HRP20130942T1 - Aminodiazepini kao modulatori toll-u sliäśnih receptora - Google Patents
Aminodiazepini kao modulatori toll-u sliäśnih receptora Download PDFInfo
- Publication number
- HRP20130942T1 HRP20130942T1 HRP20130942TT HRP20130942T HRP20130942T1 HR P20130942 T1 HRP20130942 T1 HR P20130942T1 HR P20130942T T HRP20130942T T HR P20130942TT HR P20130942 T HRP20130942 T HR P20130942T HR P20130942 T1 HRP20130942 T1 HR P20130942T1
- Authority
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- Croatia
- Prior art keywords
- alkyl
- compound according
- amino
- alkynyl
- alkenyl
- Prior art date
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- IRTBTAFDVGMKON-UHFFFAOYSA-N 1H-diazepin-3-amine Chemical class NC1=NNC=CC=C1 IRTBTAFDVGMKON-UHFFFAOYSA-N 0.000 title 1
- 102000002689 Toll-like receptor Human genes 0.000 title 1
- 108020000411 Toll-like receptor Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 21
- 229910052760 oxygen Inorganic materials 0.000 claims 10
- 229910052717 sulfur Inorganic materials 0.000 claims 10
- 125000005842 heteroatom Chemical group 0.000 claims 9
- 125000006711 (C2-C12) alkynyl group Chemical group 0.000 claims 8
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 8
- 125000004429 atom Chemical group 0.000 claims 8
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 5
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 4
- 101000800483 Homo sapiens Toll-like receptor 8 Proteins 0.000 claims 4
- 102100033110 Toll-like receptor 8 Human genes 0.000 claims 4
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 125000004404 heteroalkyl group Chemical group 0.000 claims 3
- 206010020751 Hypersensitivity Diseases 0.000 claims 2
- 206010061598 Immunodeficiency Diseases 0.000 claims 2
- 208000029462 Immunodeficiency disease Diseases 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 206010052779 Transplant rejections Diseases 0.000 claims 2
- 208000026935 allergic disease Diseases 0.000 claims 2
- 230000007815 allergy Effects 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 230000005784 autoimmunity Effects 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 230000007813 immunodeficiency Effects 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000006340 pentafluoro ethyl group Chemical group FC(F)(F)C(F)(F)* 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- ZGUWVOMFPNBEOK-UHFFFAOYSA-N 2-amino-n,n-diethyl-3,5-dihydro-1,4-benzodiazepine-4-carboxamide Chemical compound N1=C(N)CN(C(=O)N(CC)CC)CC2=CC=CC=C21 ZGUWVOMFPNBEOK-UHFFFAOYSA-N 0.000 claims 1
- MEHMTLFJLQZZBT-UHFFFAOYSA-N 2-methylpropyl 2-amino-3,5-dihydro-1,4-benzodiazepine-4-carboxylate Chemical compound N1=C(N)CN(C(=O)OCC(C)C)CC2=CC=CC=C21 MEHMTLFJLQZZBT-UHFFFAOYSA-N 0.000 claims 1
- 125000005330 8 membered heterocyclic group Chemical group 0.000 claims 1
- 125000002837 carbocyclic group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- KSPYSBGOHKNAHP-UHFFFAOYSA-N ethyl 2-amino-3,5-dihydro-1,4-benzodiazepine-4-carboxylate Chemical compound N1=C(N)CN(C(=O)OCC)CC2=CC=CC=C21 KSPYSBGOHKNAHP-UHFFFAOYSA-N 0.000 claims 1
- NVXCDARDGHKOLX-UHFFFAOYSA-N ethyl 2-amino-3-methyl-3,5-dihydro-1,4-benzodiazepine-4-carboxylate Chemical compound N1=C(N)C(C)N(C(=O)OCC)CC2=CC=CC=C21 NVXCDARDGHKOLX-UHFFFAOYSA-N 0.000 claims 1
- IVPMMBXZIDYKIZ-UHFFFAOYSA-N ethyl 2-amino-5-methyl-3,5-dihydro-1,4-benzodiazepine-4-carboxylate Chemical compound CC1N(C(=O)OCC)CC(N)=NC2=CC=CC=C21 IVPMMBXZIDYKIZ-UHFFFAOYSA-N 0.000 claims 1
- WGRCOFNVDKASBU-UHFFFAOYSA-N ethyl 2-amino-8-(1,1,2,2,2-pentafluoroethyl)-3,5-dihydro-1,4-benzodiazepine-4-carboxylate Chemical compound N1=C(N)CN(C(=O)OCC)CC2=CC=C(C(F)(F)C(F)(F)F)C=C21 WGRCOFNVDKASBU-UHFFFAOYSA-N 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 210000000987 immune system Anatomy 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- UVXMBSIOKDIPEM-UHFFFAOYSA-N propan-2-yl 2-amino-3,5-dihydro-1,4-benzodiazepine-4-carboxylate Chemical compound N1=C(N)CN(C(=O)OC(C)C)CC2=CC=CC=C21 UVXMBSIOKDIPEM-UHFFFAOYSA-N 0.000 claims 1
- SBLURDIHFKMKJO-UHFFFAOYSA-N propyl 2-amino-3,5-dihydro-1,4-benzodiazepine-4-carboxylate Chemical compound N1=C(N)CN(C(=O)OCCC)CC2=CC=CC=C21 SBLURDIHFKMKJO-UHFFFAOYSA-N 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/20—Nitrogen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Otolaryngology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70966705P | 2005-08-19 | 2005-08-19 | |
| PCT/US2006/032099 WO2007040840A2 (en) | 2005-08-19 | 2006-08-17 | Aminodiazepines as toll-like receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20130942T1 true HRP20130942T1 (hr) | 2013-11-08 |
Family
ID=37890540
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20130942TT HRP20130942T1 (hr) | 2005-08-19 | 2013-10-07 | Aminodiazepini kao modulatori toll-u sliäśnih receptora |
Country Status (10)
Families Citing this family (146)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI382019B (zh) | 2005-08-19 | 2013-01-11 | Array Biopharma Inc | 作為類鐸受體（ｔｏｌｌ-ｌｉｋｅ ｒｅｃｅｐｔｏｒ）調節劑之胺基二氮雜呯 |
| TW201402124A (zh) * | 2005-08-19 | 2014-01-16 | Array Biopharma Inc | 作為類鐸受體（ｔｏｌｌ-ｌｉｋｅ ｒｅｃｅｐｔｏｒ）調節劑之８-經取代苯并氮雜呯 |
| DK2313111T3 (da) | 2008-08-01 | 2013-12-02 | Ventirx Pharmaceuticals Inc | Toll-lignende receptoragonistformuleringer og anvendelse deraf |
| EP2940009B1 (en) | 2008-11-06 | 2018-10-17 | VentiRx Pharmaceuticals, Inc. | Methods of synthesis of benzazepine derivatives |
| US8691809B2 (en) * | 2009-08-18 | 2014-04-08 | Ventirx Pharmaceuticals, Inc. | Substituted benzoazepines as toll-like receptor modulators |
| RU2580320C2 (ru) | 2009-08-18 | 2016-04-10 | Вентиркс Фармасьютикалз, Инк. | Замещенные бензоазепины в качестве модуляторов toll-подобного рецептора |
| AU2010290896B2 (en) | 2009-09-02 | 2014-07-03 | Glaxosmithkline Biologicals S.A. | Immunogenic compositions including TLR activity modulators |
| EP2575876B1 (en) | 2010-05-26 | 2017-12-06 | Selecta Biosciences, Inc. | Multivalent synthetic nanocarrier vaccines |
| CN103313725B (zh) | 2010-09-01 | 2016-06-29 | 诺华有限公司 | 免疫增强剂吸附不溶性金属离子 |
| WO2012061717A1 (en) | 2010-11-05 | 2012-05-10 | Selecta Biosciences, Inc. | Modified nicotinic compounds and related methods |
| CN106749023A (zh) * | 2011-01-12 | 2017-05-31 | 帆德制药股份有限公司 | 作为toll样受体调节剂的取代的苯并氮杂卓 |
| EP2680885B8 (en) | 2011-03-02 | 2018-07-25 | GlaxoSmithKline Biologicals SA | Combination vaccines with lower doses of antigen and/or adjuvant |
| MX2014002363A (es) | 2011-09-01 | 2014-04-14 | Novartis Ag | Formulaciones de antigenos de staphylococcus aureus con adyuvante. |
| JP2015510872A (ja) | 2012-03-07 | 2015-04-13 | ノバルティス アーゲー | Ｓｔｒｅｐｔｏｃｏｃｃｕｓｐｎｅｕｍｏｎｉａｅ抗原の増強された製剤 |
| AU2013229465A1 (en) | 2012-03-07 | 2014-09-04 | Novartis Ag | Adjuvanted formulations of rabies virus immunogens |
| RU2014140521A (ru) | 2012-03-08 | 2016-04-27 | Новартис Аг | Адъювантные составы бустерных вакцин |
| EP2659907A1 (en) | 2012-05-01 | 2013-11-06 | Affiris AG | Compositions |
| EP2659908A1 (en) | 2012-05-01 | 2013-11-06 | Affiris AG | Compositions |
| EP2659906A1 (en) | 2012-05-01 | 2013-11-06 | Affiris AG | Compositions |
| CN112587671A (zh) | 2012-07-18 | 2021-04-02 | 博笛生物科技有限公司 | 癌症的靶向免疫治疗 |
| RU2015106930A (ru) | 2012-09-06 | 2016-10-20 | Новартис Аг | Комбинированные вакцины с менингококком серогруппы в и к/д/с |
| US9228184B2 (en) | 2012-09-29 | 2016-01-05 | Dynavax Technologies Corporation | Human toll-like receptor inhibitors and methods of use thereof |
| US9868955B2 (en) | 2012-09-29 | 2018-01-16 | Dynavax Technologies Corporation | Human toll-like receptor inhibitors and methods of use thereof |
| BR112015008040A2 (pt) | 2012-10-12 | 2017-07-04 | Glaxosmithkline Biologicals Sa | composição de vacina, vacina de combinação, e, processos para preparar um componente ap e para a fabricação de uma composição de vacina |
| CN105188747A (zh) | 2013-02-01 | 2015-12-23 | 葛兰素史密斯克莱生物公司 | 包含toll样受体激动剂的免疫组合物的皮内递送 |
| EP2801372A3 (en) | 2013-05-10 | 2015-02-18 | Novartis AG | Avoiding narcolepsy risk in influenza vaccines |
| AU2015205753A1 (en) | 2014-01-10 | 2016-07-21 | Birdie Biopharmaceuticals Inc. | Compounds and compositions for treating HER2 positive tumors |
| LT3122378T (lt) | 2014-03-26 | 2020-02-10 | Glaxosmithkline Biologicals S.A. | Mutantų stafilokokiniai antigenai |
| CA2954446A1 (en) | 2014-07-09 | 2016-01-14 | Shanghai Birdie Biotech, Inc. | Anti-pd-l1 combinations for treating tumors |
| CN112546231A (zh) | 2014-07-09 | 2021-03-26 | 博笛生物科技有限公司 | 用于治疗癌症的联合治疗组合物和联合治疗方法 |
| CN112546238A (zh) | 2014-09-01 | 2021-03-26 | 博笛生物科技有限公司 | 用于治疗肿瘤的抗-pd-l1结合物 |
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| US20120208801A1 (en) | 2012-08-16 |
| WO2007040840A2 (en) | 2007-04-12 |
| US8673898B2 (en) | 2014-03-18 |
| JP5246865B2 (ja) | 2013-07-24 |
| US8163738B2 (en) | 2012-04-24 |
| WO2007040840A3 (en) | 2007-06-14 |
| HK1122018A1 (en) | 2009-05-08 |
| SI1928845T1 (sl) | 2013-10-30 |
| US20080306050A1 (en) | 2008-12-11 |
| TWI382019B (zh) | 2013-01-11 |
| JP2009504764A (ja) | 2009-02-05 |
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