HRP20201916T1 - Trifluorometil supstituirani pirazoli kao inhibitori kalikreina u ljudskoj plazmi - Google Patents

Trifluorometil supstituirani pirazoli kao inhibitori kalikreina u ljudskoj plazmi Download PDF

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Publication number
HRP20201916T1
HRP20201916T1 HRP20201916TT HRP20201916T HRP20201916T1 HR P20201916 T1 HRP20201916 T1 HR P20201916T1 HR P20201916T T HRP20201916T T HR P20201916TT HR P20201916 T HRP20201916 T HR P20201916T HR P20201916 T1 HRP20201916 T1 HR P20201916T1
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Croatia
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image
compound
pharmaceutically acceptable
compound according
acceptable salt
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HRP20201916TT
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English (en)
Croatian (hr)
Inventor
Pravin L. Kotian
Yarlagadda Sudhakara Babu
Minwan Wu
Venkat R. CHINTAREDDY
Satish V. Kumar
Weihe Zhang
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Biocryst Pharmaceuticals, Inc.
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Publication of HRP20201916T1 publication Critical patent/HRP20201916T1/hr

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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
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  • Endocrinology (AREA)
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  • Otolaryngology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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HRP20201916TT 2014-03-07 2015-03-09 Trifluorometil supstituirani pirazoli kao inhibitori kalikreina u ljudskoj plazmi HRP20201916T1 (hr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201461949808P 2014-03-07 2014-03-07
US201461981515P 2014-04-18 2014-04-18
EP15759254.4A EP3113772B8 (en) 2014-03-07 2015-03-09 Trifluoromethyl substituted pyrazoles as human plasma kallikrein inhibitors
PCT/US2015/019535 WO2015134998A1 (en) 2014-03-07 2015-03-09 Human plasma kallikrein inhibitors

Publications (1)

Publication Number Publication Date
HRP20201916T1 true HRP20201916T1 (hr) 2021-01-22

Family

ID=54055948

Family Applications (2)

Application Number Title Priority Date Filing Date
HRP20201916TT HRP20201916T1 (hr) 2014-03-07 2015-03-09 Trifluorometil supstituirani pirazoli kao inhibitori kalikreina u ljudskoj plazmi
HRP20221373TT HRP20221373T1 (hr) 2014-03-07 2015-03-09 Supstituirani pirazoli kao inhibitori kalikreina u ljudskoj plazmi

Family Applications After (1)

Application Number Title Priority Date Filing Date
HRP20221373TT HRP20221373T1 (hr) 2014-03-07 2015-03-09 Supstituirani pirazoli kao inhibitori kalikreina u ljudskoj plazmi

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US (14) US10125102B2 (enExample)
EP (4) EP4180424B1 (enExample)
JP (4) JP6574435B2 (enExample)
KR (2) KR102510427B1 (enExample)
CN (2) CN106257976B (enExample)
AU (3) AU2015226855C1 (enExample)
BR (1) BR112016020199A8 (enExample)
CA (2) CA2941380C (enExample)
CY (2) CY1123810T1 (enExample)
DK (2) DK3113772T3 (enExample)
EA (1) EA036251B1 (enExample)
ES (3) ES2836373T3 (enExample)
FR (1) FR21C1048I2 (enExample)
HR (2) HRP20201916T1 (enExample)
HU (3) HUE052668T2 (enExample)
IL (2) IL280785B2 (enExample)
LT (3) LT3828173T (enExample)
LU (1) LUC00233I2 (enExample)
MA (1) MA53399B1 (enExample)
MX (2) MX377845B (enExample)
MY (1) MY199131A (enExample)
NL (1) NL301142I2 (enExample)
NO (1) NO2022046I1 (enExample)
NZ (2) NZ724250A (enExample)
PH (1) PH12016501750B1 (enExample)
PL (2) PL3113772T3 (enExample)
PT (2) PT3828173T (enExample)
RS (2) RS63763B1 (enExample)
SG (2) SG11201607267SA (enExample)
SI (1) SI3113772T1 (enExample)
SM (2) SMT202100031T1 (enExample)
WO (1) WO2015134998A1 (enExample)
ZA (1) ZA201606320B (enExample)

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US10081623B2 (en) 2014-09-04 2018-09-25 Bristol-Myers Squibb Company Diamide macrocycles that are FXIa inhibitors
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