PL2473507T3 - Trwałe kompozycje SNS-595 i sposoby ich wytwarzania - Google Patents

Trwałe kompozycje SNS-595 i sposoby ich wytwarzania

Info

Publication number
PL2473507T3
PL2473507T3 PL10759761T PL10759761T PL2473507T3 PL 2473507 T3 PL2473507 T3 PL 2473507T3 PL 10759761 T PL10759761 T PL 10759761T PL 10759761 T PL10759761 T PL 10759761T PL 2473507 T3 PL2473507 T3 PL 2473507T3
Authority
PL
Poland
Prior art keywords
compositions
preparation
methods
sns
stable
Prior art date
Application number
PL10759761T
Other languages
English (en)
Inventor
Anantha Sudhakar
Jeff Jacobs
Ahmad Hashash
Sean Ritchie
Hengqin Cheng
Original Assignee
Sunesis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sunesis Pharmaceuticals Inc filed Critical Sunesis Pharmaceuticals Inc
Publication of PL2473507T3 publication Critical patent/PL2473507T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PL10759761T 2009-09-04 2010-09-03 Trwałe kompozycje SNS-595 i sposoby ich wytwarzania PL2473507T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24016109P 2009-09-04 2009-09-04
PCT/US2010/047776 WO2011028979A1 (en) 2009-09-04 2010-09-03 Stable sns-595 compositions and methods of preparation
EP10759761.9A EP2473507B1 (en) 2009-09-04 2010-09-03 Stable sns-595 compositions and methods of preparation

Publications (1)

Publication Number Publication Date
PL2473507T3 true PL2473507T3 (pl) 2014-08-29

Family

ID=42990341

Family Applications (1)

Application Number Title Priority Date Filing Date
PL10759761T PL2473507T3 (pl) 2009-09-04 2010-09-03 Trwałe kompozycje SNS-595 i sposoby ich wytwarzania

Country Status (26)

Country Link
US (5) US8586601B2 (pl)
EP (2) EP2473507B1 (pl)
JP (3) JP6339315B2 (pl)
KR (3) KR20180112103A (pl)
CN (2) CN104177359B (pl)
AU (1) AU2010289337B2 (pl)
BR (1) BR112012004916A2 (pl)
CA (2) CA2772291A1 (pl)
CL (1) CL2012000565A1 (pl)
CO (1) CO6511211A2 (pl)
DK (1) DK2473507T3 (pl)
EA (2) EA201270377A1 (pl)
ES (1) ES2462502T3 (pl)
HK (1) HK1172032A1 (pl)
HR (1) HRP20140372T1 (pl)
IL (3) IL218404A (pl)
MX (1) MX2012002573A (pl)
NZ (2) NZ598467A (pl)
PH (1) PH12014500714B1 (pl)
PL (1) PL2473507T3 (pl)
PT (1) PT2473507E (pl)
SG (3) SG2014013163A (pl)
TW (2) TWI615391B (pl)
UA (1) UA110465C2 (pl)
WO (1) WO2011028979A1 (pl)
ZA (1) ZA201201469B (pl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX349188B (es) 2004-03-15 2017-07-17 Sunesis Pharmaceuticals Inc Sns - 595 y metodos para utilizar el mismo.
WO2008016678A2 (en) * 2006-08-01 2008-02-07 Sunesis Pharmaceuticals, Inc. Pharmaceutical dosage forms for (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid
WO2009054935A1 (en) 2007-10-22 2009-04-30 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid in combination therapy
EP2649997B1 (en) 2007-12-10 2019-01-23 Sunesis Pharmaceuticals, Inc. (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for use in the treatment of myelodyspastic syndrome
KR20170090535A (ko) 2008-12-31 2017-08-07 선에시스 파마슈티컬스 인코포레이티드 (+)-1,4-다이하이드로-7-[(3s,4s)-3-메톡시-4-(메틸아미노)-1-피롤리딘일]-4-옥소-1-(2-티아졸릴)-1,8-나프티리딘-3-카복실산의 제조 방법
UA110465C2 (en) 2009-09-04 2016-01-12 Sunesis Pharmaceutecals Inc Stable sns-595 composition

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6233176A (ja) * 1985-08-05 1987-02-13 Toyama Chem Co Ltd 1,4−ジヒドロ−4−オキソナフチリジン誘導体およびその塩
EP0787726B1 (en) * 1994-06-14 2001-11-28 Dainippon Pharmaceutical Co., Ltd. Novel compound, process for producing the same, and antitumor agent
JPH10173986A (ja) 1996-12-16 1998-06-26 Sony Corp 移動体撮影装置
JP4294121B2 (ja) 1998-06-05 2009-07-08 大日本住友製薬株式会社 ピリドンカルボン酸誘導体の製造方法およびその中間体
JP4178783B2 (ja) 2001-10-19 2008-11-12 三菱化学株式会社 光学記録媒体
MX349188B (es) 2004-03-15 2017-07-17 Sunesis Pharmaceuticals Inc Sns - 595 y metodos para utilizar el mismo.
US8580814B2 (en) 2006-04-03 2013-11-12 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4- oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer
EP2043645A2 (en) * 2006-06-12 2009-04-08 Sunesis Pharmaceuticals, Inc. Compounds and compositions for treatment of cancer
WO2008016678A2 (en) 2006-08-01 2008-02-07 Sunesis Pharmaceuticals, Inc. Pharmaceutical dosage forms for (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid
DK2049109T3 (en) 2006-08-02 2016-01-11 Sunesis Pharmaceuticals Inc Combined use of (+) - 1,4-dihydro-7 - [(3S, 4S) -3-methoxy-4- (methylamino) -1-pyrrolidinyl] -4-oxo-1- (2-thiazolyl) -1,8-naphthyridine-3-carboxylic acid and cytarabine (Ara-C) for the treatment of leukemia
WO2009054935A1 (en) 2007-10-22 2009-04-30 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid in combination therapy
EP2649997B1 (en) 2007-12-10 2019-01-23 Sunesis Pharmaceuticals, Inc. (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for use in the treatment of myelodyspastic syndrome
KR20170090535A (ko) 2008-12-31 2017-08-07 선에시스 파마슈티컬스 인코포레이티드 (+)-1,4-다이하이드로-7-[(3s,4s)-3-메톡시-4-(메틸아미노)-1-피롤리딘일]-4-옥소-1-(2-티아졸릴)-1,8-나프티리딘-3-카복실산의 제조 방법
CN104688732A (zh) 2009-02-27 2015-06-10 逊尼希思制药公司 利用sns-595治疗具有降低的brca2活性的癌症对象的方法
UA110465C2 (en) 2009-09-04 2016-01-12 Sunesis Pharmaceutecals Inc Stable sns-595 composition
WO2011056566A2 (en) 2009-10-26 2011-05-12 Sunesis Pharmaceuticals, Inc. Compounds and methods for treatment of cancer

Also Published As

Publication number Publication date
HK1172032A1 (en) 2013-04-12
US20170226104A1 (en) 2017-08-10
US20190084978A1 (en) 2019-03-21
PH12014500714A1 (en) 2015-09-07
EP2473507A1 (en) 2012-07-11
US8138202B2 (en) 2012-03-20
EP2473507B1 (en) 2014-03-19
US20110086876A1 (en) 2011-04-14
SG178956A1 (en) 2012-04-27
ES2462502T3 (es) 2014-05-23
CO6511211A2 (es) 2012-08-31
KR20120078711A (ko) 2012-07-10
PT2473507E (pt) 2014-05-23
EA201400683A1 (ru) 2015-05-29
SG10201808097QA (en) 2018-10-30
TW201114767A (en) 2011-05-01
SG2014013163A (en) 2014-09-26
IL218404A (en) 2015-07-30
CA3002440A1 (en) 2011-03-10
TWI519535B (zh) 2016-02-01
CN104177359A (zh) 2014-12-03
CA2772291A1 (en) 2011-03-10
TWI615391B (zh) 2018-02-21
CN102596948A (zh) 2012-07-18
US9469635B2 (en) 2016-10-18
WO2011028979A1 (en) 2011-03-10
KR101811763B1 (ko) 2017-12-22
KR20170102568A (ko) 2017-09-11
CL2012000565A1 (es) 2012-12-07
US9969730B2 (en) 2018-05-15
JP2016104769A (ja) 2016-06-09
KR20180112103A (ko) 2018-10-11
IL247929B (en) 2018-01-31
AU2010289337A1 (en) 2012-03-22
JP2013503899A (ja) 2013-02-04
CN102596948B (zh) 2015-07-22
UA110465C2 (en) 2016-01-12
BR112012004916A2 (pt) 2017-07-04
IL218404A0 (en) 2012-04-30
HRP20140372T1 (hr) 2014-06-20
NZ623780A (en) 2015-10-30
DK2473507T3 (da) 2014-04-22
US8586601B2 (en) 2013-11-19
EP2674431A1 (en) 2013-12-18
CN104177359B (zh) 2018-06-01
US20140275547A1 (en) 2014-09-18
EA201270377A1 (ru) 2013-01-30
AU2010289337B2 (en) 2014-10-30
JP6339315B2 (ja) 2018-06-06
US20110082169A1 (en) 2011-04-07
NZ598467A (en) 2014-04-30
JP2018127457A (ja) 2018-08-16
MX2012002573A (es) 2012-04-10
PH12014500714B1 (en) 2015-09-07
TW201504240A (zh) 2015-02-01
IL237724A (en) 2016-10-31
ZA201201469B (en) 2013-05-29

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