HRP20130204T1 - Monoklonalna protutijela koja se vežu na hgm-csf i medicinski sastavi koji ih sadrže - Google Patents
Monoklonalna protutijela koja se vežu na hgm-csf i medicinski sastavi koji ih sadrže Download PDFInfo
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- HRP20130204T1 HRP20130204T1 HRP20130204AT HRP20130204T HRP20130204T1 HR P20130204 T1 HRP20130204 T1 HR P20130204T1 HR P20130204A T HRP20130204A T HR P20130204AT HR P20130204 T HRP20130204 T HR P20130204T HR P20130204 T1 HRP20130204 T1 HR P20130204T1
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- 239000000203 mixture Substances 0.000 title 1
- 239000000427 antigen Substances 0.000 claims 29
- 102000036639 antigens Human genes 0.000 claims 29
- 108091007433 antigens Proteins 0.000 claims 29
- 239000012634 fragment Substances 0.000 claims 29
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 108020004414 DNA Proteins 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 208000006673 asthma Diseases 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 239000013598 vector Substances 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 208000036487 Arthropathies Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 101000746373 Homo sapiens Granulocyte-macrophage colony-stimulating factor Proteins 0.000 claims 1
- 208000029523 Interstitial Lung disease Diseases 0.000 claims 1
- 208000012659 Joint disease Diseases 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 208000024716 acute asthma Diseases 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 238000001516 cell proliferation assay Methods 0.000 claims 1
- 208000029771 childhood onset asthma Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 230000014509 gene expression Effects 0.000 claims 1
- 102000046157 human CSF2 Human genes 0.000 claims 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 208000025113 myeloid leukemia Diseases 0.000 claims 1
- 230000002018 overexpression Effects 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 206010039083 rhinitis Diseases 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/243—Colony Stimulating Factors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (24)
1. Izolirano anti-hGM-CSF monoklonalno protutijelo ili njegov fragment koji se veže na antigen, naznačen(o) time, da spomenuto protutijelo ili njegov fragment koji se veže na antigen, obuhvaća:
(a) jaki lanac koji uključuje sekvencu koja sadrži VH-CDR1, sekvencu koja sadrži VH-CDR2 i sekvencu koja sadrži VH-CDR3, pri čemu:
(i) sekvenca koja sadrži VH-CDR1 je SYGMH (SEQ ID NO: 4),
(ii) sekvenca koja sadrži VH-CDR2 je LTYHHGNRKFYADSVRG (SEQ ID NO: 5) i
(iii) sekvenca koja sadrži VH-CDR3 je ESMGAINDN (SEQ ID NO: 6); i
(b) slabi lanac koji uključuje sekvencu koja sadrži VL-CDR1, sekvencu koja sadrži VL-CDR2 i sekvencu koja sadrži VL-CDR3, pri čemu:
(i) sekvenca koja sadrži VL-CDR1 je IGNNNNIGSHAVG (SEQ ID NO: 7),
(ii) sekvenca koja sadrži VL-CDR2 je GRSPPS (SEQ ID NO: 8) i
(iii) sekvenca koja sadrži VL-CDR3 je STWDSSLSAVV (SEQ ID NO: 9).
2. Protutijelo ili njegov fragment koji se veže na antigen prema zahtjevu 1, naznačen(o) time, da se protutijelo ili njegov fragment koji se veže na antigen, povezuje na humani GM-CSF s jednim KD manjim od 400 pM.
3. Protutijelo ili njegov fragment koji se veže na antigen prema zahtjevu 1, naznačen(o) time, da protutijelo ili njegov fragment koji se veže na antigen neutralizira djelovanje od hGM-CSF, tako da protutijelo ili njegov fragment koji veže antigen ima IC50-vrijednost manju od 100 pM, kao što je utvrđeno prema ispitivanju proliferacije TF-1 na ED80.
4. Protutijelo ili njegov fragment koji se veže na antigen prema zahtjevu 1 ili 2, naznačen(o) time, da je jaki lanac odabran iz skupine koja se sastoji od gama 1 (γ1), gama 2 (γ2), gama 3 (γ3) i gama 4 (γ4).
5. Protutijelo ili njegov fragment koji se veže na antigen prema zahtjevu 4, naznačen(o) time, da jaki lanac je gama 1 (γ1).
6. Protutijelo ili njegov fragment koji se veže na antigen prema zahtjevu 4 ili 5, naznačen(o) time, da slabi lanac je lambda slabi lanac.
7. Protutijelo ili njegov fragment koji se veže na antigen prema jednom od zahtjeva 1 do 6, naznačen(o) time, da jaki lanac ima jednu amino kiselinsku sekvencu od SEQ ID NO:46 ili od SEQ ID NO: 51.
8. Protutijelo ili njegov fragment koji se veže na antigen prema zahtjevu 7, naznačen(o) time, da jaki lanac ima jednu amino kiselinsku sekvencu od SEQ ID NO:51.
9. Protutijelo ili njegov fragment koji se veže na antigen prema jednom od zahtjeva 1 do 8, naznačen(o) time, da slabi lanac ima jednu amino kiselinsku sekvencu od SEQ ID NO: 36.
10. Protutijelo ili njegov fragment koji se veže na antigen prema jednom od zahtjeva 1 do 6, naznačen(o) time, da sekvenca od varijabilnog područja jakog lanca je SEQ ID NO: 348 ili je SEQ ID NO: 361, i pri čemu sekvenca varijabilnog područja slabog lanca je SEQ ID NO: 365.
11. Protutijelo ili njegov fragment koji se veže na antigen prema zahtjevu 10, naznačen(o) time, da sekvenca od varijabilnog područja jakog lanca je SEQ ID NO: 361.
12. Protutijelo ili njegov fragment koji se veže na antigen prema jednom od zahtjeva 1 do 6, naznačen(o) time, da sekvenca jakog lanca je SEQ ID NO: 46 ili je SEQ ID NO: 51, i pri čemu sekvenca slabog lanca je SEQ ID NO: 36.
13. Protutijelo ili njegov fragment koji se veže na antigen prema zahtjevu 12, naznačen(o) time, da sekvenca jakog lanca je SEQ ID NO: 51.
14. Farmaceutski sastav, naznačen time, da obuhvaća protutijelo ili njegov fragment koji se veže na antigen, prema bilo kojem od zahtjeva 1 do 13, i farmaceutski prihvatljiv nosač.
15. Garnitura, naznačena time, da obuhvaća:
(a) protutijelo ili njegov fragment koji se veže na antigen, prema bilo kojem od zahtjeva 1 do 13, i
(b) jedan ili više spremnika koji sadrže protutijelo ili njegov fragment koji se veže na antigen.
16. Izolirana nukleinska kiselina, naznačena time, da ona kodira za anti-hGM-CSF monoklonalno protutijelo ili njegov fragment koji se veže na antigen, prema bilo kojem od zahtjeva 1 do 13.
17. Izolirana nukleinska kiselina, naznačena time, da nukleinska kiselina je DNK.
18. Vektor, naznačen time, da on obuhvaća DNK prema zahtjevu 17.
19. Stanica domaćina, naznačena time, da uključuje vektor prema zahtjevu 18, pri čemu taj vektor je vektor ekspresije.
20. Protutijelo ili njegov fragment koji se veže na antigen prema jednom od zahtjeva 1 do 13, ili farmaceutski sastav prema zahtjevu 14, naznačen(o) time, da se upotrebljava kao lijek.
21. Protutijelo ili njegov fragment koji se veže na antigen prema jednom od zahtjeva 1 do 13, ili farmaceutski sastav prema zahtjevu 14, naznačen(o) time, da se upotrebljava za liječenje subjekta od bolesti ili poremećaja koji(a) je povezan(a) s prekomjernom ekspresijom hGM-CSF.
22. Protutijelo ili njegov fragment koji se veže na antigen prema zahtjevu 21, naznačen(o) time, da se kod subjekta primjenjuje određena doza protutijela ili njegovog fragmenta koji se veže na antigen, koja ne premašuje 500 mg.
23. Protutijelo ili njegov fragment koji se veže na antigen prema zahtjevu 21 ili 22, naznačen(o) time, da je bolest ili poremećaj odabran(a) iz skupine koju čine: kronična opstrukcijska plućna bolest (COPD), astma, bronhijalna astma, pedijatrijska astma, teška astma, akutni astmatični napadaji, cistična fibroza, intersticijalna plućna bolest, rinitis, artritis i s njime povezane artropatije, reumatoidni artritis, psorijaza, mijeloidna leukemija i multipla skleroza.
24. Postupak za proizvodnju anti-hGM-CSF monoklonalnog protutijela prema zahtjevu 1 ili njegovog fragmenta koji se veže na antigen prema zahtjevu 1, te koji se veže na hGM-CSF, gdje protutijelo ili njegov fragment koji se veže na antigen obuhvaća najmanje jednu sekvencu koja sadrži VH-CDR1, jednu sekvencu koja sadrži VH-CDR2, jednu skevencu koja sadrži VH-CDR3, jednu sekvencu koja sadrži VL-CDR1, jednu sekvencu koja sadrži VL-CDR2 i jednu sekvencu koja sadrži VL-CDR3, u stanici domaćina, naznačen time, da postupak uključuje:
(i) dobivanje stanice domaćina koja obuhvaća najmanje jednu DNK sekvencu koja kodira barem za sekvencu koja sadrži VH-CDR1, sekvencu koja sadrži VH-CDR2, sekvencu koja sadrži VH-CDR3, sekvencu koja sadrži VL-CDR1, sekvencu koja sadrži VL-CDR2 te za sekvencu koja sadrži VL-CDR3, gdje:
(a) sekvenca koja sadrži VH-CDR1 je SYGMH (SEQ ID NO: 4),
(b) sekvenca koja sadrži VH-CDR2 je LTYHHGNRKFYADSVRG (SEQ ID NO: 5),
(c) sekvenca koja sadrži VH-CDR3 je ESMGAINDN (SEQ ID NO: 6),
(d) sekvenca koja sadrži VL-CDR1 je IGNNNNIGSHAVG (SEQ ID NO: 7),
(e) sekvenca koja sadrži VL-CDR2 je GRSPPS (SEQ ID NO: 8) i
(f) sekvenca koja sadrži VL-CDR3 je STWDSSLSAVV (SEQ ID NO: 9);
te
(ii) kultiviranje stanice domaćina pod prikladnim uvjetima za ekspresiju DNK i za proizvodnju protutijela ili njegovog fragmenta koji se veže na antigen.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007294945 | 2007-11-13 | ||
| JP2008052471 | 2008-02-14 | ||
| PCT/US2008/012680 WO2009064399A1 (en) | 2007-11-13 | 2008-11-12 | Monoclonal antibodies that bind to hgm-csf and medical compositions comprising same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20130204T1 true HRP20130204T1 (hr) | 2013-04-30 |
Family
ID=40329216
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20130204AT HRP20130204T1 (hr) | 2007-11-13 | 2013-03-08 | Monoklonalna protutijela koja se vežu na hgm-csf i medicinski sastavi koji ih sadrže |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US8679502B2 (hr) |
| EP (3) | EP2559706A1 (hr) |
| KR (1) | KR20100102108A (hr) |
| CN (2) | CN101970489B (hr) |
| AR (1) | AR069290A1 (hr) |
| AU (1) | AU2008321429A1 (hr) |
| BR (1) | BRPI0820530A2 (hr) |
| CA (1) | CA2705539A1 (hr) |
| CL (1) | CL2008003361A1 (hr) |
| CO (1) | CO6382188A2 (hr) |
| DK (1) | DK2215119T3 (hr) |
| EC (1) | ECSP10010251A (hr) |
| ES (1) | ES2401536T3 (hr) |
| HK (1) | HK1146729A1 (hr) |
| HR (1) | HRP20130204T1 (hr) |
| IL (1) | IL205576A0 (hr) |
| MA (1) | MA31899B1 (hr) |
| ME (1) | ME01005B (hr) |
| MX (1) | MX2010005291A (hr) |
| NZ (2) | NZ597023A (hr) |
| PE (1) | PE20091420A1 (hr) |
| PL (1) | PL2215119T3 (hr) |
| PT (1) | PT2215119E (hr) |
| RS (1) | RS52713B (hr) |
| RU (2) | RU2517596C2 (hr) |
| SG (1) | SG176499A1 (hr) |
| SI (1) | SI2215119T1 (hr) |
| TN (1) | TN2010000210A1 (hr) |
| TW (2) | TWI434854B (hr) |
| UY (1) | UY31466A1 (hr) |
| WO (1) | WO2009064399A1 (hr) |
| ZA (1) | ZA201003467B (hr) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| DE102005035891A1 (de) | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
| PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
| CN101687926A (zh) * | 2007-05-23 | 2010-03-31 | 哮喘和气道Crc有限公司 | 中和抗体 |
| WO2009062238A1 (en) * | 2007-11-12 | 2009-05-22 | Crc For Asthma And Airways Ltd | Epitope for neutralizing antibodies |
| KR20100102108A (ko) | 2007-11-13 | 2010-09-20 | 에베크 인코포레이티드 | ｈＧＭ-ＣＳＦ에 결합하는 모노클로날 항체 및 이를 포함하는 의약 조성물 |
| PE20091730A1 (es) | 2008-04-03 | 2009-12-10 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
| UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
| AU2009290911A1 (en) | 2008-09-10 | 2010-03-18 | Boehringer Ingelheim International Gmbh | Combination therapy for the treatment of diabetes and related conditions |
| CN106397591A (zh) * | 2008-12-22 | 2017-02-15 | 墨尔本大学 | 骨关节炎治疗 |
| CN102256621B (zh) | 2008-12-22 | 2017-12-12 | 墨尔本大学 | 疼痛治疗 |
| KR20190050871A (ko) | 2010-06-24 | 2019-05-13 | 베링거 인겔하임 인터내셔날 게엠베하 | 당뇨병 요법 |
| AR083878A1 (es) | 2010-11-15 | 2013-03-27 | Boehringer Ingelheim Int | Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento |
| AU2012280267B2 (en) | 2011-07-06 | 2016-04-21 | Morphosys Ag | Therapeutic combinations of anti-cd20 and anti-gm-csf antibodies and uses thereof |
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