HRP20120331T1 - Postupak sprječavanja ili liječenja infekcije bakterijom m. tuberculosis - Google Patents
Postupak sprječavanja ili liječenja infekcije bakterijom m. tuberculosis Download PDFInfo
- Publication number
- HRP20120331T1 HRP20120331T1 HRP20120331TT HRP20120331T HRP20120331T1 HR P20120331 T1 HRP20120331 T1 HR P20120331T1 HR P20120331T T HRP20120331T T HR P20120331TT HR P20120331 T HRP20120331 T HR P20120331T HR P20120331 T1 HRP20120331 T1 HR P20120331T1
- Authority
- HR
- Croatia
- Prior art keywords
- pharmaceutical preparation
- preparation according
- fusion protein
- seq
- nucleic acid
- Prior art date
Links
- 201000008827 tuberculosis Diseases 0.000 title claims abstract 6
- 208000015181 infectious disease Diseases 0.000 title claims abstract 5
- 238000000034 method Methods 0.000 title abstract 3
- 108020001507 fusion proteins Proteins 0.000 claims abstract 12
- 102000037865 fusion proteins Human genes 0.000 claims abstract 12
- 102000039446 nucleic acids Human genes 0.000 claims abstract 9
- 108020004707 nucleic acids Proteins 0.000 claims abstract 9
- 150000007523 nucleic acids Chemical class 0.000 claims abstract 9
- 239000002246 antineoplastic agent Substances 0.000 claims abstract 6
- 229940127089 cytotoxic agent Drugs 0.000 claims abstract 6
- 239000002671 adjuvant Substances 0.000 claims abstract 3
- 239000012634 fragment Substances 0.000 claims abstract 3
- 230000002163 immunogen Effects 0.000 claims abstract 3
- 230000007420 reactivation Effects 0.000 claims abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 23
- 241000124008 Mammalia Species 0.000 claims 7
- 229920001184 polypeptide Polymers 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 241000187479 Mycobacterium tuberculosis Species 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 208000032420 Latent Infection Diseases 0.000 claims 2
- 241001302239 Mycobacterium tuberculosis complex Species 0.000 claims 2
- 208000037771 disease arising from reactivation of latent virus Diseases 0.000 claims 2
- 241000193830 Bacillus <bacterium> Species 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 241000186359 Mycobacterium Species 0.000 claims 1
- 229960000190 bacillus calmette–guérin vaccine Drugs 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 229960003350 isoniazid Drugs 0.000 claims 1
- QRXWMOHMRWLFEY-UHFFFAOYSA-N isoniazide Chemical compound NNC(=O)C1=CC=NC=C1 QRXWMOHMRWLFEY-UHFFFAOYSA-N 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000007764 o/w emulsion Substances 0.000 claims 1
- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 claims 1
- 229960001225 rifampicin Drugs 0.000 claims 1
- 230000000973 chemotherapeutic effect Effects 0.000 abstract 1
- 238000004904 shortening Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67654905P | 2005-04-29 | 2005-04-29 | |
| US77701706P | 2006-02-27 | 2006-02-27 | |
| PCT/EP2006/004319 WO2006117240A2 (fr) | 2005-04-29 | 2006-04-27 | Nouvelle methode de prevention ou de traitement d'une infection par m tuberculosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20120331T1 true HRP20120331T1 (hr) | 2012-05-31 |
Family
ID=36972897
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20120331TT HRP20120331T1 (hr) | 2005-04-29 | 2012-04-13 | Postupak sprječavanja ili liječenja infekcije bakterijom m. tuberculosis |
| HRP20141125TT HRP20141125T1 (hr) | 2005-04-29 | 2014-11-19 | Postupak sprjeäśavanja ili lijeäśenja infekcije bakterijom m. tuberculosis |
| HRP20141184TT HRP20141184T1 (en) | 2005-04-29 | 2014-12-08 | Novel method for preventing or treating m. tuberculosis infection |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20141125TT HRP20141125T1 (hr) | 2005-04-29 | 2014-11-19 | Postupak sprjeäśavanja ili lijeäśenja infekcije bakterijom m. tuberculosis |
| HRP20141184TT HRP20141184T1 (en) | 2005-04-29 | 2014-12-08 | Novel method for preventing or treating m. tuberculosis infection |
Country Status (24)
| Country | Link |
|---|---|
| US (6) | US8470338B2 (fr) |
| EP (3) | EP2457926B1 (fr) |
| JP (4) | JP5164830B2 (fr) |
| KR (4) | KR101352806B1 (fr) |
| CN (3) | CN101273055B (fr) |
| AT (1) | ATE543832T1 (fr) |
| AU (1) | AU2006243357B2 (fr) |
| BR (1) | BRPI0611347A2 (fr) |
| CA (2) | CA2607715C (fr) |
| CY (1) | CY1112851T1 (fr) |
| DK (3) | DK1877426T3 (fr) |
| EA (1) | EA012576B1 (fr) |
| ES (3) | ES2524572T3 (fr) |
| HR (3) | HRP20120331T1 (fr) |
| IL (2) | IL186654A (fr) |
| MA (1) | MA29678B1 (fr) |
| NO (3) | NO340766B1 (fr) |
| NZ (1) | NZ562729A (fr) |
| PH (1) | PH12013502449A1 (fr) |
| PL (3) | PL2426141T3 (fr) |
| PT (3) | PT2426141E (fr) |
| SI (3) | SI2457926T1 (fr) |
| WO (1) | WO2006117240A2 (fr) |
| ZA (1) | ZA200709209B (fr) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2457926B1 (fr) * | 2005-04-29 | 2014-09-24 | GlaxoSmithKline Biologicals S.A. | Nouveau procédé pour la prévention ou le traitement d'une infection de tuberculose M. |
| TWI457133B (zh) | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | 新穎組合物 |
| CN101438166A (zh) * | 2006-03-14 | 2009-05-20 | 俄勒冈健康科学大学 | 产生针对结核病的免疫应答的方法 |
| US9717788B2 (en) | 2007-03-02 | 2017-08-01 | Glaxosmithkline Biologicals Sa | Method of inducing an immune response against HIV employing HIV immunogens, adenoviral vectors encoding said immunogens, and adjuvant |
| BRPI0808553A2 (pt) * | 2007-03-02 | 2014-08-19 | Glaxosmithkline Biolog Sa | Métodos para elevar uma resposta imune contra um patógeno, para estimar a produção de células t cd4+ e/ou cd8+ e/ou anticorpos específicos de patógeno em mamíferos e para estimular uma resposta imune em um mamífero, composição de vacina, uso da mesma, e, kit |
| US8394839B2 (en) * | 2007-08-21 | 2013-03-12 | Stc.Unm | Rationally improved isoniazid and ethionamide derivatives and activity through selective isotopic substitution |
| WO2009158284A2 (fr) * | 2008-06-26 | 2009-12-30 | Mayo Foundation For Medical Education And Research | Méthodes et matériaux de production de réponses immunitaires contre des polypeptides impliqués dans la résistance aux antibiotiques |
| KR20110044883A (ko) | 2008-07-25 | 2011-05-02 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 신규한 조성물 및 방법 |
| EA201100070A1 (ru) * | 2008-07-25 | 2011-10-31 | Глаксо Груп Лимитед | Туберкулезный белок rv2386c, композиции и их применения |
| MX2011000981A (es) | 2008-07-25 | 2011-03-02 | Glaxosmithkline Biolog Sa | Composiciones y metodos novedosos. |
| GB0815872D0 (en) | 2008-09-01 | 2008-10-08 | Pasteur Institut | Novel method and compositions |
| MX370744B (es) | 2009-04-24 | 2019-12-20 | Una vacuna antituberculosis tb para evitar la reactivación. | |
| EA201290590A1 (ru) | 2010-01-27 | 2013-03-29 | Глаксосмитклайн Байолоджикалс С.А. | Модифицированные туберкулезные антигены |
| CN103260642B (zh) * | 2010-12-14 | 2018-03-16 | 葛兰素史密丝克莱恩生物有限公司 | 分枝杆菌抗原组合物 |
| GB201022007D0 (en) | 2010-12-24 | 2011-02-02 | Imp Innovations Ltd | DNA-sensor |
| PL2661253T3 (pl) | 2011-01-04 | 2017-08-31 | Archivel Farma, Sl | Preparat liposomowy odpowiedni do leczenia lub zapobiegania gruźlicy |
| GB201116248D0 (en) | 2011-09-20 | 2011-11-02 | Glaxosmithkline Biolog Sa | Liposome production using isopropanol |
| WO2013090897A1 (fr) * | 2011-12-15 | 2013-06-20 | The Trustees Of The University Of Pennsylvania | Utilisation d'immunité adaptative pour détecter une résistance aux médicaments |
| CN104411326B (zh) | 2012-01-12 | 2018-02-02 | 阿尔西维尔法尔玛公司 | 抗哮喘的mtb‑c疫苗 |
| WO2014042780A1 (fr) * | 2012-08-03 | 2014-03-20 | Infectious Disease Research Institute | Compositions et méthodes de traitement d'une infection active par le bacille de koch |
| US20150240201A1 (en) * | 2012-09-27 | 2015-08-27 | Chengdu Yongan Pharmaceutical Co., Ltd. | Modified bcg strains with reduced or eliminated activity of lsr2 and pharmaceutical composition comprising same |
| CN102994595B (zh) * | 2012-11-30 | 2018-10-26 | 广州白云山拜迪生物医药有限公司 | 一种融合蛋白包涵体的制备方法 |
| CN102993266B (zh) * | 2012-11-30 | 2019-08-23 | 广州白云山拜迪生物医药有限公司 | 一种融合蛋白的纯化和复性方法 |
| GB201405921D0 (en) * | 2014-04-02 | 2014-05-14 | Glaxosmithkline Biolog Sa | Novel methods for inducing an immune response |
| US10588980B2 (en) * | 2014-06-23 | 2020-03-17 | Novartis Ag | Fatty acids and their use in conjugation to biomolecules |
| US10335374B2 (en) | 2014-12-04 | 2019-07-02 | University System of Georgia, Valdosta State University | Tablet composition for anti-tuberculosis antibiotics |
| US10672502B2 (en) * | 2015-04-02 | 2020-06-02 | Biodesy, Inc. | Methods for determining protein structure using a surface-selective nonlinear optical technique |
| WO2016179231A1 (fr) * | 2015-05-04 | 2016-11-10 | Board Of Trustees Of Michigan State University | Compositions et procédés pour l'inhibition de la croissance bactérienne |
| GB201513176D0 (en) * | 2015-07-27 | 2015-09-09 | Glaxosmithkline Biolog Sa | Novel methods for inducing an immune response |
| CN110035770B (zh) | 2016-12-07 | 2023-06-16 | 葛兰素史密丝克莱恩生物有限公司 | 新方法 |
| US11717519B2 (en) | 2017-04-21 | 2023-08-08 | Washington University In St. Louis | Use of fatty acid oxidation inhibitors as antimicrobials |
| WO2019178472A1 (fr) * | 2018-03-16 | 2019-09-19 | Washington University In St. Louis | Utilisation d'inhibiteurs d'oxydation d'acides gras comme agents antimicrobiens |
| GB201707700D0 (en) | 2017-05-12 | 2017-06-28 | Glaxosmithkline Biologicals Sa | Dried composition |
| TW202237116A (zh) * | 2020-12-02 | 2022-10-01 | 日商塩野義製藥股份有限公司 | 以組合細胞色素bc1抑制劑與克拉黴素或阿奇黴素為特徵之用於治療分枝桿菌感染之藥物 |
| AU2022339918A1 (en) | 2021-08-31 | 2024-02-08 | Vir Biotechnology, Inc. | Tuberculosis vaccines |
| KR102534846B1 (ko) | 2021-12-14 | 2023-05-19 | 재단법인 환동해산업연구원 | 결핵균에 항균 활성을 가지는 해조류 추출물 |
| CN116162141B (zh) * | 2022-11-30 | 2024-04-12 | 中国疾病预防控制中心传染病预防控制所 | 一种结核分枝杆菌抗原epcra013及其应用 |
Family Cites Families (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235877A (en) | 1979-06-27 | 1980-11-25 | Merck & Co., Inc. | Liposome particle containing viral or bacterial antigenic subunit |
| US4603112A (en) | 1981-12-24 | 1986-07-29 | Health Research, Incorporated | Modified vaccinia virus |
| US4769330A (en) | 1981-12-24 | 1988-09-06 | Health Research, Incorporated | Modified vaccinia virus and methods for making and using the same |
| US4436727A (en) | 1982-05-26 | 1984-03-13 | Ribi Immunochem Research, Inc. | Refined detoxified endotoxin product |
| US4866034A (en) | 1982-05-26 | 1989-09-12 | Ribi Immunochem Research Inc. | Refined detoxified endotoxin |
| US4751180A (en) | 1985-03-28 | 1988-06-14 | Chiron Corporation | Expression using fused genes providing for protein product |
| GB8508845D0 (en) | 1985-04-04 | 1985-05-09 | Hoffmann La Roche | Vaccinia dna |
| US4777127A (en) | 1985-09-30 | 1988-10-11 | Labsystems Oy | Human retrovirus-related products and methods of diagnosing and treating conditions associated with said retrovirus |
| US4935233A (en) | 1985-12-02 | 1990-06-19 | G. D. Searle And Company | Covalently linked polypeptide cell modulators |
| US4877611A (en) | 1986-04-15 | 1989-10-31 | Ribi Immunochem Research Inc. | Vaccine containing tumor antigens and adjuvants |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5075109A (en) | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
| US6024983A (en) | 1986-10-24 | 2000-02-15 | Southern Research Institute | Composition for delivering bioactive agents for immune response and its preparation |
| GB8702816D0 (en) | 1987-02-07 | 1987-03-11 | Al Sumidaie A M K | Obtaining retrovirus-containing fraction |
| CA1340522C (fr) | 1987-03-10 | 1999-05-04 | Heinz Dobeli | Proteins hybrides renfermant des histidines voisines pour une purification amelioree |
| US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| CA1331443C (fr) | 1987-05-29 | 1994-08-16 | Charlotte A. Kensil | Adjuvant a saponine |
| US4897268A (en) | 1987-08-03 | 1990-01-30 | Southern Research Institute | Drug delivery system and method of making the same |
| WO1989001973A2 (fr) | 1987-09-02 | 1989-03-09 | Applied Biotechnology, Inc. | Virus variolique recombinant d'immunisation contre des antigenes associes a une tumeur |
| JPH04505547A (ja) | 1988-01-04 | 1992-10-01 | イー・アイ・デユポン・ド・ネモアース・アンド・コンパニー | 細胞混合物から特定の細胞を単離するための多段アフィニティー法 |
| US5215926A (en) | 1988-06-03 | 1993-06-01 | Cellpro, Inc. | Procedure for designing efficient affinity cell separation processes |
| AP129A (en) | 1988-06-03 | 1991-04-17 | Smithkline Biologicals S A | Expression of retrovirus gag protein eukaryotic cells |
| US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| US5549910A (en) | 1989-03-31 | 1996-08-27 | The Regents Of The University Of California | Preparation of liposome and lipid complex compositions |
| US5725871A (en) | 1989-08-18 | 1998-03-10 | Danbiosyst Uk Limited | Drug delivery compositions comprising lysophosphoglycerolipid |
| EP0487587A1 (fr) | 1989-08-18 | 1992-06-03 | Chiron Corporation | Retrovirus de recombinaison apportant des constructions de vecteur a des cellules cibles |
| KR920007887B1 (ko) | 1989-08-29 | 1992-09-18 | 스즈키 지도오샤 고오교오 가부시키가이샤 | 내연기관의 배기가스 정화장치 |
| US5707644A (en) | 1989-11-04 | 1998-01-13 | Danbiosyst Uk Limited | Small particle compositions for intranasal drug delivery |
| US5466468A (en) | 1990-04-03 | 1995-11-14 | Ciba-Geigy Corporation | Parenterally administrable liposome formulation comprising synthetic lipids |
| WO1991016116A1 (fr) | 1990-04-23 | 1991-10-31 | Cellpro Incorporated | Dispositif et procede d'immunoselection |
| SE466259B (sv) | 1990-05-31 | 1992-01-20 | Arne Forsgren | Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal |
| JP3218637B2 (ja) | 1990-07-26 | 2001-10-15 | 大正製薬株式会社 | 安定なリポソーム水懸濁液 |
| EP0468520A3 (en) | 1990-07-27 | 1992-07-01 | Mitsui Toatsu Chemicals, Inc. | Immunostimulatory remedies containing palindromic dna sequences |
| JP2958076B2 (ja) | 1990-08-27 | 1999-10-06 | 株式会社ビタミン研究所 | 遺伝子導入用多重膜リポソーム及び遺伝子捕捉多重膜リポソーム製剤並びにその製法 |
| DE69126620T2 (de) | 1990-10-18 | 1997-10-02 | Cellpro Inc | Vorrichtung und verfahren zur trennung von partikeln mittels eines biegsamen gefässes |
| US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| US5399363A (en) | 1991-01-25 | 1995-03-21 | Eastman Kodak Company | Surface modified anticancer nanoparticles |
| EP0878545A3 (fr) | 1991-08-15 | 1998-12-16 | SMITHKLINE BEECHAM BIOLOGICALS s.a. | Protéines OspA des sous-groupes borrelia burgdorferi, gènes codants et vaccins |
| US5240856A (en) | 1991-10-23 | 1993-08-31 | Cellpro Incorporated | Apparatus for cell separation |
| US5756353A (en) | 1991-12-17 | 1998-05-26 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol-and liposome-based delivery |
| DK0641192T3 (da) | 1992-05-18 | 1998-03-02 | Minnesota Mining & Mfg | Anordning til transmucosal lægemiddelafgivelse |
| US5792451A (en) | 1994-03-02 | 1998-08-11 | Emisphere Technologies, Inc. | Oral drug delivery compositions and methods |
| JP3755890B2 (ja) | 1992-06-25 | 2006-03-15 | スミスクライン・ビーチャム・バイオロジカルス（ソシエテ・アノニム） | アジュバント含有ワクチン組成物 |
| ES2131676T3 (es) | 1993-01-11 | 1999-08-01 | Dana Farber Cancer Inst Inc | Induccion de respuestas con linfocitos t citotoxicos. |
| FR2702160B1 (fr) | 1993-03-02 | 1995-06-02 | Biovecteurs As | Vecteurs particulaires synthétiques et procédé de préparation. |
| CN1087176C (zh) | 1993-03-23 | 2002-07-10 | 史密斯克莱·比奇曼生物公司 | 含有3－o脱酰基单磷酰脂a的疫苗制剂 |
| FR2704145B1 (fr) | 1993-04-21 | 1995-07-21 | Pasteur Institut | Vecteur particulaire et composition pharmaceutique le contenant. |
| US5955077A (en) | 1993-07-02 | 1999-09-21 | Statens Seruminstitut | Tuberculosis vaccine |
| US5543158A (en) | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
| GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
| US5741516A (en) | 1994-06-20 | 1998-04-21 | Inex Pharmaceuticals Corporation | Sphingosomes for enhanced drug delivery |
| US5551622A (en) | 1994-07-13 | 1996-09-03 | Yoon; Inbae | Surgical stapler |
| ES2267100T5 (es) | 1994-07-15 | 2011-04-08 | The University Of Iowa Research Foundation | Oligonucleótidos inmunomoduladores. |
| FR2723849B1 (fr) | 1994-08-31 | 1997-04-11 | Biovector Therapeutics Sa | Procede pour augmenter l'immunogenicite, produit obtenu et composition pharmaceutique |
| AUPM873294A0 (en) | 1994-10-12 | 1994-11-03 | Csl Limited | Saponin preparations and use thereof in iscoms |
| US5795587A (en) | 1995-01-23 | 1998-08-18 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
| US5580579A (en) | 1995-02-15 | 1996-12-03 | Nano Systems L.L.C. | Site-specific adhesion within the GI tract using nanoparticles stabilized by high molecular weight, linear poly (ethylene oxide) polymers |
| IE80468B1 (en) | 1995-04-04 | 1998-07-29 | Elan Corp Plc | Controlled release biodegradable nanoparticles containing insulin |
| UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| JPH11506332A (ja) | 1995-06-02 | 1999-06-08 | インサイト・ファーマスーティカルズ・インコーポレイテッド | 全長ｃＤＮＡ配列を獲得する改良された方法 |
| US5738868A (en) | 1995-07-18 | 1998-04-14 | Lipogenics Ltd. | Liposome compositions and kits therefor |
| IL123506A (en) | 1995-09-01 | 2004-12-15 | Corixa Corp | Polypeptide compounds and preparations for immunotherapy and diagnosis of tuberculosis |
| MX9801687A (es) | 1995-09-01 | 1998-11-29 | Corixa Corp | Compuestos y metodos para el diagnostico de tuberculosis. |
| US6290969B1 (en) | 1995-09-01 | 2001-09-18 | Corixa Corporation | Compounds and methods for immunotherapy and diagnosis of tuberculosis |
| WO1997024447A1 (fr) | 1996-01-02 | 1997-07-10 | Chiron Corporation | Immunostimulation a mediation par cellules dendritiques modifiees par des genes |
| US5856462A (en) | 1996-09-10 | 1999-01-05 | Hybridon Incorporated | Oligonucleotides having modified CpG dinucleosides |
| JP4111403B2 (ja) | 1996-10-11 | 2008-07-02 | ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア | 免疫刺激ポリヌクレオチド／免疫調節分子複合体 |
| WO1998016645A2 (fr) | 1996-10-11 | 1998-04-23 | Corixa Corporation | Composes et procedes pour diagnostiquer la tuberculose |
| US5655998A (en) | 1996-12-03 | 1997-08-12 | Yu; Chih-An | Space walking exerciser |
| CN1326564C (zh) | 1997-04-01 | 2007-07-18 | 科里克萨有限公司 | 单磷酰基脂质a的水性免疫佐剂组合物 |
| GB9727262D0 (en) | 1997-12-24 | 1998-02-25 | Smithkline Beecham Biolog | Vaccine |
| DK1659179T3 (da) | 1998-02-05 | 2011-10-10 | Glaxosmithkline Biolog Sa | Tumor-associerede antigenderivater fra MAGE-familien og nucleinsyresekvenser kodende for dem anvendt til fremstilling af fusionsproteiner og sammensætninger til vaccination |
| WO1999051748A2 (fr) | 1998-04-07 | 1999-10-14 | Corixa Corporation | Proteines hybrides d'antigenes de mycobacterium tuberculosis et leurs utilisations |
| AU779978B2 (en) | 1999-10-07 | 2005-02-24 | Corixa Corporation | Fusion proteins of mycobacterium tuberculosis |
| US7472098B2 (en) | 2000-02-14 | 2008-12-30 | Ubs Financial Services, Inc. | System and method for execution of trades made pursuant to stock option and purchase plans |
| PT1542732E (pt) * | 2000-06-20 | 2009-11-06 | Corixa Corp | Proteínas de fusão de mycobacterium tuberculosis |
| US20030143240A1 (en) | 2000-06-27 | 2003-07-31 | Cabezon-Silva Teresa Elisa Virginia | Prostase protein vaccine comprising derivatised thiol residues and methods for producing said antigen |
| WO2002072792A2 (fr) * | 2001-03-13 | 2002-09-19 | Corixa Corporation | Constructions de proteines de fusion heterologues comprenant un antigene de leishmania |
| ATE434637T1 (de) | 2002-02-14 | 2009-07-15 | Mitsui Chemicals Inc | Polyesterharz und katalysator für die polyesterherstellung, verfahren zur herstellung von polyesterharz mit dem katalysator. |
| US7026465B2 (en) * | 2002-02-15 | 2006-04-11 | Corixa Corporation | Fusion proteins of Mycobacterium tuberculosis |
| GB0411411D0 (en) | 2004-05-21 | 2004-06-23 | Glaxosmithkline Biolog Sa | Vaccines |
| JP2008527947A (ja) | 2005-01-19 | 2008-07-24 | パンデュイット・コーポレーション | 抑制コアを備えた通信チャンネル |
| EP2457926B1 (fr) * | 2005-04-29 | 2014-09-24 | GlaxoSmithKline Biologicals S.A. | Nouveau procédé pour la prévention ou le traitement d'une infection de tuberculose M. |
| JP4468858B2 (ja) | 2005-06-01 | 2010-05-26 | オリンパスイメージング株式会社 | データ符号化装置、データ符号化方法、プログラム |
| US7296798B2 (en) | 2006-01-31 | 2007-11-20 | Matt Overfield | Gameboard, games played on board and methods of play requiring strategy and luck |
| MX370744B (es) | 2009-04-24 | 2019-12-20 | Una vacuna antituberculosis tb para evitar la reactivación. | |
| CA2768777C (fr) | 2009-07-21 | 2017-11-28 | Cooper Technologies Company | Raccordement d'un module de diode electroluminescente (del) a un ensemble dissipateur thermique, un reflecteur de lumiere et des circuits electriques |
| CN103260642B (zh) | 2010-12-14 | 2018-03-16 | 葛兰素史密丝克莱恩生物有限公司 | 分枝杆菌抗原组合物 |
| US9119754B2 (en) | 2011-10-08 | 2015-09-01 | Michael Dennis | Mattress overlay system with positionally adjustable, lateral ramp-wedge bolster structure |
| US9051890B2 (en) | 2013-10-28 | 2015-06-09 | Ford Global Technologies, Llc | Method for estimating charge air cooler condensation storage with an intake oxygen sensor |
| US9903268B2 (en) | 2015-04-02 | 2018-02-27 | Ford Global Technologies, Llc | Internal combustion engine with two-stage supercharging capability and with exhaust-gas aftertreatment arrangement, and method for operating an internal combustion engine |
| US9810514B2 (en) | 2015-09-08 | 2017-11-07 | Deufol Sunman Inc. | Ammunition carrier consumer package |
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