HRP20171202T1 - Nove molekule jnk inhibitora - Google Patents
Nove molekule jnk inhibitora Download PDFInfo
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- HRP20171202T1 HRP20171202T1 HRP20171202TT HRP20171202T HRP20171202T1 HR P20171202 T1 HRP20171202 T1 HR P20171202T1 HR P20171202T T HRP20171202T T HR P20171202TT HR P20171202 T HRP20171202 T HR P20171202T HR P20171202 T1 HRP20171202 T1 HR P20171202T1
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- jnk inhibitor
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- amino acid
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- 229940118135 JNK inhibitor Drugs 0.000 title claims 28
- 239000012825 JNK inhibitor Substances 0.000 title claims 28
- 229940024606 amino acid Drugs 0.000 claims 16
- 235000001014 amino acid Nutrition 0.000 claims 16
- 150000001413 amino acids Chemical group 0.000 claims 16
- 238000000034 method Methods 0.000 claims 12
- 210000004027 cell Anatomy 0.000 claims 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- 230000002401 inhibitory effect Effects 0.000 claims 6
- 108010078791 Carrier Proteins Proteins 0.000 claims 5
- 150000008574 D-amino acids Chemical group 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 230000001225 therapeutic effect Effects 0.000 claims 5
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 4
- 241000283707 Capra Species 0.000 claims 3
- 150000008575 L-amino acids Chemical group 0.000 claims 3
- 241000699666 Mus <mouse, genus> Species 0.000 claims 3
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 3
- 241000700159 Rattus Species 0.000 claims 3
- 230000003053 immunization Effects 0.000 claims 3
- 238000002649 immunization Methods 0.000 claims 3
- 230000016784 immunoglobulin production Effects 0.000 claims 3
- 238000002955 isolation Methods 0.000 claims 3
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims 2
- 229930064664 L-arginine Natural products 0.000 claims 2
- 235000014852 L-arginine Nutrition 0.000 claims 2
- 235000019454 L-leucine Nutrition 0.000 claims 2
- 239000004395 L-leucine Substances 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 229960003136 leucine Drugs 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 239000012228 culture supernatant Substances 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
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- Epidemiology (AREA)
- Mycology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Food Science & Technology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (25)
1. JNK inhibitor koji sadrži inhibirajuću peptidnu sekvencu prema sljedećoj općoj formuli
X1-X2-X3-R-X4-X5-X6-L-X7-L-X8 (SEQ ID NO: 1),
pri čemu X1 je amino kiselina koja se bira od amino kiselina R, P i Q,
pri čemu X2 je amino kiselina koja se bira od amino kiselina R, P i G,
pri čemu X3 je amino kiselina koja se bira od amino kiselina K, R, k i r,
pri čemu X4 je amino kiselina koja se bira od amino kiselina P i K,
pri čemu X5 je amino kiselina koja se bira od amino kiselina T, a, s, q, k ili je odsutan, pri čemu X6 je amino kiselina koja se bira od amino kiselina T, D i A,
pri čemu X7 je amino kiselina koja se bira od amino kiselina N, n, r i K; i
pri čemu X8 je amino kiselina koja se bira od F, f i w, te
pri čemu aminokiselinski ostatak naveden velikim slovima označava ostatak L-amino kiseline, dok aminokiselinski ostatak naveden malim slovima označava ostatak D-amino kiseline,
pod uvjetom da je/su barem jedna od amino kiselina odabrana iz skupine koja sadrži X3, X5, X7 i X8 D-amino kiselinu(e).
2. JNK inhibitor prema zahtjevu 1, naznačen time da je inhibirajuća peptidna sekvenca odabrana iz bilo koje od SEQ ID NOs: 3-20, 22-24 i 27.
3. JNK inhibitor prema zahtjevu 1 ili 2, naznačen time da JNK inhibitor sadrži inhibirajuću peptidnu sekvencu koja dijeli barem 80% identičnosti sekvence sa sekvencom odabranom iz bilo koje od SEQ ID NOs: 3-20, 22-24 i 27.
4. JNK inhibitor prema bilo kojem od prethodnih zahtjeva, naznačen time da JNK inhibitor sadrži SEQ ID NO: 8 ili inhibirajuću peptidnu sekvencu koja dijeli barem 80% identičnosti sekvence sa SEQ ID NO: 8.
5. JNK inhibitor prema bilo kojem od prethodnih zahtjeva, naznačen time da JNK inhibitor sadrži transporter sekvencu.
6. JNK inhibitor prema zahtjevu 5, naznačen time da se inhibirajuća peptidna sekvenca i transporter sekvenca preklapaju.
7. JNK inhibitor prema zahtjevu 5 ili 6, naznačen time da transporter sekvenca sadrži sekvencu naizmjeničnih D- i L-amino kiselina prema bilo kojoj od SEQ ID NOs: 28-30, ili transporter sekvencu odabranu iz bilo koje od SEQ ID NOs: 31-170.
8. JNK inhibitor prema bilo kojem od zahtjeva 5 ili 7, naznačen time da je navedena transporter sekvenca smještena izravno na N-terminalnom kraju ili izravno na C-terminalnom kraju inhibirajuće peptidne sekvence.
9. JNK inhibitor prema bilo kojem od zahtjeva 5-8, naznačen time da JNK inhibitor sadrži
a) sekvencu prema bilo kojoj od SEQ ID NOs: 171-183, 185-187 ili 190 ili
b) sekvencu koja dijeli barem 50% identičnosti sekvence sa barem jednom od SEQ ID NOs: 171-190, pod uvjetom da navedena sekvenca dijeli identičnost sekvence sa bilo kojom od SEQ ID NOs: 171-190:
i) održava ostatak L-arginin (R) na položaju 4 u njegovom odsječku sekvence koji odgovara SEQ ID NO: 1,
ii) održava dva ostatka L-leucin (L) u njihovom odsječku sekvence koji odgovara SEQ ID NO: 1, i
iii) ima barem jednu D-amino kiselinu na položajima X3, X5, X7 ili X8 u njegovom odsječku sekvence koji odgovara SEQ ID NO: 1.
10. JNK inhibitor prema zahtjevu 9, naznačen time da JNK inhibitor sadrži
a) sekvencu prema SEQ ID NO: 172 ili
b) sekvencu koja dijeli barem 50% identičnosti sekvence sa SEQ ID NO: 172, pod uvjetom da navedena sekvenca koja dijeli identičnosti sekvence sa SEQ ID NO: 172:
i) održava ostatak L-arginin (R) na položaju 4 u njegovom odsječku sekvence koji odgovara SEQ ID NO: 1,
ii) održava dva ostatka L-leucin (L) u njihovom odsječku sekvence koji odgovara SEQ ID NO: 1, i
iii) ima barem jednu D-amino kiselinu na položajima X3, X5, X7 ili X8 u njegovom odsječku sekvence koji odgovara SEQ ID NO: 1.
11. JNK inhibitor prema zahtjevu 10, naznačen time da JNK inhibitor obuhvaća sekvencu prema SEQ ID NO: 172.
12. Postupak ne-terapeutskog imuniziranja neljudske životinje s JNK inhibitorom prema bilo kojem od zahtjeva 1-11, naznačen time da postupak obuhvaća slijedeći korak:
- ne-terapeutsko dovođenje u kontakt neljudske životinje pogodne za proizvodnju protutijela s JNK inhibitorom prema bilo kojem od zahtjeva 1-11.
13. Postupak ne-terapeutskog imuniziranja neljudske životinje prema zahtjevu 12, naznačen time da neljudska životinja je sisavac koji nije čovjek.
14. Postupak ne-terapeutskog imuniziranja neljudske životinje prema zahtjevu 13, naznačen time da je neljudska životinja odabrana od koze, miša, štakora i zeca.
15. Postupak za proizvodnju protutijela koje prepoznaje JNK inhibitor prema bilo kojem od zahtjeva 1-11, naznačen time da postupak obuhvaća korak:
- izoliranja protutijela koje prepoznaje navedeni JNK inhibitor iz neljudske životinje prikladne za proizvodnju protutijela, koja je bila u prethodnom ne-terapeutskom kontaktu s JNK inhibitorom prema bilo kojem od zahtjeva 1-11.
16. Postupak za proizvodnju protutijela prema zahtjevu 15, naznačen time da neljudska životinja je sisavac koji nije čovjek.
17. Postupak za proizvodnju protutijela prema zahtjevu 16, naznačen time da neljudska životinja je odabrana od koze, miša, štakora i zeca.
18. Postupak izoliranja stanice koja proizvodi protutijelo koje prepoznaje JNK inhibitor prema bilo kojem od zahtjeva 1-11, naznačen time da postupak obuhvaća korak:
- izoliranja, iz neljudske životinje prikladne za proizvodnju protutijela, koja je bila u prethodnom ne-terapeutskom kontaktu s JNK inhibitorom prema bilo kojem od zahtjeva 1-11, stanice koja proizvodi navedeno protutijelo koje prepoznaje navedeni JNK inhibitor.
19. Postupak izoliranja stanice prema zahtjevu 18, naznačen time da neljudska životinja je sisavac koji nije čovjek.
20. Postupak izoliranja stanice prema zahtjevu 19, naznačen time da je neljudska životinja odabrana od koze, miša, štakora i zeca
21. Postupak izoliranja stanice prema bilo kojem od zahtjeva 18 - 20, naznačen time da stanica koja proizvodi navedeno protutijelo je imortalizirana.
22. Postupak za proizvodnju protutijela koje specifično prepoznaje JNK inhibitor prema bilo kojem od zahtjeva 1-11, naznačen time da postupak obuhvaća korak:
izoliranja protutijela koje specifično prepoznaje JNK inhibitor prema bilo kojem od zahtjeva 1-11, iz supernatanta stanične kulture od stanice koja proizvodi navedeno protutijelo.
23. Postupak za proizvodnju protutijela prema zahtjevu 22, naznačen time da stanica koja proizvodi navedeno protutijelo je imortalizirana.
24. Protutijelo koje se može proizvesti s bilo kojim od postupaka prema bilo kojem od zahtjeva 15 - 17 ili 22 - 23, naznačeno time da protutijelo prepoznaje barem jedan peptid odabran iz bilo koje od SEQ ID NOs: 1, 3-20, 22-24 i 27, ali ne prepoznaje uglavnom iste peptide s L-amino kiselinama na mjestu D-amino kiselina.
25. Stanica koja se može proizvesti postupkom prema bilo kojem od zahtjeva 18-21, naznačena time da stanica proizvodi protutijelo prema zahtjevu 24.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2010/003729 WO2011160653A1 (en) | 2010-06-21 | 2010-06-21 | Novel jnk inhibitor molecules |
EP11727401.9A EP2582714B1 (en) | 2010-06-21 | 2011-06-21 | Novel jnk inhibitor molecules |
PCT/EP2011/003074 WO2011160827A2 (en) | 2010-06-21 | 2011-06-21 | Novel jnk inhibitor molecules |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20171202T1 true HRP20171202T1 (hr) | 2017-10-06 |
Family
ID=43413497
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20171202TT HRP20171202T1 (hr) | 2010-06-21 | 2017-08-07 | Nove molekule jnk inhibitora |
Country Status (23)
Country | Link |
---|---|
US (2) | US8981052B2 (hr) |
EP (2) | EP2993180B1 (hr) |
JP (2) | JP5926250B2 (hr) |
KR (1) | KR20130037218A (hr) |
CN (2) | CN103025754B (hr) |
AU (1) | AU2011269329B2 (hr) |
BR (1) | BR112012032738A2 (hr) |
CA (1) | CA2798100C (hr) |
CY (1) | CY1119173T1 (hr) |
DK (1) | DK2582714T3 (hr) |
ES (2) | ES2637277T3 (hr) |
HK (1) | HK1222181A1 (hr) |
HR (1) | HRP20171202T1 (hr) |
HU (1) | HUE033828T2 (hr) |
IL (1) | IL223136A0 (hr) |
LT (1) | LT2582714T (hr) |
MX (1) | MX337203B (hr) |
PL (2) | PL2993180T3 (hr) |
PT (1) | PT2582714T (hr) |
RU (1) | RU2570417C2 (hr) |
SG (2) | SG10201507857WA (hr) |
SI (1) | SI2582714T1 (hr) |
WO (2) | WO2011160653A1 (hr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040082509A1 (en) | 1999-10-12 | 2004-04-29 | Christophe Bonny | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
WO2007031098A1 (en) | 2005-09-12 | 2007-03-22 | Xigen S.A. | Cell-permeable peptide inhibitors of the jnk signal transduction pathway |
WO2009143864A1 (en) | 2008-05-30 | 2009-12-03 | Xigen S.A. | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory digestive diseases |
WO2009143865A1 (en) | 2008-05-30 | 2009-12-03 | Xigen S.A. | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
WO2010072228A1 (en) | 2008-12-22 | 2010-07-01 | Xigen S.A. | Novel transporter constructs and transporter cargo conjugate molecules |
WO2011160653A1 (en) | 2010-06-21 | 2011-12-29 | Xigen S.A. | Novel jnk inhibitor molecules |
US9150618B2 (en) | 2010-10-14 | 2015-10-06 | Xigen Inflammation Ltd. | Use of cell-permeable peptide inhibitors of the JNK signal transduction pathway for the treatment of chronic or non-chronic inflammatory eye diseases |
WO2013091670A1 (en) * | 2011-12-21 | 2013-06-27 | Xigen S.A. | Novel jnk inhibitor molecules for treatment of various diseases |
WO2014206427A1 (en) | 2013-06-26 | 2014-12-31 | Xigen Inflammation Ltd. | New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
CN105307670A (zh) | 2013-06-26 | 2016-02-03 | 埃克西金炎症有限公司 | Jnk信号转导途径的细胞渗透肽抑制剂用于治疗多种疾病的新用途 |
WO2014206426A1 (en) * | 2013-06-26 | 2014-12-31 | Xigen Inflammation Ltd. | New use for jnk inhibitor molecules for treatment of various diseases |
WO2015197097A1 (en) * | 2014-06-26 | 2015-12-30 | Xigen Inflammation Ltd. | New use for jnk inhibitor molecules for treatment of various diseases |
EP3160989A2 (en) * | 2014-06-26 | 2017-05-03 | Xigen Inflammation Ltd. | New use for jnk inhibitor molecules for treatment of various diseases |
WO2018029336A1 (en) | 2016-08-12 | 2018-02-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for determining whether a subject was administered with an activator of the ppar beta/delta pathway. |
Family Cites Families (128)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1195304B (it) | 1981-12-22 | 1988-10-12 | Anic Spa | Metodo per la preparazione di gem-diammino derivati n-monoacilati |
US4631211A (en) | 1985-03-25 | 1986-12-23 | Scripps Clinic & Research Foundation | Means for sequential solid phase organic synthesis and methods using the same |
US4698327A (en) | 1985-04-25 | 1987-10-06 | Eli Lilly And Company | Novel glycopeptide derivatives |
IT1190389B (it) | 1985-09-19 | 1988-02-16 | Eniricerche Spa | Esapeptidi ad attivita' ipotensiva |
US5169933A (en) | 1988-08-15 | 1992-12-08 | Neorx Corporation | Covalently-linked complexes and methods for enhanced cytotoxicity and imaging |
IT1227907B (it) | 1988-12-23 | 1991-05-14 | Eniricerche S P A Milano Sclav | Procedimento per la sintesi di peptidi retro-inversi e nuovi intermediin tale procedimento |
US5747641A (en) | 1989-12-21 | 1998-05-05 | Biogen Inc | Tat-derived transport polypeptide conjugates |
US6316003B1 (en) | 1989-12-21 | 2001-11-13 | Whitehead Institute For Biomedical Research | Tat-derived transport polypeptides |
US5804604A (en) | 1989-12-21 | 1998-09-08 | Biogen, Inc. | Tat-derived transport polypeptides and fusion proteins |
US5840313A (en) | 1990-09-27 | 1998-11-24 | Syntello Vaccine Development Kb | Peptides for use in vaccination and induction of neutralizing antibodies against human immunodeficiency virus |
WO1992018138A1 (en) | 1991-04-10 | 1992-10-29 | The General Hospital Corporation | Mammalian gap-43 compositions and methods of use |
US5350835A (en) | 1991-11-05 | 1994-09-27 | Board Of Regents, University Of Texas | Cellular nucleic acid binding protein and uses thereof in regulating gene expression and in the treatment of aids |
US5994108A (en) | 1991-11-05 | 1999-11-30 | Board Of Regents, The University Of Texas System | Mutant TAR virus and transdominant tat mutants as pharmacological agents |
EP0632722A4 (en) | 1992-03-20 | 1997-07-30 | Baylor College Medicine | DNA TRANSPORTATION SYSTEM AND INSTRUCTIONS FOR USE. |
ES2221920T3 (es) | 1992-04-03 | 2005-01-16 | The Regents Of The University Of California | Sistema de liberacion de polinucleotidos de autoensamblaje que comprende un peptido cationico anfipatico. |
EP0673385A4 (en) | 1992-08-13 | 1995-11-29 | Gen Hospital Corp | HUMAN GAP-43 COMPOSITIONS AND METHODS FOR THEIR USE. |
DE69321962T2 (de) | 1992-08-21 | 1999-07-01 | Biogen Inc | Von tat abgeleitete transportpolypeptide |
DE69333397T2 (de) | 1992-08-27 | 2004-12-09 | Bioclones (Proprietary) Ltd., Sandton | Retro-, inverso-, und retro-inverso synthetische peptidanaloge |
US5545551A (en) | 1992-08-28 | 1996-08-13 | Mt. Sinai School Of Medicine Of The City University Of New York | Cloning and expression of pur protein |
EP0693939A1 (de) | 1993-04-14 | 1996-01-31 | Roche Diagnostics GmbH | Nukleinsäure-transferpeptide und deren verwendung zur einschleusung von nukleinsäuren in eukaryontische zellen |
CA2153480A1 (en) | 1993-11-12 | 1995-06-01 | Kenichi Matsubara | Gene signature |
US5807746A (en) | 1994-06-13 | 1998-09-15 | Vanderbilt University | Method for importing biologically active molecules into cells |
EP0767833A1 (en) | 1995-04-25 | 1997-04-16 | Baxter International Inc. | Composition containing collagenase and chymopapain for isolating hepatocytes and pancreatic islet cells |
US6184038B1 (en) | 1995-07-28 | 2001-02-06 | Marie Curie Cancer Care | Transport proteins and their uses |
AU7366896A (en) | 1995-09-21 | 1997-04-09 | Innapharma, Inc. | Peptides and peptidomimetics inhibiting the oncogenic action of p21 ras |
IE80466B1 (en) | 1995-11-10 | 1998-07-29 | Elan Corp Plc | Peptides which enhance transport across tissues and methods of identifying and using the same |
US5877282A (en) | 1996-09-20 | 1999-03-02 | Bristol-Myers Squibb Company | Peptide inhibitors of nuclear protein translocation having nuclear localization sequences and methods of use thereof |
US6187817B1 (en) | 1996-10-03 | 2001-02-13 | Southern Illinois University School Of Medicine | Therapeutic use of d-methionine to reduce the toxicity of platinum-containing anti-tumor compounds |
US6361938B1 (en) | 1996-11-08 | 2002-03-26 | Elan Corporation, Plc | Peptides which enhance transport across tissues and methods of identifying and using the same |
AU7410998A (en) | 1996-11-26 | 1998-06-22 | Johns Hopkins University, The | Ligand detection system and methods of use thereof |
US5989814A (en) | 1997-04-01 | 1999-11-23 | Reagents Of The University Of California | Screening methods in eucaryotic cells |
US5880261A (en) | 1997-04-03 | 1999-03-09 | Waeber; Gerard | Transcription factor Islet-Brain 1 (IB1) |
WO1998047913A2 (en) | 1997-04-18 | 1998-10-29 | The University Of Medicine And Dentistry Of New Jersey | Inhibition of hiv-1 replication by a tat rna-binding domain peptide analog |
US6043083A (en) | 1997-04-28 | 2000-03-28 | Davis; Roger J. | Inhibitors of the JNK signal transduction pathway and methods of use |
CA2290756A1 (en) | 1997-05-15 | 1998-11-19 | Cytogen Corporation | Random peptides that bind to gastro-intestinal tract (git) transport receptors and related methods |
US20040152084A1 (en) | 2003-01-31 | 2004-08-05 | Slattum Paul M. | Compounds and processes for single-pot attachment of a label to nucleic acid |
ATE251913T1 (de) | 1997-05-21 | 2003-11-15 | Univ Leland Stanford Junior | Zusammensetzung und verfahren zur verzögerung des transports durch biologische membranen |
FR2767323B1 (fr) | 1997-08-12 | 2001-01-05 | Synt Em | Peptides lineaires derives de peptides antibiotiques, leur preparation et leur utilisation pour vectoriser des substances actives |
EP0897002A3 (en) | 1997-08-14 | 2001-10-04 | Smithkline Beecham Plc | U62317, a protein having a JNK-binding domain |
AU9402898A (en) | 1997-09-26 | 1999-04-23 | Washington University | Cell death agonists |
US6420031B1 (en) | 1997-11-03 | 2002-07-16 | The Trustees Of Princeton University | Highly transparent non-metallic cathodes |
ID27124A (id) | 1997-10-20 | 2001-03-01 | Hoffmann La Roche | Penghambat kinase bisiklik |
US6270956B1 (en) | 1997-12-11 | 2001-08-07 | The Salk Institute For Biological Studies | Transcriptional coactivator that interacts with Tat protein and regulates its binding to TAR RNA, methods for modulating Tat transactivation, and uses therefor |
EP0947524A1 (en) | 1998-03-30 | 1999-10-06 | Upither B.V. | Novel peptides for the treatment of autoimmune diseases |
US6248558B1 (en) | 1998-03-31 | 2001-06-19 | Vanderbilt University | Sequence and method for genetic engineering of proteins with cell membrane translocating activity |
WO1999055682A1 (en) | 1998-04-29 | 1999-11-04 | Georgetown University | Methods of identifying and using hla binding compounds as hla-agonists and antagonists |
EP1076711A2 (en) | 1998-05-13 | 2001-02-21 | Incyte Pharmaceuticals, Inc. | Human apoptosis associated proteins |
US6811992B1 (en) | 1998-05-14 | 2004-11-02 | Ya Fang Liu | Method for identifying MLK inhibitors for the treatment of neurological conditions |
AU3714499A (en) | 1998-05-14 | 1999-11-29 | Pasteur Merieux Serums Et Vaccins | Hepatitis c virus mimotopes |
WO1999066061A1 (fr) | 1998-06-18 | 1999-12-23 | Dnavec Research, Inc. | Phage de transfert d'acide nucleique |
US6589503B1 (en) | 1998-06-20 | 2003-07-08 | Washington University | Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy |
US6348185B1 (en) | 1998-06-20 | 2002-02-19 | Washington University School Of Medicine | Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy |
ATE258946T1 (de) | 1998-08-28 | 2004-02-15 | Gryphon Sciences | Verfahren zur herstellung von polyamidketten von genauer länge und deren konjugate mit proteinen |
CN1329034C (zh) | 1998-09-25 | 2007-08-01 | 赛福伦公司 | 预防/治疗感觉毛细胞和耳蜗神经元损伤的药物 |
US6656474B1 (en) | 1999-01-15 | 2003-12-02 | Regeneron Pharmaceuticals, Inc. | Methods of using a neurotrophin and its analogues for the treatment of gastrointestinal hypomotility disorders |
US6673908B1 (en) | 1999-02-22 | 2004-01-06 | Nuvelo, Inc. | Tumor necrosis factor receptor 2 |
JP2003506071A (ja) | 1999-05-28 | 2003-02-18 | アポプトシス テクノロジー,アイエヌシー. | アポトーシスを制御する化合物および方法ならびにアポトーシスを制御する化合物を製造およびスクリーニングする方法 |
US7510824B2 (en) | 1999-06-02 | 2009-03-31 | Nono Inc. | Method of screening peptides useful in treating traumatic injury to the brain or spinal cord |
AU5316900A (en) | 1999-06-03 | 2000-12-28 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-jun n-terminal kinases (jnk) |
EP1102785B1 (en) | 1999-06-07 | 2013-02-13 | Arrowhead Research Corporation | COMPOSITIONS FOR DRUG DELIVERY USING pH SENSITIVE MOLECULES |
EP2269654A3 (en) | 1999-08-24 | 2011-04-13 | Cellgate Inc. | Enhancing drug delivery across and into epithelial tissues using oligo arginine moieties |
US6669951B2 (en) | 1999-08-24 | 2003-12-30 | Cellgate, Inc. | Compositions and methods for enhancing drug delivery across and into epithelial tissues |
US20030104622A1 (en) | 1999-09-01 | 2003-06-05 | Robbins Paul D. | Identification of peptides that facilitate uptake and cytoplasmic and/or nuclear transport of proteins, DNA and viruses |
EP1210362A2 (en) | 1999-09-01 | 2002-06-05 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Identification of peptides that facilitate uptake and cytoplasmic and/or nuclear transport of proteins, dna and viruses |
US6610820B1 (en) | 1999-10-12 | 2003-08-26 | University Of Lausanne | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
US20040082509A1 (en) | 1999-10-12 | 2004-04-29 | Christophe Bonny | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
US20030108539A1 (en) | 2000-02-14 | 2003-06-12 | Christophe Bonny | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
US8183339B1 (en) | 1999-10-12 | 2012-05-22 | Xigen S.A. | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
IL149933A0 (en) | 1999-12-06 | 2002-11-10 | Gen Hospital Corp | Pancreatic stem cells and their use in transplantation |
US6586403B1 (en) | 2000-07-20 | 2003-07-01 | Salpep Biotechnology, Inc. | Treating allergic reactions and inflammatory responses with tri-and dipeptides |
US6897231B2 (en) | 2000-07-31 | 2005-05-24 | Signal Pharmaceuticals, Inc. | Indazole derivatives as JNK inhibitors and compositions and methods related thereto |
JP4387669B2 (ja) | 2000-10-13 | 2009-12-16 | ザイジェン エス.アー. | 新規なトランスポーターペプチド配列による生物学的エフェクターの細胞内送達 |
US7033597B2 (en) | 2000-10-13 | 2006-04-25 | Université de Lausanne | Intracellular delivery of biological effectors |
ATE553766T1 (de) | 2000-10-17 | 2012-05-15 | Diabcell Pty Ltd | Zubereitung und xenotransplantation von langerhans-inseln von schweinen |
WO2002062792A1 (fr) | 2001-02-02 | 2002-08-15 | Takeda Chemical Industries, Ltd. | Inhibiteur de jnk |
US20030077826A1 (en) | 2001-02-02 | 2003-04-24 | Lena Edelman | Chimeric molecules containing a module able to target specific cells and a module regulating the apoptogenic function of the permeability transition pore complex (PTPC) |
AU2002240312A1 (en) | 2001-02-08 | 2002-08-19 | Pankaj Paranjp | Enhanced oral and transcompartmental delivery of therapeutic or diagnostic agents using polymer conjugates |
MXPA03007358A (es) | 2001-02-16 | 2004-12-13 | Cellgate Inc | Transportadores que contienen porciones de arginina separadas. |
DE10117281A1 (de) | 2001-04-06 | 2002-10-24 | Inst Molekulare Biotechnologie | Peptid zur Diagnose und Therapie der Alzheimer-Demenz |
DE60215626T2 (de) | 2001-04-06 | 2007-08-30 | Thomas Jefferson University | Antagonist für die multimerisierung von hiv-1 vif-protein |
AU2002322519A1 (en) | 2001-07-17 | 2003-03-03 | Incyte Genomics, Inc. | Proteins associated with cell growth, differentiation, and death |
EP1436291B1 (en) | 2001-09-19 | 2009-01-14 | Aventis Pharma S.A. | Indolizines as kinase protein inhibitors |
AU2003201733B2 (en) | 2002-01-09 | 2008-11-06 | Xigen Sa | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
AU2003217961B2 (en) | 2002-03-08 | 2008-02-28 | Signal Pharmaceuticals, Llc | Combination therapy for treating, preventing or managing proliferative disorders and cancers |
SE0201863D0 (en) | 2002-06-18 | 2002-06-18 | Cepep Ab | Cell penetrating peptides |
EP1590363A4 (en) | 2002-09-09 | 2006-11-02 | Dana Farber Cancer Inst Inc | BH3-PEPTIDES AND METHOD FOR THEIR USE |
MXPA05003063A (es) | 2002-09-20 | 2005-05-27 | Alcon Inc | Uso de inhibidores de la sintesis de citosina para el tratamiento de trastornos de ojos secos. |
ATE350480T1 (de) | 2002-10-11 | 2007-01-15 | Imvision Gmbh | Moduläre antigen-transporter moleküle (mat- moleküle) zur modulierung von immunreaktionen, zugehörige konstrukte, verfahren und verwendungen |
AU2003286611A1 (en) | 2002-10-24 | 2004-05-13 | Sangstat Medical Corporation | Cytomodulating peptides and methods for treating neurological disorders |
US20040087642A1 (en) * | 2002-10-24 | 2004-05-06 | Zeldis Jerome B. | Methods of using and compositions comprising a JNK inhibitor for the treatment, prevention, management and/or modification of pain |
EP1578365A4 (en) | 2002-11-14 | 2009-09-23 | Arbor Vita Corp | MOLECULAR INTERACTIONS IN NEURONS |
CA2506442A1 (en) | 2002-11-18 | 2004-07-01 | Celgene Corporation | Methods of using and compositions comprising (-)-3-(3,4-dimethoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamide |
US20050019366A1 (en) | 2002-12-31 | 2005-01-27 | Zeldis Jerome B. | Drug-coated stents and methods of use therefor |
US7166692B2 (en) | 2003-03-04 | 2007-01-23 | Canbrex Bio Science Walkersville, Inc. | Intracellular delivery of small molecules, proteins, and nucleic acids |
EP1599475A2 (en) | 2003-03-06 | 2005-11-30 | Eisai Co., Ltd. | Jnk inhibitors |
WO2004092339A2 (en) | 2003-04-11 | 2004-10-28 | Ilex Products, Inc. | Modulation of muc1 mediated signal transduction |
EP2351844B1 (en) | 2003-04-29 | 2014-06-11 | Sarepta Therapeutics, Inc. | Compositions for enhancing transport and antisense efficacy of nucleic acid analog into cells |
CA2529752A1 (en) | 2003-06-20 | 2005-09-15 | The Regents Of The University Of California | Polypeptide transduction and fusogenic peptides |
KR100685345B1 (ko) | 2004-03-27 | 2007-02-22 | 학교법인조선대학교 | 세포사 유도 펩타이드 |
KR20060134198A (ko) | 2004-04-08 | 2006-12-27 | 어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이. | Jnk 저해제 및 시클로스포린을 포함하는 조성물 |
EP1786781A2 (en) | 2004-08-27 | 2007-05-23 | GPC Biotech AG | Pyrimidine derivatives |
US20060094753A1 (en) | 2004-10-29 | 2006-05-04 | Alcon, Inc. | Use of inhibitors of Jun N-terminal kinases for the treatment of glaucomatous retinopathy and ocular diseases |
EP1656951A1 (en) | 2004-11-12 | 2006-05-17 | Xigen S.A. | Conjugates with enhanced cell uptake activity |
EP1676574A3 (en) | 2004-12-30 | 2006-07-26 | Johnson & Johnson Vision Care, Inc. | Methods for promoting survival of transplanted tissues and cells |
US20060223807A1 (en) | 2005-03-29 | 2006-10-05 | University Of Massachusetts Medical School, A Massachusetts Corporation | Therapeutic methods for type I diabetes |
US20070015779A1 (en) | 2005-04-29 | 2007-01-18 | John Griffin | Compositions and treatments for inhibiting kinase and/or hmg-coa reductase |
US20060258706A1 (en) | 2005-04-29 | 2006-11-16 | Manohar Saindane | Solid forms of a JNK inhibitor |
US20070003531A1 (en) | 2005-06-30 | 2007-01-04 | University Of Connecticut | Methods for improving immunotherapy by enhancing survival of antigen-specific cytotoxic T lymphocytes |
US8080517B2 (en) | 2005-09-12 | 2011-12-20 | Xigen Sa | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
WO2007031098A1 (en) * | 2005-09-12 | 2007-03-22 | Xigen S.A. | Cell-permeable peptide inhibitors of the jnk signal transduction pathway |
WO2008006046A1 (en) | 2006-07-06 | 2008-01-10 | Case Western Reserve University | Ceramide composition and use thereof in treatment of ocular diseases |
WO2008094208A2 (en) | 2006-08-02 | 2008-08-07 | Northwestern University | Protein kinase targeted therapeutics |
ES2378577T3 (es) | 2006-09-08 | 2012-04-16 | F. Hoffmann-La Roche Ag | Benzotriazol como moduladores de quinasas |
GB0702259D0 (en) | 2007-02-06 | 2007-03-14 | Eisai London Res Lab Ltd | 7-azaindole derivatives |
SI2285364T1 (sl) | 2008-05-07 | 2015-03-31 | The Regents Of The University Of California | Terapevtska regeneracija in obogatitev lubrikacije okularne površine |
WO2009143865A1 (en) * | 2008-05-30 | 2009-12-03 | Xigen S.A. | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
WO2009143864A1 (en) | 2008-05-30 | 2009-12-03 | Xigen S.A. | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory digestive diseases |
US20100183633A1 (en) | 2008-12-04 | 2010-07-22 | University Of Massachusetts | Interleukin 6 and tumor necrosis factor alpha as biomarkers of jnk inhibition |
WO2010072228A1 (en) | 2008-12-22 | 2010-07-01 | Xigen S.A. | Novel transporter constructs and transporter cargo conjugate molecules |
EP2393806B1 (en) | 2009-02-06 | 2017-10-25 | Elan Pharmaceuticals, Inc. | Inhibitors of jun n-terminal kinase |
US20120101046A1 (en) | 2009-03-30 | 2012-04-26 | Santen Pharmaceutical Co., Ltd. | Prophylactic or therapeutic agent for retinal disease and method for prophylaxis or therapy of retinal disease using jnk (c-jun amino-terminal kinase) - inhibitory peptide, and use of the peptide |
WO2011160653A1 (en) | 2010-06-21 | 2011-12-29 | Xigen S.A. | Novel jnk inhibitor molecules |
US9150618B2 (en) | 2010-10-14 | 2015-10-06 | Xigen Inflammation Ltd. | Use of cell-permeable peptide inhibitors of the JNK signal transduction pathway for the treatment of chronic or non-chronic inflammatory eye diseases |
EP2902035B1 (en) | 2010-10-14 | 2018-06-20 | Xigen Inflammation Ltd. | Cell-permeable peptide inhibitors of the JNK signal transduction pathway for use in the treatment of inflammatory eye diseases. |
US8471027B2 (en) | 2011-04-06 | 2013-06-25 | Hoffmann-La Roche Inc. | Adamantyl compounds |
WO2013091670A1 (en) | 2011-12-21 | 2013-06-27 | Xigen S.A. | Novel jnk inhibitor molecules for treatment of various diseases |
WO2014206426A1 (en) | 2013-06-26 | 2014-12-31 | Xigen Inflammation Ltd. | New use for jnk inhibitor molecules for treatment of various diseases |
EP3160989A2 (en) | 2014-06-26 | 2017-05-03 | Xigen Inflammation Ltd. | New use for jnk inhibitor molecules for treatment of various diseases |
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