HRPK20040293B3 - Supstituirani benzimidazolski spojevi i njihova primjena u liječenju neoplazma - Google Patents
Supstituirani benzimidazolski spojevi i njihova primjena u liječenju neoplazmaInfo
- Publication number
- HRPK20040293B3 HRPK20040293B3 HR20040293A HRP20040293A HRPK20040293B3 HR PK20040293 B3 HRPK20040293 B3 HR PK20040293B3 HR 20040293 A HR20040293 A HR 20040293A HR P20040293 A HRP20040293 A HR P20040293A HR PK20040293 B3 HRPK20040293 B3 HR PK20040293B3
- Authority
- HR
- Croatia
- Prior art keywords
- optionally substituted
- group
- aryl
- alkoxy
- alkyl
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 6
- 125000002252 acyl group Chemical group 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 239000002253 acid Chemical class 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 3
- -1 heteroaryl compound Chemical class 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000002924 primary amino group Chemical class [H]N([H])* 0.000 abstract 3
- 229920001774 Perfluoroether Polymers 0.000 abstract 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000003709 fluoroalkyl group Chemical group 0.000 abstract 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000005010 perfluoroalkyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
- C07D235/32—Benzimidazole-2-carbamic acids, unsubstituted or substituted; Esters thereof; Thio-analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Spoj, naznačen time, da se bira iz skupine spojeva prikazanih formulom (I) • u kojoj A predstavlja arilni ili heteroarilni spoj• u kojoj je R1 odabran iz skupine koja sadrži- alkil, po izboru supstituiran sa alkoksi, heteroalkil, aril, acil, acilne derivate, halogen- alkoksi po izboru supstituiran sa alkilom, heteroalkilom, arilom, heteroarilom, alkoksialkilom, hidroksialkilnim amidomili perfluoroalkoksi skupinom ili alkiltio po izboru supstituiranim sa amidom ili perfluoroalkiltio- aril ili heteroaril po izboru supstituiran sa jednom ili više alkilnih skupina, alkoksi skupinom, nitro skupinom, cijano skupinom, acilnim derivatom, perfluoroalkoksi skupinom, perfluoroalkilnom skupinom, heteroarilnom skupinom, ariloksi skupinom- halogen- 4 NH2- 4 NH alkilom ili cikloalkilom po izboru supstituiranim sa acilom, acilderivatom, hidroksi, amino, alkoksi, heterociklilnom ili arilnomskupinom- 4 N imidazolilom- 3 SO2 Me kada A predstavlja fenil• u kojoj je R2 odabran iz skupine koja se sastoji od- CO-alkila po izboru supstituiranog sa amino, kiselinom, derivatom kiseline, alkoksi, arilom ili OH skupinama- CO-aralkila po izboru supstituiranog sa alkoksi, halogeno, amino, kiselinom ili kiselim derivatima- CO-arila po izboru supstituiranog- CO-alkoksi po izboru supstituiranog sa arilom- CO-amino, CO-NHR3, CO-NR3R4 u kojemR3 i R4 su odabrani nezavisno između vodika, alkila, hidroksialkila, alkoksialkila, fluoroalkila, alkinila, heteroalkila, alkilheteroalkila, arila, aralkila ili zajedno tvore alkilenski lanac uključujući po izboru jedan do četiri dodatna heteroatoma- arila ili ara1kila po izboru supstituiranih sa heterocikloalkilom, alkilom, arilom, alkoksi, amino, fluoroalkilom, acilnim derivatima, halogenom ilifarmaceutski prihvatljivih soli ili predlijekovapod uvjetom da R1 ne predstavlja halogen, alkil ilialkoksi kada R2 predstavlja -CO-alkoksi. Patent sadrži još 8 patentnih zahtjeva.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01402460A EP1298125A1 (en) | 2001-09-26 | 2001-09-26 | Substituted benzimidazole compounds and their use for the treatment of cancer |
| PCT/EP2002/011353 WO2003028721A2 (en) | 2001-09-26 | 2002-09-26 | Substituted benzimidazole compounds and their use for the treatment of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20040293A2 HRP20040293A2 (en) | 2005-06-30 |
| HRPK20040293B3 true HRPK20040293B3 (hr) | 2007-06-30 |
Family
ID=8182891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20040293A HRPK20040293B3 (hr) | 2001-09-26 | 2004-03-25 | Supstituirani benzimidazolski spojevi i njihova primjena u liječenju neoplazma |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US7041668B2 (hr) |
| EP (2) | EP1298125A1 (hr) |
| JP (1) | JP4510450B2 (hr) |
| KR (1) | KR100891439B1 (hr) |
| CN (1) | CN100346786C (hr) |
| AR (1) | AR037096A1 (hr) |
| AT (1) | ATE386517T1 (hr) |
| AU (1) | AU2002337151B2 (hr) |
| BR (1) | BR0212856A (hr) |
| CA (1) | CA2461622C (hr) |
| CO (1) | CO5570675A2 (hr) |
| CY (1) | CY1107953T1 (hr) |
| DE (1) | DE60225159T2 (hr) |
| DK (1) | DK1432417T3 (hr) |
| EA (1) | EA006802B1 (hr) |
| ES (1) | ES2301682T3 (hr) |
| GT (1) | GT200200190A (hr) |
| HK (1) | HK1068551A1 (hr) |
| HR (1) | HRPK20040293B3 (hr) |
| HU (1) | HUP0401756A3 (hr) |
| IL (1) | IL161059A0 (hr) |
| ME (1) | MEP16808A (hr) |
| MX (1) | MXPA04002042A (hr) |
| MY (1) | MY135339A (hr) |
| NO (1) | NO327008B1 (hr) |
| NZ (1) | NZ531246A (hr) |
| PA (1) | PA8555501A1 (hr) |
| PE (1) | PE20030427A1 (hr) |
| PL (1) | PL369527A1 (hr) |
| PT (1) | PT1432417E (hr) |
| RS (1) | RS50896B (hr) |
| SI (1) | SI1432417T1 (hr) |
| UY (1) | UY27452A1 (hr) |
| WO (1) | WO2003028721A2 (hr) |
| ZA (1) | ZA200401887B (hr) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2011250847B2 (en) * | 2003-06-23 | 2013-06-20 | Bhi Limited Partnership | Methods and compositions for treating amyloid-related diseases |
| US20070010573A1 (en) | 2003-06-23 | 2007-01-11 | Xianqi Kong | Methods and compositions for treating amyloid-related diseases |
| US20070208166A1 (en) * | 2003-10-24 | 2007-09-06 | Exelixis, Inc. | Tao Kinase Modulators And Method Of Use |
| DE102004010207A1 (de) | 2004-03-02 | 2005-09-15 | Aventis Pharma S.A. | Neue 4-Benzimidazol-2-yl-pyridazin-3-on-Derivate |
| FR2868421B1 (fr) * | 2004-04-01 | 2008-08-01 | Aventis Pharma Sa | Nouveaux benzothiazoles et leur utilisation comme medicaments |
| EP1598348A1 (en) | 2004-05-18 | 2005-11-23 | Aventis Pharma Deutschland GmbH | Novel pyridazinone derivatives as inhibitors of CDK2 |
| US8044100B2 (en) | 2004-12-22 | 2011-10-25 | Bellus Health Inc. | Methods and compositions for treating amyloid-related diseases |
| CN101300251B (zh) * | 2005-09-06 | 2011-08-03 | 史密丝克莱恩比彻姆公司 | 作为plk抑制剂的苯并咪唑噻吩化合物 |
| FR2891273B1 (fr) * | 2005-09-27 | 2007-11-23 | Aventis Pharma Sa | NOUVEAUX DERIVES BENZIMIDAZOLES ET BENZOTHIAZOLES, LEUR PREPARATION ET LEUR UTILISATION PHARMACEUTIQUE NOTAMMENT COMME INHIBITEURS DE CMet |
| ES2891278T3 (es) | 2006-10-12 | 2022-01-26 | Bhi Lp | Métodos, compuestos, composiciones y vehículos para suministrar ácido 3-amino-1-propanosulfónico |
| PA8792501A1 (es) | 2007-08-09 | 2009-04-23 | Sanofi Aventis | Nuevos derivados de 6-triazolopiridacina-sulfanil benzotiazol y bencimidazol,su procedimiento de preparación,su aplicación como medicamentos,composiciones farmacéuticas y nueva utilización principalmente como inhibidores de met. |
| CN105367554A (zh) * | 2007-10-12 | 2016-03-02 | 艾伯维巴哈马有限公司 | 2-((r)-2-甲基吡咯烷-2-基)-1h-苯并咪唑-4-甲酰胺晶形1 |
| FR2922550B1 (fr) | 2007-10-19 | 2009-11-27 | Sanofi Aventis | Nouveaux derives de 6-aryl/heteroalkyloxy benzothiazole et benzimidazole, application comme medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de cmet |
| FR2941952B1 (fr) | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-substitue-triazolopyridazine-sulfanyl) 5-fluoro-benzothiazoles et 5-fluoro-benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
| FR2941950B1 (fr) | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-o-substitue-triazolopyridazine-sulfanyl) benzothiazoles et benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
| FR2941949B1 (fr) | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-o-cycloalkyl ou 6-nh-cycloalkyl- triazolopyridazine-sulfanyl)benzothiazoles et benzimidazoles preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
| FR2941951B1 (fr) | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-nh-substitue-triazolopyridazine-sulfanyl) benzothiazoles et benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
| WO2011091152A1 (en) * | 2010-01-22 | 2011-07-28 | Pablo Gastaminza | Inhibitors of hepatitis c virus infection |
| CN114939124A (zh) | 2015-08-25 | 2022-08-26 | 阿尔尼拉姆医药品有限公司 | 治疗前蛋白转化酶枯草杆菌蛋白酶kexin(pcsk9)基因相关障碍的方法和组合物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2441201C2 (de) * | 1974-08-28 | 1986-08-07 | Hoechst Ag, 6230 Frankfurt | Anthelminthisch wirksame 2-Carbalkoxyamino-5(6)-phenyl-sulfonyloxy-benzimidazole und Verfahren zu ihrer Herstellung |
| DE2541752A1 (de) * | 1975-09-19 | 1977-03-24 | Hoechst Ag | Anthelminthisch wirksame 2-carbalkoxyamino-5(6)-phenyl-sulfonyloxy- benzimidazole und verfahren zu ihrer herstellung |
| DE3247615A1 (de) * | 1982-12-23 | 1984-07-05 | Hoechst Ag, 6230 Frankfurt | Substituierte phenylsulfonyloxybenzimidazolcarbaminate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| GB9900752D0 (en) * | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| US6693125B2 (en) * | 2001-01-24 | 2004-02-17 | Combinatorx Incorporated | Combinations of drugs (e.g., a benzimidazole and pentamidine) for the treatment of neoplastic disorders |
-
2001
- 2001-09-26 EP EP01402460A patent/EP1298125A1/en not_active Withdrawn
-
2002
- 2002-09-17 PE PE2002000913A patent/PE20030427A1/es not_active Application Discontinuation
- 2002-09-24 UY UY27452A patent/UY27452A1/es unknown
- 2002-09-25 MY MYPI20023586A patent/MY135339A/en unknown
- 2002-09-25 GT GT200200190A patent/GT200200190A/es unknown
- 2002-09-26 DE DE60225159T patent/DE60225159T2/de not_active Expired - Lifetime
- 2002-09-26 BR BR0212856-0A patent/BR0212856A/pt not_active IP Right Cessation
- 2002-09-26 JP JP2003532053A patent/JP4510450B2/ja not_active Expired - Fee Related
- 2002-09-26 KR KR1020047004365A patent/KR100891439B1/ko not_active IP Right Cessation
- 2002-09-26 CN CNB028187458A patent/CN100346786C/zh not_active Expired - Fee Related
- 2002-09-26 AU AU2002337151A patent/AU2002337151B2/en not_active Ceased
- 2002-09-26 EA EA200400475A patent/EA006802B1/ru not_active IP Right Cessation
- 2002-09-26 CA CA002461622A patent/CA2461622C/en not_active Expired - Fee Related
- 2002-09-26 HU HU0401756A patent/HUP0401756A3/hu unknown
- 2002-09-26 RS YUP-214/04A patent/RS50896B/sr unknown
- 2002-09-26 SI SI200230686T patent/SI1432417T1/sl unknown
- 2002-09-26 IL IL16105902A patent/IL161059A0/xx unknown
- 2002-09-26 PL PL02369527A patent/PL369527A1/xx not_active Application Discontinuation
- 2002-09-26 NZ NZ531246A patent/NZ531246A/en not_active IP Right Cessation
- 2002-09-26 ME MEP-168/08A patent/MEP16808A/xx unknown
- 2002-09-26 DK DK02772370T patent/DK1432417T3/da active
- 2002-09-26 PT PT02772370T patent/PT1432417E/pt unknown
- 2002-09-26 WO PCT/EP2002/011353 patent/WO2003028721A2/en active IP Right Grant
- 2002-09-26 AR ARP020103629A patent/AR037096A1/es unknown
- 2002-09-26 PA PA20028555501A patent/PA8555501A1/es unknown
- 2002-09-26 MX MXPA04002042A patent/MXPA04002042A/es active IP Right Grant
- 2002-09-26 EP EP02772370A patent/EP1432417B1/en not_active Expired - Lifetime
- 2002-09-26 AT AT02772370T patent/ATE386517T1/de active
- 2002-09-26 ES ES02772370T patent/ES2301682T3/es not_active Expired - Lifetime
-
2004
- 2004-03-08 ZA ZA200401887A patent/ZA200401887B/en unknown
- 2004-03-23 NO NO20041214A patent/NO327008B1/no not_active IP Right Cessation
- 2004-03-25 HR HR20040293A patent/HRPK20040293B3/hr not_active IP Right Cessation
- 2004-03-25 US US10/808,889 patent/US7041668B2/en not_active Expired - Fee Related
- 2004-03-25 CO CO04028337A patent/CO5570675A2/es not_active Application Discontinuation
-
2005
- 2005-02-07 HK HK05101028A patent/HK1068551A1/xx not_active IP Right Cessation
-
2008
- 2008-05-20 CY CY20081100526T patent/CY1107953T1/el unknown
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