MA29096B1 - Combinaisons d'agents therapeutiques destines a traiter le cancer - Google Patents

Combinaisons d'agents therapeutiques destines a traiter le cancer

Info

Publication number
MA29096B1
MA29096B1 MA29998A MA29998A MA29096B1 MA 29096 B1 MA29096 B1 MA 29096B1 MA 29998 A MA29998 A MA 29998A MA 29998 A MA29998 A MA 29998A MA 29096 B1 MA29096 B1 MA 29096B1
Authority
MA
Morocco
Prior art keywords
inhibitor
kinase inhibitor
cancer
combinations
treatment
Prior art date
Application number
MA29998A
Other languages
English (en)
Inventor
Sara Zaknoen
Margaret Ma Woo
Richard William Versace
Claudio Pisano
Loredana Vesci
Original Assignee
Novartis Ag
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36463409&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA29096(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag, Sigma Tau Ind Farmaceuti filed Critical Novartis Ag
Publication of MA29096B1 publication Critical patent/MA29096B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
MA29998A 2004-12-15 2007-06-18 Combinaisons d'agents therapeutiques destines a traiter le cancer MA29096B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63643904P 2004-12-15 2004-12-15

Publications (1)

Publication Number Publication Date
MA29096B1 true MA29096B1 (fr) 2007-12-03

Family

ID=36463409

Family Applications (1)

Application Number Title Priority Date Filing Date
MA29998A MA29096B1 (fr) 2004-12-15 2007-06-18 Combinaisons d'agents therapeutiques destines a traiter le cancer

Country Status (26)

Country Link
US (1) US8975248B2 (fr)
EP (1) EP1827437B1 (fr)
JP (1) JP5345323B2 (fr)
KR (1) KR101367516B1 (fr)
CN (1) CN101080227B (fr)
AT (1) ATE531371T1 (fr)
AU (1) AU2005316652B2 (fr)
BR (1) BRPI0515774A (fr)
CA (1) CA2589521C (fr)
CY (1) CY1112368T1 (fr)
DK (1) DK1827437T3 (fr)
ES (1) ES2374828T3 (fr)
HR (1) HRP20110960T1 (fr)
IL (1) IL183595A0 (fr)
MA (1) MA29096B1 (fr)
MX (1) MX2007007212A (fr)
NO (1) NO20073552L (fr)
NZ (1) NZ555370A (fr)
PL (1) PL1827437T3 (fr)
PT (1) PT1827437E (fr)
RU (1) RU2400232C2 (fr)
SI (1) SI1827437T1 (fr)
TN (1) TNSN07224A1 (fr)
TW (1) TW200628151A (fr)
WO (1) WO2006065780A2 (fr)
ZA (1) ZA200704701B (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1534340B1 (fr) 2002-09-06 2011-11-16 Cerulean Pharma Inc. Polymeres a base de cyclodextrine pour l'administration de medicaments lies par liaison covalente
KR101367516B1 (ko) 2004-12-15 2014-02-27 씨그마-토 인더스트리에 파마슈티체 리유니테 에스. 피. 에이. 암치료용 치료제의 조합물
US20080219977A1 (en) * 2005-07-27 2008-09-11 Isaiah Josh Fidler Combinations Comprising Gemcitabine and Tyrosine Kinase Inhibitors for the Treatment of Pancreatic Cancer
SI2275103T1 (sl) * 2005-11-21 2014-07-31 Novartis Ag mTor inhibitorji pri zdravljenju endokrinih tumorjev
WO2007094026A1 (fr) * 2006-02-17 2007-08-23 Paolo La Colla Traitement prophylactique et/ou thérapeutique de maladies prolifératives et conformationnelles
AU2007234379A1 (en) * 2006-04-05 2007-10-11 Novartis Ag. Combinations of therapeutic agents for treating cancer
CA2645633A1 (fr) 2006-04-05 2007-11-01 Novartis Ag Combinaisons d'agents therapeutiques pour traiter un cancer
RU2452492C2 (ru) * 2006-04-05 2012-06-10 Новартис Аг КОМБИНАЦИИ, ВКЛЮЧАЮЩИЕ ИНГИБИТОРЫ Bcr-Abl/c-Kit/PDGF-R TK, ДЛЯ ЛЕЧЕНИЯ РАКА
JP2010516625A (ja) 2007-01-24 2010-05-20 インサート セラピューティクス， インコーポレイテッド 制御された薬物送達のためのテザー基を有するポリマー−薬物コンジュゲート
EP2060565A1 (fr) * 2007-11-16 2009-05-20 4Sc Ag Nouveaux composés bifonctionnels inhibiteurs de protéine kinases et d'histone deacetylases
WO2009117669A2 (fr) 2008-03-21 2009-09-24 The University Of Chicago Traitement avec des antagonistes des opioïdes et des inhibiteurs mtor
CN101837129B (zh) * 2009-03-19 2012-12-12 鼎泓国际投资（香港）有限公司 含cMet抑制剂、HDAC抑制剂与EGFR酪氨酸激酶抑制剂的药物组合物及其应用
US20120114658A1 (en) * 2009-09-15 2012-05-10 John Ryan Treatment of cancer
WO2011133479A2 (fr) * 2010-04-19 2011-10-27 Niiki Pharma Inc. Polythérapie avec un inhibiteur du protéasome et un complexe de gallium
ES2790414T3 (es) 2010-11-12 2020-10-27 Pharma Mar Sa Terapia de combinación con un inhibidor de topoisomerasa
CN102731516B (zh) * 2011-04-07 2014-07-02 宁波天衡药业股份有限公司 一类具有抗肿瘤活性的喜树碱衍生物
WO2014055493A1 (fr) 2012-10-02 2014-04-10 Cerulean Pharma Inc. Procédés et systèmes s'appliquant à la précipitation de polymères et à la génération de particules
WO2015154064A2 (fr) 2014-04-04 2015-10-08 Del Mar Pharmaceuticals Utilisation de dianhydrogalactitol et de leurs analogues ou dérivés dans le traitement du carcinome non à petites cellules des poumons et du cancer des ovaires
RU2693463C2 (ru) * 2014-04-04 2019-07-03 Тайхо Фармасьютикал Ко., Лтд. Противоопухолевое средство, содержащее таксановое соединение и усилитель противоопухолевого эффекта
WO2016201481A1 (fr) 2015-06-15 2016-12-22 Newsouth Innovations Pty Limited Combinaisons pharmaceutiques de composés d'organo-arsénoxyde et inhibiteurs de mtor
CN107951888A (zh) * 2017-12-19 2018-04-24 天津科技大学 阿法替尼与10-羟基喜树碱的药物组合及其应用
CN109091480A (zh) * 2018-09-19 2018-12-28 天津科技大学 癌组合物10-羟基喜树碱和克唑替尼治疗肺癌及用途
EP3903828A4 (fr) * 2018-12-21 2022-10-05 Daiichi Sankyo Company, Limited Combinaison d'un conjugué anticorps-médicament et d'un inhibiteur de kinase
CN111789903A (zh) * 2019-04-08 2020-10-20 石小和 治疗尿道癌的药物组合物及其制备方法
CN115814076A (zh) * 2021-07-01 2023-03-21 江苏先声药业有限公司 抗人vegf抗体与化药联用在制备治疗卵巢癌的药物中的应用
WO2023165603A1 (fr) * 2022-03-03 2023-09-07 Zai Lab (Shanghai) Co., Ltd. Inhibiteur d'adn-pk et son utilisation en combinaison

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2206478T3 (es) 1994-11-11 2004-05-16 Debiopharm S.A. Composiciones carcinostaticas que contienen cis-oxaliplatino y otra u otras sustancias carcinostaticas compatibles.
JPH08169825A (ja) * 1994-12-15 1996-07-02 Tanaka Kikinzoku Kogyo Kk 抗癌剤の併用投与方法及び併用可能な抗癌剤
US20020103141A1 (en) 1998-12-23 2002-08-01 Mckearn John P. Antiangiogenic combination therapy for the treatment of cancer
US7105492B2 (en) * 1999-03-09 2006-09-12 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Camptothecin derivatives having antitumor activity
ATE216998T1 (de) * 1999-03-09 2002-05-15 Sigma Tau Ind Farmaceuti Camptothecin-derivate mit antitumor-wirkung
GB0119249D0 (en) * 2001-08-07 2001-10-03 Novartis Ag Organic compounds
US20050038048A1 (en) 2001-10-29 2005-02-17 Ball Howard Ashley Use of 7h-pyrrollo{2,3-d}pyrimidine derivatives in the treatment of solid tumor diseases
US7323479B2 (en) 2002-05-17 2008-01-29 Celgene Corporation Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline
CA2492059A1 (fr) * 2002-07-11 2004-01-22 Combinatorx, Incorporated Association de medicaments pour le traitement de tumeurs
WO2004103358A2 (fr) 2003-05-21 2004-12-02 Novartis Ag Combinaison d'inhibiteurs d'histone deacetylase avec des agents chimiotherapeutiques
JP2008501677A (ja) * 2004-06-04 2008-01-24 ファイザー・プロダクツ・インク 異常な細胞増殖を治療する方法
KR101367516B1 (ko) 2004-12-15 2014-02-27 씨그마-토 인더스트리에 파마슈티체 리유니테 에스. 피. 에이. 암치료용 치료제의 조합물
JP4702322B2 (ja) 2006-12-14 2011-06-15 トヨタ自動車株式会社 内燃機関の制御装置

Also Published As

Publication number Publication date
PT1827437E (pt) 2012-01-12
HRP20110960T1 (hr) 2012-01-31
CY1112368T1 (el) 2015-12-09
DK1827437T3 (da) 2012-02-13
EP1827437A2 (fr) 2007-09-05
MX2007007212A (es) 2007-11-07
EP1827437B1 (fr) 2011-11-02
US8975248B2 (en) 2015-03-10
CN101080227B (zh) 2011-08-31
WO2006065780A2 (fr) 2006-06-22
PL1827437T3 (pl) 2013-06-28
JP5345323B2 (ja) 2013-11-20
ZA200704701B (en) 2008-09-25
TNSN07224A1 (en) 2008-11-21
AU2005316652A1 (en) 2006-06-22
WO2006065780A3 (fr) 2006-08-17
KR20070091286A (ko) 2007-09-10
JP2008524225A (ja) 2008-07-10
CA2589521A1 (fr) 2006-06-22
BRPI0515774A (pt) 2008-08-05
CA2589521C (fr) 2014-04-01
IL183595A0 (en) 2007-10-31
RU2007126978A (ru) 2009-01-27
US20100028338A1 (en) 2010-02-04
RU2400232C2 (ru) 2010-09-27
SI1827437T1 (sl) 2012-02-29
TW200628151A (en) 2006-08-16
CN101080227A (zh) 2007-11-28
AU2005316652B2 (en) 2009-07-23
ATE531371T1 (de) 2011-11-15
NZ555370A (en) 2010-03-26
NO20073552L (no) 2007-09-12
ES2374828T3 (es) 2012-02-22
KR101367516B1 (ko) 2014-02-27

Similar Documents

Publication Publication Date Title
MA29096B1 (fr) Combinaisons d'agents therapeutiques destines a traiter le cancer
MXPA06003163A (es) Combinacion de un inhibidor de receptor de vegf con un agente quimioterapeutico.
MXPA05013642A (es) Composicion de un antagonista de vegf y un agente antiproliferativo y su uso para el tratamiento de cancer.
JP2007523862A5 (fr)
RU2008152435A (ru) Композиции и способы регулирования развития сосудов
CY1115782T1 (el) Φαρμακευτικες συνθεσεις για θεραπεια καρκινου
NO20014560L (no) Quinasoliner og terapautisk anvendelse derav
MXPA02011913A (es) Triazolopirimidinas sustituidas como agentes anticancer.
TW200744636A (en) Combined treatment with and composition of 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitor and anti-cancer agents
EA200801309A1 (ru) ВВЕДЕНИЕ ИНГИБИТОРА mTOR ДЛЯ ЛЕЧЕНИЯ ПАЦИЕНТОВ СО ЗЛОКАЧЕСТВЕННОЙ ОПУХОЛЬЮ
BG108072A (en) The use of epothilone derivatives for the treatment of refractory tumors
Wei et al. Effect of captopril on radiation-induced TGF-β1 secretion in EA. Hy926 human umbilical vein endothelial cells
DE60320398D1 (de) Methoden und medizinische zusammensetzungen zur intravesikalen behandlung von blasenkrebs
JP2014144979A (ja) 治療におけるアポトーシスを増加させるための有糸分裂の阻害剤
JP2008516921A (ja) 多剤耐性の治療および予防
MX2019010732A (es) Uso de moduladores de receptor de glucocorticoide en el tratamiento de tumores secretores de catecolamina.
ATE381930T1 (de) Kombinationsmedikationen mit einem selektiven cyclooxygenase-2-inhibitor
Dougherty et al. Photoradiation therapy of human tumors
AR063459A1 (es) Metodo para administrar un inhibidor de aurora en el tratamiento del cancer
BR0308976A (pt) Terapia combinada contra tumores compreendendo derivados de acriloil distamicina substituìda e radioterapia
RU99126204A (ru) Способ лечения рака легкого
EA202092513A1 (ru) Комбинированная терапия
DK1687642T3 (da) Screeningsfremgangsmåder til kombinationer af biologiske forbindelser
RU2004101687A (ru) Способ лечения рака предстательной железы
TW200503798A (en) Arsenic-containing pharmaceutical composition for treatment of tumor/cancer in conjunction with radiation therapy