) * 1973-12-03 1977-11-04 Fabre Sa Pierre
DE3015699C2 (de) * 1979-04-26 1982-07-15 Asahi Kasei Kogyo K.K., Osaka Herstellung eines Plasminogen-Aktivators
US4766075A (en) * 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
JPS5951220A (ja) * 1982-08-02 1984-03-24 Asahi Chem Ind Co Ltd 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤
GB2138824B (en) * 1982-10-29 1986-12-31 Mitsui Toatsu Chemicals Novel plasminogen activator process for its preparation and thrombolytic drug containing the same
AU554862B2 (en) * 1982-12-14 1986-09-04 Implico B.V. Plasminogen activator isolated by affinity chromatography
NZ206699A (en) * 1982-12-30 1989-08-29 Bio Response Inc Process for the production of serum independent cell lines
JPS59196824A (ja) * 1983-04-21 1984-11-08 Kowa Co 吸着防止剤
DE3584902D1 (de) * 1984-02-29 1992-01-30 Asahi Chemical Ind Waessrige loesung eines darin in erhoehter konzentration aufgeloesten gewebe-plasminogen-aktivators und herstellungsverfahren.
DE3439980A1 (de) * 1984-11-02 1986-05-07 Behringwerke Ag, 3550 Marburg Verfahren zur reinigung sowie pasteurisierung von urokinase
EP0201153A3 (en) * 1985-02-09 1987-10-07 Beecham Group Plc Modified enzyme and process for its preparation
GB8513358D0 (en) * 1985-05-28 1985-07-03 Wellcome Found Formulation
ZW14486A1 (en) * 1985-07-29 1986-10-22 Smithkline Beckman Corp Pharmaceutical dosage unit
JPH0672105B2 (ja) * 1985-10-02 1994-09-14 持田製薬株式会社 血栓溶解剤及びその製法

Also Published As

Publication number Publication date
ES557374A0 (es) 1988-06-01
DK246786D0 (da) 1986-05-27
ES8802439A1 (es) 1988-06-01
GB8612780D0 (en) 1986-07-02
NO171345C (no) 1993-03-03
FR2583984B1 (fr) 1989-06-02
DE3617752C2 (cg-RX-API-DMAC7.html) 1988-06-30
LU86444A1 (fr) 1986-12-05
IT1191926B (it) 1988-03-31
AU5796486A (en) 1986-12-04
NO862096L (no) 1986-12-01
HUT41638A (en) 1987-05-28
FI85335B (fi) 1991-12-31
US4929444A (en) 1990-05-29
GR861366B (en) 1986-09-29
JPH06183995A (ja) 1994-07-05
IT8648065A0 (it) 1986-05-27
CH665356A5 (de) 1988-05-13
ES8800601A1 (es) 1987-11-16
SE8602405L (sv) 1986-11-29
ES555353A0 (es) 1987-11-16
FI862227L (fi) 1986-11-29
SE8602405D0 (sv) 1986-05-27
DK163173B (da) 1992-02-03
US4968617A (en) 1990-11-06
CA1300008C (en) 1992-05-05
SE462016B (sv) 1990-04-30
NO171345B (no) 1992-11-23
GB2176702A (en) 1987-01-07
PT82646A (en) 1986-06-01
GB2176702B (en) 1989-07-05
FI862227A0 (fi) 1986-05-27
JPH0759517B2 (ja) 1995-06-28
IL78938A0 (en) 1986-09-30
DE3617752A1 (de) 1986-12-04
DK163173C (da) 1992-06-22
AU567236B2 (en) 1987-11-12
BE904830A (fr) 1986-11-27
NL8601355A (nl) 1986-12-16
PT82646B (pt) 1989-01-30
IL78938A (en) 1993-02-21
FI85335C (fi) 1992-04-10
FR2583984A1 (fr) 1987-01-02
NZ216307A (en) 1989-10-27
DK246786A (da) 1986-11-29

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Legal Events

Date Code Title Description
HU90 Patent valid on 900628
HMM4 Cancellation of final prot. due to non-payment of fee