HRP20150154T1 - Raspršivi farmaceutski pripravak koji sadrži analog vitamina d i kortikosteroid - Google Patents

Raspršivi farmaceutski pripravak koji sadrži analog vitamina d i kortikosteroid Download PDF

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HRP20150154T1
HRP20150154T1 HRP20150154AT HRP20150154T HRP20150154T1 HR P20150154 T1 HRP20150154 T1 HR P20150154T1 HR P20150154A T HRP20150154A T HR P20150154AT HR P20150154 T HRP20150154 T HR P20150154T HR P20150154 T1 HRP20150154 T1 HR P20150154T1
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composition according
propellant
ether
group
corticosteroid
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HRP20150154AT
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Marianne Lind
Gritt Rasmussen
Mette Rydahl Sonne
Jens Hansen
Karsten Petersson
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Leo Pharma A/S
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Publication of HRP20150154T1 publication Critical patent/HRP20150154T1/hr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A61K9/122—Foams; Dry foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A61K9/124—Aerosols; Foams characterised by the propellant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M35/00—Devices for applying media, e.g. remedies, on the human body
    • A61M35/003—Portable hand-held applicators having means for dispensing or spreading integral media
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/04—Skin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
    • B65D83/16—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant characterised by the actuating means
    • B65D83/20—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant characterised by the actuating means operated by manual action, e.g. button-type actuator or actuator caps
    • B65D83/207—Actuators comprising a manually operated valve and being attachable to the aerosol container, e.g. downstream a valve fitted to the container; Actuators associated to container valves with valve seats located outside the aerosol container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
    • B65D83/75—Aerosol containers not provided for in groups B65D83/16 - B65D83/74
    • B65D83/752—Aerosol containers not provided for in groups B65D83/16 - B65D83/74 characterised by the use of specific products or propellants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Mechanical Engineering (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Claims (25)

1. Topička kompozicija koja se može raspršivati, stabilna pri čuvanju i u suštini bezvodna, koja sadrži terapeutski efektivnu količinu derivata ili analoga vitamina D i terapeutski efektivnu količinu kortikosteroida, pri čemu su derivat ili analog vitamina D i kortikosteroid otopljeni u farmaceutski prihvatljivom pogonskom sredstvu koje je izabrano iz grupe koja se sastoji od dimetil etera, dietil etera i metiletil etera ili smjese pogonskih sredstava koja sadrži prvo pogonsko sredstvo, koje je izabrano iz grupe koja se sastoji od dimetil etera, dietil etera i metiletil etera, i drugo pogonsko sredstvo koje je izabrano iz grupe koja se sastoji od C3-5 alkana, hidrofluoroalkana, hidrokloroalkana, fluoroalkana i klorofluoroalkana, a kompozicija dalje sadrži farmaceutski prihvatljivi lipidni nosač koji je rastvoren ili suspendiran u spomenutom pogonskom sredstvu ili smjesi pogonskih sredstava, pri čemu lipidni nosač sadrži jedan ili više lipida koji poslije nanošenja na kožu i isparavanja pogonskog sredstva formiraju polu-čvrsti i okluzivni sloj na mjestu nanošenja.
2. Kompozicija prema zahtjevu 1, pri čemu je derivat ili analog vitamina D izabran iz grupe koja se sastoji od kalcipotriola, kalcitriola, takalcitola, maksakalcitola, parikalcitola i alfakalcidola.
3. Kompozicija prema zahtjevu 2, pri čemu je analog vitamina D kalcipotriol ili kalcipotriol monohidrat.
4. Kompozicija prema bilo kojem od zahtjeva 1-3, pri čemu je kortikosteroid izabran iz grupe koja se sastoji od betametazona, budesonida, klobetazola, klobetazona, dezoksimetazona, diflukortolona, diflorazona, fluocinonida, fluocinolona, halcinonida, halobetazola, hidrokortizona, mometazona i triamcinolona ili je njegov farmaceutski prihvatljivi ester.
5. Kompozicija prema zahtjevu 4, pri čemu je ester kortikosteroida betametazon dipropionat, betametazon valerat, klobetazol propionat ili hidrokortizon acetat ili hidrokortizon butirat.
6. Kompozicija prema bilo kojem od zahtjeva 1-5 koja dalje sadrži ne-isparljivi uljni ko-rastvarač koji je izabran iz najmanje jedne od sljedećih klasa rastvarača (a) spoj opće formule I H(OCH2C(CH3)H)xOR1 pri čemu je R1ravnolančani ili razgranati C1-20 alkil, i x je cijeli broj od 2-60; (b) izopropil ester ravnolančane ili razgranate C10-18 alkanske ili alkenske kiseline; (c) propilen glikol diester C8-14 alkanske ili alkenske kiseline; (d) ravnolančani ili razgranati C8-24 alkanol ili alkenol; (e) visoko rafinirana biljna ulja, kao što su trigliceridi s lancem srednje dužine ili trigliceridi s dugim lancem; i (f) N-alkilpirolidon ili N-alkilpiperidon.
7. Kompozicija prema zahtjevu 6, pri čemu je spoj opće formule I polioksipropilen-15-stearil eter, polioksipropilen-11-stearil eter, polioksipropilen-14-butil eter, polioksipropilen-10-cetil eter ili polioksipropilen-3-miristil eter.
8. Kompozicija prema zahtjevu 6, pri čemu je izopropil ester ravnolančane ili razgranate C10-18 alkanske ili alkenske kiseline izopropil miristat, izopropil palmitat, izopropil izostearat, izopropil linoleat ili izopropil monooleat.
9. Kompozicija prema zahtjevu 6, pri čemu propilen glikol diester C8-14 alkanske kiseline je propilen glikol dipelargonat.
10. Kompozicija prema zahtjevu 6, pri čemu je ravnolančani C8-24 alkanol kapril, lauril, cetil, stearil, oleil, linoleil ili miristil alkohol, ili pri čemu je razgranati C8-24 alkanol razgranati C18-24 alkanol, kao što je 2-oktildodekanol.
11. Kompozicija prema zahtjevu 6, pri čemu N-alkilpirolidon je N-metilpirolidon.
12. Kompozicija prema bilo kojem od zahtjeva 1-11, pri čemu je pogonsko sredstvo dimetil eter.
13. Kompozicija prema bilo kojem od zahtjeva 1-11, pri čemu je prvo pogonsko sredstvo smjese pogonskih sredstava dimetil eter.
14. Kompozicija prema bilo kojem od zahtjeva 1-13, pri čemu je drugo pogonsko sredstvo smjese pogonskih sredstava C3-5alkan, a prvenstveno je izabran iz grupe koja se sastoji od n-propana, izopropana, n-butana i izobutana.
15. Kompozicija prema zahtjevu 14, pri čemu je C3-5alkan n-butan i/ili izobutan.
16. Kompozicija prema zahtjevu 15, pri čemu je odnos n-butana i/ili izobutana prema dimetil eteru u rasponu od 6:1-0:1 v/v, kao što su 5:1-1:2, 4:1-1:1, 4:2-1:1, 4:2-4:3 ili 4:2-1:1.
17. Kompozicija prema zahtjevu 1, koja sadrži (a) 0,00001-0,05% w/w derivata ili analoga vitamina D, (b) 0,0005-1% w/w kortikosteroida, (c) 5-55% w/w lipidnog nosača, i (d) 45-95% w/w pogonskog sredstva ili smjese pogonskih sredstava.
18. Kompozicija prema zahtjevu 17 koja sadrži 10-50% w/w, 15-45% w/w, ili 20-40% w/w lipidnog nosača.
19. Kompozicija prema zahtjevima 17-18 koja sadrži 50-90% w/w ili 55-70% w/w pogonskog sredstva ili smjese pogonskih sredstava.
20. Kompozicija prema bilo kojem od zahtjeva 17-19, koja dalje sadrži 0,1-10% w/w uljnog ko-rastvarača prema zahtjevu 6, kao što je 0,5-3% w/w, 1-2,5% w/w ili 1,5-2% w/w uljnog rastvarača.
21. Kompozicija prema bilo kojem od zahtjeva 1-20, pri čemu lipidni nosač sadrži najmanje jedan parafin koji je izabran između parafina koji se sastoje od ugljikovodika sa dužinom lanca od C5 do C60, pri čemu je dužina lanca najveća za C14-16, C18-22, C20-22, C20-26, C28-40, i C40-44 (što je određeno plinskom kromatografijom), ili lipofilni agens za povećanje viskoznosti koji može prenijeti lipidnom nosaču svojstvo formiranja polu-čvrstog i okluzivnog sloja na koži poslije nanošenja i isparavanja pogonskog sredstva, pri čemu je spomenuti agens za povećanje viskoznosti izabran iz grupe koja se sastoji od mikro kristalnog voska, silikonskog voska i hidrogeniziranog ricinusovog ulja ili njihovih smjesa, ili izoparafin, kao što je izoheksadekan.
22. Spremnik pod pritiskom koji je prilagođen za disperziranje topičke kompozicije na oboljelompodručju kože, pri čemu spremnik sadrži tijelo spremnika, koje sadrži kompoziciju prema bilo kojem od zahtjeva 1-21 i ventilski sklop koji sadrži aktuator za oslobađanje kompozicije u obliku spreja.
23. Spremnik prema zahtjevu 22, pri čemu ventilski sklop sadrži najmanje jedan otvor promjera od 0,05-1 mm.
24. Spremnik prema zahtjevu 22, pri čemu aktuator ima ulazni otvor promjera od 0,3-1,5 mm.
25. Kompozicija prema bilo kom od zahtjeva 1-21 za primjenu u liječenju dermatoloških bolesti ili stanja izabranih iz grupe koja se sastoji od psorijaze, pustuloze palmoplantaris, ihtioze, dermatitisa, rozacee i akni.
HRP20150154AT 2010-06-11 2015-02-09 Raspršivi farmaceutski pripravak koji sadrži analog vitamina d i kortikosteroid HRP20150154T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35389310P 2010-06-11 2010-06-11
EP11726055.4A EP2579852B1 (en) 2010-06-11 2011-06-10 A pharmaceutical spray composition comprising a vitamin d analogue and a corticosteroid
PCT/DK2011/000060 WO2011154004A1 (en) 2010-06-11 2011-06-10 A pharmaceutical spray composition comprising a vitamin d analogue and a corticosteroid

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HRP20150154T1 true HRP20150154T1 (hr) 2015-04-10

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US (11) US9119781B2 (hr)
EP (2) EP2579852B1 (hr)
JP (3) JP5945268B2 (hr)
KR (2) KR101749514B1 (hr)
CN (1) CN102939078B (hr)
AU (1) AU2011264198B2 (hr)
BR (1) BR112012030653B1 (hr)
CA (1) CA2800181C (hr)
CY (1) CY1115991T1 (hr)
DK (1) DK2579852T3 (hr)
ES (1) ES2529506T3 (hr)
HK (1) HK1182321A1 (hr)
HR (1) HRP20150154T1 (hr)
IL (2) IL222865A (hr)
MX (1) MX2012013591A (hr)
MY (1) MY167691A (hr)
NZ (1) NZ603470A (hr)
PL (1) PL2579852T3 (hr)
PT (1) PT2579852E (hr)
RS (1) RS53809B1 (hr)
RU (1) RU2576607C2 (hr)
SG (1) SG185521A1 (hr)
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