HRP20110883T1 - Postupak za pripremanje raspršivanjem osušenih formulacija tmc125 - Google Patents
Postupak za pripremanje raspršivanjem osušenih formulacija tmc125 Download PDFInfo
- Publication number
- HRP20110883T1 HRP20110883T1 HR20110883T HRP20110883T HRP20110883T1 HR P20110883 T1 HRP20110883 T1 HR P20110883T1 HR 20110883 T HR20110883 T HR 20110883T HR P20110883 T HRP20110883 T HR P20110883T HR P20110883 T1 HRP20110883 T1 HR P20110883T1
- Authority
- HR
- Croatia
- Prior art keywords
- tmc125
- polymer
- microcrystalline cellulose
- weight ratio
- powder
- Prior art date
Links
- PYGWGZALEOIKDF-UHFFFAOYSA-N etravirine Chemical compound CC1=CC(C#N)=CC(C)=C1OC1=NC(NC=2C=CC(=CC=2)C#N)=NC(N)=C1Br PYGWGZALEOIKDF-UHFFFAOYSA-N 0.000 title claims abstract 11
- 229960002049 etravirine Drugs 0.000 title claims 10
- 239000000203 mixture Substances 0.000 title claims 4
- 238000004519 manufacturing process Methods 0.000 title claims 2
- 238000009472 formulation Methods 0.000 title 1
- 239000007921 spray Substances 0.000 title 1
- 238000000034 method Methods 0.000 claims abstract 15
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims abstract 7
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims abstract 7
- 239000008108 microcrystalline cellulose Substances 0.000 claims abstract 7
- 229940016286 microcrystalline cellulose Drugs 0.000 claims abstract 7
- 239000000843 powder Substances 0.000 claims abstract 5
- 229920003169 water-soluble polymer Polymers 0.000 claims abstract 4
- 239000007962 solid dispersion Substances 0.000 claims abstract 3
- 150000001875 compounds Chemical class 0.000 claims abstract 2
- 229920000642 polymer Polymers 0.000 claims 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- 239000002245 particle Substances 0.000 claims 3
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical group OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 238000001694 spray drying Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000007909 solid dosage form Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 230000036436 anti-hiv Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06115029 | 2006-06-06 | ||
PCT/EP2007/055607 WO2007141308A1 (en) | 2006-06-06 | 2007-06-06 | Process for preparing spray dried formulations of tmc125 |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20110883T1 true HRP20110883T1 (hr) | 2012-01-31 |
Family
ID=37179187
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20110883T HRP20110883T1 (hr) | 2006-06-06 | 2011-11-28 | Postupak za pripremanje raspršivanjem osušenih formulacija tmc125 |
Country Status (27)
Country | Link |
---|---|
US (2) | US20090197903A1 (pt) |
EP (1) | EP2029110B1 (pt) |
JP (1) | JP5089685B2 (pt) |
KR (1) | KR101179905B1 (pt) |
CN (1) | CN101453989B (pt) |
AT (1) | ATE522202T1 (pt) |
AU (1) | AU2007255418C1 (pt) |
BR (1) | BRPI0712346B8 (pt) |
CA (1) | CA2651665C (pt) |
CY (1) | CY1112154T1 (pt) |
DK (1) | DK2029110T3 (pt) |
EC (1) | ECSP088938A (pt) |
ES (1) | ES2372983T3 (pt) |
HK (1) | HK1129579A1 (pt) |
HR (1) | HRP20110883T1 (pt) |
IL (1) | IL195710A (pt) |
ME (1) | ME01305B (pt) |
MX (1) | MX2008015686A (pt) |
NO (1) | NO343652B1 (pt) |
NZ (1) | NZ572702A (pt) |
PL (1) | PL2029110T3 (pt) |
PT (1) | PT2029110E (pt) |
RS (1) | RS52053B (pt) |
RU (1) | RU2406502C2 (pt) |
SI (1) | SI2029110T1 (pt) |
WO (1) | WO2007141308A1 (pt) |
ZA (1) | ZA200810345B (pt) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR065720A1 (es) | 2007-03-14 | 2009-06-24 | Tibotec Pharm Ltd | Polvos para reconstitucion que comprenden rilpivirina dispersos en ciertos polimeros. uso. proceso. |
US9050326B2 (en) | 2008-04-02 | 2015-06-09 | Astellas Pharma Inc. | Amido derivatives-contained pharmaceutical composition |
WO2010006697A2 (en) * | 2008-06-30 | 2010-01-21 | Tibotec Pharmaceuticals | Powders for reconstitution |
US8703786B2 (en) * | 2011-12-07 | 2014-04-22 | Texas Southern University | Etravirine formulations and uses thereof |
EP2911651B1 (en) * | 2012-09-27 | 2016-06-22 | Basf Se | A storage-stable dust-free homogeneous particulate formulation comprising at least one water-soluble vitamin e-derivative and at least one hydrophilic polymer |
CN112105680A (zh) * | 2018-05-11 | 2020-12-18 | 株式会社三养社 | 固体分散体、其制备方法、使用其的扩链聚氨酯和包含其的环氧树脂组合物 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2920956B2 (ja) * | 1989-10-06 | 1999-07-19 | 藤沢薬品工業株式会社 | ニルバジピン含有持続性錠剤 |
US6395303B1 (en) | 1996-06-10 | 2002-05-28 | Edward Mendell Co., Inc. | Process for preparing a directly compressible solid dosage form containing microcrystalline cellulose |
JPH107558A (ja) * | 1996-06-19 | 1998-01-13 | Eisai Co Ltd | 溶解性改善製剤 |
SK287270B6 (sk) | 1998-11-10 | 2010-05-07 | Janssen Pharmaceutica N. V. | Derivát pyrimidínu |
ATE400252T1 (de) * | 1999-02-10 | 2008-07-15 | Pfizer Prod Inc | Pharmazeutische feste dispersionen |
DE19945982A1 (de) | 1999-09-24 | 2001-03-29 | Knoll Ag | Geschwindigkeitsbestimmte Partikel |
NZ517025A (en) * | 1999-09-24 | 2003-07-25 | Janssen Pharmaceutica Nv | Antiviral compositions |
US6531158B1 (en) * | 2000-08-09 | 2003-03-11 | Impax Laboratories, Inc. | Drug delivery system for enhanced bioavailability of hydrophobic active ingredients |
CN1787808A (zh) * | 2002-02-01 | 2006-06-14 | 辉瑞产品公司 | 应用压力喷嘴制备均匀的喷雾干燥固态无定形药物分散体的方法 |
WO2004050068A1 (en) * | 2002-11-29 | 2004-06-17 | Janssen Pharmaceutica N.V. | Pharmaceutical compositions comprising a basic respectively acidic drug compound, a surfactant and a physiologically tolerable water-soluble acid respectively base |
DE60311875T2 (de) * | 2002-12-19 | 2007-08-30 | Pharmacia Corp. | Nicht-hygroskopische formulierung, die einen hygroskopischen wirkstoff enthält |
CN1822843B (zh) * | 2003-07-17 | 2010-04-28 | 泰博特克药品有限公司 | 制备含有抗病毒药物颗粒的方法 |
JP2007513937A (ja) * | 2003-12-09 | 2007-05-31 | ファイザー インコーポレイテッド | Hivプロテアーゼ阻害剤を含む組成物 |
-
2007
- 2007-06-06 EP EP07729974A patent/EP2029110B1/en active Active
- 2007-06-06 RU RU2008152411/15A patent/RU2406502C2/ru active
- 2007-06-06 BR BRPI0712346A patent/BRPI0712346B8/pt active IP Right Grant
- 2007-06-06 PL PL07729974T patent/PL2029110T3/pl unknown
- 2007-06-06 DK DK07729974.1T patent/DK2029110T3/da active
- 2007-06-06 CA CA2651665A patent/CA2651665C/en active Active
- 2007-06-06 ME MEP-2011-187A patent/ME01305B/me unknown
- 2007-06-06 KR KR1020087029032A patent/KR101179905B1/ko active IP Right Grant
- 2007-06-06 RS RS20110527A patent/RS52053B/en unknown
- 2007-06-06 US US12/302,366 patent/US20090197903A1/en not_active Abandoned
- 2007-06-06 NZ NZ572702A patent/NZ572702A/en unknown
- 2007-06-06 WO PCT/EP2007/055607 patent/WO2007141308A1/en active Application Filing
- 2007-06-06 PT PT07729974T patent/PT2029110E/pt unknown
- 2007-06-06 SI SI200730770T patent/SI2029110T1/sl unknown
- 2007-06-06 AT AT07729974T patent/ATE522202T1/de active
- 2007-06-06 AU AU2007255418A patent/AU2007255418C1/en active Active
- 2007-06-06 JP JP2009513696A patent/JP5089685B2/ja active Active
- 2007-06-06 CN CN2007800197802A patent/CN101453989B/zh active Active
- 2007-06-06 ES ES07729974T patent/ES2372983T3/es active Active
- 2007-06-06 MX MX2008015686A patent/MX2008015686A/es active IP Right Grant
-
2008
- 2008-12-03 EC EC2008008938A patent/ECSP088938A/es unknown
- 2008-12-04 IL IL195710A patent/IL195710A/en active IP Right Grant
- 2008-12-05 ZA ZA2008/10345A patent/ZA200810345B/en unknown
-
2009
- 2009-01-06 NO NO20090061A patent/NO343652B1/no unknown
- 2009-08-24 HK HK09107764.0A patent/HK1129579A1/xx unknown
-
2011
- 2011-11-28 HR HR20110883T patent/HRP20110883T1/hr unknown
- 2011-11-30 CY CY20111101185T patent/CY1112154T1/el unknown
-
2012
- 2012-02-16 US US13/398,400 patent/US9603803B2/en active Active
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