|
EP0888349B1
(en)
*
|
1996-01-23 |
2002-05-22 |
Novartis AG |
Pyrrolopyrimidines and processes for their preparation
|
|
DK0880508T3
(da)
|
1996-02-13 |
2003-06-30 |
Astrazeneca Ab |
Quinazolinderivater som VEGF-inhibitorer
|
|
CN1116286C
(zh)
|
1996-03-05 |
2003-07-30 |
曾尼卡有限公司 |
4-苯胺基喹唑啉衍生物
|
|
GB9707800D0
(en)
|
1996-05-06 |
1997-06-04 |
Zeneca Ltd |
Chemical compounds
|
|
HRP970371A2
(en)
*
|
1996-07-13 |
1998-08-31 |
Kathryn Jane Smith |
Heterocyclic compounds
|
|
ATE300521T1
(de)
|
1996-09-25 |
2005-08-15 |
Astrazeneca Ab |
Chinolin-derivate die den effekt von wachstumsfaktoren wie vegf vezögern
|
|
GB9718972D0
(en)
|
1996-09-25 |
1997-11-12 |
Zeneca Ltd |
Chemical compounds
|
|
ZA986729B
(en)
*
|
1997-07-29 |
1999-02-02 |
Warner Lambert Co |
Irreversible inhibitors of tyrosine kinases
|
|
ATE368665T1
(de)
|
1997-08-22 |
2007-08-15 |
Astrazeneca Ab |
Oxindolylchinazolinderivate als angiogenesehemmer
|
|
PA8474101A1
(es)
*
|
1998-06-19 |
2000-09-29 |
Pfizer Prod Inc |
Compuestos de pirrolo [2,3-d] pirimidina
|
|
EP1087970B1
(en)
|
1998-06-19 |
2004-04-28 |
Pfizer Products Inc. |
PYRROLO 2,3-d]PYRIMIDINE COMPOUNDS
|
|
UA71945C2
(en)
*
|
1999-01-27 |
2005-01-17 |
Pfizer Prod Inc |
Substituted bicyclic derivatives being used as anticancer agents
|
|
TR200201051T2
(tr)
|
1999-10-19 |
2002-09-23 |
Merck & Co., Inc. |
Tirosin kinaz inhibitörleri.
|
|
US6794393B1
(en)
|
1999-10-19 |
2004-09-21 |
Merck & Co., Inc. |
Tyrosine kinase inhibitors
|
|
EP1676845B1
(en)
|
1999-11-05 |
2008-06-11 |
AstraZeneca AB |
New quinazoline derivatives
|
|
KR100477818B1
(ko)
|
1999-12-10 |
2005-03-22 |
화이자 프로덕츠 인코포레이티드 |
피롤로[2,3-d] 피리미딘 화합물
|
|
EP1244672B1
(en)
|
1999-12-21 |
2005-07-20 |
Sugen, Inc. |
4-substituted 7-aza-indolin-2-ones and their use as protein kinase inhibitors
|
|
US6313138B1
(en)
|
2000-02-25 |
2001-11-06 |
Merck & Co., Inc. |
Tyrosine kinase inhibitors
|
|
US6420382B2
(en)
|
2000-02-25 |
2002-07-16 |
Merck & Co., Inc. |
Tyrosine kinase inhibitors
|
|
ES2267748T3
(es)
|
2000-04-07 |
2007-03-16 |
Astrazeneca Ab |
Compuestos de quinazolina.
|
|
US6608053B2
(en)
|
2000-04-27 |
2003-08-19 |
Yamanouchi Pharmaceutical Co., Ltd. |
Fused heteroaryl derivatives
|
|
WO2001094353A1
(en)
|
2000-06-06 |
2001-12-13 |
Pfizer Products Inc. |
Thiophene derivatives useful as anticancer agents
|
|
HRP20021000A2
(en)
|
2000-06-26 |
2005-02-28 |
Pfizer Products Inc. |
PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS AS IMMUNOSUPPRESSIVE AGENTS
|
|
DE60113286T2
(de)
|
2000-10-17 |
2006-06-22 |
Merck & Co., Inc. |
Oral aktive salze mit tyrosinkinaseaktivität
|
|
DE60137273D1
(de)
|
2000-10-20 |
2009-02-12 |
Eisai R&D Man Co Ltd |
Verfahren zur Herstellung von 4-Phenoxy chinolin Derivaten
|
|
CN100525768C
(zh)
|
2000-10-23 |
2009-08-12 |
史密丝克莱恩比彻姆公司 |
新化合物
|
|
TWI238824B
(en)
|
2001-05-14 |
2005-09-01 |
Novartis Ag |
4-amino-5-phenyl-7-cyclobutyl-pyrrolo[2,3-d]pyrimidine derivatives
|
|
US7301023B2
(en)
|
2001-05-31 |
2007-11-27 |
Pfizer Inc. |
Chiral salt resolution
|
|
AU2002345792A1
(en)
|
2001-06-21 |
2003-01-08 |
Pfizer Inc. |
Thienopyridine and thienopyrimidine anticancer agents
|
|
GB0115393D0
(en)
*
|
2001-06-23 |
2001-08-15 |
Aventis Pharma Ltd |
Chemical compounds
|
|
US7169788B2
(en)
|
2001-10-30 |
2007-01-30 |
Merck & Co., Inc. |
Tyrosine kinase inhibitors
|
|
WO2003062209A2
(en)
*
|
2002-01-17 |
2003-07-31 |
Neurogen Corporation |
Substituted quinazolin-4-ylamine analogues as modulators of capsaicin
|
|
CA2478050A1
(en)
|
2002-03-01 |
2003-09-12 |
Pfizer Inc. |
Indolyl-urea derivatives of thienopyridines useful as anti-angiogenic agents
|
|
UA77303C2
(en)
|
2002-06-14 |
2006-11-15 |
Pfizer |
Derivatives of thienopyridines substituted by benzocondensed heteroarylamide useful as therapeutic agents, pharmaceutical compositions and methods for their use
|
|
CN1717236A
(zh)
|
2002-11-26 |
2006-01-04 |
辉瑞产品公司 |
治疗移植排斥的方法
|
|
EP1569925A1
(en)
*
|
2002-12-13 |
2005-09-07 |
Neurogen Corporation |
2-substituted quinazolin-4-ylamine analogues as capsaicin receptor modulators
|
|
US7329664B2
(en)
*
|
2003-07-16 |
2008-02-12 |
Neurogen Corporation |
Substituted (7-pyridyl-4-phenylamino-quinazolin-2-yl)-methanol analogues
|
|
ATE412655T1
(de)
|
2003-08-29 |
2008-11-15 |
Pfizer |
Als neue antiangiogene mittel geeignete thienopyridinphenylacetamide und derivate davon
|
|
US20070105865A1
(en)
*
|
2003-09-09 |
2007-05-10 |
Neurogen Corporation |
Substituted bicyclic quinazolin-4-ylamine derivatives
|
|
CN100450998C
(zh)
|
2003-11-11 |
2009-01-14 |
卫材R&D管理有限公司 |
脲衍生物的制备方法
|
|
EP1687309A1
(en)
|
2003-11-17 |
2006-08-09 |
Pfizer Products Inc. |
Pyrrolopyrimidine compounds useful in treatment of cancer
|
|
KR100807920B1
(ko)
|
2003-12-23 |
2008-02-27 |
화이자 인코포레이티드 |
신규한 퀴놀린 유도체
|
|
CA2566160C
(en)
|
2004-05-27 |
2011-01-18 |
Pfizer Products Inc. |
Pyrrolopyrimidine derivatives useful in cancer treatment
|
|
BRPI0511768A
(pt)
*
|
2004-06-02 |
2008-01-08 |
Takeda Pharmaceutical |
composto, pró-droga, métodos para a produção de um composto, e para a profilaxia ou tratamento de cáncer em um mamìfero, agente farmacêutico, e, uso de um composto
|
|
ZA200610669B
(en)
*
|
2004-06-02 |
2008-06-25 |
Takeda Pharmaceutical |
Fused heterocyclic compound
|
|
EP1797881B1
(en)
|
2004-09-17 |
2009-04-15 |
Eisai R&D Management Co., Ltd. |
Medicinal composition with improved stability and reduced gelation properties
|
|
GB0423554D0
(en)
*
|
2004-10-22 |
2004-11-24 |
Cancer Rec Tech Ltd |
Therapeutic compounds
|
|
US7423043B2
(en)
|
2005-02-18 |
2008-09-09 |
Lexicon Pharmaceuticals, Inc. |
4-Piperidin-1-yl-7H-pyrrolo[2,3-d]pyrimidine compounds
|
|
US7541367B2
(en)
*
|
2005-05-31 |
2009-06-02 |
Janssen Pharmaceutica, N.V. |
3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders
|
|
WO2007015578A1
(ja)
|
2005-08-02 |
2007-02-08 |
Eisai R & D Management Co., Ltd. |
血管新生阻害物質の効果を検定する方法
|
|
CA2633752A1
(en)
*
|
2005-12-21 |
2007-07-19 |
Abbott Laboratories |
Anti-viral compounds
|
|
EP2345652A1
(en)
|
2005-12-21 |
2011-07-20 |
Abbott Laboratories |
Antiviral compounds
|
|
WO2007076034A2
(en)
|
2005-12-21 |
2007-07-05 |
Abbott Laboratories |
Anti-viral compounds
|
|
EP1971611B1
(en)
|
2005-12-21 |
2012-10-10 |
Abbott Laboratories |
Anti-viral compounds
|
|
WO2007076035A2
(en)
|
2005-12-21 |
2007-07-05 |
Abbott Laboratories |
Anti-viral compounds
|
|
TW200738707A
(en)
*
|
2005-12-21 |
2007-10-16 |
Abbott Lab |
Anti-viral compounds
|
|
US7851468B2
(en)
*
|
2006-05-15 |
2010-12-14 |
Cephalon, Inc. |
Substituted pyrazolo[3,4-d]pyrimidines
|
|
CA2652442C
(en)
|
2006-05-18 |
2014-12-09 |
Eisai R & D Management Co., Ltd. |
Antitumor agent for thyroid cancer
|
|
US8865737B2
(en)
|
2006-08-28 |
2014-10-21 |
Eisai R&D Management Co., Ltd. |
Antitumor agent for undifferentiated gastric cancer
|
|
US20100004238A1
(en)
|
2006-12-12 |
2010-01-07 |
Takeda Pharmaceutical Company Limited |
Fused heterocyclic compound
|
|
CA2672737A1
(en)
|
2006-12-20 |
2008-11-06 |
Abbott Laboratories |
Anti-viral compounds
|
|
US8962655B2
(en)
|
2007-01-29 |
2015-02-24 |
Eisai R&D Management Co., Ltd. |
Composition for treatment of undifferentiated gastric cancer
|
|
KR101513326B1
(ko)
|
2007-11-09 |
2015-04-17 |
에자이 알앤드디 매니지먼트 가부시키가이샤 |
혈관 신생 저해 물질과 항종양성 백금 착물의 병용
|
|
EP2222162B1
(en)
*
|
2007-11-28 |
2016-11-16 |
Dana-Farber Cancer Institute, Inc. |
Small molecule myristate inhibitors of bcr-abl and methods of use
|
|
TW200944528A
(en)
|
2008-03-12 |
2009-11-01 |
Takeda Pharmaceutical |
Fused heterocyclic compound
|
|
CA2733359C
(en)
|
2008-08-20 |
2014-08-05 |
Pfizer Inc. |
Pyrrolo[2,3-d]pyrimidine compounds
|
|
WO2011018894A1
(en)
*
|
2009-08-10 |
2011-02-17 |
Raqualia Pharma Inc. |
Pyrrolopyrimidine derivatives as potassium channel modulators
|
|
ME02359B
(me)
|
2009-08-19 |
2016-06-20 |
Eisai R&D Man Co Ltd |
Farmaceutska kompozicija koja sadrži derivate hinolina
|
|
RU2560683C2
(ru)
|
2010-06-25 |
2015-08-20 |
Эйсай Ар Энд Ди Менеджмент Ко., Лтд. |
Противоопухолевое средство, задействующее соединения с ингибирующим эффектом к киназам в комбинации
|
|
EP2670244B1
(en)
|
2011-02-04 |
2018-04-11 |
Duquesne University of The Holy Spirit |
Bicyclic and tricyclic pyrimidine tyrosine kinase inhibitors with antitubulin activity and methods of treating a patient
|
|
EP2700403B1
(en)
|
2011-04-18 |
2015-11-25 |
Eisai R&D Management Co., Ltd. |
Therapeutic agent for tumor
|
|
ES2841809T3
(es)
|
2011-06-03 |
2021-07-09 |
Eisai R&D Man Co Ltd |
Biomarcadores para pronosticar y evaluar el grado de respuesta de sujetos con cáncer de tiroides y de riñón a compuestos de lenvatinib
|
|
WO2013174735A1
(en)
|
2012-05-21 |
2013-11-28 |
Bayer Pharma Aktiengesellschaft |
Substituted benzothienopyrimidines
|
|
MD20140130A2
(ro)
*
|
2012-06-29 |
2015-04-30 |
Pfizer Inc. |
4-(amino-substituite)-7H-pirolo[2,3-d]pirimidine noi ca inhibitori de LRRK2
|
|
TW201412740A
(zh)
*
|
2012-09-20 |
2014-04-01 |
Bayer Pharma AG |
經取代之吡咯并嘧啶胺基苯并噻唑酮
|
|
EP2900670A1
(en)
|
2012-09-26 |
2015-08-05 |
Bayer Pharma Aktiengesellschaft |
Substituted indazol-pyrrolopyrimidines useful in the treatment of hyperfoliferative disorders
|
|
EP2900671A1
(en)
|
2012-09-26 |
2015-08-05 |
Bayer Pharma Aktiengesellschaft |
Substituted indazol-pyrrolopyrimidines useful in the treatment of hyperproliferative diseases
|
|
WO2014085528A1
(en)
|
2012-11-29 |
2014-06-05 |
Merck Patent Gmbh |
Azaquinazoline carboxamide derivatives
|
|
BR112015009004A8
(pt)
|
2012-12-21 |
2021-07-20 |
Eisai R&D Man Co Ltd |
forma amorfa de derivado de quinolina e método de produção da mesma
|
|
MX368099B
(es)
|
2013-05-14 |
2019-09-19 |
Eisai R&D Man Co Ltd |
Biomarcadores para predecir y evaluar el grado de respuesta de sujetos con cancer de endometrio a compuestos de tipo lenvatinib.
|
|
CA2933767C
(en)
|
2013-12-17 |
2018-11-06 |
Pfizer Inc. |
Novel 3,4-disubstituted-1h-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7h-pyrrolo[2,3-c]pyridazines as lrrk2 inhibitors
|
|
PL3177612T3
(pl)
|
2014-08-04 |
2022-08-08 |
Nuevolution A/S |
Opcjonalnie skondensowane pochodne pirymidyny podstawione heterocyklilem, użyteczne w leczeniu chorób zapalnych, metabolicznych, onkologicznych i autoimmunologicznych
|
|
JO3783B1
(ar)
|
2014-08-28 |
2021-01-31 |
Eisai R&D Man Co Ltd |
مشتق كوينولين عالي النقاء وطريقة لإنتاجه
|
|
JP6792546B2
(ja)
|
2015-02-25 |
2020-11-25 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
キノリン誘導体の苦味抑制方法
|
|
CA2978226C
(en)
|
2015-03-04 |
2025-02-18 |
Eisai R&D Management Co., Ltd. |
COMBINATION OF A PD-1 ANTAGONIST AND A VEGFR/FGFR/RET TYROSINE KINASE INHIBITOR TO TREAT CANCER
|
|
AU2016272881C1
(en)
|
2015-06-04 |
2019-10-03 |
Pfizer Inc. |
Solid dosage forms of palbociclib
|
|
JP6757959B2
(ja)
|
2015-06-16 |
2020-09-23 |
株式会社 PRISM BioLab |
抗がん剤
|
|
RU2718048C2
(ru)
|
2015-08-20 |
2020-03-30 |
Эйсай Ар Энд Ди Менеджмент Ко., Лтд. |
Противоопухолевое терапевтическое средство
|
|
MX377305B
(es)
|
2015-09-14 |
2025-03-07 |
Pfizer |
DERIVADOS DE IMIDAZO[4,5-c]QUINOLINA E IMIDAZO[4,5-c][1,5]NAFTIRIDINA NOVEDOSOS COMO INHIBIDORES DE LRRK2.
|
|
GB201520499D0
(en)
|
2015-11-20 |
2016-01-06 |
Medical Res Council Technology |
Compounds
|
|
US10233188B2
(en)
|
2016-08-15 |
2019-03-19 |
Pfizer Inc. |
CDK2/4/6 inhibitors
|
|
ES2971448T3
(es)
|
2017-02-08 |
2024-06-05 |
Eisai R&D Man Co Ltd |
Composición farmacéutica para el tratamiento de tumores
|
|
MX2019013014A
(es)
|
2017-05-16 |
2020-08-06 |
Eisai R&D Man Co Ltd |
Tratamiento de carcinoma hepatocelular.
|
|
US11633399B2
(en)
|
2018-12-25 |
2023-04-25 |
Sol-Gel Technologies Ltd. |
Treatment of skin disorders with compositions comprising an EGFR inhibitor
|
|
NL2022471B1
(en)
|
2019-01-29 |
2020-08-18 |
Vationpharma B V |
Solid state forms of oclacitinib
|
|
KR20220053557A
(ko)
|
2019-07-17 |
2022-04-29 |
2692372 온타리오 인크. |
벤젠술폰아미드 유도체 및 그의 용도
|
|
NZ786543A
(en)
|
2019-12-20 |
2026-01-30 |
Nuevolution As |
Compounds active towards nuclear receptors
|
|
US11447479B2
(en)
|
2019-12-20 |
2022-09-20 |
Nuevolution A/S |
Compounds active towards nuclear receptors
|
|
CA3174176A1
(en)
|
2020-03-31 |
2021-10-07 |
Sanne Schroder Glad |
Compounds active towards nuclear receptors
|
|
CA3174252A1
(en)
|
2020-03-31 |
2021-10-07 |
Nuevolution A/S |
Compounds active towards nuclear receptors
|
|
TW202309022A
(zh)
|
2021-04-13 |
2023-03-01 |
美商努法倫特公司 |
用於治療具egfr突變之癌症之胺基取代雜環
|