HU171572B - Sposob poluchenija proizvodnykh vinblastina, levrozidina i levrokhristina - Google Patents

Sposob poluchenija proizvodnykh vinblastina, levrozidina i levrokhristina

Info

Publication number
HU171572B
HU171572B HU74EI00000538A HUEI000538A HU171572B HU 171572 B HU171572 B HU 171572B HU 74EI00000538 A HU74EI00000538 A HU 74EI00000538A HU EI000538 A HUEI000538 A HU EI000538A HU 171572 B HU171572 B HU 171572B
Authority
HU
Hungary
Prior art keywords
leurochristine
leurosidine
vinblastine
preparing derivatives
derivatives
Prior art date
Application number
HU74EI00000538A
Other languages
English (en)
Hungarian (hu)
Inventor
George J Cullinan
Koert Gerzon
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of HU171572B publication Critical patent/HU171572B/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04Dimeric indole alkaloids, e.g. vincaleucoblastine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Fodder In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HU74EI00000538A 1973-04-02 1974-04-01 Sposob poluchenija proizvodnykh vinblastina, levrozidina i levrokhristina HU171572B (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34727573A 1973-04-02 1973-04-02

Publications (1)

Publication Number Publication Date
HU171572B true HU171572B (hu) 1978-02-28

Family

ID=23363051

Family Applications (1)

Application Number Title Priority Date Filing Date
HU74EI00000538A HU171572B (hu) 1973-04-02 1974-04-01 Sposob poluchenija proizvodnykh vinblastina, levrozidina i levrokhristina

Country Status (28)

Country Link
JP (2) JPS5919117B2 (sv)
AR (2) AR204004A1 (sv)
AT (1) AT340605B (sv)
BE (1) BE813168A (sv)
BG (3) BG21235A3 (sv)
CA (1) CA1042428A (sv)
CH (1) CH603669A5 (sv)
CS (1) CS185223B2 (sv)
CY (1) CY1044A (sv)
DD (1) DD113538A5 (sv)
DE (1) DE2415980A1 (sv)
DK (1) DK141511B (sv)
ES (2) ES424882A1 (sv)
FR (1) FR2223044B1 (sv)
GB (1) GB1463575A (sv)
HK (1) HK20180A (sv)
HU (1) HU171572B (sv)
IE (1) IE39071B1 (sv)
IL (1) IL44415A (sv)
KE (1) KE3028A (sv)
MY (1) MY8100025A (sv)
NL (1) NL181079C (sv)
PH (1) PH13623A (sv)
RO (2) RO73524B (sv)
SE (1) SE416206B (sv)
SU (4) SU731900A3 (sv)
YU (3) YU39719B (sv)
ZA (1) ZA741674B (sv)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL48685A (en) * 1975-01-09 1980-03-31 Lilly Co Eli Amides of vincadioline and vinblastine
GR69783B (sv) * 1976-09-08 1982-07-07 Lilly Co Eli
US4096148A (en) * 1976-12-06 1978-06-20 Eli Lilly And Company Oxazolidinedione derivatives of Vinca alkaloids
USRE30560E (en) * 1976-12-06 1981-03-31 Eli Lilly And Company Oxazolidinedione derivatives of Vinca alkaloids
USRE30561E (en) 1976-12-06 1981-03-31 Eli Lilly And Company Vinca alkaloid intermediates
US4203898A (en) 1977-08-29 1980-05-20 Eli Lilly And Company Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids
US4199504A (en) * 1978-05-15 1980-04-22 Eli Lilly And Company Bridged cathranthus alkaloid dimers
US4357334A (en) 1980-03-20 1982-11-02 Eli Lilly And Company Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms
OA06421A (fr) * 1980-06-10 1981-09-30 Omnium Chimique Sa Procédé de préparation de dérivés N-(vinblastinoyl-23) d'acides aminés et de peptides.
LU83822A1 (fr) * 1981-12-08 1983-09-01 Omnichem Sa Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique
FR2623504B1 (fr) * 1987-11-25 1990-03-09 Adir Nouveaux derives n-(vinblastinoyl-23) d'acide amino-1 methylphosphonique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
HUT76925A (hu) * 1995-04-04 1998-01-28 MTA Enzimológiai Intézet Bisz-indol-származékok, eljárás előállításukra és az azokat tartalmazó gyógyszerkészítmények
US5948750A (en) * 1996-10-30 1999-09-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US6326402B1 (en) 1998-08-12 2001-12-04 Octamer, Inc. Methods for treating viral infections using a compound capable of inhibiting microtubules
WO2006077424A1 (en) 2005-01-21 2006-07-27 Astex Therapeutics Limited Pharmaceutical compounds
SG164368A1 (en) 2005-07-18 2010-09-29 Bipar Sciences Inc Treatment of cancer
WO2008030891A2 (en) 2006-09-05 2008-03-13 Bipar Sciences, Inc. Inhibition of fatty acid synthesis by parp inhibitors and methods of treatment thereof
CA2662517A1 (en) 2006-09-05 2008-03-13 Jerome Moore Treatment of cancer
WO2008044045A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
US7732491B2 (en) 2007-11-12 2010-06-08 Bipar Sciences, Inc. Treatment of breast cancer with a PARP inhibitor alone or in combination with anti-tumor agents
AU2014253584B2 (en) * 2013-04-19 2017-02-02 Jinan University Vinca Alkaloid Derivatives, Preparation Method therefor and Application thereof
CN113456797B (zh) * 2021-06-18 2024-03-08 暨南大学 长春碱类衍生物在制备治疗骨肉瘤和/或软组织肉瘤药物中的应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097137A (en) * 1960-05-19 1963-07-09 Canadian Patents Dev Vincaleukoblastine

Also Published As

Publication number Publication date
HK20180A (en) 1980-04-25
RO73524A (ro) 1984-10-31
ZA741674B (en) 1975-10-29
AT340605B (de) 1977-12-27
IL44415A (en) 1978-08-31
IE39071B1 (en) 1978-08-02
FR2223044B1 (sv) 1978-06-30
ES424882A1 (es) 1976-12-16
YU39876B (en) 1985-04-30
DE2415980A1 (de) 1974-10-10
MY8100025A (en) 1981-12-31
NL181079C (nl) 1987-06-16
DK141511B (da) 1980-04-08
CH603669A5 (sv) 1978-08-31
ES446571A1 (es) 1977-06-16
JPS6033837B2 (ja) 1985-08-05
RO77533A (ro) 1982-02-01
FR2223044A1 (sv) 1974-10-25
KE3028A (en) 1980-03-28
NL181079B (nl) 1987-01-16
BG21235A3 (bg) 1976-03-20
AR203882A1 (es) 1975-10-31
BG22831A3 (bg) 1977-04-20
SU623522A3 (ru) 1978-09-05
YU113980A (en) 1982-05-31
YU39719B (en) 1985-04-30
BG21612A3 (bg) 1976-07-20
BE813168A (fr) 1974-10-02
IL44415A0 (en) 1974-06-30
RO73524B (ro) 1984-11-30
SU652896A3 (ru) 1979-03-15
SE416206B (sv) 1980-12-08
CS185223B2 (en) 1978-09-15
YU81774A (en) 1982-05-31
JPS59193895A (ja) 1984-11-02
GB1463575A (en) 1977-02-02
IE39071L (en) 1974-10-02
DK141511C (sv) 1980-09-29
SU731900A3 (ru) 1980-04-30
DD113538A5 (sv) 1975-06-12
SU784783A3 (ru) 1980-11-30
AR204004A1 (es) 1975-11-12
NL7404423A (sv) 1974-10-04
PH13623A (en) 1980-08-07
YU39875B (en) 1985-04-30
YU113880A (en) 1982-05-31
DE2415980C2 (sv) 1989-11-09
ATA267974A (de) 1977-04-15
CY1044A (en) 1980-08-01
CA1042428A (en) 1978-11-14
JPS49128000A (sv) 1974-12-07
AU6671974A (en) 1975-09-18
JPS5919117B2 (ja) 1984-05-02

Similar Documents

Publication Publication Date Title
HU171572B (hu) Sposob poluchenija proizvodnykh vinblastina, levrozidina i levrokhristina
ZA74701B (en) Indole derivatives and process for preparing the same
HU171483B (hu) Sposob poluchenija izokhinolina
YU34883B (en) Process for preparing derivatives of phenyl-3-oxadiazol-1,3,4-one-2
EG11318A (en) Process for the preparation of 7-amino-3-cephem derivatives
IL45823A0 (en) Basically substituted 1,4-dihydro-2h-isoquinoline derivatives and process for preparing them
IL46600A0 (en) Process for the preparation of 1,2,4-triazole derivatives
HU171726B (hu) Sposob poluchenija proizvodnykh 1-fenoksi-3-amino-propan-2-ola
HU171874B (hu) Sposob poluchenija proizvodnykh 5,6-benzo-gamma-pirona
IL46084A0 (en) Cephem derivatives and process for preparing them
HU171325B (hu) Sposob poluchenija 2-amino-2-imidazolina
GB1407658A (en) Process for the manufacture of indole derivatives
YU35893B (en) Process for obtaining novel leurosine derivatives
YU240574A (en) Process for obtaining dimeric indole-vincristine,de-n-methyl vinblastine and vinblastine
ZA744425B (en) Dibenzoxepin derivatives and process for the preparation thereof
YU40242B (en) Process for preparing new rifamycin s and derivatives
CH609345A5 (en) Process for the preparation of pyrimidinoaminomethylergoline derivatives
ZA738274B (en) Process for the manufacture of 9,10-seco-oestrane derivatives
NL7512120A (nl) Werkwijze ter bereiding van nieuwe derivaten van vinblastine, vincristine en leurosidine.
PH11837A (en) Process for the production of 1,2,4-triazole derivatives
HU170835B (hu) Sposob poluchenija proizvodnykh ftoro-tiamfenikola
ZA741172B (en) 1,4-dihydro-2-h-isoquinoline derivatives and process for their manufacture
ZA746632B (en) Basically substiduted 1,4-dihydro-2h-isoquinoline derivatives and process for preparing them
IL44834A0 (en) 1-alkyl-2-(pyridylthiomethyl)-5-nitro-imidazoles and derivatives thereof and process for their manufacture
CH612956A5 (en) Process for the preparation of 1H-tetrazole-5-thiol derivatives

Legal Events

Date Code Title Description
HU90 Patent valid on 900628