HRP960250A2 - Stable reagents for the preparation of radiopharmaceuticals - Google Patents

Stable reagents for the preparation of radiopharmaceuticals Download PDF

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Publication number
HRP960250A2
HRP960250A2 HR08/476,296A HRP960250A HRP960250A2 HR P960250 A2 HRP960250 A2 HR P960250A2 HR P960250 A HRP960250 A HR P960250A HR P960250 A2 HRP960250 A2 HR P960250A2
Authority
HR
Croatia
Prior art keywords
group
substituted
alkyl
independently selected
case
Prior art date
Application number
HR08/476,296A
Other languages
English (en)
Croatian (hr)
Inventor
Shuang Liu
Original Assignee
Shuang Liu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shuang Liu filed Critical Shuang Liu
Publication of HRP960250A2 publication Critical patent/HRP960250A2/hr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/008—Peptides; Proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HR08/476,296A 1995-06-07 1996-06-04 Stable reagents for the preparation of radiopharmaceuticals HRP960250A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/476,296 US5750088A (en) 1993-03-30 1995-06-07 Stable hydrazones linked to a peptide moiety as reagents for the preparation of radiopharmaceuticals

Publications (1)

Publication Number Publication Date
HRP960250A2 true HRP960250A2 (en) 1997-12-31

Family

ID=23891282

Family Applications (1)

Application Number Title Priority Date Filing Date
HR08/476,296A HRP960250A2 (en) 1995-06-07 1996-06-04 Stable reagents for the preparation of radiopharmaceuticals

Country Status (29)

Country Link
US (2) US5750088A (fr)
EP (1) EP0832068B1 (fr)
JP (1) JPH11507364A (fr)
KR (1) KR19990022573A (fr)
CN (1) CN1192733A (fr)
AR (1) AR003959A1 (fr)
AT (1) ATE233241T1 (fr)
AU (1) AU718683B2 (fr)
BR (1) BR9609003A (fr)
CA (1) CA2222183A1 (fr)
CZ (1) CZ380197A3 (fr)
DE (1) DE69626392T2 (fr)
EA (1) EA000742B1 (fr)
EE (1) EE9700313A (fr)
ES (1) ES2193245T3 (fr)
HR (1) HRP960250A2 (fr)
HU (1) HUP9901469A3 (fr)
IL (1) IL118468A0 (fr)
LT (1) LT4380B (fr)
LV (1) LV12044B (fr)
MX (1) MX9709126A (fr)
MY (1) MY133974A (fr)
NO (1) NO975678L (fr)
NZ (1) NZ310799A (fr)
PL (1) PL323995A1 (fr)
SI (1) SI9620076B (fr)
SK (1) SK163497A3 (fr)
WO (1) WO1996040637A1 (fr)
ZA (1) ZA964854B (fr)

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US6416733B1 (en) 1996-10-07 2002-07-09 Bristol-Myers Squibb Pharma Company Radiopharmaceuticals for imaging infection and inflammation
CN1239895A (zh) * 1996-10-07 1999-12-29 杜邦药品公司 用于对感染和炎症部位造影的放射药物
US20030124053A1 (en) * 1996-10-07 2003-07-03 Barrett John Andrew Radiopharmaceuticals for imaging infection and inflammation
US6403054B1 (en) * 1997-05-28 2002-06-11 Bristol-Myers Squibb Pharma Company Ternary ligand complexes useful as radiopharmaceuticals
US6537520B1 (en) * 1998-03-31 2003-03-25 Bristol-Myers Squibb Pharma Company Pharmaceuticals for the imaging of angiogenic disorders
US6524553B2 (en) 1998-03-31 2003-02-25 Bristol-Myers Squibb Pharma Company Quinolone vitronectin receptor antagonist pharmaceuticals
AU3119199A (en) * 1998-04-03 1999-10-25 Du Pont Pharmaceuticals Company Radiopharmaceuticals for imaging infection and inflammation and for imaging and treatment of cancer
HRP990317A2 (en) * 1998-10-13 2000-06-30 Du Pont Pharm Co A process for the preparation of a thrombus imaging agent
US6794518B1 (en) * 1998-12-18 2004-09-21 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
US6511649B1 (en) 1998-12-18 2003-01-28 Thomas D. Harris Vitronectin receptor antagonist pharmaceuticals
EP1140864A2 (fr) * 1998-12-18 2001-10-10 Du Pont Pharmaceuticals Company Medicaments antagonistes du recepteur de la vitronectine
CA2727746A1 (fr) 1998-12-18 2000-06-22 Bristol-Myers Squibb Pharma Company Medicaments antagonistes du recepteur de la vitronectine de quinolone
US6808698B1 (en) 1999-03-26 2004-10-26 Bristol-Myers Squibb Pharma Company Method for localization of blood clots
WO2000057787A2 (fr) * 1999-03-26 2000-10-05 Du Pont Pharmaceuticals Company Methode pour localiser des caillots de sang
US6656448B1 (en) * 2000-02-15 2003-12-02 Bristol-Myers Squibb Pharma Company Matrix metalloproteinase inhibitors
US20030220646A1 (en) * 2002-05-23 2003-11-27 Thelen Sarah L. Method and apparatus for reducing femoral fractures
US6534038B2 (en) 2000-04-07 2003-03-18 Bristol-Myers Squibb Pharma Company Ternary ligand complexes useful as radiopharmaceuticals
EP1347784A2 (fr) * 2000-11-03 2003-10-01 Bristol-Myers Squibb Pharma Company Double imagerie isotopique simultanee d'une perfusion et d'une inflammation cardiaque
GB0031592D0 (en) * 2000-12-28 2001-02-07 Nycomed Amersham Plc Stabilised radiopharmaceutical compositions
US6838074B2 (en) 2001-08-08 2005-01-04 Bristol-Myers Squibb Company Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent
HUP0401904A3 (en) * 2001-08-08 2009-01-28 Bristol Myers Squibb Pharma Co Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent
US7297709B2 (en) 2003-05-22 2007-11-20 Abbott Laboratories Indazole, benzisoxazole, and benzisothiazole kinase inhibitors
US7319149B2 (en) * 2003-06-13 2008-01-15 Bristol-Myers Squibb Pharma Company Chelants and macrocyclic metal complex radiopharmaceuticals thereof
US7317104B2 (en) 2003-06-13 2008-01-08 Bristol-Myers Squibb Pharma Company Chelants and macrocyclic metal complex radiopharmaceuticals thereof
CN100418585C (zh) * 2003-07-24 2008-09-17 伯拉考成像股份公司 稳定的放射性药物组合物及制备方法
US20050106100A1 (en) * 2003-09-03 2005-05-19 Harris Thomas D. Compounds containing matrix metalloproteinase substrates and methods of their use
WO2007005491A1 (fr) * 2005-06-30 2007-01-11 Bristol-Myers Squibb Pharma Company Conjugues d'hydrazide en tant qu'agents d'imagerie
WO2007046411A1 (fr) * 2005-10-19 2007-04-26 Dainippon Sumitomo Pharma Co., Ltd. Procede de stabilisation d'un compose d'isoxazole
US7465795B2 (en) * 2005-12-20 2008-12-16 Astrazeneca Ab Compounds and uses thereof
CN104592128A (zh) * 2005-12-20 2015-05-06 阿斯利康(瑞典)有限公司 作为gabaa受体调节剂的取代的噌啉衍生物及其合成方法
CA2673683C (fr) 2007-01-11 2014-07-29 Critical Outcome Technologies, Inc. Composes et methode de traitement un cancer
TW200911760A (en) * 2007-06-19 2009-03-16 Astrazeneca Ab Compounds and uses thereof
CA2710039C (fr) * 2007-12-26 2018-07-03 Critical Outcome Technologies, Inc. Semicarbazones, thiosemicarnazones et composes associes, et methodes de traitement du cancer
EP3023426A1 (fr) 2008-07-17 2016-05-25 Critical Outcome Technologies, Inc. Composés inhibiteurs à base de thiosemicarbazone et procédés de traitement du cancer
FR2940652B1 (fr) * 2008-12-29 2011-02-11 Sanofi Aventis Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one,leur preparation et leur application en therapeutique
ES2511917T3 (es) 2008-12-29 2014-10-23 Sanofi Derivados de 2-piridin-2-il-pirazol-3(2H)-ona, su preparación y su aplicación en terapéutica
EP2382205B1 (fr) 2008-12-29 2014-04-23 Sanofi Dérivés de 2-pyridin-2-yl-pyrazol-3(2h)-one, leur préparation et leur application en thérapeutique comme activateurs de hif
FR2949468B1 (fr) * 2009-08-28 2011-09-30 Sanofi Aventis Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one, leur preparation et leur application en therapeutique
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Also Published As

Publication number Publication date
PL323995A1 (en) 1998-04-27
EA199800025A1 (ru) 1998-06-25
HUP9901469A2 (hu) 1999-08-30
MY133974A (en) 2007-11-30
DE69626392D1 (de) 2003-04-03
WO1996040637A1 (fr) 1996-12-19
HUP9901469A3 (en) 2000-02-28
AR003959A1 (es) 1998-09-30
EP0832068B1 (fr) 2003-02-26
KR19990022573A (ko) 1999-03-25
NO975678L (no) 1998-02-06
MX9709126A (es) 1998-03-31
BR9609003A (pt) 1999-12-14
SI9620076A (sl) 1998-08-31
SK163497A3 (en) 1998-10-07
JPH11507364A (ja) 1999-06-29
LV12044B (en) 1998-09-20
NZ310799A (en) 2000-01-28
AU718683B2 (en) 2000-04-20
EA000742B1 (ru) 2000-02-28
ES2193245T3 (es) 2003-11-01
CZ380197A3 (cs) 1998-07-15
EP0832068A1 (fr) 1998-04-01
NO975678D0 (no) 1997-12-05
LT97191A (en) 1998-04-27
DE69626392T2 (de) 2004-04-22
IL118468A0 (en) 1996-09-12
LT4380B (lt) 1998-09-25
US5750088A (en) 1998-05-12
EE9700313A (et) 1998-06-15
LV12044A (lv) 1998-05-20
ATE233241T1 (de) 2003-03-15
CA2222183A1 (fr) 1996-12-19
AU6166196A (en) 1996-12-30
SI9620076B (sl) 2000-02-29
CN1192733A (zh) 1998-09-09
ZA964854B (en) 1997-12-08
US6015904A (en) 2000-01-18

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