HRP20230279T1 - Benzenesulfonil-asimetrične uree i njihove medicinske uporabe - Google Patents

Benzenesulfonil-asimetrične uree i njihove medicinske uporabe Download PDF

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HRP20230279T1
HRP20230279T1 HRP20230279TT HRP20230279T HRP20230279T1 HR P20230279 T1 HRP20230279 T1 HR P20230279T1 HR P20230279T T HRP20230279T T HR P20230279TT HR P20230279 T HRP20230279 T HR P20230279T HR P20230279 T1 HRP20230279 T1 HR P20230279T1
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pharmaceutically acceptable
acceptable salt
compound according
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HRP20230279TT
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Claudio Giuliano
Antoine Daina
Claudio Pietra
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Helsinn Healthcare S.A.
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    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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Claims (22)

1. Spoj formule IV: [image] ili njegova farmaceutski prihvatljiva sol, gdje: isprekidana linija označava izbornu vezu; X je veza, CO ili CR7R8; k je 0-2; Z je halo, metoksi ili C1-3 alkil izborno supstituiran sa halo; R1 i R2 su svaki neovisno, H, C1-3 alkil, metoksi, halo ili OH; ili R1 i R2 uzeti zajedno sa atomima za koje su vezani formiraju 5-6 -člani prsten; ili R1 i X uzeti zajedno sa atomima za koje su vezani formiraju 5-6 -člani prsten; R3 je H, C1-3 alkil, metoksi, halo, OH, COOR12, CR13R14OH, COHNR15, cikloalkil ili heteroaril; R4 je veza ili CR9R10; U je C, N, S ili O; R’ je halo, heteroaril, C1-6 alkoksi, C1-6 alkil, heterocikloalkil, CN cikloalkil, CO2(C1-6 alkil) ili CO(C1-6 alkil); ili dva R’ uzeti zajedno sa atomima za koje su vezani formiraju 5-6 -člani prsten; R7 i R8 su svaki, neovisno, H ili C1-3 alkil, ili CONH2, pri čemu navedeni C1-3 alkil je izborno supstituiran sa halo; R9 i R10 su svaki, neovisno, H ili C1-3 alkil, pri čemu navedeni C1-3 alkil je izborno supstituiran sa halo; R12, R13, R14 i R15 su svaki neovisno H ili C1-3 alkil. R16 je H ili C1-3 alkil; R17 je H, halo, ili C1-3 alkil; l je 0-3; m je 0-3; n je 0-3, i p je 1-3.
2. Spoj prema patentnom zahtjevu 1, naznačen time što p je 1 ili 2.
3. Spoj prema patentnom zahtjevu 1 ili njegova farmaceutski prihvatljiva sol, izabrani iz grupe koja se sastoji od sljedećih: [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image]
4. Spoj prema patentnom zahtjevu 1, izabran iz grupe koja se sastoji od: [image] , [image] , [image] , [image] , [image] , [image] , [image] , [image] , [image] , [image] , [image] , [image] [image] , [image] , [image] , [image] , [image] , ili njegova farmaceutski prihvatljiva sol.
5. Spoj prema patentnom zahtjevu 1, koji ima strukturu: [image] ili njegova farmaceutski prihvatljiva sol.
6. Spoj prema patentnom zahtjevu 1, koji ima strukturu: [image] ili njegova farmaceutski prihvatljiva sol.
7. Spoj prema patentnom zahtjevu 1, koji ima strukturu: [image] ili njegova farmaceutski prihvatljiva sol.
8. Spoj prema patentnom zahtjevu 1, koji ima strukturu: [image] ili njegova farmaceutski prihvatljiva sol.
9. Spoj prema patentnom zahtjevu 1, koji ima strukturu: [image] ili njegova farmaceutski prihvatljiva sol.
10. Spoj prema patentnom zahtjevu 1, koji ima strukturu: [image] ili njegova farmaceutski prihvatljiva sol.
11. Spoj prema patentnom zahtjevu 1, koji ima strukturu: [image] ili njegova farmaceutski prihvatljiva sol.
12. Spoj prema patentnom zahtjevu 1, koji ima strukturu: [image] ili njegova farmaceutski prihvatljiva sol.
13. Spoj prema patentnom zahtjevu 1, koji ima strukturu: [image] ili njegova farmaceutski prihvatljiva sol.
14. Spoj prema patentnom zahtjevu 1, koji ima strukturu: [image] ili njegova farmaceutski prihvatljiva sol.
15. Spoj prema patentnom zahtjevu 1, koji ima strukturu: [image] ili njegova farmaceutski prihvatljiva sol.
16. Spoj prema patentnom zahtjevu 1, koji ima strukturu: [image] ili njegova farmaceutski prihvatljiva sol.
17. Spoj prema patentnom zahtjevu 1, koji ima strukturu: [image] ili njegova farmaceutski prihvatljiva sol.
18. Spoj prema patentnom zahtjevu 1, koji ima strukturu: [image] ili njegova farmaceutski prihvatljiva sol.
19. Spoj prema patentnom zahtjevu 1, koji ima strukturu: [image] ili njegova farmaceutski prihvatljiva sol.
20. Spoj prema patentnom zahtjevu 1, koji ima strukturu: [image] ili njegova farmaceutski prihvatljiva sol.
21. Spoj prema patentnom zahtjevu 1, koji ima strukturu: [image] ili njegova farmaceutski prihvatljiva sol.
22. Spoj formule IV prema bilo kojem od patentnih zahtjeva 1-21, za uporabu u prevenciji i/ili liječenju bolesti koja je patofiziološki povezana sa receptorom grelina kod subjekta.
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