HRP960129B1 - NOVEL PYRIDO(3,2-e) PYRAZINONES WITH ANTIASTHMATIC ACTIVITY AND PROCESS FOR THEIR PREPARATION - Google Patents

NOVEL PYRIDO(3,2-e) PYRAZINONES WITH ANTIASTHMATIC ACTIVITY AND PROCESS FOR THEIR PREPARATION

Info

Publication number
HRP960129B1
HRP960129B1 HR960129A HRP960129A HRP960129B1 HR P960129 B1 HRP960129 B1 HR P960129B1 HR 960129 A HR960129 A HR 960129A HR P960129 A HRP960129 A HR P960129A HR P960129 B1 HRP960129 B1 HR P960129B1
Authority
HR
Croatia
Prior art keywords
pyrazinones
preparation
novel pyrido
antiasthmatic activity
antiasthmatic
Prior art date
Application number
HR960129A
Other languages
English (en)
Inventor
Norbert Hoefgen
Thomas Buechner
Ute Achterrath-Tuckermann
Stefan Szelenyi
Bernhard Kutscher
Original Assignee
Asta Medica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica Ag filed Critical Asta Medica Ag
Publication of HRP960129A2 publication Critical patent/HRP960129A2/hr
Publication of HRP960129B1 publication Critical patent/HRP960129B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HR960129A 1995-03-24 1996-03-20 NOVEL PYRIDO(3,2-e) PYRAZINONES WITH ANTIASTHMATIC ACTIVITY AND PROCESS FOR THEIR PREPARATION HRP960129B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19510965A DE19510965A1 (de) 1995-03-24 1995-03-24 Neue Pyrido/3,2-e/pyrazinone mit antiasthmatischer Wirksamkeit und Verfahren zu deren Herstellung

Publications (2)

Publication Number Publication Date
HRP960129A2 HRP960129A2 (en) 1997-08-31
HRP960129B1 true HRP960129B1 (en) 2002-12-31

Family

ID=7757727

Family Applications (1)

Application Number Title Priority Date Filing Date
HR960129A HRP960129B1 (en) 1995-03-24 1996-03-20 NOVEL PYRIDO(3,2-e) PYRAZINONES WITH ANTIASTHMATIC ACTIVITY AND PROCESS FOR THEIR PREPARATION

Country Status (30)

Country Link
US (1) US5723463A (cs)
EP (1) EP0736532B1 (cs)
JP (1) JP4124280B2 (cs)
KR (1) KR100401395B1 (cs)
CN (1) CN1058968C (cs)
AR (1) AR002039A1 (cs)
AT (1) ATE217624T1 (cs)
AU (1) AU697908B2 (cs)
BR (1) BR9601093A (cs)
CA (1) CA2172472C (cs)
CZ (1) CZ290784B6 (cs)
DE (2) DE19510965A1 (cs)
DK (1) DK0736532T3 (cs)
ES (1) ES2174989T3 (cs)
HR (1) HRP960129B1 (cs)
HU (1) HUP9600731A3 (cs)
IL (1) IL117621A (cs)
MX (1) MX9601069A (cs)
NO (1) NO307091B1 (cs)
NZ (1) NZ286232A (cs)
PL (1) PL184800B1 (cs)
PT (1) PT736532E (cs)
RU (1) RU2143433C1 (cs)
SG (1) SG43249A1 (cs)
SI (1) SI0736532T1 (cs)
SK (1) SK36596A3 (cs)
TR (1) TR199600217A2 (cs)
TW (1) TW426682B (cs)
UA (1) UA45319C2 (cs)
ZA (1) ZA962270B (cs)

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EA200100792A1 (ru) * 1999-01-20 2002-10-31 Арцнаймиттельверк Дрезден Гмбх Применение имидазо[1,5-a]-пиридо[3,2-e]-пиразинонов в качестве лекарственных средств
DE19961302A1 (de) * 1999-12-18 2001-06-21 Dresden Arzneimittel Verwendung von Imidazo(1,5-a)-pyrido(3,2-e)-pyrazinonen als duale Inhibitoren der Phosphodiesterase 5 und der Phosphodiesterase 3 zur Therapie der Herzinsuffizienz, von pulmonaler Hypertonie und Gefäßerkrankungen, die mit einer Minderdurchblutung einhergehen
TR200201317T2 (tr) 1999-08-21 2002-11-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Sinerjistik kombinasyon.
DE10012373A1 (de) * 2000-03-14 2001-09-20 Dresden Arzneimittel Verwendung von Pyrido[3,2-e]-pyrazinonen als Inhibitoren der Phosphodiesterase 5 zur Therapie von erektiler Dysfunktion
US6465465B1 (en) 2000-03-14 2002-10-15 Arzneimittelwerk Dresden Gmbh Process for the treatment of erectile dysfunction and product therefor
AU2003215675B2 (en) * 2002-04-03 2007-07-12 F. Hoffmann-La Roche Ag Imidazo fused compounds
DE60334015D1 (de) * 2002-10-30 2010-10-14 Merck Frosst Canada Ltd Pyridopyrrolizin- und pyridoindolizinderivate
US7153824B2 (en) 2003-04-01 2006-12-26 Applied Research Systems Ars Holding N.V. Inhibitors of phosphodiesterases in infertility
GB0420722D0 (en) * 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
TWI417095B (zh) 2006-03-15 2013-12-01 Janssen Pharmaceuticals Inc １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途
TW200817400A (en) * 2006-05-30 2008-04-16 Elbion Ag Pyrido [3,2-e] pyrazines, their use as inhibitors of phosphodiesterase 10, and processes for preparing them
EP2848620B1 (en) * 2006-12-13 2016-09-28 ASKA Pharmaceutical Co., Ltd. Quinoxaline derivatives
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en) * 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200927731A (en) * 2007-09-14 2009-07-01 Ortho Mcneil Janssen Pharm 1,3-disubstituted-4-phenyl-1H-pyridin-2-ones
WO2009033704A1 (en) 2007-09-14 2009-03-19 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h, 1'h-[1, 4'] bipyridinyl-2'-ones
TW200922566A (en) 2007-09-14 2009-06-01 Ortho Mcneil Janssen Pharm 1,3 disubstituted 4-(aryl-X-phenyl)-1H-pyridin-2-ones
JP5433582B2 (ja) * 2007-11-14 2014-03-05 ジャンセン ファーマシューティカルズ， インコーポレイテッド． イミダゾ［１，２−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体の正のアロステリック調節因子としてのその使用
WO2009068320A1 (en) * 2007-11-30 2009-06-04 Elbion Gmbh Aryl and heteroaryl fused imidazo (1,5-a) pyrazines as inhibitors of phosphodiesterase 10
JP2011505366A (ja) 2007-11-30 2011-02-24 ワイス・エルエルシー ホスホエステラーゼ１０の阻害剤としてのアリールおよびヘテロアリール縮合イミダゾ［１，５−ａ］ピラジン
CA2735764C (en) 2008-09-02 2016-06-14 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
MX2011003691A (es) 2008-10-16 2011-09-06 Ortho Mcneil Janssen Pharm Derivados de indol y benzomorfolina como moduladores de los receptores de glutamato metabotropico.
WO2010060589A1 (en) 2008-11-28 2010-06-03 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
SG176021A1 (en) 2009-05-12 2011-12-29 Janssen Pharmaceuticals Inc 1,2,4-triazolo [4,3-a] pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders
EA020671B1 (ru) 2009-05-12 2014-12-30 Янссен Фармасьютикалз, Инк. ПРОИЗВОДНЫЕ 1,2,4-ТРИАЗОЛО[4,3-a]ПИРИДИНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ПОЛОЖИТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
EP2643320B1 (en) 2010-11-08 2015-03-04 Janssen Pharmaceuticals, Inc. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
ES2552879T3 (es) 2010-11-08 2015-12-02 Janssen Pharmaceuticals, Inc. Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2
US9271967B2 (en) 2010-11-08 2016-03-01 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
LT3431106T (lt) 2014-01-21 2021-02-10 Janssen Pharmaceutica Nv Deriniai, apimantys 2 potipio metabotropinio glutamaterginio receptoriaus teigiamus alosterinius moduliatorius arba ortosterinius agonistus, ir jų panaudojimas
AU2015208233B2 (en) 2014-01-21 2019-08-29 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use

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US5055465A (en) * 1989-05-31 1991-10-08 Berlex Laboratories, Inc. Imidazoquinoxalinones, their aza analogs and process for their preparation
US5166344A (en) * 1989-05-31 1992-11-24 Berlex Laboratories, Inc. Process for the preparation of imidazoquinoxalinones
US5153196A (en) * 1991-06-05 1992-10-06 Eli Lilly And Company Excitatory amino acid receptor antagonists and methods for the use thereof
CA2110942A1 (en) * 1991-06-14 1992-12-23 Pharmacia & Upjohn Company Llc Imidazo¬1,5-a|quinoxalines
US5182386A (en) * 1991-08-27 1993-01-26 Neurogen Corporation Certain imidazoquinoxalinones; a new class of gaba brain receptor ligands
AU3767793A (en) * 1992-04-03 1993-11-08 Yamanouchi Pharmaceutical Co., Ltd. Fused quinoxalinone derivative and pharmaceutical composition containing the same
DE4228095A1 (de) * 1992-08-24 1994-03-03 Asta Medica Ag Neue 4,5-Dihydro-4-oxo-pyrrolo[1,2-a]chinoxaline und entsprechende Aza-analoga und Verfahren zu deren Herstellung
JP3252483B2 (ja) * 1992-10-20 2002-02-04 東レ株式会社 ３環性トリアゾロ誘導体の製造方法
JP3252484B2 (ja) * 1992-10-20 2002-02-04 東レ株式会社 ４，５−ジヒドロ［１，２，４］トリアゾロ［４，３−ａ］キノキサリン誘導体の製造方法
DE4329970A1 (de) * 1993-03-31 1994-10-06 Basf Ag Neue Imidazolo-chinoxalinone, ihre Hestellung und Verwendung
FR2704547B1 (fr) * 1993-04-30 1995-06-09 Adir Nouveaux composés pyrrolopyraziniques, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
CA2162023A1 (en) * 1993-05-06 1994-11-24 Poul Jacobsen [1,2,4]triazolo[4,3-a]quinoxaline compounds, their preparation and use
CA2112290C (en) * 1993-12-23 2004-06-01 John R. Francis A clock recovery circuit for serial digital video
JP3240462B2 (ja) * 1996-05-24 2001-12-17 株式会社ケンウッド 光ディスク装置の光ピックアップサーボ装置

Also Published As

Publication number Publication date
DE59609201D1 (de) 2002-06-20
US5723463A (en) 1998-03-03
ES2174989T3 (es) 2002-11-16
DE19510965A1 (de) 1996-09-26
NO961173L (no) 1996-09-25
AU4825796A (en) 1996-10-03
TW426682B (en) 2001-03-21
EP0736532A1 (de) 1996-10-09
JP4124280B2 (ja) 2008-07-23
SK36596A3 (en) 1997-02-05
ATE217624T1 (de) 2002-06-15
CZ290784B6 (cs) 2002-10-16
SI0736532T1 (en) 2002-08-31
EP0736532B1 (de) 2002-05-15
HRP960129A2 (en) 1997-08-31
JPH08269059A (ja) 1996-10-15
CN1058968C (zh) 2000-11-29
NO307091B1 (no) 2000-02-07
KR100401395B1 (ko) 2003-12-24
HUP9600731A2 (en) 1997-01-28
CZ74796A3 (en) 1996-10-16
MX9601069A (es) 1997-02-28
DK0736532T3 (da) 2002-09-02
BR9601093A (pt) 1998-01-06
AU697908B2 (en) 1998-10-22
PL313434A1 (en) 1996-09-30
SG43249A1 (en) 1997-10-17
PL184800B1 (pl) 2002-12-31
RU2143433C1 (ru) 1999-12-27
NO961173D0 (no) 1996-03-22
UA45319C2 (uk) 2002-04-15
CA2172472A1 (en) 1996-09-25
PT736532E (pt) 2002-10-31
NZ286232A (en) 1996-10-28
CN1140173A (zh) 1997-01-15
KR960034204A (ko) 1996-10-22
AR002039A1 (es) 1998-01-07
IL117621A (en) 1999-05-09
TR199600217A2 (tr) 1996-10-21
IL117621A0 (en) 1996-07-23
HU9600731D0 (en) 1996-05-28
ZA962270B (en) 1996-09-30
HUP9600731A3 (en) 1997-04-28
CA2172472C (en) 2000-01-18

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