HRP20140372T1 - Stabilni sns-595 pripravci i postupci za njihovu pripremu - Google Patents
Stabilni sns-595 pripravci i postupci za njihovu pripremu Download PDFInfo
- Publication number
- HRP20140372T1 HRP20140372T1 HRP20140372AT HRP20140372T HRP20140372T1 HR P20140372 T1 HRP20140372 T1 HR P20140372T1 HR P20140372A T HRP20140372A T HR P20140372AT HR P20140372 T HRP20140372 T HR P20140372T HR P20140372 T1 HRP20140372 T1 HR P20140372T1
- Authority
- HR
- Croatia
- Prior art keywords
- sns
- substance
- compound
- image
- hydrate
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 9
- 239000000203 mixture Substances 0.000 title 1
- XZAFZXJXZHRNAQ-STQMWFEESA-N vosaroxin Chemical compound C1[C@H](OC)[C@@H](NC)CN1C1=CC=C2C(=O)C(C(O)=O)=CN(C=3SC=CN=3)C2=N1 XZAFZXJXZHRNAQ-STQMWFEESA-N 0.000 claims 17
- 239000000126 substance Substances 0.000 claims 11
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 6
- 238000006386 neutralization reaction Methods 0.000 claims 5
- 238000006243 chemical reaction Methods 0.000 claims 4
- 229940126214 compound 3 Drugs 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 claims 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 claims 2
- 229940125904 compound 1 Drugs 0.000 claims 2
- 229940125782 compound 2 Drugs 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 229940125898 compound 5 Drugs 0.000 claims 1
- 230000018044 dehydration Effects 0.000 claims 1
- 238000006297 dehydration reaction Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Compounds Of Unknown Constitution (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Claims (8)
1. Postupak za pripravu tvari SNS-595, koji podrazumijeva:
(a) reakciju spoja 3
[image]
sa prvom vodenom bazom, nakon čega slijedi neutraliziranje da se dobije primarni SNS-595 hidrat ;
(b) dehidriranje primarnog SNS-595 hidrata iz koraka (a) i reakciju isušenog produkta s drugom vodenom bazom, nakon čega slijedi neutraliziranje da se dobije sekundarni SNS-595 hidrat ; i
(c) dehidriranje sekundarnog SNS-595 hidrata dobivenog u koraku (b), da se dobije tvar SNS-595.
2. Postupak prema zahtjevu 1, naznačen time, da su prva i druga vodena baza odabrane između kalijeva hidroksida, natrijeva hidroksida, i litij hidroksida ; neutralizacijski koraci (a) i (b) se postižu s octenom kiselinom ; i dehidracije koraka (b) i (c) se postiže s etanolom.
3. Postupak prema zahtjevu 2, naznačen time, da su prva i druga vodena baza natrijev hidroksid.
4. Postupak prema bilo kojem od zahtjeva 1 do 3, naznačen time, da tvar SNS-595 dobivena iz koraka (c) sadrži 0 do 0,01% Spoja 4 :
[image]
na temelju ukupne težine tvari SNS-595.
5. Postupak prema bilo kojem od zahtjeva 1 do 4, naznačen time, da tvar SNS-595 dobivena iz koraka (c) sadrži 0 do 0,02% Spoja 5 :
[image]
na temelju ukupne težine tvari SNS-595.
6. Postupak prema bilo kojem od zahtjeva 1 do 5, naznačen time, da tvar SNS-595 dobivena iz koraka (c) sadrži 0 do 0.1% Spoja 7 :
[image]
na temelju ukupne težine tvari SNS-595.
7. Postupak prema zahtjevu 1, naznačen time, da se Spoj 3 dobiva reakcijom spoja 1
[image]
sa spojem 2
[image]
8. Postupak prema zahtjevu 1, naznačen time, da podrazumijeva:
(a) reakciju spoja 1
[image]
sa spojem 2
[image]
u prisustvu DIPEA i vode da bi se dobio spoj 3
[image]
(b) reakciju Spoja 3 sa prvom vodenom bazom, nakon čega slijedi neutraliziranje da se dobije primarni SNS-595 hidrat ;
(c) dehidriranje primarnog SNS-595 hidrata dobivenog u koraku (b), čime se dobije tvar 595-SNS;
(d) reakciju SNS-595 tvari iz stupnja (c) s drugom vodenom bazom, nakon čega slijedi neutraliziranje da se dobije sekundarni SNS-595 hidrat ; i
(e) dehidriranje sekundarnog SNS-595 hidrata dobivenog u koraku (d) da se dobije tvar 595-SNS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24016109P | 2009-09-04 | 2009-09-04 | |
PCT/US2010/047776 WO2011028979A1 (en) | 2009-09-04 | 2010-09-03 | Stable sns-595 compositions and methods of preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20140372T1 true HRP20140372T1 (hr) | 2014-06-20 |
Family
ID=42990341
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20140372AT HRP20140372T1 (hr) | 2009-09-04 | 2014-04-22 | Stabilni sns-595 pripravci i postupci za njihovu pripremu |
Country Status (26)
Country | Link |
---|---|
US (5) | US8586601B2 (hr) |
EP (2) | EP2674431A1 (hr) |
JP (3) | JP6339315B2 (hr) |
KR (3) | KR20170102568A (hr) |
CN (2) | CN102596948B (hr) |
AU (1) | AU2010289337B2 (hr) |
BR (1) | BR112012004916A2 (hr) |
CA (2) | CA3002440A1 (hr) |
CL (1) | CL2012000565A1 (hr) |
CO (1) | CO6511211A2 (hr) |
DK (1) | DK2473507T3 (hr) |
EA (2) | EA201400683A1 (hr) |
ES (1) | ES2462502T3 (hr) |
HK (1) | HK1172032A1 (hr) |
HR (1) | HRP20140372T1 (hr) |
IL (3) | IL218404A (hr) |
MX (1) | MX2012002573A (hr) |
NZ (2) | NZ623780A (hr) |
PH (1) | PH12014500714A1 (hr) |
PL (1) | PL2473507T3 (hr) |
PT (1) | PT2473507E (hr) |
SG (3) | SG10201808097QA (hr) |
TW (2) | TWI615391B (hr) |
UA (1) | UA110465C2 (hr) |
WO (1) | WO2011028979A1 (hr) |
ZA (1) | ZA201201469B (hr) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3053579A1 (en) | 2004-03-15 | 2016-08-10 | Sunesis Pharmaceuticals, Inc. | Use of sns-595 for treating ovarian cancer |
US20100048609A1 (en) * | 2006-08-01 | 2010-02-25 | Jacobs Jeffrey W | Pharmaceutical dosage forms for (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid |
WO2009054935A1 (en) | 2007-10-22 | 2009-04-30 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid in combination therapy |
US20110008371A1 (en) | 2007-12-10 | 2011-01-13 | Sunesis Pharmaceuticals, Inc | Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of antecedent hematologic disorders |
SG10201504789RA (en) | 2008-12-31 | 2015-07-30 | Sunesis Pharmaceuticals Inc | Method Of Preparing (+)-1,4-Dihydro-7-[(3s,4s)-3methoxy-4-(Methylamino)-1-Pyrrolidinyl]-4-Oxo-1-(2-Thiazolyl)-1,8-Naphthyridine-3-Carboxylic Acid |
UA110465C2 (en) | 2009-09-04 | 2016-01-12 | Sunesis Pharmaceutecals Inc | Stable sns-595 composition |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6233176A (ja) * | 1985-08-05 | 1987-02-13 | Toyama Chem Co Ltd | 1,4−ジヒドロ−4−オキソナフチリジン誘導体およびその塩 |
RO117793B1 (ro) | 1994-06-14 | 2002-07-30 | Dainippon Pharmaceutical Co | Derivati de acid piridoncarboxilic si compozitie farmaceutica care ii contine |
JPH10173986A (ja) | 1996-12-16 | 1998-06-26 | Sony Corp | 移動体撮影装置 |
JP4294121B2 (ja) * | 1998-06-05 | 2009-07-08 | 大日本住友製薬株式会社 | ピリドンカルボン酸誘導体の製造方法およびその中間体 |
JP4178783B2 (ja) | 2001-10-19 | 2008-11-12 | 三菱化学株式会社 | 光学記録媒体 |
EP3053579A1 (en) | 2004-03-15 | 2016-08-10 | Sunesis Pharmaceuticals, Inc. | Use of sns-595 for treating ovarian cancer |
US8580814B2 (en) * | 2006-04-03 | 2013-11-12 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4- oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer |
WO2007146335A2 (en) | 2006-06-12 | 2007-12-21 | Sunesis Pharmaceuticals, Inc. | Compounds and compositions for treatment of cancer |
US20100048609A1 (en) * | 2006-08-01 | 2010-02-25 | Jacobs Jeffrey W | Pharmaceutical dosage forms for (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid |
US20080063642A1 (en) * | 2006-08-02 | 2008-03-13 | Adelman Daniel C | Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of certain hematologic disorders |
WO2009054935A1 (en) * | 2007-10-22 | 2009-04-30 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid in combination therapy |
US20110008371A1 (en) * | 2007-12-10 | 2011-01-13 | Sunesis Pharmaceuticals, Inc | Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of antecedent hematologic disorders |
SG10201504789RA (en) * | 2008-12-31 | 2015-07-30 | Sunesis Pharmaceuticals Inc | Method Of Preparing (+)-1,4-Dihydro-7-[(3s,4s)-3methoxy-4-(Methylamino)-1-Pyrrolidinyl]-4-Oxo-1-(2-Thiazolyl)-1,8-Naphthyridine-3-Carboxylic Acid |
SG10201400258SA (en) | 2009-02-27 | 2014-05-29 | Sunesis Pharmaceuticals Inc | Methods Of Using SNS-595 For Treatment Of Cancer Subjects With Reduced BRCA2 Activity |
UA110465C2 (en) | 2009-09-04 | 2016-01-12 | Sunesis Pharmaceutecals Inc | Stable sns-595 composition |
WO2011056566A2 (en) | 2009-10-26 | 2011-05-12 | Sunesis Pharmaceuticals, Inc. | Compounds and methods for treatment of cancer |
-
2010
- 2010-03-09 UA UAA201204145A patent/UA110465C2/uk unknown
- 2010-09-03 EA EA201400683A patent/EA201400683A1/ru unknown
- 2010-09-03 EP EP13184180.1A patent/EP2674431A1/en not_active Withdrawn
- 2010-09-03 EP EP10759761.9A patent/EP2473507B1/en active Active
- 2010-09-03 SG SG10201808097QA patent/SG10201808097QA/en unknown
- 2010-09-03 EA EA201270377A patent/EA201270377A1/ru unknown
- 2010-09-03 PL PL10759761T patent/PL2473507T3/pl unknown
- 2010-09-03 AU AU2010289337A patent/AU2010289337B2/en not_active Ceased
- 2010-09-03 BR BR112012004916A patent/BR112012004916A2/pt not_active Application Discontinuation
- 2010-09-03 JP JP2012528076A patent/JP6339315B2/ja not_active Expired - Fee Related
- 2010-09-03 SG SG2012014866A patent/SG178956A1/en unknown
- 2010-09-03 WO PCT/US2010/047776 patent/WO2011028979A1/en active Application Filing
- 2010-09-03 CA CA3002440A patent/CA3002440A1/en not_active Abandoned
- 2010-09-03 DK DK10759761.9T patent/DK2473507T3/da active
- 2010-09-03 MX MX2012002573A patent/MX2012002573A/es unknown
- 2010-09-03 TW TW099129946A patent/TWI615391B/zh not_active IP Right Cessation
- 2010-09-03 ES ES10759761.9T patent/ES2462502T3/es active Active
- 2010-09-03 CN CN201080050160.7A patent/CN102596948B/zh not_active Expired - Fee Related
- 2010-09-03 KR KR1020177024177A patent/KR20170102568A/ko active Application Filing
- 2010-09-03 CA CA2772291A patent/CA2772291A1/en not_active Abandoned
- 2010-09-03 US US12/875,927 patent/US8586601B2/en active Active
- 2010-09-03 PT PT107597619T patent/PT2473507E/pt unknown
- 2010-09-03 NZ NZ623780A patent/NZ623780A/en not_active IP Right Cessation
- 2010-09-03 SG SG2014013163A patent/SG2014013163A/en unknown
- 2010-09-03 KR KR1020127008282A patent/KR101811763B1/ko active IP Right Grant
- 2010-09-03 CN CN201410318200.1A patent/CN104177359B/zh not_active Expired - Fee Related
- 2010-09-03 NZ NZ598467A patent/NZ598467A/en not_active IP Right Cessation
- 2010-09-03 KR KR1020187028458A patent/KR20180112103A/ko not_active Application Discontinuation
- 2010-09-03 TW TW103137080A patent/TWI519535B/zh not_active IP Right Cessation
- 2010-12-30 US US12/982,785 patent/US8138202B2/en not_active Expired - Fee Related
-
2012
- 2012-02-28 ZA ZA2012/01469A patent/ZA201201469B/en unknown
- 2012-02-29 IL IL218404A patent/IL218404A/en not_active IP Right Cessation
- 2012-03-02 CL CL2012000565A patent/CL2012000565A1/es unknown
- 2012-03-05 CO CO12038188A patent/CO6511211A2/es unknown
- 2012-12-17 HK HK12112980.3A patent/HK1172032A1/xx not_active IP Right Cessation
-
2013
- 2013-10-16 US US14/055,590 patent/US9469635B2/en active Active
-
2014
- 2014-03-28 PH PH12014500714A patent/PH12014500714A1/en unknown
- 2014-04-22 HR HRP20140372AT patent/HRP20140372T1/hr unknown
-
2015
- 2015-03-12 IL IL237724A patent/IL237724A/en not_active IP Right Cessation
- 2015-12-18 JP JP2015247670A patent/JP2016104769A/ja active Pending
-
2016
- 2016-09-16 US US15/267,911 patent/US9969730B2/en active Active
- 2016-09-20 IL IL247929A patent/IL247929B/en not_active IP Right Cessation
-
2018
- 2018-03-05 JP JP2018038783A patent/JP2018127457A/ja active Pending
- 2018-04-11 US US15/951,061 patent/US20190084978A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HRP20140372T1 (hr) | Stabilni sns-595 pripravci i postupci za njihovu pripremu | |
BRPI0907444A2 (pt) | Estolides sulfonados e outros derivados de ácidos graxos, métodos de fazê-los, e composições e processos os empregam | |
EA201070345A1 (ru) | Смесь производных фурфураля и 5-алкоксиметилфурфураля из сахаров и спиртов | |
NZ603762A (en) | Production of soluble protein solutions from pulses | |
WO2013128294A8 (en) | Process for preparation of dronedarone by the use of dibutylaminopropanol reagent | |
MX2012013610A (es) | Complejo obtenido a partir de mezclas de acido hialuronico o una sal del mismo y sulfato de condroitina. | |
PT2462098E (pt) | Processos para a preparação de derivados de ácido 1-(2- halobifenil-4-il)-ciclopropanocarboxílico | |
MX2011007301A (es) | Dabigatran liofilizado. | |
PE20140200A1 (es) | Metodo para producir y usar un copolimero de carboximetilcelulosa sodica y gosipol | |
DK2152667T3 (da) | Fremgangsmåder til fremstilling af N-isobutyl-n-(2-hydroxy-3-amin-4-phenylbutyl)-p-nitrobenzenesulfonylamid-derivater | |
RU2016141383A (ru) | Увлажняющие агенты | |
CN103232430A (zh) | 一种利伐沙班中间体5-氯噻吩-2-羧酸的制备方法 | |
JP2010037221A5 (hr) | ||
EA200971019A1 (ru) | Способы получения (r)-2-метилпирролидина и (s)-2-метилпирролидина и их солей винной кислоты | |
JP2014529002A5 (hr) | ||
WO2012150607A3 (en) | Oral liquid composition comprising divalproex sodium and process for preparing thereof | |
RU2010130899A (ru) | Способ получения неостигмина метилсульфата и неостигмина йодида | |
MX2011007586A (es) | Composiciones y metodo para bloquear la respuesta de etileno en cultivos usando sal sodica de 3-(ciclopropil-1-enil)-propanoico. | |
WO2010079497A3 (en) | Novel polymorph of atazanavir sulfate | |
DK2457921T3 (da) | Aureolinsyre-derivater, en fremgangsmåde til fremstilling deraf samt anvendelser deraf | |
RU2009116482A (ru) | Способ синтеза органического соединения, предотвращающего развитие стрессовых реакций в организме животных | |
WO2009072139A8 (en) | Process for producing 2-[1-methyl-5-(4-methylbenzoyl)- pyrrol-2- yl]acetic acid or salt thereof | |
AR093929A1 (es) | Uso de ditionito sodico en el proceso de coccion de la pasta celulosica | |
MX364766B (es) | Proceso para la preparacion de un derivado sulfatado de 3,5-diiodo-o-[3-iodofenil]-l-tirosina. | |
AR087118A1 (es) | Metodo de preparacion de derivado de acido ciclohexano carboxilico |