HRP20110960T1 - Kombinacije terapijskih sredstava za liječenje raka - Google Patents
Kombinacije terapijskih sredstava za liječenje raka Download PDFInfo
- Publication number
- HRP20110960T1 HRP20110960T1 HR20110960T HRP20110960T HRP20110960T1 HR P20110960 T1 HRP20110960 T1 HR P20110960T1 HR 20110960 T HR20110960 T HR 20110960T HR P20110960 T HRP20110960 T HR P20110960T HR P20110960 T1 HRP20110960 T1 HR P20110960T1
- Authority
- HR
- Croatia
- Prior art keywords
- inhibitor
- kinase inhibitor
- combinations
- therapeutic agents
- treating cancer
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940124597 therapeutic agent Drugs 0.000 title 1
- UIVFUQKYVFCEKJ-OPTOVBNMSA-N gimatecan Chemical compound C1=CC=C2C(\C=N\OC(C)(C)C)=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UIVFUQKYVFCEKJ-OPTOVBNMSA-N 0.000 claims 4
- QXRSDHAAWVKZLJ-OXZHEXMSSA-N Epothilone B Natural products O=C1[C@H](C)[C@H](O)[C@@H](C)CCC[C@@]2(C)O[C@H]2C[C@@H](/C(=C\c2nc(C)sc2)/C)OC(=O)C[C@H](O)C1(C)C QXRSDHAAWVKZLJ-OXZHEXMSSA-N 0.000 claims 1
- HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 claims 1
- 190000008236 carboplatin Chemical compound 0.000 claims 1
- 229960004562 carboplatin Drugs 0.000 claims 1
- HESCAJZNRMSMJG-HGYUPSKWSA-N epothilone A Natural products O=C1[C@H](C)[C@H](O)[C@H](C)CCC[C@H]2O[C@H]2C[C@@H](/C(=C\c2nc(C)sc2)/C)OC(=O)C[C@H](O)C1(C)C HESCAJZNRMSMJG-HGYUPSKWSA-N 0.000 claims 1
- QXRSDHAAWVKZLJ-PVYNADRNSA-N epothilone B Chemical compound C/C([C@@H]1C[C@@H]2O[C@]2(C)CCC[C@@H]([C@@H]([C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1)O)C)=C\C1=CSC(C)=N1 QXRSDHAAWVKZLJ-PVYNADRNSA-N 0.000 claims 1
- 229960005167 everolimus Drugs 0.000 claims 1
- 229910052697 platinum Inorganic materials 0.000 claims 1
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Substances [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 1
- 125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 claims 1
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 229940124087 DNA topoisomerase II inhibitor Drugs 0.000 abstract 1
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 abstract 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 abstract 1
- 102000029749 Microtubule Human genes 0.000 abstract 1
- 108091022875 Microtubule Proteins 0.000 abstract 1
- 229940079156 Proteasome inhibitor Drugs 0.000 abstract 1
- 229940123690 Raf kinase inhibitor Drugs 0.000 abstract 1
- 239000000317 Topoisomerase II Inhibitor Substances 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 229940100198 alkylating agent Drugs 0.000 abstract 1
- 239000002168 alkylating agent Substances 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 239000002814 antineoplastic antimetabolite Substances 0.000 abstract 1
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 abstract 1
- 238000002648 combination therapy Methods 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 229940121647 egfr inhibitor Drugs 0.000 abstract 1
- 229940121372 histone deacetylase inhibitor Drugs 0.000 abstract 1
- 239000003276 histone deacetylase inhibitor Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000005865 ionizing radiation Effects 0.000 abstract 1
- 229940123729 mTOR kinase inhibitor Drugs 0.000 abstract 1
- 239000003628 mammalian target of rapamycin inhibitor Substances 0.000 abstract 1
- 210000004688 microtubule Anatomy 0.000 abstract 1
- 230000002085 persistent effect Effects 0.000 abstract 1
- 102000051624 phosphatidylethanolamine binding protein Human genes 0.000 abstract 1
- 108700021017 phosphatidylethanolamine binding protein Proteins 0.000 abstract 1
- -1 platin compound Chemical class 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 239000003207 proteasome inhibitor Substances 0.000 abstract 1
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 abstract 1
- 239000005483 tyrosine kinase inhibitor Substances 0.000 abstract 1
- 150000004917 tyrosine kinase inhibitor derivatives Chemical class 0.000 abstract 1
- 239000002525 vasculotropin inhibitor Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63643904P | 2004-12-15 | 2004-12-15 | |
| PCT/US2005/044993 WO2006065780A2 (fr) | 2004-12-15 | 2005-12-13 | Combinaisons d'agents therapeutiques pour le traitement du cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110960T1 true HRP20110960T1 (hr) | 2012-01-31 |
Family
ID=36463409
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110960T HRP20110960T1 (hr) | 2004-12-15 | 2011-12-21 | Kombinacije terapijskih sredstava za liječenje raka |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US8975248B2 (fr) |
| EP (1) | EP1827437B1 (fr) |
| JP (1) | JP5345323B2 (fr) |
| KR (1) | KR101367516B1 (fr) |
| CN (1) | CN101080227B (fr) |
| AT (1) | ATE531371T1 (fr) |
| AU (1) | AU2005316652B2 (fr) |
| BR (1) | BRPI0515774A (fr) |
| CA (1) | CA2589521C (fr) |
| CY (1) | CY1112368T1 (fr) |
| DK (1) | DK1827437T3 (fr) |
| ES (1) | ES2374828T3 (fr) |
| HR (1) | HRP20110960T1 (fr) |
| IL (1) | IL183595A0 (fr) |
| MA (1) | MA29096B1 (fr) |
| MX (1) | MX2007007212A (fr) |
| NO (1) | NO20073552L (fr) |
| NZ (1) | NZ555370A (fr) |
| PL (1) | PL1827437T3 (fr) |
| PT (1) | PT1827437E (fr) |
| RU (1) | RU2400232C2 (fr) |
| SI (1) | SI1827437T1 (fr) |
| TN (1) | TNSN07224A1 (fr) |
| TW (1) | TW200628151A (fr) |
| WO (1) | WO2006065780A2 (fr) |
| ZA (1) | ZA200704701B (fr) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102516417B (zh) | 2002-09-06 | 2014-12-10 | 天蓝制药公司 | 用于传递治疗剂的以环糊精为基础的聚合物 |
| EP1827437B1 (fr) | 2004-12-15 | 2011-11-02 | Novartis AG | Combinaisons d'agents therapeutiques pour le traitement du cancer |
| JP2009502960A (ja) * | 2005-07-27 | 2009-01-29 | ザ・ボード・オブ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・テキサス・システム | 膵臓癌の処置のためのゲムシタビンおよびチロシンキナーゼ阻害剤を含む組み合わせ |
| JP2009516671A (ja) * | 2005-11-21 | 2009-04-23 | ノバルティス アクチエンゲゼルシャフト | ｍＴＯＲ阻害剤を使用する神経内分泌腫瘍処置 |
| WO2007094026A1 (fr) * | 2006-02-17 | 2007-08-23 | Paolo La Colla | Traitement prophylactique et/ou thérapeutique de maladies prolifératives et conformationnelles |
| KR20080109068A (ko) * | 2006-04-05 | 2008-12-16 | 노파르티스 아게 | 암을 치료하기 위한 ｂｃｒ-ａｂｌ/ｃ-ｋｉｔ/ｐｄｇｆ-ｒ ｔｋ 억제제를 포함하는 조합물 |
| AU2007234379A1 (en) * | 2006-04-05 | 2007-10-11 | Novartis Ag. | Combinations of therapeutic agents for treating cancer |
| MX2008012715A (es) | 2006-04-05 | 2008-10-14 | Novartis Ag | Combinaciones de agentes terapeuticos para el tratamiento de cancer. |
| US20080176958A1 (en) | 2007-01-24 | 2008-07-24 | Insert Therapeutics, Inc. | Cyclodextrin-based polymers for therapeutics delivery |
| EP2060565A1 (fr) * | 2007-11-16 | 2009-05-20 | 4Sc Ag | Nouveaux composés bifonctionnels inhibiteurs de protéine kinases et d'histone deacetylases |
| WO2009117669A2 (fr) | 2008-03-21 | 2009-09-24 | The University Of Chicago | Traitement avec des antagonistes des opioïdes et des inhibiteurs mtor |
| CN101837129B (zh) * | 2009-03-19 | 2012-12-12 | 鼎泓国际投资（香港）有限公司 | 含cMet抑制剂、HDAC抑制剂与EGFR酪氨酸激酶抑制剂的药物组合物及其应用 |
| US20120114658A1 (en) * | 2009-09-15 | 2012-05-10 | John Ryan | Treatment of cancer |
| WO2011133479A2 (fr) * | 2010-04-19 | 2011-10-27 | Niiki Pharma Inc. | Polythérapie avec un inhibiteur du protéasome et un complexe de gallium |
| BR122017028570B1 (pt) | 2010-11-12 | 2022-03-03 | Pharma Mar, S.A | Uso de pm01183, ou um sal farmaceuticamente aceitável do mesmo, em combinação sinérgica com um inibidor da topoisomerase i e/ou ii e kit |
| CN102731516B (zh) * | 2011-04-07 | 2014-07-02 | 宁波天衡药业股份有限公司 | 一类具有抗肿瘤活性的喜树碱衍生物 |
| WO2014055493A1 (fr) | 2012-10-02 | 2014-04-10 | Cerulean Pharma Inc. | Procédés et systèmes s'appliquant à la précipitation de polymères et à la génération de particules |
| WO2015152409A1 (fr) * | 2014-04-04 | 2015-10-08 | 大鵬薬品工業株式会社 | Médicament anti-tumoral contenant un composé taxane, et renforçateur d'effet anti-tumoral |
| CN106659765B (zh) | 2014-04-04 | 2021-08-13 | 德玛医药 | 二脱水半乳糖醇及其类似物或衍生物用于治疗非小细胞肺癌和卵巢癌的用途 |
| EP3307263A4 (fr) | 2015-06-15 | 2019-02-13 | NewSouth Innovations Pty Limited | Combinaisons pharmaceutiques de composés d'organo-arsénoxyde et inhibiteurs de mtor |
| CN107951888A (zh) * | 2017-12-19 | 2018-04-24 | 天津科技大学 | 阿法替尼与10-羟基喜树碱的药物组合及其应用 |
| CN109091480A (zh) * | 2018-09-19 | 2018-12-28 | 天津科技大学 | 癌组合物10-羟基喜树碱和克唑替尼治疗肺癌及用途 |
| WO2020130125A1 (fr) * | 2018-12-21 | 2020-06-25 | 第一三共株式会社 | Combinaison d'un conjugué anticorps-médicament et d'un inhibiteur de kinase |
| CN111789903A (zh) * | 2019-04-08 | 2020-10-20 | 石小和 | 治疗尿道癌的药物组合物及其制备方法 |
| CN115814076A (zh) * | 2021-07-01 | 2023-03-21 | 江苏先声药业有限公司 | 抗人vegf抗体与化药联用在制备治疗卵巢癌的药物中的应用 |
| WO2023165603A1 (fr) * | 2022-03-03 | 2023-09-07 | Zai Lab (Shanghai) Co., Ltd. | Inhibiteur d'adn-pk et son utilisation en combinaison |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08169825A (ja) * | 1994-12-15 | 1996-07-02 | Tanaka Kikinzoku Kogyo Kk | 抗癌剤の併用投与方法及び併用可能な抗癌剤 |
| ES2206478T3 (es) | 1994-11-11 | 2004-05-16 | Debiopharm S.A. | Composiciones carcinostaticas que contienen cis-oxaliplatino y otra u otras sustancias carcinostaticas compatibles. |
| US20020103141A1 (en) * | 1998-12-23 | 2002-08-01 | Mckearn John P. | Antiangiogenic combination therapy for the treatment of cancer |
| US7105492B2 (en) * | 1999-03-09 | 2006-09-12 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Camptothecin derivatives having antitumor activity |
| EP1044977B1 (fr) | 1999-03-09 | 2002-05-02 | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. | Dérivés de camptothécine à activité anti-tumorale |
| GB0119249D0 (en) * | 2001-08-07 | 2001-10-03 | Novartis Ag | Organic compounds |
| US20050038048A1 (en) | 2001-10-29 | 2005-02-17 | Ball Howard Ashley | Use of 7h-pyrrollo{2,3-d}pyrimidine derivatives in the treatment of solid tumor diseases |
| US7323479B2 (en) | 2002-05-17 | 2008-01-29 | Celgene Corporation | Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline |
| MXPA05000485A (es) * | 2002-07-11 | 2005-04-19 | Combinatorx Inc | Combinacion de farmacos para el tratamiento de neoplasmas. |
| EP1628651A2 (fr) * | 2003-05-21 | 2006-03-01 | Novartis AG | Combinaison d'inhibiteurs d'histone deacetylase avec des agents chimiotherapeutiques |
| MXPA06014021A (es) * | 2004-06-04 | 2007-02-08 | Pfizer Prod Inc | Procedimiento para tratar crecimiento celular anormal. |
| EP1827437B1 (fr) | 2004-12-15 | 2011-11-02 | Novartis AG | Combinaisons d'agents therapeutiques pour le traitement du cancer |
| JP4702322B2 (ja) | 2006-12-14 | 2011-06-15 | トヨタ自動車株式会社 | 内燃機関の制御装置 |
-
2005
- 2005-12-13 EP EP05853820A patent/EP1827437B1/fr active Active
- 2005-12-13 WO PCT/US2005/044993 patent/WO2006065780A2/fr active Application Filing
- 2005-12-13 PL PL05853820T patent/PL1827437T3/pl unknown
- 2005-12-13 MX MX2007007212A patent/MX2007007212A/es active IP Right Grant
- 2005-12-13 JP JP2007546818A patent/JP5345323B2/ja not_active Expired - Fee Related
- 2005-12-13 BR BRPI0515774-9A patent/BRPI0515774A/pt active Search and Examination
- 2005-12-13 RU RU2007126978/14A patent/RU2400232C2/ru not_active IP Right Cessation
- 2005-12-13 AU AU2005316652A patent/AU2005316652B2/en not_active Ceased
- 2005-12-13 PT PT05853820T patent/PT1827437E/pt unknown
- 2005-12-13 SI SI200531442T patent/SI1827437T1/sl unknown
- 2005-12-13 NZ NZ555370A patent/NZ555370A/en not_active IP Right Cessation
- 2005-12-13 KR KR1020077013401A patent/KR101367516B1/ko active IP Right Grant
- 2005-12-13 ES ES05853820T patent/ES2374828T3/es active Active
- 2005-12-13 DK DK05853820.8T patent/DK1827437T3/da active
- 2005-12-13 US US11/720,776 patent/US8975248B2/en not_active Expired - Fee Related
- 2005-12-13 CN CN2005800429798A patent/CN101080227B/zh active Active
- 2005-12-13 AT AT05853820T patent/ATE531371T1/de active
- 2005-12-13 CA CA2589521A patent/CA2589521C/fr not_active Expired - Fee Related
- 2005-12-14 TW TW094144288A patent/TW200628151A/zh unknown
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2007
- 2007-05-31 IL IL183595A patent/IL183595A0/en unknown
- 2007-06-07 ZA ZA200704701A patent/ZA200704701B/xx unknown
- 2007-06-14 TN TNP2007000224A patent/TNSN07224A1/fr unknown
- 2007-06-18 MA MA29998A patent/MA29096B1/fr unknown
- 2007-07-09 NO NO20073552A patent/NO20073552L/no not_active Application Discontinuation
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2011
- 2011-12-21 HR HR20110960T patent/HRP20110960T1/hr unknown
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2012
- 2012-01-20 CY CY20121100074T patent/CY1112368T1/el unknown
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