MA42818A - Modulateurs de récepteurs de type toll pour le traitement du vih - Google Patents
Modulateurs de récepteurs de type toll pour le traitement du vihInfo
- Publication number
- MA42818A MA42818A MA042818A MA42818A MA42818A MA 42818 A MA42818 A MA 42818A MA 042818 A MA042818 A MA 042818A MA 42818 A MA42818 A MA 42818A MA 42818 A MA42818 A MA 42818A
- Authority
- MA
- Morocco
- Prior art keywords
- toll
- receptor modulators
- type receptor
- hiv treatment
- hiv
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
- Quinoline Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562218858P | 2015-09-15 | 2015-09-15 | |
US201662382550P | 2016-09-01 | 2016-09-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA42818A true MA42818A (fr) | 2018-07-25 |
Family
ID=56997570
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA042818A MA42818A (fr) | 2015-09-15 | 2016-09-13 | Modulateurs de récepteurs de type toll pour le traitement du vih |
Country Status (8)
Country | Link |
---|---|
US (2) | US20180263985A1 (fr) |
EP (1) | EP3349757A1 (fr) |
JP (1) | JP2018527366A (fr) |
AU (1) | AU2016322763A1 (fr) |
CA (1) | CA2997955A1 (fr) |
HK (1) | HK1257270A1 (fr) |
MA (1) | MA42818A (fr) |
WO (1) | WO2017048727A1 (fr) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9259426B2 (en) | 2006-07-20 | 2016-02-16 | Gilead Sciences, Inc. | 4,6-di- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections |
HRP20211456T1 (hr) | 2014-12-26 | 2021-12-24 | Emory University | Protuvirusni derivati n4-hidroksicitidina |
SI3321265T1 (sl) | 2015-03-04 | 2020-07-31 | Gilead Sciences, Inc. | Spojine 4,6-diamino-pirido(3,2-d)pirimidina in njihova uporaba kot modulatorji toličnih receptorjev |
MA46093A (fr) * | 2016-09-02 | 2021-05-19 | Gilead Sciences Inc | Composés modulateurs du recepteur de type toll |
US10640499B2 (en) * | 2016-09-02 | 2020-05-05 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
FR3066761B1 (fr) | 2017-05-23 | 2020-10-30 | Centre Nat Rech Scient | Nouveaux composes inhibiteurs des canaux ioniques |
CN108069963B (zh) * | 2017-11-17 | 2020-01-14 | 清华大学 | 吡啶并嘧啶衍生物或其盐及其制法、药物组合物和用途 |
KR102248165B1 (ko) | 2017-12-07 | 2021-05-06 | 에모리 유니버시티 | N4-하이드록시사이티딘 및 유도체 및 이와 관련된 항-바이러스 용도 |
WO2019195181A1 (fr) | 2018-04-05 | 2019-10-10 | Gilead Sciences, Inc. | Anticorps et leurs fragments qui se lient à la protéine x du virus de l'hépatite b |
BR112020026890A2 (pt) * | 2018-07-03 | 2021-03-30 | Jiangsu Hengrui Medicine Co., Ltd. | Derivado de piridopirimidina, método de preparação do mesmo e uso médico do mesmo |
CA3111784A1 (fr) | 2018-09-12 | 2020-03-19 | Silverback Therapeutics, Inc. | Compositions pour le traitement d'une maladie avec des conjugues immunostimulants |
TWI751516B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
TW202212339A (zh) * | 2019-04-17 | 2022-04-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
TW202115056A (zh) | 2019-06-28 | 2021-04-16 | 美商基利科學股份有限公司 | 類鐸受體調節劑化合物的製備方法 |
KR20220047277A (ko) | 2019-07-16 | 2022-04-15 | 길리애드 사이언시즈, 인코포레이티드 | Hiv 백신, 및 이의 제조 및 사용 방법 |
JP2022545872A (ja) * | 2019-08-19 | 2022-11-01 | シャンハイ ジムン バイオファーマ,インコーポレーテッド | 2―アミノピリミジン化合物ならびにその医薬組成物および用途 |
CN117843811A (zh) | 2019-09-30 | 2024-04-09 | 吉利德科学公司 | Hbv疫苗和治疗hbv的方法 |
WO2021067644A1 (fr) | 2019-10-01 | 2021-04-08 | Silverback Therapeutics, Inc. | Polythérapie comprenant des conjugués immunostimulants |
EP3821890A1 (fr) * | 2019-11-18 | 2021-05-19 | Strumberg, Dirk | Compositions pharmaceutiques comprenant un inhibiteur de l'histone désacétylase (hdaci) et un agoniste de récepteur de type toll 7 et/ou 8 (tlr7 et/ou tlr8) et leur utilisation dans le traitement du cancer |
CN116057068A (zh) | 2019-12-06 | 2023-05-02 | 精密生物科学公司 | 对乙型肝炎病毒基因组中的识别序列具有特异性的优化的工程化大范围核酸酶 |
US20230058425A1 (en) * | 2020-01-02 | 2023-02-23 | Jiangsu Hengrui Medicine Co., Ltd. | Crystal form of pyridopyrimidine derivative and preparation method thereof |
WO2021168274A1 (fr) | 2020-02-21 | 2021-08-26 | Silverback Therapeutics, Inc. | Conjugués d'anticorps de nectine-4 et leurs utilisations |
AU2021237718B2 (en) | 2020-03-20 | 2023-09-21 | Gilead Sciences, Inc. | Prodrugs of 4'-C-substituted-2-halo-2'-deoxyadenosine nucleosides and methods of making and using the same |
EP4175673A1 (fr) | 2020-07-01 | 2023-05-10 | ARS Pharmaceuticals Inc. | Conjugués d'anticorps anti-asgr1 et leurs utilisations |
TWI815194B (zh) | 2020-10-22 | 2023-09-11 | 美商基利科學股份有限公司 | 介白素2-Fc融合蛋白及使用方法 |
CN116437958A (zh) | 2020-11-11 | 2023-07-14 | 吉利德科学公司 | 鉴定对采用gp120 CD4结合位点导向的抗体的疗法敏感的HIV患者的方法 |
CA3202466A1 (fr) | 2021-01-14 | 2022-07-21 | Jiani LI | Vaccins contre le vih et methodes d'utilisation |
WO2022241134A1 (fr) | 2021-05-13 | 2022-11-17 | Gilead Sciences, Inc. | Combinaison d'un composé de modulation de tlr8 et agent thérapeutique anti-arnsi de vhb |
KR20240005901A (ko) | 2021-06-23 | 2024-01-12 | 길리애드 사이언시즈, 인코포레이티드 | 디아실글리세롤 키나제 조절 화합물 |
WO2022271677A1 (fr) | 2021-06-23 | 2022-12-29 | Gilead Sciences, Inc. | Composés de modulation de la diacylglycérol kinase |
WO2022271659A1 (fr) | 2021-06-23 | 2022-12-29 | Gilead Sciences, Inc. | Composés modulant les diacylglycérol kinases |
CA3235937A1 (fr) | 2021-12-03 | 2023-06-08 | Gilead Sciences, Inc. | Composes therapeutiques contre l'infection par le virus du vih |
KR20240117588A (ko) | 2021-12-03 | 2024-08-01 | 길리애드 사이언시즈, 인코포레이티드 | Hiv 바이러스 감염 치료용 화합물 |
EP4440701A1 (fr) | 2021-12-03 | 2024-10-09 | Gilead Sciences, Inc. | Composés thérapeutiques pour l'infection par le virus du vih |
TWI843506B (zh) | 2022-04-06 | 2024-05-21 | 美商基利科學股份有限公司 | 橋聯三環胺甲醯基吡啶酮化合物及其用途 |
TW202402280A (zh) | 2022-07-01 | 2024-01-16 | 美商基利科學股份有限公司 | 可用於hiv病毒感染之疾病預防性或治療性治療的治療性化合物 |
WO2024044477A1 (fr) | 2022-08-26 | 2024-02-29 | Gilead Sciences, Inc. | Régime de dosage et de planification pour anticorps largement neutralisants |
US20240226130A1 (en) | 2022-10-04 | 2024-07-11 | Gilead Sciences, Inc. | 4'-thionucleoside analogues and their pharmaceutical use |
Family Cites Families (57)
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US4724232A (en) | 1985-03-16 | 1988-02-09 | Burroughs Wellcome Co. | Treatment of human viral infections |
CS263952B1 (en) | 1985-04-25 | 1989-05-12 | Holy Antonin | Remedy with antiviral effect |
AU570853B2 (en) | 1985-08-26 | 1988-03-24 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | Inhibition of infectivity and cytopathic effect of htlv-111/ lav by purine bases |
US6492352B1 (en) | 1985-10-31 | 2002-12-10 | Astra Lakemedel Aktiebolag | Method for the control and treatment of acquired immunodeficiency syndrome (AIDS) |
US4978655A (en) | 1986-12-17 | 1990-12-18 | Yale University | Use of 3'-deoxythymidin-2'-ene (3'deoxy-2',3'-didehydrothymidine) in treating patients infected with retroviruses |
US5028595A (en) | 1987-09-18 | 1991-07-02 | Hoffmann-La Roche Inc. | Method for preventing AIDS in a subject or treating a subject infected with the AIDS virus |
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PT1877090E (pt) | 2005-05-06 | 2014-04-15 | Providence Health System | Proteína de fusão trimérica de imunoglobulina-ox40 e métodos de utilização |
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TWI382019B (zh) | 2005-08-19 | 2013-01-11 | Array Biopharma Inc | 作為類鐸受體(toll-like receptor)調節劑之胺基二氮雜呯 |
TWI404537B (zh) | 2005-08-19 | 2013-08-11 | Array Biopharma Inc | 作為類鐸受體(toll-like receptor)調節劑之8-經取代苯并氮雜呯 |
TW200840584A (en) * | 2006-12-26 | 2008-10-16 | Gilead Sciences Inc | Pyrido(3,2-d)pyrimidines useful for treating viral infections |
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JP5285709B2 (ja) | 2007-11-16 | 2013-09-11 | ギリアード サイエンシス インコーポレーテッド | ヒト免疫不全ウイルスの複製阻害薬 |
BRPI0820875B1 (pt) | 2007-12-14 | 2021-10-19 | Bristol-Myers Squibb Company | Molécula de ligação isolada, anticorpo monoclonal humano, composição, molécula de ácido nucleico, vetor e célula hospedeira |
DK2313111T3 (da) | 2008-08-01 | 2013-12-02 | Ventirx Pharmaceuticals Inc | Toll-lignende receptoragonistformuleringer og anvendelse deraf |
SI3260136T1 (sl) | 2009-03-17 | 2021-05-31 | Theraclone Sciences, Inc. | Humani imunodeficientni virus (HIV)-nevtralizirajoča protitelesa |
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ES2620629T3 (es) | 2009-08-18 | 2017-06-29 | Ventirx Pharmaceuticals, Inc. | Benzoazepinas sustituidas como moduladores del receptor tipo Toll |
WO2011022509A2 (fr) | 2009-08-18 | 2011-02-24 | Ventirx Pharmaceuticals, Inc. | Benzoazépines substituées comme modulateurs des récepteurs de type toll |
US20110305670A1 (en) | 2010-06-10 | 2011-12-15 | President And Fellows Of Harvard College | Nucleic acid encoding fusion polypeptides that prevent or inhibit hiv infection |
TWI458711B (zh) | 2010-07-02 | 2014-11-01 | Gilead Sciences Inc | 治療性化合物 |
MX2012015097A (es) | 2010-07-02 | 2013-05-28 | Gilead Sciences Inc | Derivados de acido naft-2-ilacetico para tratar sida. |
ES2774369T3 (es) | 2010-08-31 | 2020-07-20 | Theraclone Science Int | Anticuerpo de neutralización del virus de la inmunodeficiencia humana |
EP2621499B1 (fr) | 2010-10-01 | 2017-11-22 | VentiRx Pharmaceuticals, Inc. | Méthodes de traitement de maladies allergiques |
SG189071A1 (en) | 2010-10-01 | 2013-05-31 | Ventirx Pharmaceuticals Inc | Therapeutic use of a tlr agonist and combination therapy |
EP2637669A4 (fr) * | 2010-11-10 | 2014-04-02 | Infinity Pharmaceuticals Inc | Composés hétérocycliques et utilisations de ceux-ci |
MX346387B (es) | 2011-01-12 | 2017-03-02 | Ventirx Pharmaceuticals Inc | Benzoazepinas sustituidas como moduladores de receptores tipo toll. |
US9422250B2 (en) | 2011-04-08 | 2016-08-23 | Janssen Sciences Ireland Uc | Pyrimidine derivatives for the treatment of viral infections |
BR112013027070A2 (pt) | 2011-04-20 | 2019-09-24 | J Smith Larry | métodos e composições para diminuir expressão de gene utilizando componentes que auto montam em células e produzem atividade de rnai |
MX2013012266A (es) | 2011-04-21 | 2013-11-22 | Gilead Sciences Inc | Compuestos de benzotiazol y su uso farmaceutico. |
HUE036220T2 (hu) * | 2011-05-18 | 2018-06-28 | Janssen Sciences Ireland Uc | Kinazolin származékok vírusfertõzések és további betegségek kezelésére |
CN103930422A (zh) * | 2011-07-19 | 2014-07-16 | 无限药品股份有限公司 | 杂环化合物及其用途 |
BR112014019699B1 (pt) | 2012-02-08 | 2021-12-07 | Janssen Sciences Ireland Uc | Derivados de piperidino-pirimidina, seu uso no tratamento de infecções virais e composição farmacêutica que os compreende |
SG11201401189WA (en) | 2012-04-20 | 2014-09-26 | Gilead Sciences Inc | Benzothiazol- 6 -yl acetic acid derivatives and their use for treating an hiv infection |
WO2013163427A1 (fr) | 2012-04-25 | 2013-10-31 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Anticorps pour traiter les infections par le vih-1 |
ES2707885T3 (es) | 2012-08-10 | 2019-04-05 | Janssen Sciences Ireland Unlimited Co | Alquilpirimidinderivados para el tratamiento de infecciones víricas y otras enfermedades |
KR102217111B1 (ko) | 2012-10-10 | 2021-02-18 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 바이러스 감염 및 다른 질환 치료를 위한 피롤로[3,2-d]피리미딘 유도체 |
NZ706226A (en) | 2012-11-16 | 2019-09-27 | Janssen Sciences Ireland Uc | Heterocyclic substituted 2-amino-quinazoline derivatives for the treatment of viral infections |
EP2958900B1 (fr) | 2013-02-21 | 2019-04-10 | Janssen Sciences Ireland Unlimited Company | Dérivés de 2-aminopyrimidine pour le traitement d'infections virales |
SI3252058T1 (sl) | 2013-07-12 | 2021-03-31 | Gilead Sciences, Inc. | Policiklične karbamoilpiridonske spojine in njihova uporaba za zdravljenje okužb s HIV |
NO2865735T3 (fr) | 2013-07-12 | 2018-07-21 | ||
SI3321265T1 (sl) * | 2015-03-04 | 2020-07-31 | Gilead Sciences, Inc. | Spojine 4,6-diamino-pirido(3,2-d)pirimidina in njihova uporaba kot modulatorji toličnih receptorjev |
-
2016
- 2016-09-13 WO PCT/US2016/051545 patent/WO2017048727A1/fr active Application Filing
- 2016-09-13 EP EP16770854.4A patent/EP3349757A1/fr not_active Withdrawn
- 2016-09-13 MA MA042818A patent/MA42818A/fr unknown
- 2016-09-13 AU AU2016322763A patent/AU2016322763A1/en not_active Abandoned
- 2016-09-13 US US15/759,177 patent/US20180263985A1/en not_active Abandoned
- 2016-09-13 JP JP2018513529A patent/JP2018527366A/ja active Pending
- 2016-09-13 US US15/264,401 patent/US20170071944A1/en not_active Abandoned
- 2016-09-13 CA CA2997955A patent/CA2997955A1/fr not_active Abandoned
-
2018
- 2018-12-21 HK HK18116414.4A patent/HK1257270A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
JP2018527366A (ja) | 2018-09-20 |
WO2017048727A1 (fr) | 2017-03-23 |
CA2997955A1 (fr) | 2017-03-23 |
AU2016322763A1 (en) | 2018-04-19 |
EP3349757A1 (fr) | 2018-07-25 |
HK1257270A1 (zh) | 2019-10-18 |
US20170071944A1 (en) | 2017-03-16 |
US20180263985A1 (en) | 2018-09-20 |
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